Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

Molecular portraits of human breast tumours

Perou, C., Sørlie, T., Eisen, M., van de Rijn, M., Jeffrey, S., Rees, C. A., Pollack, J., Ross, D., Johnsen, H., Akslen, L., et al. (2000) · Nature · doi:10.1038/35021093 · Cited by 16,551 · see citing works

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

Sørlie, T., Perou, C., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M., van de Rijn, M., Jeffrey, S., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.191367098 · Cited by 11,695 · see citing works

Chromatin modifications and their function

Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M. W., Reinhard, F., Zhang, C. C., Shipitsin, M. V., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,679 · see citing works

Untitled work

(2008) · doi:10.1038/nrg2290 · Cited by 5,199 · see citing works

Cancer genes and the pathways they control

Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,245 · see citing works

Complex networks orchestrate epithelial–mesenchymal transitions

Thiery, J. P., & Sleeman, J. P. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1835 · Cited by 3,947 · see citing works

TGFβ in Cancer

Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907 · see citing works

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852 · see citing works

Gene Silencing in Cancer in Association with Promoter Hypermethylation

Herman, J. G., & Baylin, S. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023075 · Cited by 3,425 · see citing works

Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?

Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121 · see citing works

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

Yang, J., & Weinberg, R. A. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.05.009 · Cited by 3,016 · see citing works

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605 · see citing works

The history of cancer epigenetics

Feinberg, A. P., & Tycko, B. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1279 · Cited by 2,350 · see citing works

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

Park, S.-M., Gaur, A. B., Lengyel, E., & Peter, M. E. (2008) · Genes & Development · doi:10.1101/gad.1640608 · Cited by 2,272 · see citing works

The Role of DNA Methylation in Mammalian Epigenetics

Jones, P. A., & Takai, D. (2001) · Science · doi:10.1126/science.1063852 · Cited by 2,063 · see citing works

let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells

Yu, F., Yao, H., Zhu, P., Zhang, X., Pan, Q., Gong, C., Huang, Y., Hu, X., Su, F., Lieberman, J., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.054 · Cited by 1,906 · see citing works

Endogenous human microRNAs that suppress breast cancer metastasis

Tavazoie, S. F., Alarcón, C. R., Óskarsson, T., Padua, D. M., Wang, Q., Bos, P. D., Gerald, W. L., & Massagué, J. (2008) · Nature · doi:10.1038/nature06487 · Cited by 1,858 · see citing works

The epigenetic progenitor origin of human cancer

Feinberg, A. P., OHLSSON, R. I., & Henikoff, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1748 · Cited by 1,851 · see citing works

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

Li, X., Lewis, M. T., Huang, J., Gutiérrez, C., Osborne, C. K., Wu, M.-F., Hilsenbeck, S. G., Pavlick, A. C., Zhang, X., Chamness, G. C., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn123 · Cited by 1,794 · see citing works

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

Morel, A., Lièvre, M., Thomas, C., Hinkal, G., Ansieau, S., & Puisieux, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002888 · Cited by 1,673 · see citing works

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

Baylin, S. B., & Ohm, J. E. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1799 · Cited by 1,632 · see citing works

Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition

Zhou, B. P., Deng, J., Xia, W., Xu, J., Li, Y. M., Gunduz, M., & Hung, M.-C. (2004) · Nature Cell Biology · doi:10.1038/ncb1173 · Cited by 1,581 · see citing works

Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways

Önder, T. T., Gupta, P. B., Mani, S. A., Yang, J., Lander, E. S., & Weinberg, R. A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2938 · Cited by 1,527 · see citing works

The impact of O2 availability on human cancer

Bertout, J. A., Patel, S. A., & Simon, M. C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2540 · Cited by 1,365 · see citing works

Small non-coding RNAs in animal development

Stefani, G., & Slack, F. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2347 · Cited by 1,361 · see citing works

Molecular Definition of Breast Tumor Heterogeneity

Shipitsin, M. V., Campbell, L. L., Argani, P., Weremowicz, S., Bloushtain-Qimron, N., Yao, J., Nikolskaya, T., Serebryiskaya, T., Beroukhim, R., Hu, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.013 · Cited by 1,358 · see citing works

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

Radisky, D. C., Levy, D. D., Littlepage, L. E., Liu, H., Nelson, C. M., Fata, J. E., Leake, D., Godden, E. L., Albertson, D. G., Angela Nieto, M., et al. (2005) · Nature · doi:10.1038/nature03688 · Cited by 1,284 · see citing works

