The discovery of receptor tyrosine kinases: targets for cancer therapy

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ <i>neu</i> Oncogene

Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., & McGuire, W. L. (1987) · Science · doi:10.1126/science.3798106 · Cited by 11,760 · see citing works

Tumor angiogenesis: therapeutic implications

Sherwood, L. M., Parris, E. E., & Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197111182852108 · Cited by 10,187 · see citing works

TGF-β SIGNAL TRANSDUCTION

Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571 · see citing works

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

Slamon, D. J., Godolphin, W. J., Jones, L. A., Holt, J. A., Wong, S., Keith, D. E., Levin, W. J., Stuart, S. G., Udove, J. A., Ullrich, A., et al. (1989) · Science · doi:10.1126/science.2470152 · Cited by 6,817 · see citing works

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

Marshall, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90401-8 · Cited by 4,557 · see citing works

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,114 · see citing works

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931 · see citing works

Oncogenic kinase signalling.

Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738 · see citing works

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O’Shea, K. S., Powell-Braxton, L., Hillan, K. J., & Moore, M. W. (1996) · Nature · doi:10.1038/380439a0 · Cited by 3,624 · see citing works

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

Druker, B. J., Tamura, S., Buchdunger, E., Ohno-Jones, S., Segal, G. M., Fanning, S., Zimmermann, J., & Lydon, N. (1996) · Nature Medicine · doi:10.1038/nm0596-561 · Cited by 3,618 · see citing works

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., & Ferrara, N. (1993) · Nature · doi:10.1038/362841a0 · Cited by 3,605 · see citing works

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149 · see citing works

Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification

Gorre, M. E., Mohammed, M., Ellwood, K., Hsu, N., Paquette, R., Rao, P. N., & Sawyers, C. L. (2001) · Science · doi:10.1126/science.1062538 · Cited by 3,104 · see citing works

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

Ullrich, A., Coussens, L. M., Hayflick, J. S., Dull, T. J., Gray, A., Tam, A. W., Lee, J., Yarden, Y., Libermann, T. A., Schlessinger, J., et al. (1984) · Nature · doi:10.1038/309418a0 · Cited by 2,751 · see citing works

Transplacental Carcinogenesis by Stilbestrol

Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197108122850711 · Cited by 2,640 · see citing works

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

Fong, G.-H., Rossant, J., Gertsenstein, M., & Breitman, M. L. (1995) · Nature · doi:10.1038/376066a0 · Cited by 2,606 · see citing works

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

Downward, J., Yarden, Y., Mayes, E., Scrace, G., Totty, N., Stockwell, P., Ullrich, A., Schlessinger, J., & Waterfield, M. D. (1984) · Nature · doi:10.1038/307521a0 · Cited by 2,516 · see citing works

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

Hunter, T. R., & Sefton, B. M. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1311 · Cited by 2,333 · see citing works

Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor

Heinrich, M. C., Corless, C. L., Demetri, G. D., Blanke, C. D., von Mehren, M., Joensuu, H., McGreevey, L. S., Chen, C.-J., den Abbeele, A. D. V., Druker, B. J., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.04.190 · Cited by 2,297 · see citing works

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

Ullrich, A., Bell, J. R., Chen, E. Y., Herrera, R., Petruzzelli, L., Dull, T. J., Gray, A., Coussens, L. M., Liao, Y.-C., Tsubokawa, M., et al. (1985) · Nature · doi:10.1038/313756a0 · Cited by 2,251 · see citing works

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

Cohen, S. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83739-0 · Cited by 2,202 · see citing works

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Science · doi:10.1126/science.8140422 · Cited by 2,070 · see citing works

Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor

Joensuu, H., Roberts‎, P., Sarlomo‐Rikala, M., Andersson, L. C., Tervahartiala, P. O., Tuveson, D. A., Silberman, S., Capdeville, R., Dimitrijević, S., Druker, B. J., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104053441404 · Cited by 2,030 · see citing works

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

de Vries, C. J. M., Escobedo, J. A., Ueno, H., Houck, K. A., Ferrara, N., & Williams, L. T. (1992) · Science · doi:10.1126/science.1312256 · Cited by 2,019 · see citing works

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Franke, T. F., Yang, S., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., & Tsichlis, P. N. (1995) · Cell · doi:10.1016/0092-8674(95)90534-0 · Cited by 2,006 · see citing works

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

Millauer, B., Wizigmann-Voos, S., Schnürch, H., Martínez, R., Møller, N. P. H., Risau, W., & Ullrich, A. (1993) · Cell · doi:10.1016/0092-8674(93)90573-9 · Cited by 1,925 · see citing works

