The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mammalian Homolog of Drosophila Tumor Suppressor Lethal (2) Giant Larvae Interacts with Basolateral Exocytic Machinery in Madin-Darby Canine Kidney Cells
Open accessAbstract
The Drosophila tumor suppressor protein lethal (2) giant larvae [l(2)gl] is involved in the establishment of epithelial cell polarity during development. Recently, a yeast homolog of the protein has been shown to interact with components of the post-Golgi exocytic machinery and to regulate a late step in protein secretion. Herein, we characterize a mammalian homolog of l(2)gl, called Mlgl, in the epithelial cell line Madin-Darby canine kidney (MDCK). Consistent with a role in cell polarity, Mlgl redistributes from a cytoplasmic localization to the lateral membrane after contact-naive MDCK cells make cell-cell contacts and establish a polarized phenotype. Phosphorylation within a highly conserved region of Mlgl is required to restrict the protein to the lateral domain, because a recombinant phospho-mutant is distributed in a nonpolar manner. Membrane-bound Mlgl from MDCK cell lysates was coimmunoprecipitated with syntaxin 4, a component of the exocytic machinery at the basolateral membrane, but not with other plasma membrane solubleN-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins that are either absent from or not restricted to the basolateral membrane domain. These data suggest that Mlgl contributes to apico-basolateral polarity by regulating basolateral exocytosis.
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Cites
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417
Gateff, E. (1978) · Science · doi:10.1126/science.96525 · Cited by 461 · cited 2×
“In concert with the PDZ-proteins scribble and dlg, l(2)gl contributes to the correct targeting of apical determinants for epithelial cell polarity and mutations in l(2)gl lead to a loss of monolayer organization and the formation of epithelial-derived tumors (Gateff, 1978; Bilder et al., 2000).”
Cited by
Adaptation of core mechanisms to generate cell polarity
Nelson, W. J. (2003) · Nature · doi:10.1038/nature01602 · Cited by 716
Self-citationOrganization of vesicular trafficking in epithelia
Rodriguez-Boulan, E., Kreitzer, G., & Müsch, A. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1593 · Cited by 574
Self-citationPKC and the control of localized signal dynamics
Rosse, C., Linch, M., Kermorgant, S., Cameron, A. J. M., Boeckeler, K., & Parker, P. J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2847 · Cited by 477
Assémat, E., Bazellières, E., Pallesi-Pocachard, E., Le Bivic, A., & Massey-Harroche, D. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.029 · Cited by 470
Dare to Be Different: Asymmetric Cell Division in Drosophila, C. elegans and Vertebrates
Betschinger, J., & Knoblich, J. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.017 · Cited by 448
Metadata
- Authors
- Mu∸sch, A., Cohen, D., Yeaman, C., Nelson, W. J., Rodriguez-Boulan, E., & Brennwald, P. J.
- Venue
- Molecular Biology of the Cell
- Published
- 2002-01
- Volume
- 13
- Issue
- 1
- Pages
- 158-168
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2157488888
- Cited by
- 186
- References
- 2
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Mu∸sch, A., Cohen, D., Yeaman, C., Nelson, W. J., Rodriguez-Boulan, E., & Brennwald, P. J. (2002). Mammalian Homolog of Drosophila Tumor Suppressor Lethal (2) Giant Larvae Interacts with Basolateral Exocytic Machinery in Madin-Darby Canine Kidney Cells. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.01-10-0496
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