Systemic Spread Is an Early Step in Breast Cancer

Hüsemann, Y., Geigl, J. B., Schubert, F., Musiani, P., Meyer, M., Burghart, E., Forni, G., Eils, R., Fehm, T. N., Riethmüller, G., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2007.12.003 · Cited by 1,175 · see citing works

Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression

Hugo, H. J., Ackland, M. L., Blick, T., Lawrence, M. G., Clements, J. A., Williams, E. D., & Thompson, E. W. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21223 · Cited by 1,091 · see citing works

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

Suzuki, H., Watkins, D. N., Jair, K.-W., Schuebel, K. E., Markowitz, S. D., Chen, W. D., Pretlow, T. P., Yang, B., Akiyama, Y., van Engeland, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1330 · Cited by 1,070 · see citing works

Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype

Sarrió, D., Rodríguez-Pinilla, S. M., Hardisson, D., Cano, A., Moreno‐Bueno, G., & Palacios, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2017 · Cited by 1,057 · see citing works

Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

Brabletz, T., Jung, A., Reu, S., Porzner, M., Hlubek, F., Kunz‐Schughart, L. A., Knuechel, R., & Kirchner, T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171610498 · Cited by 1,048 · see citing works

CD44+/CD24-breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis

Sheridan, C. A., Kishimoto, H., Fuchs, R. K., Mehrotra, S., Bhat‐Nakshatri, P., Turner, C. H., Goulet, R. J., Badve, S., & Nakshatri, H. (2006) · Breast Cancer Research · doi:10.1186/bcr1610 · Cited by 995 · see citing works

The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells

Liu, R., Wang, X., Chen, G., Dalerba, P. D., Gurney, A. L., Hoey, T. C., Sherlock, G. J., Lewicki, J. A., Shedden, K., & Clarke, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063994 · Cited by 984 · see citing works

TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells

James, D., Levine, A. J., Besser, D., & Hemmati‐Brivanlou, A. (2005) · Development · doi:10.1242/dev.01706 · Cited by 896 · see citing works

Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity

Ozdamar, B., Bose, R., Barrios-Rodiles, M., Wang, H.-R., Zhang, Y., & Wrana, J. L. (2005) · Science · doi:10.1126/science.1105718 · Cited by 881 · see citing works

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

Sahlgren, C., Gustafsson, M. V., Jin, S., Poellinger, L., & Lendahl, U. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802047105 · Cited by 823 · see citing works

MicroRNA expression and function in cancer

Garzon, R., Fabbri, M., Cimmino, A., Calin, G. A., & Croce, C. M. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.10.006 · Cited by 782 · see citing works

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

Ansieau, S., Bastid, J., Doreau, A., Morel, A., Bouchet, B. P., Thomas, C., Fauvet, F., Puisieux, I., Doglioni, C., Piccinin, S., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.06.005 · Cited by 713 · see citing works

A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial–mesenchymal transitionPreprint

Beltran-Nebot, M., Puig, I., Peña, C., García, J. M., Álvarez, A. B., Peña, R., Bonilla, F., & de Herreros, A. G. (2008) · Genes & Development · doi:10.1101/gad.455708 · Cited by 677 · see citing works

Transcriptional regulation of cell polarity in EMT and cancer

Moreno‐Bueno, G., Portillo, F., & Cano, A. (2008) · Oncogene · doi:10.1038/onc.2008.346 · Cited by 610 · see citing works

Mesenchyme Forkhead 1 ( FOXC2 ) plays a key role in metastasis and is associated with aggressive basal-like breast cancers

Mani, S. A., Yang, J., Brooks, M. W., Schwaninger, G., Zhou, A. Y., Miura, N., Kutok, J. L., Hartwell, K. A., Richardson, A. L., & Weinberg, R. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703900104 · Cited by 576 · see citing works

The CD44+/CD24-phenotype is enriched in basal-like breast tumors

Honeth, G., Bendahl, P., Ringnér, M., Saal, L. H., Gruvberger-Saal, S. K., Lövgren, K., Grabau, D. A., Fernö, M., Borg, Å., & Hegardt, C. (2008) · Breast Cancer Research · doi:10.1186/bcr2108 · Cited by 553 · see citing works

MicroRNAs as regulators of epithelial-mesenchymal transition

Gregory, P. A., Bracken, C. P., Bert, A. G., & Goodall, G. J. (2008) · Cell Cycle · doi:10.4161/cc.7.20.6851 · Cited by 506 · see citing works

Expression of the Transcription Factors Snail, Slug, and Twist and Their Clinical Significance in Human Breast Cancer

Martin, T. A., Goyal, A., Watkins, G., & Jiang, W. G. (2005) · Annals of Surgical Oncology · doi:10.1245/aso.2005.04.010 · Cited by 484 · see citing works

E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.

