The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx
Open accessAbstract
Signaling via the epidermal growth factor receptor (EGFR), which has critical roles in development and diseases such as cancer, is regulated by proteolytic shedding of its membrane-tethered ligands. Sheddases for EGFR-ligands are therefore key signaling switches in the EGFR pathway. Here, we determined which ADAMs (a disintegrin and metalloprotease) can shed various EGFR-ligands, and we analyzed the regulation of EGFR-ligand shedding by two commonly used stimuli, phorbol esters and calcium influx. Phorbol esters predominantly activate ADAM17, thereby triggering a burst of shedding of EGFR-ligands from a late secretory pathway compartment. Calcium influx stimulates ADAM10, requiring its cytoplasmic domain. However, calcium influx-stimulated shedding of transforming growth factor α and amphiregulin does not require ADAM17, even though ADAM17 is essential for phorbol ester-stimulated shedding of these EGFR-ligands. This study provides new insight into the machinery responsible for EGFR-ligand release and thus EGFR signaling and demonstrates that dysregulated EGFR-ligand shedding may be caused by increased expression of constitutively active sheddases or activation of different sheddases by distinct stimuli.
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ADAMs: key components in EGFR signalling and development
Blobel, C. P. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1548 · Cited by 1,090
Self-citationDistinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
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Self-citationMEMBRANE-ANCHORED GROWTH FACTORS
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Cited by
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The ADAMs: signalling scissors in the tumour microenvironment
Murphy, G. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2459 · Cited by 451
Self-citationDulauroy, S., Di Carlo, S. E., Langa, F., Eberl, G., & Peduto, L. (2012) · Nature Medicine · doi:10.1038/nm.2848 · Cited by 418
Tumor-Associated MICA Is Shed by ADAM Proteases
Waldhauer, I., Goehlsdorf, D., Gieseke, F., Weinschenk, T., Wittenbrink, M., Ludwig, A., Stevanovic, S., Rammensee, H.-G., & Steinle, A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6768 · Cited by 375
In search of partners: linking extracellular proteases to substrates
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Metadata
- Authors
- Horiuchi, K., Le Gall, S., Schulte, M., Yamaguchi, T., Reiss, K., Murphy, G., Toyama, Y., Hartmann, D., Saftig, P., & Blobel, C. P.
- Venue
- Molecular Biology of the Cell
- Published
- 2007-01
- Volume
- 18
- Issue
- 1
- Pages
- 176-188
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2129033989
- Cited by
- 310
- References
- 42
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Horiuchi, K., Le Gall, S., Schulte, M., Yamaguchi, T., Reiss, K., Murphy, G., Toyama, Y., Hartmann, D., Saftig, P., & Blobel, C. P. (2007). Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e06-01-0014
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