Insulin‐like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

Ullrich, A., Gray, A., Tam, A. W., Yang‐Feng, T. L., Tsubokawa, M., Collins, C. M., Henzel, W. J., Bon, T. L., Kathuria, S., & Chen, E. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04528.x · Cited by 1,843 · see citing works

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

Coussens, L. M., Yang‐Feng, T. L., Liao, Y.-C., Chen, E., Gray, A., McGrath, J. P., Seeburg, P. H., Libermann, T. A., Schlessinger, J., Francke, U., et al. (1985) · Science · doi:10.1126/science.2999974 · Cited by 1,815 · see citing works

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

Lowenstein, E. J., Daly, R. J., Batzer, A., Li, W., Margolis, B. L., Lammers, R., Ullrich, A., Skolnik, E. Y., Bar‐Sagi, D., & Schlessinger, J. (1992) · Cell · doi:10.1016/0092-8674(92)90167-b · Cited by 1,632 · see citing works

An Essential Role for Ectodomain Shedding in Mammalian Development

Peschon, J. J., Slack, J. L., Reddy, P., Stocking, K. L., Sunnarborg, S. W., Lee, D. C., Russell, W. E., Castner, B. J., Johnson, R. S., Fitzner, J. N., et al. (1998) · Science · doi:10.1126/science.282.5392.1281 · Cited by 1,606 · see citing works

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

Presta, L. G., Chen, H., O'Connor, S. J., Chisholm, V., Meng, Y. G., KRUMMEN, L. A., Winkler, M., & Ferrara, N. (1997) · PubMed · Cited by 1,602 · see citing works

ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

Graus-Porta, D., Beerli, R. R., Daly, J. M., & Hynes, N. E. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1647 · Cited by 1,593 · see citing works

Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

Yarden, Y., Kuang, W.-J., Yang‐Feng, T. L., Coussens, L. M., Munemitsu, S. M., Dull, T. J., Chen, E., Schlessinger, J., Francke, U., & Ullrich, A. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02655.x · Cited by 1,573 · see citing works

VEGF and the quest for tumour angiogenesis factors

Ferrara, N. (2002) · Nature Reviews Cancer · doi:10.1038/nrc909 · Cited by 1,536 · see citing works

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

Terman, B. I., Dougher-Vermazen, M., Carrion, M. E., Dimitrov, D. S., Armellino, D. C., Gospodarowicz, D., & Böhlen, P. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90483-2 · Cited by 1,519 · see citing works

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

Prenzel, N., Zwick, E., Daub, H., Leserer, M., Abraham, R., Wallasch, C., & Ullrich, A. (1999) · Nature · doi:10.1038/47260 · Cited by 1,507 · see citing works

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

Ebina, Y., Ellis, L., Jarnagin, K., Edery, M., Gráf, L., Clauser, É., Ou, J. J., Masiarz, F. R., Kan, Y. W., Goldfine, I. D., et al. (1985) · Cell · doi:10.1016/0092-8674(85)90334-4 · Cited by 1,477 · see citing works

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

Daub, H., Weiß, F. U., Wallasch, C., & Ullrich, A. (1996) · Nature · doi:10.1038/379557a0 · Cited by 1,476 · see citing works

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U. F., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., et al. (1995) · Science · doi:10.1126/science.7618084 · Cited by 1,460 · see citing works

Requirement for neuregulin receptor erbB2 in neural and cardiac development

Lee, K., Simon, H. H., Chen, H., Bates, B., Hung, M., & Hauser, C. (1995) · Nature · doi:10.1038/378394a0 · Cited by 1,291 · see citing works

Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors

Buchdunger, E., Cioffi, C. L., Law, N. M., Stover, D. R., Ohno-Jones, S., Druker, B. J., & Lydon, N. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38879-2 · Cited by 1,272 · see citing works

Rat Insulin Genes: Construction of Plasmids Containing the Coding Sequences

Ullrich, A., Shine, J., Chirgwin, J. M., PICTET, R. L., Tischer, E., Rutter, W. J., & Goodman, H. M. (1977) · Science · doi:10.1126/science.325648 · Cited by 1,239 · see citing works

Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains

Ogiso, H., Ishitani, R., Nureki, O., Fukai, S., Yamanaka, M., Kim, J.-H., Saito, K., Sakamoto, A., Inoue, M., Shirouzu, M., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00963-7 · Cited by 1,227 · see citing works