Berx, G., Cleton-Jansen, A., Strumane, K., et al. (1996) · PubMed · Cited by 467 · see citing works

Role for DNA methylation in the control of cell type–specific maspin expression

Futscher, B. W., Oshiro, M. M., Wozniak, R. J., Holtan, N., Hanigan, C. L., Duan, H., & Domann, F. E. (2002) · Nature Genetics · doi:10.1038/ng886 · Cited by 442 · see citing works

Snail, Slug, and Smad‐interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma

Elloul, S., Elstrand, M. B., Nesland, J. M., Tropé, C. G., Kvalheim, G., Goldberg, I., Reich, R., & Davidson, B. (2005) · Cancer · doi:10.1002/cncr.20946 · Cited by 429 · see citing works

Transitions between epithelial and mesenchymal states in development and disease

Baum, B., Settleman, J. E., & Quinlan, M. P. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.02.001 · Cited by 398 · see citing works

Methylation Patterns of the E-cadherin 5′ CpG Island Are Unstable and Reflect the Dynamic, Heterogeneous Loss of E-cadherin Expression during Metastatic Progression

Graff, J. R., Gabrielson, E. W., Fujii, H., Baylin, S. B., & Herman, J. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2727 · Cited by 393 · see citing works

Is cancer a disease of self-seeding?

Norton, L., & Massagué, J. (2006) · Nature Medicine · doi:10.1038/nm0806-875 · Cited by 346 · see citing works

E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines

Lombaerts, M., van Wezel, T., Philippo, K., Dierssen, J. W. F., Zimmerman, R. M. E., Oosting, J., van Eijk, R., Eilers, P. H. C., van de Water, B., Cornelisse, C. J., et al. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6602996 · Cited by 344 · see citing works

Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

Aguilera, Ó., Fraga, M. F., Ballestar, E., Paz, M. F., Herranz, M., Espada, J., García, J. M., Múñoz, A., Esteller, M., & González‐Sancho, J. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209439 · Cited by 338 · see citing works

Mesenchymal to Epithelial Transition in Development and Disease

Chaffer, C. L., Thompson, E. W., & Williams, E. D. (2007) · Cells Tissues Organs · doi:10.1159/000101298 · Cited by 322 · see citing works

Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers

Sabbah, M., Emami, S., Redeuilh, G., Julien-Grille, S., Prevost, G. P., Zimber, A., Ouelaa-Benslama, R., Bracke, M., Wever, O. D., & Gespach, C. P. (2008) · Drug Resistance Updates · doi:10.1016/j.drup.2008.07.001 · Cited by 322 · see citing works

Review: Biological relevance of disseminated tumor cells in cancer patients

Riethdorf, S., Wikman, H., & Pantel, K. (2008) · International Journal of Cancer · doi:10.1002/ijc.23825 · Cited by 310 · see citing works

Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells

Cannito, S., Novo, E., Compagnone, A., di Bonzo, L. V., Busletta, C., Zamara, E., Paternostro, C., Povero, D., Bandino, A., Bozzo, F., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn216 · Cited by 309 · see citing works

Aberrant methylation of the estrogen receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer.

Nass, S. J., Herman, J. G., Gabrielson, E. W., et al. (2000) · PubMed · Cited by 294 · see citing works

The Wnt Antagonist sFRP1 in Colorectal Tumorigenesis

Caldwell, G. M., Jones, C., Gensberg, K., Jan, S., Hardy, R. G., Byrd, P. J., Chughtai, S., Wallis, Y., Matthews, G. M., & Morton, D. G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1346 · Cited by 281 · see citing works

Snail and Slug Play Distinct Roles during Breast Carcinoma Progression

Côme, C., Magnino, F., Bibeau, F., Barbara, P. D. S., Becker, K., Theillet, C. G., & Savagner, P. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0478 · Cited by 261 · see citing works

SLUG (SNAI2) deletions in patients with Waardenburg disease

Sánchez‐Martín, M. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.25.3231 · Cited by 258 · see citing works

