The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Convergence of Non-clathrin- and Clathrin-derived Endosomes Involves Arf6 Inactivation and Changes in Phosphoinositides
Open accessAbstract
The trafficking of two plasma membrane (PM) proteins that lack clathrin internalization sequences, major histocompatibility complex class I (MHCI), and interleukin 2 receptor α subunit (Tac) was compared with that of PM proteins internalized via clathrin. MHCI and Tac were internalized into endosomes that were distinct from those containing clathrin cargo. At later times, a fraction of these internalized membranes were observed in Arf6-associated, tubular recycling endosomes whereas another fraction acquired early endosomal autoantigen 1 (EEA1) before fusion with the “classical” early endosomes containing the clathrin-dependent cargo, LDL. After convergence, cargo molecules from both pathways eventually arrived, in a Rab7-dependent manner, at late endosomes and were degraded. Expression of a constitutively active mutant of Arf6, Q67L, caused MHCI and Tac to accumulate in enlarged PIP 2-enriched vacuoles, devoid of EEA1 and inhibited their fusion with clathrin cargo-containing endosomes and hence blocked degradation. By contrast, trafficking and degradation of clathrin-cargo was not affected. A similar block in transport of MHCI and Tac was reversibly induced by a PI3-kinase inhibitor, implying that inactivation of Arf6 and acquisition of PI3P are required for convergence of endosomes arising from these two pathways.
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Vlahos, C. J., Matter, W. F., Hui, K. Y., & Brown, R. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37680-9 · Cited by 3,240
Brown, D. A., & Rose, J. K. (1992) · Cell · doi:10.1016/0092-8674(92)90189-j · Cited by 2,921
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
Simonsen, A., Lippe, R., Christoforidis, S., Gaullier, J.-M., Brech, A., Callaghan, J., Toh, B.-H., Murphy, C., Zerial, M., & Stenmark, H. (1998) · Nature · doi:10.1038/28879 · Cited by 1,133
Rab7: A Key to Lysosome Biogenesis
Bucci, C., Thomsen, P., Nicoziani, P., McCarthy, J., & van Deurs, B. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.2.467 · Cited by 1,085
Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.
Stenmark, H., Parton, R. G., Steele‐Mortimer, O., Lütcke, A., Gruenberg, J., & Zerial, M. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06381.x · Cited by 968
Várnai, P., & Balla, T. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.501 · Cited by 859
Molecular cloning and expression of cDNAs for the human interleukin-2 receptor
Leonard, W. J., Depper, J. M., Crabtree, G. R., Rudikoff, S., Pumphrey, J., Robb, R. J., Krönke, M., Svetlik, P. B., Peffer, N. J., Waldmann, T. A., et al. (1984) · Nature · doi:10.1038/311626a0 · Cited by 850
The endocytic pathway: a mosaic of domains
Gruenberg, J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096054 · Cited by 702
Rab 7: an important regulator of late endocytic membrane traffic.
Feng, Y., Press, B., & Wandinger-Ness, A. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.6.1435 · Cited by 638
Letourneur, F., & Klausner, R. D. (1992) · Cell · doi:10.1016/0092-8674(92)90636-q · Cited by 536
Cited by
Maxfield, F. R., & McGraw, T. E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1315 · Cited by 1,729
Pathways and mechanisms of endocytic recycling
Grant, B. D., & Donaldson, J. G. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2755 · Cited by 1,424
Self-citationARF proteins: roles in membrane traffic and beyond
D'Souza-Schorey, C., & Chavrier, P. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1910 · Cited by 1,378
Regulation of Receptor Trafficking by GRKs and Arrestins
Moore, C. A. C., Milano, S. K., & Benovic, J. L. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.022405.154712 · Cited by 676
Endocytosis unplugged: Multiple ways to enter the cell
Kumari, S., MG, S., & Mayor, S. (2010) · Cell Research · doi:10.1038/cr.2010.19 · Cited by 599
Metadata
- Authors
- Naslavsky, N., Weigert, R., & Donaldson, J. G.
- Venue
- Molecular Biology of the Cell
- Published
- 2003-02
- Volume
- 14
- Issue
- 2
- Pages
- 417-431
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W1996453362
- Cited by
- 278
- References
- 39
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Naslavsky, N., Weigert, R., & Donaldson, J. G. (2003). Convergence of Non-clathrin- and Clathrin-derived Endosomes Involves Arf6 Inactivation and Changes in Phosphoinositides. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.02-04-0053
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