The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Caveolin-1 in oncogenic transformation, cancer, and metastasis
Abstract
Caveolae are 50- to 100-nm omega-shaped invaginations of the plasma membrane that function as regulators of signal transduction. Caveolins are a class of oligomeric structural proteins that are both necessary and sufficient for caveolae formation. Interestingly, caveolin-1 has been implicated in the pathogenesis of oncogenic cell transformation, tumorigenesis, and metastasis. Here, we review the available experimental evidence (gleaned from cultured cells, animal models, and human tumor samples) that caveolin-1 (Cav-1) functions as a “tumor and/or metastasis modifier gene.” Genetic evidence from the study of Cav-1(−/−) null mice and human breast cancer mutations [CAV-1 (P132L)] supports the idea that caveolin-1 normally functions as a negative regulator of cell transformation and mammary tumorigenesis. In contrast, caveolin-1 may function as a tumor promoter in prostate cancers. We discuss possible molecular mechanisms to explain these intriguing, seemingly opposing, findings. More specifically, caveolin-1 phosphorylation (at Tyr14 and Ser80) and mutations (P132L) may override or inactivate the growth inhibitory activity of the caveolin-scaffolding domain (residues 82–101).
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Cites
Caveolin, a protein component of caveolae membrane coats
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Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
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Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities
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Self-citationCaveolae: From Cell Biology to Animal Physiology
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Self-citationIdentification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain
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Self-citationDissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin
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The multiple faces of caveolae
Parton, R. G., & Simons, K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2122 · Cited by 1,454
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Life history of eNOS: partners and pathways
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Metadata
- Authors
- Williams, T. M., & Lisanti, M. P.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2005-03
- Volume
- 288
- Issue
- 3
- Pages
- C494-C506
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2172064884
- Cited by
- 511
- References
- 110
- FWCI
- 15.58
- Type
- journal article
- Language
- en
- Open access
- closed
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