Global loss of imprinting leads to widespread tumorigenesis in adult mice

Holm, T. M., Jackson‐Grusby, L., Brambrink, T., Yamada, Y., Rideout, W. M., & Jaenisch, R. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.09.007 · Cited by 252 · see citing works

Cell type-specific DNA methylation patterns in the human breast

Bloushtain-Qimron, N., Yao, J., Snyder, E. L., Shipitsin, M., Campbell, L. L., Mani, S. A., Hu, M., Chen, H., Ustyansky, V., Antosiewicz, J., et al. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0805206105 · Cited by 243 · see citing works

Expression of Snail protein in tumor–stroma interface

Francı́, C., Takkunen, M., Dave, N., Alameda, F., Gómez, S., Rodríguez, R., Escrivà, M., Montserrat-Sentís, B., Baró, T., Garrido, M., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209519 · Cited by 220 · see citing works

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers

Dumont, N., Wilson, M. B., Crawford, Y., Reynolds, P. A., Sigaroudinia, M., & Tlsty, T. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807146105 · Cited by 210 · see citing works

Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins

Bailey, J. M., Singh, P. K., & Hollingsworth, M. A. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21509 · Cited by 209 · see citing works

The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression

Vincan, E., & Barker, N. (2008) · Clinical & Experimental Metastasis · doi:10.1007/s10585-008-9156-4 · Cited by 198 · see citing works

Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions

Barr, S. M., Thomson, S., Buck, E. A., Russo, S. M., Petti, F., Sujka-Kwok, I., Eyzaguirre, A., Rosenfeld-Franklin, M., Gibson, N. W., Miglarese, M. R., et al. (2008) · Clinical & Experimental Metastasis · doi:10.1007/s10585-007-9121-7 · Cited by 197 · see citing works

Epigenetic Inactivation of the Canonical Wnt Antagonist SRY-Box Containing Gene 17 in Colorectal Cancer

Zhang, W., Glöckner, S. C., Guo, M., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6349 · Cited by 186 · see citing works

Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway

Pérez‐Losada, J., Sánchez‐Martín, M., Rodrı́guez-Garcı́a, A., Sánchez, M. L., Órfão, A., Flores, T., & Sánchez-Garcı́a, I. (2002) · Blood · doi:10.1182/blood.v100.4.1274.h81602001274_1274_1286 · Cited by 182 · see citing works

Hypoxic Regulation of Metastasis via Hypoxia-Inducible Factors

Vooijs, M., Gort, E. H., Groot, A. J., van der Wall, E., & van Diest, P. J. (2008) · Current Molecular Medicine · doi:10.2174/156652408783565568 · Cited by 146 · see citing works

Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin

Yates, C. C., Shepard, C. R., Stolz, D. B., et al. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603700 · Cited by 143 · see citing works

Hereditary diffuse gastric cancer: association with lobular breast cancer

Schrader, K. A., Masciari, S., Boyd, N., Wiyrick, S. J., Kaurah, P., Senz, J., Burke, W., Lynch, H. T., Garber, J. E., & Huntsman, D. D. (2007) · Familial Cancer · doi:10.1007/s10689-007-9172-6 · Cited by 128 · see citing works

Pharmacological Inhibition of DNA Methylation Induces Proinvasive and Prometastatic Genes In Vitro and In Vivo

Ateeq, B., Unterberger, A., Moshe Szyf, A., & Rabbani, S. A. (2008) · Neoplasia · doi:10.1593/neo.07947 · Cited by 120 · see citing works

Regulation of DNA Methylation in Human Breast Cancer

Guo, Y., Pakneshan, P., Gladu, J., Slack, A., Moshe Szyf, A., & Rabbani, S. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201864200 · Cited by 119 · see citing works

Disseminated Tumor Cells in Bone Marrow and Circulating Tumor Cells in Blood of Breast Cancer Patients: Current State of Detection and Characterization

Riethdorf, S., & Pantel, K. (2008) · Pathobiology · doi:10.1159/000123852 · Cited by 111 · see citing works

Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition

Cano, A., & Nieto, M. A. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.05.005 · Cited by 107 · see citing works

Cancer epigenomics

Plass, C. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.20.2479 · Cited by 105 · see citing works

Epithelial-to-mesenchymal transition confers resistance to apoptosis in three murine mammary epithelial cell lines

