The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos

Saneyoshi, Takeo; Kume, Shoen; Amasaki, Yoshiharu; Mikoshiba, Katsuhiko

doi:10.1038/417295a

Cited by 322Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationSignaling Pathways in Disease

The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos

Saneyoshi, Takeo, Kume, Shoen, Amasaki, Yoshiharu, Mikoshiba, Katsuhiko·2002·Nature

DOI 10.1038/417295a

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Abstract

It is thought that inositol-1,4,5-trisphosphate (Ins(1,4,5)P(3))-Ca(2+) signalling has a function in dorsoventral axis formation in Xenopus embryos; however, the immediate target of free Ca(2+) is unclear. The secreted Wnt protein family comprises two functional groups, the canonical Wnt and Wnt/Ca(2+) pathways. The Wnt/Ca(2+) pathway interferes with the canonical Wnt pathway, but the underlying molecular mechanism is poorly understood. Here, we cloned the complementary DNA coding for the Xenopus homologue of nuclear factor of activated T cells (XNF-AT). A gain-of-function, calcineurin-independent active XNF-AT mutation (CA XNF-AT) inhibited anterior development of the primary axis, as well as Xwnt-8-induced ectopic dorsal axis development in embryos. A loss-of-function, dominant negative XNF-AT mutation (DN XNF-AT) induced ectopic dorsal axis formation and expression of the canonical Wnt signalling target molecules siamois and Xnr3 (ref. 4). Xwnt-5A induced translocation of XNF-AT from the cytosol to the nucleus. These data indicate that XNF-AT functions as a downstream target of the Wnt/Ca(2+) and Ins(1,4,5)P(3)-Ca(2+) pathways, and has an essential role in mediating ventral signals in the Xenopus embryo through suppression of the canonical Wnt pathway.

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Authors: Saneyoshi, T., Kume, S., Amasaki, Y., & Mikoshiba, K.
Affiliations: Institute of Medical Science, The University of Tokyo (JP)
Japan Science and Technology Agency (JP)
RIKEN Center for Brain Science (JP)
Corresponding author: Kume, Shoen
Mikoshiba, Katsuhiko
ORCID: Saneyoshi, Takeo
Kume, Shoen
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-05
Volume: 417
Issue: 6886
Pages: 295-299
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/417295a
OpenAlex: W2000352591
Cited by: 322
References: 30
Citations by year: 2026: 6 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 11 · 2019: 3 · 2018: 7 · 2017: 10 · 2016: 10 · 2015: 12 · 2014: 17 · 2013: 19 · 2012: 14
FWCI: 8.44
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Tokyo Tech Research Repository (Tokyo Institute of Technology) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: Wnt/Ca2+ pathway, NFAT, calcium signaling, inositol 1,4,5-trisphosphate, canonical Wnt pathway, Siamois, Xenopus embryo, nuclear translocation
MeSH terms: Animals, DNA-Binding Proteins, Models, Biological, Molecular Sequence Data, Nuclear Proteins, Proto-Oncogene Proteins, RNA, Messenger, Transcription Factors, Xenopus laevis, Inositol 1,4,5-Trisphosphate, Cell Lineage, Body Patterning, Calcineurin, Calcium Signaling, Reverse Transcriptase Polymerase Chain Reaction, Protein Transport, Xenopus Proteins, Zebrafish Proteins, NFATC Transcription Factors, Wnt Proteins

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The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos

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