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Caveolae Are a Novel Pathway for Membrane-Type 1 Matrix Metalloproteinase Traffic in Human Endothelial Cells
Open accessAbstract
The extracellular matrix (ECM) distinctly modulates membrane type 1-matrix metalloproteinase (MT1-MMP) in human endothelial cells (ECs). Herein, ECM-dependent RhoA activation is shown to regulate MT1-MMP localization and activity as well as clathrin-independent internalization in confluent ECs. In this regard, caveolae are revealed as the major MT1-MMP endocytic pathway in human ECs. Thus, MT1-MMP is present at caveolae with caveolin-1 and both proteins together with αvβ3 integrin colocalize at endothelial motility-associated extensions. Remarkably, caveolae traffic is required for proper MT1-MMP localization, activity, and function in migratory ECs as demonstrated by both treatment with caveolae-disrupting agents or selective targeting caveolin-1 expression by interference RNA. Thus, caveolae-mediated traffic constitutes a novel mechanism for MT1-MMP regulation in ECs during angiogenesis.
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Cited by
Caveolin-1 in oncogenic transformation, cancer, and metastasis
Williams, T. M., & Lisanti, M. P. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00458.2004 · Cited by 511
Integrins: masters and slaves of endocytic transport
Caswell, P. T., Vadrevu, S., & Norman, J. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2799 · Cited by 460
Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead
van Hinsbergh, V. W. M., & Koolwijk, P. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvm102 · Cited by 420
Multifunctional intracellular matrix metalloproteinases: implications in disease
Bassiouni, W., Ali, M. A. M., & Schulz, R. (2021) · The FEBS Journal · doi:10.1111/febs.15701 · Cited by 377
Cauwe, B., & Opdenakker, G. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2010.501783 · Cited by 299
Metadata
- Authors
- Gálvez, B. G., Matías-Román, S., Yáñez-Mó, M., Vicente-Manzanares, M., Sánchez-Madrid, F., & Arroyo, A. G.
- Venue
- Molecular Biology of the Cell
- Published
- 2004-02
- Volume
- 15
- Issue
- 2
- Pages
- 678-687
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2083308488
- Cited by
- 180
- References
- 0
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Caveolae Are a Novel Pathway for Membrane-Type 1 Matrix Metalloproteinase Traffic in Human Endothelial Cells. https://app.cochat.ai/papers/10.1091/mbc.e03-07-0516
- The paper
- Gálvez, B. G., Matías-Román, S., Yáñez-Mó, M., Vicente-Manzanares, M., Sánchez-Madrid, F., & Arroyo, A. G. (2004). Caveolae Are a Novel Pathway for Membrane-Type 1 Matrix Metalloproteinase Traffic in Human Endothelial Cells. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e03-07-0516
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