Robson, E. J. D., Khaled, W. T., Abell, K., & Watson, C. J. (2006) · Differentiation · doi:10.1111/j.1432-0436.2006.00075.x · Cited by 103 · see citing works

The transcription factor ZEB1 (δEF1) represses Plakophilin 3 during human cancer progression

Aigner, K., Descovich, L., Mikula, M., et al. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.03.026 · Cited by 92 · see citing works

The epithelial cell default‐phenotype hypothesis and its implications for cancer

Frisch, S. M. (1997) · BioEssays · doi:10.1002/bies.950190811 · Cited by 92 · see citing works

Comparison of bone marrow, disseminated tumour cells and blood-circulating tumour cells in breast cancer patients after primary treatment

Slade, M. J., Payne, R., Riethdorf, S., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604773 · Cited by 79 · see citing works

Role of myofibroblasts in innate chemoresistance of pancreatic carcinoma—Epigenetic downregulation of caspases

Müerköster, S. S., Werbing, V., Koch, D., Sipos, B., Ammerpohl, O., Kalthoff, H., Tsao, M., Fölsch, U. R., & Schäfer, H. (2008) · International Journal of Cancer · doi:10.1002/ijc.23703 · Cited by 71 · see citing works

Signal pathway profiling of epithelial and stromal compartments of colonic carcinoma reveals epithelial-mesenchymal transition

Sheehan, K. M., Gulmann, C., Eichler, G. S., Weinstein, J. N., Barrett, H. L., Kay, E. W., Conroy, R. M., Liotta, L. A., & Petricoin, E. F. (2007) · Oncogene · doi:10.1038/sj.onc.1210647 · Cited by 59 · see citing works

Hereditary diffuse gastric cancer

Dunbier, A. K., & Guilford, P. (2001) · Advances in cancer research · doi:10.1016/s0065-230x(01)83002-5 · Cited by 43 · see citing works

The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression

Aigner, K., Descovich, L., Mikula, M., et al. (2007) · VUBIR (Vrije Universiteit Brussel) · Cited by 41 · see citing works

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Immunity, Inflammation, and Cancer

Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755 · see citing works

EMT: 2016

Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492 · see citing works

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

Shibue, T., & Weinberg, R. A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.44 · Cited by 2,539 · see citing works

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

Singh, A., & Settleman, J. (2010) · Oncogene · doi:10.1038/onc.2010.215 · Cited by 2,545 · see citing works

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

Yu, M., Bardia, A., Wittner, B. S., Stott, S. L., Smas, M. E., Ting, D. T., Isakoff, S. J., Ciciliano, J. C., Wells, M. N., Shah, A. M., et al. (2013) · Science · doi:10.1126/science.1228522 · Cited by 2,476 · see citing works

EMT and Dissemination Precede Pancreatic Tumor Formation

Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.025 · Cited by 2,136 · see citing works

Proteogenomic characterization of human colon and rectal cancer

CPTAC, T. N., Zhang, B., Wang, J., Wang, X., Zhu, J., Liu, Q., Shi, Z., Chambers, M. C., Zimmerman, L. J., Shaddox, K. F., et al. (2014) · Nature · doi:10.1038/nature13438 · Cited by 1,462 · see citing works

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

Zhang, Z., Lee, J. C., Lin, L., Olivas, V., Au, V., LaFramboise, T., Abdel-Rahman, M., Wang, X., Levine, A. D., Rho, J. K., et al. (2012) · Nature Genetics · doi:10.1038/ng.2330 · Cited by 1,224 · see citing works

Anoikis molecular pathways and its role in cancer progression

Paoli, P., Giannoni, E., & Chiarugi, P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.026 · Cited by 1,160 · see citing works

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

Hirsch, H. A., Iliopoulos, D., Tsichlis, P. N., & Struhl, K. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2994 · Cited by 1,115 · see citing works

The Roles of Autophagy in Cancer

Yun, C. W., & Lee, S. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113466 · Cited by 965 · see citing works

Epithelial-mesenchymal transition in cancer development and its clinical significance

Iwatsuki, M., Mimori, K., Yokobori, T., Ishi, H., Beppu, T., Nakamori, S., Baba, H., & Mori, M. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2009.01419.x · Cited by 780 · see citing works

Epithelial-mesenchymal transitions: insights from development

Lim, J., & Thiery, J. P. (2012) · Development · doi:10.1242/dev.071209 · Cited by 661 · see citing works

