The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Use of the Novel Plk1 Inhibitor ZK-Thiazolidinone to Elucidate Functions of Plk1 in Early and Late Stages of Mitosis
Open accessAbstract
Polo-like kinase 1 (Plk1) is a key regulator of mitotic progression and cell division in eukaryotes. It is highly expressed in tumor cells and considered a potential target for cancer therapy. Here, we report the discovery and application of a novel potent small-molecule inhibitor of mammalian Plk1, ZK-Thiazolidinone (TAL). We have extensively characterized TAL in vitro and addressed TAL specificity within cells by studying Plk1 functions in sister chromatid separation, centrosome maturation, and spindle assembly. Moreover, we have used TAL for a detailed analysis of Plk1 in relation to PICH and PRC1, two prominent interaction partners implicated in spindle assembly checkpoint function and cytokinesis, respectively. Specifically, we show that Plk1, when inactivated by TAL, spreads over the arms of chromosomes, resembling the localization of its binding partner PICH, and that both proteins are mutually dependent on each other for correct localization. Finally, we show that Plk1 activity is essential for cleavage furrow formation and ingression, leading to successful cytokinesis.
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Blangy, A., Lane, H. A., d'Hérin, P., Harper, M., Kress, M., & Niggt, E. A. (1995) · Cell · doi:10.1016/0092-8674(95)90142-6 · Cited by 952
Wapl controls the dynamic association of cohesin with chromatin
Kueng, S., Hegemann, B., Peters, B. H., Lipp, J. J., Schleiffer, A., Mechtler, K., & Peters, J.-M. (2006) · Cell · doi:10.1016/j.cell.2006.09.040 · Cited by 624
Silljé, H. H. W., Nagel, S., Körner, R., & Nigg, E. A. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.070 · Cited by 267
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Cited by
Traffic control: regulation of kinesin motors
Verhey, K. J., & Hammond, J. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2782 · Cited by 546
Polo on the Rise—from Mitotic Entry to Cytokinesis with Plk1
Petronczki, M., Lénárt, P., & Peters, J.-M. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.04.014 · Cited by 485
Wolfe, B. A., Takaki, T., Petronczki, M., & Glotzer, M. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000110 · Cited by 225
Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
Fernández-Casañas, M., Karanika, E., Aliyaskarova, U., Olukoga, T., Herbert, A. D., Oliver, A. W., Day, M., Crncec, A., & Chan, K.-L. (2025) · Nature Communications · doi:10.1038/s41467-025-62966-6 · Cited by 5
Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
(2024) · doi:10.1101/2024.05.21.595148 · Cited by 2
Metadata
- Authors
- Santamaria, A., Neef, R., Eberspächer, U., Eis, K., Husemann, M., Mumberg, D., Prechtl, S., Schulze, V., Siemeister, G., Wortmann, L., Barr, F. A., & Nigg, E. A.
- Venue
- Molecular Biology of the Cell
- Published
- 2007-10
- Volume
- 18
- Issue
- 10
- Pages
- 4024-4036
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2023742279
- Cited by
- 199
- References
- 3
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Santamaria, A., Neef, R., Eberspächer, U., Eis, K., Husemann, M., Mumberg, D., Prechtl, S., Schulze, V., Siemeister, G., Wortmann, L., Barr, F. A., & Nigg, E. A. (2007). Use of the Novel Plk1 Inhibitor ZK-Thiazolidinone to Elucidate Functions of Plk1 in Early and Late Stages of Mitosis. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e07-05-0517
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