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

Millauer, B., Shawver, L. K., Plate, K. H., Risaui, W., & Ullrich, A. (1994) · Nature · doi:10.1038/367576a0 · Cited by 1,219 · see citing works

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

Yarden, Y., Escobedo, J. A., Kuang, W.-J., Yang‐Feng, T. L., Daniel, T. O., Tremble, P., Chen, E. Y., Ando, M. E., Harkins, R. N., Francke, U., et al. (1986) · Nature · doi:10.1038/323226a0 · Cited by 1,208 · see citing works

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

Ushiro, H., & Cohen, S. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43497-7 · Cited by 1,184 · see citing works

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

Schechter, A. L., Stern, D. F., Vaidyanathan, L., Decker, S. J., Drebin, J. A., Greene, M. I., & Weinberg, R. A. (1984) · Nature · doi:10.1038/312513a0 · Cited by 1,177 · see citing works

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

Gassmann, M., Casagranda, F., Orioli, D., Simon, H. H., Lai, C., Klein, R., & Lemke, G. (1995) · Nature · doi:10.1038/378390a0 · Cited by 1,151 · see citing works

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

King, C. R., Kraus, M. H., & Aaronson, S. A. (1985) · Science · doi:10.1126/science.2992089 · Cited by 1,054 · see citing works

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

Miettinen, P. J., Berger, J. E., Meneses, J. J., Phung, Y. T., Pedersen, R. A., Werb, Z., & Derynck, R. (1995) · Nature · doi:10.1038/376337a0 · Cited by 1,038 · see citing works

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

Fong, T. A. T., Shawver, L. K., Sun, L., Tang, C., App, H., Powell, T., Kim, Y. H., Schreck, R., Wang, X., Risau, W., et al. (1999) · PubMed · Cited by 1,032 · see citing works

Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

Sibilia, M., & Wagner, E. F. (1995) · Science · doi:10.1126/science.7618085 · Cited by 1,002 · see citing works

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.Preprint

Soriano, P. M. (1994) · Genes & Development · doi:10.1101/gad.8.16.1888 · Cited by 988 · see citing works

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

Meisenhelder, J., Suh, P., Rhee, S. G., & Hunter, T. R. (1989) · Cell · doi:10.1016/0092-8674(89)90048-2 · Cited by 955 · see citing works

Human transforming growth factor-α: Precursor structure and expression in E. coli

Derynck, R., Roberts, A. B., Winkler, M. E., Chen, E. Y., & Goeddel, D. V. (1984) · Cell · doi:10.1016/0092-8674(84)90550-6 · Cited by 877 · see citing works

Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

Agus, D. B., Akita, R. W., Fox, W. D., Lewis, G. D., Higgins, B., Pisacane, P. I., Lofgren, J. A., Tindell, C., Evans, D. P., Maiese, K., et al. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00097-1 · Cited by 873 · see citing works

SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo

O'Farrell, A. M., Abrams, T. J., Yuen, H. A., Ngai, T. J., Louie, S. G., Yee, K. W. H., Wong, L. M., Hong, W., Lee, L. B., Town, A., et al. (2003) · Blood · doi:10.1182/blood-2002-07-2307 · Cited by 865 · see citing works

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptorPreprint

Levkowitz, G., Waterman, H., Zamir, E., Kam, Z., Oved, S., Langdon, W. Y., Beguinot, L., Geiger, B., & Yarden, Y. (1998) · Genes & Development · doi:10.1101/gad.12.23.3663 · Cited by 865 · see citing works

Expression in Escherichia coli of a Chemically Synthesized Gene for the Hormone Somatostatin

Itakura, K., Hirose, T., Crea, R., Riggs, A. D., Heyneker, H. L., Bolívar, F. G., & Boyer, H. W. (1977) · Science · doi:10.1126/science.412251 · Cited by 853 · see citing works

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.

Wood, J. M., Bold, G., Buchdunger, E., Cozens, R. M., Ferrari, S. M., Frei, J., Hofmann, F., Mestan, J., Mett, H., O'Reilly, T., et al. (2000) · PubMed · Cited by 844 · see citing works

A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

Fry, D. W., Kraker, A. J., McMichael, A., Ambroso, L. A., Nelson, J. M., Leopold, W. R., Connors, R. W., & Bridges, A. J. (1994) · Science · doi:10.1126/science.8066447 · Cited by 806 · see citing works

ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.