Collagen as a double-edged sword in tumor progression

Fang, M., Yuan, J., Peng, C., & Li, Y. (2014) · Tumor Biology · doi:10.1007/s13277-013-1511-7 · Cited by 580 · see citing works

Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness

Giannoni, E., Bianchini, F., Masieri, L., Serni, S., Torre, E., Calorini, L., & Chiarugi, P. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0785 · Cited by 596 · see citing works

Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

Gjerdrum, C., Tiron, C., Høiby, T., Stefansson, I., Haugen, H., Sandal, T., Collett, K., Li, S., McCormack, E., Gjertsen, B. T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909333107 · Cited by 594 · see citing works

Mechanisms Governing Metastatic Dormancy and Reactivation

Giancotti, F. G. (2013) · Cell · doi:10.1016/j.cell.2013.10.029 · Cited by 586 · see citing works

Stem cell programs in cancer initiation, progression, and therapy resistance

Huang, T., Song, X., Xu, D., Tiek, D., Goenka, A., Wu, B., Sastry, N., Hu, B., & Cheng, S.-Y. (2020) · Theranostics · doi:10.7150/thno.41648 · Cited by 524 · see citing works

The p53 orchestra: Mdm2 and Mdmx set the tone

Wade, M., Wang, Y. V., & Wahl, G. M. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.01.009 · Cited by 450 · see citing works

Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

Iliopoulos, D., Lindahl-Allen, M., Polytarchou, C., Hirsch, H. A., Tsichlis, P. N., & Struhl, K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.013 · Cited by 399 · see citing works

Cellular zinc metabolism and zinc signaling: From biological functions to diseases and therapeutic targets

Chen, B., Yu, P., Chan, W. N., Xie, F., Zhang, Y., Liang, L., Leung, K. T., Lo, K. W., Yu, J., Tse, G. M. K., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01679-y · Cited by 420 · see citing works

Adult stem cells in the endometrium

Gargett, C. E., & Masuda, H. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq061 · Cited by 361 · see citing works

The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis

Han, L., Wu, Y., Fang, K., Sweeney, S., Roesner, U. K., Parrish, M., Patel, K., Walter, T., Piermattei, J., Trimboli, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-34464-6 · Cited by 369 · see citing works

The Mdm2–p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

Manfredi, J. J. (2010) · Genes & Development · doi:10.1101/gad.1941710 · Cited by 344 · see citing works

Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

Chen, J., Imanaka, N., Chen, J., & Griffin, J. D. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605486 · Cited by 346 · see citing works

Pathogenesis of uterine adenomyosis, invagination or metaplasia?

García-Solares, J., Donnez, J., Donnez, O., & Dolmans, M.-M. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.12.030 · Cited by 339 · see citing works

Pathogenesis of adenomyosis, an update on molecular mechanisms

Vannuccini, S., Tosti, C., Carmona, F., Huang, S. J., Chapron, C., Guo, S.-W., & Petraglia, F. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.06.016 · Cited by 326 · see citing works

Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma

Shan, J., Shen, J., Liu, L., Xia, F., Xu, C., Duan, G., Xu, Y., Ma, Q., Yang, Z., Zhang, Q., et al. (2012) · Hepatology · doi:10.1002/hep.25745 · Cited by 296 · see citing works

Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells

Liu, Z., Li, Q., Li, K., Chen, L., Li, W., Hou, M., Liu, T., Yang, J., Lindvall, C., Björkholm, M., et al. (2013) · Oncogene · doi:10.1038/onc.2012.441 · Cited by 276 · see citing works

Epithelial-mesenchymal transition: From molecular mechanisms, redox regulation to implications in human health and disease

Cannito, S., Novo, E., di Bonzo, L. V., Busletta, C., Colombatto, S., & Parola, M. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2737 · Cited by 239 · see citing works

The morphological and molecular features of the epithelial-to-mesenchymal transition

Moreno-Bueno, G., Peinado, H., Molina, P., Olmeda, D., Cubillo, E., Santos, V., Palacios, J., Portillo, F., & Cano, A. (2009) · Nature Protocols · doi:10.1038/nprot.2009.152 · Cited by 221 · see citing works

Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan

Elgundi, Z., Papanicolaou, M., Major, G., Cox, T. R., Melrose, J., Whitelock, J. M., & Farrugia, B. L. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01482 · Cited by 176 · see citing works

Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer

Nurwidya, F., Takahashi, F., Murakami, A., & Takahashi, K. (2012) · Cancer Research and Treatment · doi:10.4143/crt.2012.44.3.151 · Cited by 177 · see citing works

