The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Wnt5a Signaling Induces Proliferation and Survival of Endothelial Cells In Vitro and Expression of MMP-1 and Tie-2
Open accessAbstract
Wnts are lipid-modified secreted glycoproteins that regulate diverse biological processes. We report that Wnt5a, which functions in noncanonical Wnt signaling, has activity on endothelial cells. Wnt5a is endogenously expressed in human primary endothelial cells and is expressed in murine vasculature at several sites in mouse embryos and tissues. Expression of exogenous Wnt5a in human endothelial cells promoted angiogenesis. Wnt5a induced noncanonical Wnt signaling in endothelial cells, as measured by Dishevelled and ERK1/2 phosphorylation, and inhibition of canonical Wnt signaling, a known property of Wnt5a. Wnt5a induced endothelial cell proliferation and enhanced cell survival under serum-deprived conditions. The Wnt5a-mediated proliferation was blocked by Frizzled-4 extracellular domain. Wnt5a expression enhanced capillary-like network formation, whereas reduction of Wnt5a expression decreased network formation. Reduced Wnt5a expression inhibited endothelial cell migration. Screening for Wnt5a-regulated genes in cultured endothelial cells identified several encoding angiogenic regulators, including matrix metalloproteinase-1, an interstitial collagenase, and Tie-2, a receptor for angiopoietins. Thus, Wnt5a acts through noncanonical Wnt signaling to promote angiogenesis.
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Cites
Slusarski, D. C., Corces, V. G., & Moon, R. T. (1997) · Nature · doi:10.1038/37138 · Cited by 680 · cited 5×
“For example, expression of Wnt5a in zebra fish or Xenopus embryos can stimulate intracellular Ca 2ϩ fluxes (Slusarski et al., 1997), and Wnt5a regulates morphogenetic movements during gastrulation independently of canonical signaling (Kilian et al., 2003).”
BackgroundInfluentialDishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
Chen, W., ten Berge, D., Brown, J., Ahn, S., Hu, L. A., Miller, W. E., Caron, M. G., Barak, L. S., Nusse, R., & Lefkowitz, R. J. (2003) · Science · doi:10.1126/science.1082808 · Cited by 334
The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos
Saneyoshi, T., Kume, S., Amasaki, Y., & Mikoshiba, K. (2002) · Nature · doi:10.1038/417295a · Cited by 322 · cited 2×
“Address correspondence to: Jan Kitajewski (jkk9@columbia.edu). pathway by several different mechanisms (Saneyoshi et al., 2002; Ishitani et al., 2003; Topol et al., 2003).”
Background
Cited by
Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis
Daneman, R., Agalliu, D., Zhou, L., Kuhnert, F., Kuo, C. J., & Barres, B. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805165106 · Cited by 753
Self-citationCanonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature
Stenman, J. M., Rajagopal, J., Carroll, T. J., Ishibashi, M., McMahon, J., & McMahon, A. P. (2008) · Science · doi:10.1126/science.1164594 · Cited by 641
Brain endothelial cells and the glio-vascular complex
Wolburg, H., Noell, S., Mack, A., Wolburg-Buchholz, K., & Fallier-Becker, P. (2009) · Cell and Tissue Research · doi:10.1007/s00441-008-0658-9 · Cited by 438
The Role of Wnt Signaling in Physiological and Pathological Angiogenesis
Dejana, E. (2010) · Circulation Research · doi:10.1161/circresaha.110.223750 · Cited by 347
Chen, Y., Hu, Y., Lu, K., Flannery, J. G., & Ma, J.-X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611289200 · Cited by 92
Metadata
- Authors
- Masckauchán, T. N. H., Agalliu, D., Vorontchikhina, M., Ahn, A., Parmalee, N. L., Li, C.-M., Khoo, A., Tycko, B., Brown, A. M. C., & Kitajewski, J.
- Venue
- Molecular Biology of the Cell
- Published
- 2006-12
- Volume
- 17
- Issue
- 12
- Pages
- 5163-5172
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2132576204
- Cited by
- 223
- References
- 3
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Masckauchán, T. N. H., Agalliu, D., Vorontchikhina, M., Ahn, A., Parmalee, N. L., Li, C.-M., Khoo, A., Tycko, B., Brown, A. M. C., & Kitajewski, J. (2006). Wnt5a Signaling Induces Proliferation and Survival of Endothelial Cells In Vitro and Expression of MMP-1 and Tie-2. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e06-04-0320
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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