Wedge, S. R., Ogilvie, D., Dukes, M., Kendrew, J., Chester, R., Jackson, J. A., Boffey, S. J., Valentine, P. J., Curwen, J., Musgrove, H. L., et al. (2002) · PubMed · Cited by 797 · see citing works

Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.

Kawamoto, T., Sato, J. D., Le, A., Polikoff, J., SATO, G. H., & Mendelsohn, J. M. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.5.1337 · Cited by 791 · see citing works

Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α

Garrett, T., McKern, N. M., Lou, M., ELLEMAN, T. C., Adams, T. E., Lovrecz, G. O., Zhu, H., Walker, F., Frenkel, M. J., Hoyne, P. A., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00940-6 · Cited by 783 · see citing works

Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.

Quinn, T. P., Peters, K. G., de Vries, C. J. M., Ferrara, N., & Williams, L. T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7533 · Cited by 754 · see citing works

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

Margolis, B. L., Rhee, S. G., Felder, S., Mervič, M., Lyall, R. M., Levitzki, A., Ullrich, A., Zilberstein, A., & Schlessinger, J. (1989) · Cell · doi:10.1016/0092-8674(89)90047-0 · Cited by 753 · see citing works

p185 HER2 Monoclonal Antibody Has Antiproliferative Effects In Vitro and Sensitizes Human Breast Tumor Cells to Tumor Necrosis Factor

Hudziak, R. M., Phillips, G. D. L., Winget, M., FENDLY, B. M., Shepard, H. M., & Ullrich, A. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.3.1165-1172.1989 · Cited by 750 · see citing works

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

Asakura, M., Kitakaze, M., Takashima, S., Liao, Y., Ishikura, F., Yoshinaka, T., Ohmoto, H., Node, K., Yoshino, K., Ishiguro, H., et al. (2002) · Nature Medicine · doi:10.1038/nm0102-35 · Cited by 724 · see citing works

The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites

Soriano, P. M. (1997) · Development · doi:10.1242/dev.124.14.2691 · Cited by 709 · see citing works

Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system

Kasuga, M., Zick, Y., Blithe, D., Crettaz, M., & Kahn, C. R. (1982) · Nature · doi:10.1038/298667a0 · Cited by 680 · see citing works

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

Hunter, T. R., & Cooper, J. A. (1981) · Cell · doi:10.1016/0092-8674(81)90100-8 · Cited by 670 · see citing works

TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

Luetteke, N., Qiu, T. H., Peiffer, R. L., Oliver, P. M., Smithies, O., & Lee, D. C. (1993) · Cell · doi:10.1016/0092-8674(93)90228-i · Cited by 658 · see citing works

Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor

Ek, B., Westermark, B., Wasteson, Å., & Heldin, C. (1982) · Nature · doi:10.1038/295419a0 · Cited by 658 · see citing works

Requirement for c-ras proteins during viral oncogene transformation

Smith, M. R., DeGudicibus, S. J., & Stacey, D. W. (1986) · Nature · doi:10.1038/320540a0 · Cited by 653 · see citing works

Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors

Yaish, P., Gazit, A., Gilon, C., & Levitzki, A. (1988) · Science · doi:10.1126/science.3263702 · Cited by 587 · see citing works

Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion‐dependent cell survival

Moro, L., Venturino, M., Bozzo, C., Silengo, L., Altruda, F., Beguinot, L., Tarone, G., & Defilippi, P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6622 · Cited by 585 · see citing works

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

Mann, G. B., Fowler, K. J., Gabriel, A., Nice, E. C., Williams, R. L., & Dunn, A. R. (1993) · Cell · doi:10.1016/0092-8674(93)90227-h · Cited by 583 · see citing works

Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development

Luetteke, N., Qiu, T. H., Fenton, S. E., Troyer, K. L., Riedel, R. F., Chang, A. Y., & Lee, D. C. (1999) · Development · doi:10.1242/dev.126.12.2739 · Cited by 568 · see citing works

An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates

Eckhart, W., Hutchinson, M. A., & Hunter, T. R. (1979) · Cell · doi:10.1016/0092-8674(79)90205-8 · Cited by 539 · see citing works

How receptors turn Ras on

McCormick, F. P. (1993) · Nature · doi:10.1038/363015a0 · Cited by 530 · see citing works

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

Gray, A., Dull, T. J., & Ullrich, A. (1983) · Nature · doi:10.1038/303722a0 · Cited by 514 · see citing works

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

Honegger, A. (1987) · Cell · doi:10.1016/0092-8674(87)90147-4 · Cited by 491 · see citing works

Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers

Bardelli, A., Parsons, D. W., Silliman, N., Ptak, J., Szabo, S., Saha, S., Markowitz, S. D., Willson, J. K. V., Parmigiani, G., Kinzler, K. W., et al. (2003) · Science · doi:10.1126/science.1082596 · Cited by 485 · see citing works

Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor

Wiesmann, C., Fuh, G., Christinger, H. W., Eigenbrot, C. W., Wells, J. A., & de Vos, A. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80456-0 · Cited by 484 · see citing works

Human β-nerve growth factor gene sequence highly homologous to that of mouse

Ullrich, A., Gray, A., Berman, C., & Dull, T. J. (1983) · Nature · doi:10.1038/303821a0 · Cited by 480 · see citing works

ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2- and heregulin-deficient mice

Erickson, S. L., O’Shea, K. S., Ghaboosi, N., Loverro, L., Frantz, G. D., Bauer, M., Lu, L. H., & Moore, M. W. (1997) · Development · doi:10.1242/dev.124.24.4999 · Cited by 467 · see citing works

Src homology region 2 domains direct protein-protein interactions in signal transduction.

Moran, M. F., Koch, C. A., Anderson, D. M., Ellis, C. A., England, L. J., Martin, G. S., & Pawson, T. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8622 · Cited by 462 · see citing works

Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors.

Sato, J. D., Kawamoto, T., Le, A. D., Mendelsohn, J. M., Polikoff, J., & SATO, G. H. (1983) · PubMed · Cited by 458 · see citing works

Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro

Carpenter, G. F., King, L. E., & Cohen, S. (1978) · Nature · doi:10.1038/276409a0 · Cited by 454 · see citing works

Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

Coussens, L. M., Beveren, C. V., Smith, D. H., Chen, E., Mitchell, R. L., Isacke, C. M., Verma, I. M., & Ullrich, A. (1986) · Nature · doi:10.1038/320277a0 · Cited by 447 · see citing works

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

Scott, J., Urdea, M. S., Quiroga, M., Sánchez-Pescador, R., Fong, N. M., Selby, M., Rutter, W. J., & Bell, G. I. (1983) · Science · doi:10.1126/science.6602382 · Cited by 443 · see citing works

Characterization of the binding of 125-I-labeled epidermal growth factor to human fibroblasts

Carpenter, G., Lembach, K. J., Morrison, M., & Cohen, S. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41417-8 · Cited by 435 · see citing works

The stimulation of epidermal proliferation by a specific protein (EGF)

Cohen, S. (1965) · Developmental Biology · doi:10.1016/0012-1606(65)90005-9 · Cited by 431 · see citing works

Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

Matsuda, M., Mayer, B. J., Fukui, Y., et al. (1990) · Science · doi:10.1126/science.1694307 · Cited by 426 · see citing works

Defective valvulogenesis in HB‐EGF and TACE‐null mice is associated with aberrant BMP signaling

Jackson, L. F., Qiu, T. H., Sunnarborg, S. W., Chang, A., Zhang, C., Patterson, C., & Lee, D. C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg264 · Cited by 417 · see citing works

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

Wiesmann, C., Ultsch, M. H., Bass, S., & de Vos, A. M. (1999) · Nature · doi:10.1038/43705 · Cited by 416 · see citing works

Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.

Millauer, B., Longhi, M. P., Plate, K. H., Shawver, L. K., Risau, W., Ullrich, A., & Strawn, L. M. (1996) · PubMed · Cited by 413 · see citing works

Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability

Sunnarborg, S. W., Hinkle, C. L., Stevenson, M. C., Russell, W. E., Raska, C. S., Peschon, J. J., Castner, B. J., GERHART, M. J., Paxton, R. J., Black, R. A., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112050200 · Cited by 413 · see citing works

Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product.

FENDLY, B. M., Winget, M., Hudziak, R. M., Lipari, M. T., Napier, M. A., & Ullrich, A. (1990) · PubMed · Cited by 403 · see citing works

Human Growth Hormone: Complementary DNA Cloning and Expression in Bacteria

MARTIAL, J. A., Hallewell, R. A., Baxter, J. D., & Goodman, H. M. (1979) · Science · doi:10.1126/science.377496 · Cited by 401 · see citing works

Signal transduction by allosteric receptor oligomerization

Schlessinger, J. (1988) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(88)90219-8 · Cited by 399 · see citing works

Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.