The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance

Ahmed, S., Bradshaw, A.-D., Gera, S., Dewan, M., & Xu, R. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6010005 · Cited by 174 · see citing works

An integrative ENCODE resource for cancer genomics

Zhang, J., Lee, D., Dhiman, V., Jiang, P., Xu, J., McGillivray, P., Yang, H., Liu, J., Meyerson, W., Clarke, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14743-w · Cited by 172 · see citing works

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

Kozono, S., Lin, Y.-M., Seo, H.-S., Pinch, B., Lian, X., Qiu, C., Herbert, M. K., Chen, C.-H., Tan, L., Gao, Z. J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05402-2 · Cited by 168 · see citing works

Combined Mutation of <i>Apc, Kras</i> , and <i>Tgfbr2</i> Effectively Drives Metastasis of Intestinal Cancer

Sakai, E., Nakayama, M., Oshima, H., Kouyama, Y., Niida, A., Fujii, S., Ochiai, A., Nakayama, K. I., Mimori, K., Suzuki, Y., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3303 · Cited by 133 · see citing works

The Fluid Mechanics of Cancer and Its Therapy

Koumoutsakos, P., Pivkin, I., & Milde, F. (2013) · Annual Review of Fluid Mechanics · doi:10.1146/annurev-fluid-120710-101102 · Cited by 129 · see citing works

Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment

Brown, N. F., & Marshall, J. F. (2019) · Cancers · doi:10.3390/cancers11091221 · Cited by 116 · see citing works

Mesenchymal stem cells and cancer: Friends or enemies?

Hong, I.-S., Lee, H.-Y., & Kang, K.-S. (2014) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2014.01.006 · Cited by 82 · see citing works

O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis

Taparra, K., Wang, H., Malek, R., Lafargue, A., Barbhuiya, M. A., Wang, X., Simons, B. W., Ballew, M., Nugent, K., Groves, J., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci94844 · Cited by 80 · see citing works

Neutralization of terminal differentiation in gliomagenesis

Hu, J., Ho, A. L., Yuan, L., Hu, B., Hua, S., Hwang, S. S., Zhang, J., Hu, T., Zheng, H., Gan, B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308610110 · Cited by 76 · see citing works

Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer (Review)

DI, C., & ZHAO, Y. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.2141 · Cited by 72 · see citing works

Identification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environment

Bai, J., Tu, T.-Y., Kim, C., Thiery, J. P., & Kamm, R. D. (2015) · Oncotarget · doi:10.18632/oncotarget.5464 · Cited by 70 · see citing works

Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions

Vazquez-Martin, A., López-Bonetc, E., Cufí, S., Oliveras-Ferraros, C., Del Barco, S., Martin-Castillo, B., & Menendez, J. A. (2011) · Drug Resistance Updates · doi:10.1016/j.drup.2011.04.003 · Cited by 66 · see citing works

Upregulation of CD36, a fatty acid translocase, promotes colorectal cancer metastasis by increasing MMP28 and decreasing e-cadherin expression

Drury, J., Rychahou, P. G., Kelson, C. O., Geisen, M. E., Wu, Y., He, D., Wang, C., Lee, E. Y., Evers, B. M., & Zaytseva, Y. Y. (2022) · Cancers · doi:10.3390/cancers14010252 · Cited by 64 · see citing works

Human cancer stem cells are a target for cancer prevention using (−)-epigallocatechin gallate

Fujiki, H., Sueoka, E., Rawangkan, A., & Suganuma, M. (2017) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-017-2515-2 · Cited by 64 · see citing works

Highly sensitive profiling of CD44+/CD24− breast cancer stem cells by combining global mRNA amplification and next generation sequencing: Evidence for a hyperactive PI3K pathway

Hardt, O., Wild, S., Oerlecke, I., Hofmann, K., Luo, S., Wiencek, Y., Kantelhardt, E., Vess, C., Smith, G. P., Schroth, G. P., et al. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.06.010 · Cited by 64 · see citing works

Survival Benefit of Metformin Adjuvant Treatment For Pancreatic Cancer Patients: a Systematic Review and Meta-Analysis

Wan, G., Sun, X., Li, F., Wang, X., Li, C., Li, H., Yu, X., & Cao, F. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493214 · Cited by 57 · see citing works

