GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis
Open accessAbstract
Chemotaxis requires precisely coordinated polymerization and depolymerization of the actin cytoskeleton at leading fronts of migrating cells. However, GPCR activation-controlled F-actin depolymerization remains largely elusive. Here, we reveal a novel signaling pathway, including Gαi, PLC, PKCβ, protein kinase D (PKD), and SSH2, in control of cofilin phosphorylation and actin cytoskeletal reorganization, which is essential for neutrophil chemotaxis. We show that PKD is essential for neutrophil chemotaxis and that GPCR-mediated PKD activation depends on PLC/PKC signaling. More importantly, we discover that GPCR activation recruits/activates PLCγ2 in a PI3K-dependent manner. We further verify that PKCβ specifically interacts with PKD1 and is required for chemotaxis. Finally, we identify slingshot 2 (SSH2), a phosphatase of cofilin (actin depolymerization factor), as a target of PKD1 that regulates cofilin phosphorylation and remodeling of the actin cytoskeleton during neutrophil chemotaxis.
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Recruitment of PLCγ2 to the membrane has been observed during chemotaxis of neutrophils, with PLCγ2 localised to the leading edge of migrating cells.
“Recruitment of PLCγ2 to the membrane, a well-characterized mechanism of PLC activation, has been observed during chemotaxis of neutrophils, with PLCγ2 being localised to the leading edge of migrating cells51.”
From PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages (2021) · cites this paper as [51]
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- Authors
- Xu, X., Gera, N., Li, H., Yun, M., Zhang, L., Wang, Y., Wang, Q. J., & Jin, T.
- Affiliations
- National Institutes of Health (US)
- University of Pittsburgh (US)
- Venue
- Molecular Biology of the Cell
- Published
- 2015-03
- Volume
- 26
- Issue
- 5
- Pages
- 874-886
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC4342024
- OpenAlex
- W2155467489
- Cited by
- 55
- References
- 38
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 10 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 3
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- Molecular Biology of the Cell (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA129127, R01CA142580)
- National Institute of Allergy and Infectious Diseases
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Keywords
- neutrophil chemotaxis, G protein-coupled receptor signaling, protein kinase C beta, protein kinase D, cofilin dephosphorylation, actin cytoskeleton remodeling, F-actin depolymerization, Gαi, PI3K signaling, PLCγ2, PKD1
- MeSH terms
- Animals, Chemotaxis, Leukocyte, Female, Humans, Male, Actin Cytoskeleton, Neutrophils, Phosphoprotein Phosphatases, Protein Kinase C, Signal Transduction, Receptors, G-Protein-Coupled, Cofilin 1, Mice, Phospholipase C gamma, Phospholipase C beta, Protein Kinase C beta
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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