The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
Open accessAbstract
Epithelial-mesenchymal transition (EMT) is a form of cellular plasticity that is critical for embryonic development and tumor metastasis. A double-negative feedback loop involving the miR-200 family and ZEB (zinc finger E-box-binding homeobox) transcription factors has been postulated to control the balance between epithelial and mesenchymal states. Here we demonstrate using the epithelial Madin Darby canine kidney cell line model that, although manipulation of the ZEB/miR-200 balance is able to repeatedly switch cells between epithelial and mesenchymal states, the induction and maintenance of a stable mesenchymal phenotype requires the establishment of autocrine transforming growth factor-β (TGF-β) signaling to drive sustained ZEB expression. Furthermore, we show that prolonged autocrine TGF-β signaling induced reversible DNA methylation of the miR-200 loci with corresponding changes in miR-200 levels. Collectively, these findings demonstrate the existence of an autocrine TGF-β/ZEB/miR-200 signaling network that regulates plasticity between epithelial and mesenchymal states. We find a strong correlation between ZEBs and TGF-β and negative correlations between miR-200 and TGF-β and between miR-200 and ZEBs, in invasive ductal carcinomas, consistent with an autocrine TGF-β/ZEB/miR-200 signaling network being active in breast cancers.
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The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
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Self-citationTransitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
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Okugawa, Y., Grady, W. M., & Goel, A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.011 · Cited by 782
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Metadata
- Authors
- Gregory, P. A., Bracken, C. P., Smith, E., Bert, A. G., Wright, J. A., Roslan, S., Morris, M., Wyatt, L., Farshid, G., Lim, Y.-Y., Lindeman, G. J., Shannon, M. F., Drew, P. A., Khew-Goodall, Y., & Goodall, G. J.
- Venue
- Molecular Biology of the Cell
- Published
- 2011-05-15
- Volume
- 22
- Issue
- 10
- Pages
- 1686-1698
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2124803006
- Cited by
- 552
- References
- 60
- FWCI
- 19.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Gregory, P. A., Bracken, C. P., Smith, E., Bert, A. G., Wright, J. A., Roslan, S., Morris, M., Wyatt, L., Farshid, G., Lim, Y.-Y., Lindeman, G. J., Shannon, M. F., Drew, P. A., Khew-Goodall, Y., & Goodall, G. J. (2011). An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e11-02-0103
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