The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Telomerase regulation during entry into the cell cycle in normal human T cells.
Open accessAbstract
Telomerase activity is involved in telomere length maintenance. Leukocytes, unlike many human somatic tissues, have detectable telomerase activity. These cells provide a normal human cell type in which to study telomerase. We studied the regulation of telomerase activity and the telomerase RNA component as leukocytes were stimulated to enter the cell cycle. In primary human leukocytes stimulated with phytohemagglutinin, telomerase activity increased > 10-fold as naturally quiescent cells entered the cell cycle. Antibodies to the T cell receptor (TCR)/CD3 complex and the costimulatory CD28 receptor induced telomerase activity in a T cell-enriched population of cells. Rapamycin, an immunosuppressant that blocks TCR/CD3 signal transduction pathways and cdk2 activation, blocked telomerase induction. Hydroxyurea, an inhibitor of S phase, did not block cdk2 kinase activity or telomerase activation. In summary, telomerase is regulated in G1 phase as normal human T cells enter the cell cycle.
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Cites
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Cited by
Essential role of mouse telomerase in highly proliferative organs
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Self-citationHuman Telomerase and Its Regulation
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The rate of telomere sequence loss in human leukocytes varies with age
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TIN2, a new regulator of telomere length in human cells
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Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
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Metadata
- Authors
- Buchkovich, K. J., & Greider, C. W.
- Venue
- Molecular Biology of the Cell
- Published
- 1996-09
- Volume
- 7
- Issue
- 9
- Pages
- 1443-1454
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W1969956511
- Cited by
- 198
- References
- 15
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Buchkovich, K. J., & Greider, C. W. (1996). Telomerase regulation during entry into the cell cycle in normal human T cells. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.7.9.1443
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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