Humphrey, P. A., Wong, A. J., Vogelstein, B., Zalutsky, M. R., Fuller, G. N., Archer, G. E., Friedman, H. S., Kwatra, M. M., Bigner, S. H., & Bigner, D. D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4207 · Cited by 382 · see citing works

The c‐sis gene encodes a precursor of the B chain of platelet‐derived growth factor.

Johnsson, A., Heldin, C., Wasteson, Å., et al. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb01908.x · Cited by 377 · see citing works

Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins

Cooper, J. A., Bowen‐Pope, D. F., Raines, E. W., et al. (1982) · Cell · doi:10.1016/0092-8674(82)90426-3 · Cited by 369 · see citing works

Two EGF molecules contribute additively to stabilization of the EGFR dimer

Lemmon, M. A., Bu, Z., Ladbury, J. E., Zhou, M., Pinchasi, D., Lax, I., Engelman, D. M., & Schlessinger, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.2.281 · Cited by 368 · see citing works

Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells

Lemjabbar, H., & Basbaum, C. B. (2002) · Nature Medicine · doi:10.1038/nm0102-41 · Cited by 355 · see citing works

TACE cleavage of proamphiregulin regulates GPCR‐induced proliferation and motility of cancer cells

Gschwind, A., Hart, S., Fischer, O. M., & Ullrich, A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg231 · Cited by 344 · see citing works

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

Iwamoto, R., Yamazaki, S., Asakura, M., Takashima, S., Hasuwa, H., Miyado, K., Adachi, S., Kitakaze, M., Hashimoto, K., Raab, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0537588100 · Cited by 341 · see citing works

Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis.

Shaheen, R. M., Davis, D. W., Liu, W., Zebrowski, B. K., Wilson, M. R., Bucana, C. D., McConkey, D. J., McMahon, G., & Ellis, L. M. (1999) · PubMed · Cited by 334 · see citing works

Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

Yamauchi, T., Ueki, K., Tobe, K., Tamemoto, H., Sekine, N., Wada, M., Honjo, M., Takahashi, M., Takahashi, T., Hirai, H., et al. (1997) · Nature · doi:10.1038/36369 · Cited by 284 · see citing works

Insulin-like growth factor II precursor gene organization in relation to insulin gene family

Dull, T. J., Gray, A., Hayflick, J. S., & Ullrich, A. (1984) · Nature · doi:10.1038/310777a0 · Cited by 280 · see citing works

Epidermal‐Growth‐Factor‐Dependent Activation of the Src‐Family Kinases

Osherov, N., & Levitzki, A. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.1047b.x · Cited by 279 · see citing works

EFFECTS OF THE EXTRACT OF THE MOUSE SUBMAXILLARY SALIVARY GLANDS ON THE SYMPATHETIC SYSTEM OF MAMMALS*

Levi‐Montalcini, R., & Cohen, S. (1960) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1960.tb49963.x · Cited by 272 · see citing works

EFFECTS OF MOUSE TUMOR TRANSPLANTATION ON THE NERVOUS SYSTEM

Levi‐Montalcini, R. (1952) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1952.tb26548.x · Cited by 269 · see citing works

Escape from Cbl-mediated downregulation

Peschard, P., & Park, M. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00136-3 · Cited by 235 · see citing works

Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB‐2 protein in the mammary tumor cell line SK‐BR‐3.

King, C. R., Borrello, I., Bellot, F., Comoglio, P. M., & Schlessinger, J. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02991.x · Cited by 225 · see citing works

EGF‐stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.

Stern, D. F., & Kamps, M. P. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02906.x · Cited by 223 · see citing works

A Cytosolic Protein Catalyzes the Release of GDP from p21 ras

Wolfman, A., & Macara, I. G. (1990) · Science · doi:10.1126/science.2181667 · Cited by 223 · see citing works

Critical Role of Calcium- dependent Epidermal Growth Factor Receptor Transactivation in PC12 Cell Membrane Depolarization and Bradykinin Signaling

Zwick, E., Daub, H., Aoki, N., Yamaguchi-Aoki, Y., Tinhofer, I., Maly, K., & Ullrich, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.24767 · Cited by 200 · see citing works

cag+ Helicobacter pylori Induce Transactivation of the Epidermal Growth Factor Receptor in AGS Gastric Epithelial Cells

Keates, S. E., Sougioultzis, S., Keates, A. C., Zhao, D., Peek, R. M., Shaw, L. M., & Kelly, C. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107630200 · Cited by 194 · see citing works

Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteins

Kamata, T., & Feramisco, J. R. (1984) · Nature · doi:10.1038/310147a0 · Cited by 194 · see citing works

A Mutant Epidermal Growth Factor Receptor with Defective Protein Tyrosine Kinase Is Unable To Stimulate Proto-Oncogene Expression and DNA Synthesis

Honegger, A., Szapary, D., Schmidt, A., Lyall, R. M., OBBERGHEN, E. V., Dull, T. J., Ullrich, A., & Schlessinger, J. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.12.4568 · Cited by 189 · see citing works

Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation.