Colorectal premalignancy is associated with consensus molecular subtypes 1 and 2

Chang, K., Willis, J. A., Reumers, J., Taggart, M. W., San Lucas, F. A., Thirumurthi, S., Kanth, P., Delker, D. A., Hagedorn, C. H., Lynch, P. M., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy337 · Cited by 51 · see citing works

Circumventing senescence is associated with stem cell properties and metformin sensitivity

Deschênes‐Simard, X., Parisotto, M., Rowell, M., Le Calvé, B., Igelmann, S., Moineau‐Vallée, K., Saint‐Germain, E., Kalegari, P., Bourdeau, V., Kottakis, F., et al. (2019) · Aging Cell · doi:10.1111/acel.12889 · Cited by 45 · see citing works

Biomarkers for early diagnosis of pancreatic cancer

Jenkinson, C., Earl, J., Ghaneh, P., Halloran, C., Carrato, A., Greenhalf, W., Neoptolemos, J., & Costello, E. (2015) · Expert Review of Gastroenterology &amp; Hepatology · doi:10.1586/17474124.2015.965145 · Cited by 42 · see citing works

Estrone, the major postmenopausal estrogen, binds ERa to induce SNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancer metastasis

Qureshi, R., Picon-Ruiz, M., Sho, M., Van Booven, D., Nunes de Paiva, V., Diaz-Ruano, A. B., Ince, T. A., & Slingerland, J. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111672 · Cited by 37 · see citing works

A link between premenopausal iron deficiency and breast cancer malignancy

Jian, J., Yang, Q., Shao, Y., Axelrod, D., Smith, J., Singh, B., Krauter, S., Chiriboga, L., Yang, Z., Li, J., et al. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-307 · Cited by 37 · see citing works

Engaging plasticity: Differentiation therapy in solid tumors

Bar-Hai, N., & Ishay-Ronen, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.944773 · Cited by 35 · see citing works

SALL4 is a marker of poor prognosis in serous ovarian carcinoma promoting invasion and metastasis

YANG, M., XIE, X., & DING, Y. (2016) · Oncology Reports · doi:10.3892/or.2016.4545 · Cited by 30 · see citing works

SMAD4 Y353C promotes the progression of PDAC

Wang, Z., Li, Y., Zhan, S., Zhang, L., Zhang, S., Tang, Q., Li, M., Tan, Z., Liu, S., & Xing, X. (2019) · BMC Cancer · doi:10.1186/s12885-019-6251-7 · Cited by 25 · see citing works

Synergy of EGFR and AURKA Inhibitors in <i>KRAS</i> -mutated Non–small Cell Lung Cancers

Bagnyukova, T., Egleston, B. L., Pavlov, V. A., Serebriiskii, I. G., Golemis, E. A., & Borghaei, H. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0482 · Cited by 14 · see citing works

Thymosin β4 is rapidly internalized by cells and does not induce intracellular Ca²⁺ elevation

Cierniewski, C. S., Sobierajska, K., Selmi, A., Kryczka, J., & Bednarek, R. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06685.x · Cited by 14 · see citing works

Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1

Thüring, E.-M., Hartmann, C., Maddumage, J. C., Javorsky, A., Michels, B. E., Gerke, V., Banks, L., Humbert, P. O., Kvansakul, M., & Ebnet, K. (2023) · Communications Biology · doi:10.1038/s42003-023-05088-3 · Cited by 7 · see citing works

Disruption of Circulating Extracellular Vesicles as a Novel Therapeutic Strategy against Cancer Metastasis

Nishida-Aoki, N., Tominaga, N., Takeshita, F., Sonoda, H., Yoshioka, Y., & Ochiya, T. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.10.009 · Cited by 208 · see citing works

Reasons for cancer metastasis: A holistic perspective

Wang, R., Lu, Y., & Fan, D.-M. (2015) · Molecular and Clinical Oncology · doi:10.3892/mco.2015.623 · Cited by 21 · see citing works

Cancer Metastasis and Cancer Stem Cells

Liu, H., Wang, H., & Qian, H. (2014) · Journal of cancer research updates · doi:10.6000/1929-2279.2014.03.04.2

The relationship between hypoglycemia-inducing O-GlcNAcylation and epithelial mesenchymal transition.

Kim, E., & Cho, J. W. (2016) · 한국당과학회 학술대회

The new therapeutic strategy for inhibition of cancer metastasis: targeting extravasation of cancer cells

Yun-lon, S. (2014) · Tumori