Bjorge, J. D., Chan, T. O., Antczak, M., Kung, H. J., & Fujita, D. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3816 · Cited by 180 · see citing works

Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor

Chiu, E. I.-M., Reddy, P., Givol, D., et al. (1984) · Cell · doi:10.1016/0092-8674(84)90307-6 · Cited by 170 · see citing works

Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines

Wakeling, A. E., Barker, A. J., Davies, D. H., Brown, D. S., Green, L. R., Cartlidge, S. A., & Woodburn, J. R. (1996) · Breast Cancer Research and Treatment · doi:10.1007/bf01803785 · Cited by 166 · see citing works

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.

Matuoka, K., Shibata, M., Yamakawa, A., & Takenawa, T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9015 · Cited by 165 · see citing works

A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor

Riedel, H., Dull, T. J., Schlessinger, J., et al. (1986) · Nature · doi:10.1038/324068a0 · Cited by 164 · see citing works

Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene

Drebin, J. A., Stern, D. F., Link, V. C., et al. (1984) · Nature · doi:10.1038/312545a0 · Cited by 160 · see citing works

Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme.

Malden, L. T., Novak, U., Kaye, A. H., et al. (1988) · PubMed · Cited by 158 · see citing works

Identification of a nucleotide exchange-promoting activity for p21ras.

Downward, J., Riehl, R., Wu, L., & Weinberg, R. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.15.5998 · Cited by 142 · see citing works

A new avian erythroblastosis virus, AEV-H, carries erbB gene responsible for the induction of both erythroblastosis and sarcomas

Yamamoto, T. S., Hihara, H., Nishida, T., et al. (1983) · Cell · doi:10.1016/0092-8674(83)90153-8 · Cited by 137 · see citing works

Ash/Grb‐2, a SH2/SH3‐containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF.

Matuoka, K., Shibasaki, F., Shibata, M. S., et al. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06021.x · Cited by 134 · see citing works

Anti-Oncogenic Activity of Signalling-Defective Epidermal Growth Factor Receptor Mutants

Redemann, N. H., Holzmann, B., von Rüden, T., Wagner, E. F., Schlessinger, J., & Ullrich, A. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.2.491 · Cited by 125 · see citing works

Purification and properties of a nerve growth-promoting factor isolated from mouse sarcoma 180.

Cohen, S., & Levi‐Montalcini, R. (1957) · PubMed · Cited by 94 · see citing works

Anti-sense transforming growth factor alpha oligonucleotides inhibit autocrine stimulated proliferation of a colon carcinoma cell line.

Sizeland, A. M., & Burgess, A. W. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.11.1235 · Cited by 77 · see citing works

Nucleotide Sequence of Human Preproinsulin Complementary DNA

Sures, I., Goeddel, D. V., Gray, A., et al. (1980) · Science · doi:10.1126/science.6927840 · Cited by 61 · see citing works

Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl

Thien, C. B. F., & Langdon, W. Y. (1997) · Oncogene · doi:10.1038/sj.onc.1201468 · Cited by 57 · see citing works

Ligand-independent tyrosine phosphorylation of EGF receptor and the erbB-2/neu proto-oncogene product is induced by hyperosmotic shock.

Cr, K., Borrello, I., Porter, L., et al. (1989) · PubMed · Cited by 41 · see citing works

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

Shigematsu, H., Lin, L., Takahashi, T., Nomura, M., Suzuki, M., Wistuba, I. I., Fong, K. M., Lee, H., Toyooka, S., Shimizu, N., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji055 · Cited by 2,377 · see citing works

The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

Burslem, G. M., Smith, B. E., Lai, A. C., Jaime-Figueroa, S., McQuaid, D. C., Bondeson, D. P., Toure, M., Dong, H., Qian, Y., Wang, J., et al. (2018) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.09.009 · Cited by 686 · see citing works

Epidermal growth factor receptor targeting in cancer: a review of trends and strategies

Yewale, C., Baradia, D., Vhora, I., Patil, S., & Misra, A. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.100 · Cited by 533 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works

Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression

Buchheit, C. L., Weigel, K. J., & Schafer, Z. T. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3789 · Cited by 367 · see citing works

EGFR family: Structure physiology signalling and therapeutic targets ^†

Burgess, A. W. (2008) · Growth Factors · doi:10.1080/08977190802312844 · Cited by 288 · see citing works

Somatic Mutations of <i>ERBB2</i> Kinase Domain in Gastric, Colorectal, and Breast Carcinomas

Lee, J. W., Soung, Y. H., Seo, S. H., Kim, S. Y., Park, C. H., Wang, Y. P., Park, K., Nam, S. W., Park, W. S., Kim, S. H., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0976 · Cited by 228 · see citing works

Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

Gonzales, A. J., Hook, K. E., Althaus, I. W., Ellis, P. A., Trachet, E., Delaney, A. M., Harvey, P. J., Ellis, T. A., Amato, D. M., Nelson, J. M., et al. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2232 · Cited by 226 · see citing works

Epidermal growth factor receptor is a preferred target for treating Amyloid-β–induced memory loss

Wang, L., Chiang, H.-C., Wu, W., Liang, B., Xie, Z., Yao, X., Ma, W., Du, S., & Zhong, Y. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208011109 · Cited by 190 · see citing works

EGFR-mutated lung cancer: a paradigm of molecular oncology

Zhang, Z., Stiegler, A. L., Boggon, T. J., Kobayashi, S., & Halmos, B. (2010) · Oncotarget · doi:10.18632/oncotarget.186 · Cited by 197 · see citing works

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells

Winter-Vann, A. M., Baron, R. A., Wong, W., dela Cruz, J., York, J. D., Gooden, D. M., Bergo, M. O., Young, S. G., Toone, E. J., & Casey, P. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408107102 · Cited by 178 · see citing works

Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling

Liu, C., Lu, H., Wang, H., Loo, A., Zhang, X., Yang, G., Kowal, C., Delach, S., Wang, Y., Goldoni, S., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-2718 · Cited by 167 · see citing works

Progress toward Overcoming Hypoxia-Induced Resistance to Solid Tumor Therapy

Reginato, M., & Karakashev, S. (2015) · Cancer Management and Research · doi:10.2147/cmar.s58285 · Cited by 95 · see citing works

Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling

Quinn, B. J., Dallos, M., Kitagawa, H., Kunnumakkara, A. B., Memmott, R. M., Hollander, M. C., Gills, J. J., & Dennis, P. A. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0058-t · Cited by 85 · see citing works

Targeting key steps in metastatic tumour progression

Eccles, S. A. (2005) · Current Opinion in Genetics &amp; Development · doi:10.1016/j.gde.2004.12.001 · Cited by 73 · see citing works

Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model

Ding, C., Li, L., Yang, T., Fan, X., & Wu, G. (2016) · BMC Cancer · doi:10.1186/s12885-016-2834-8 · Cited by 56 · see citing works

HER2 in high-risk rectal cancer patients treated in EXPERT-C, a randomized phase II trial of neoadjuvant capecitabine and oxaliplatin (CAPOX) and chemoradiotherapy (CRT) with or without cetuximab

Sclafani, F., Roy, A., Cunningham, D., Wotherspoon, A., Peckitt, C., Gonzalez de Castro, D., Tabernero, J., Glimelius, B., Cervantes, A., Eltahir, Z., et al. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt408 · Cited by 33 · see citing works

EGFR inhibition reverses epithelial‑mesenchymal transition, and decreases tamoxifen resistance via Snail and Twist downregulation in breast cancer cells

Takeda, T., Tsubaki, M., Matsuda, T., Kimura, A., Jinushi, M., Obana, T., Takegami, M., & Nishida, S. (2022) · Oncology Reports · doi:10.3892/or.2022.8320 · Cited by 17 · see citing works

Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor β during steady-state growth of human mesangial cells

Kobayashi, T., Furukawa, Y., Kikuchi, J., et al. (2009) · Kidney International · doi:10.1038/ki.2009.44 · Cited by 23 · see citing works

Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor β-receptor (β-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases

Zaman, G. J. R., Vink, P. M., van der Doelen, A. A., Veeneman, G. H., & Theunissen, H. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00271-8 · Cited by 24 · see citing works

Ambiguous Origin: Two Sides of an Ephrin Receptor Tyrosine Kinase

Becker, C. F. W. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.03.004

Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development

DeChiara, T. M., Kimble, R. B., Poueymirou, W. T., et al. (2000) · Nature Genetics · doi:10.1038/73488 · Cited by 257 · see citing works