Cited by 61Cellular transport and secretionAlzheimer's disease research and treatmentsLysosomal Storage Disorders Research
GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production
Open accessToh, Wei Hong, Chia, Pei Zhi Cheryl, Hossain, Mohammed Iqbal, Gleeson, Paul A.·2018·Molecular Biology of the Cell
Abstract
The diversion of the β-secretase BACE1 from the endo-lysosomal pathway to recycling endosomes is important in the regulation of amyloid beta production. Here we define BACE1 transport from early to recycling endosomes and identify essential roles for the SNX4-mediated, signal-independent pathway and for a signal-mediated, GGA1-dependent pathway.
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GGA1 interacts with a DISLL motif in cytoplasmic tail of BACE1 and is required for endosomal sorting of BACE1.
“GGA1, which can interact with a DISLL motif in the cytoplasmic tail of BACE1, is required for the endosomal sorting of BACE1 (He et al., 2002, 2005; Toh et al., 2018).”
From Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production (2020) · cites this paper as Toh et al., 2018
The Introduction places the DISLL motif in BACE1’s cytoplasmic tail, and the Discussion says GGA1 recognizes its phosphorylated form. The Discussion also describes a separate SNX4-dependent sorting pathway and reports that GGA1 silencing reduces transport to recycling endosomes by about 30%. Thus, GGA1 is required for the signal-dependent pathway, not for all endosomal sorting of BACE1. (LLM, conf=0.88)
Experimental — accuracy not yet measuredExtended residency of BACE1 at early endosomes leads to an increase in Aβ production.
“an extended residency time of BACE1 at the early endosomes also leads to an increase in Aβ production (Toh et al., 2018).”
From Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production (2020) · cites this paper as Toh et al., 2018
Internalized BACE1 traffics to early endosomes and recycles back to the plasma membrane via recycling endosomes.
“The intracellular itinerary of internalized BACE1 to the early endosomes followed by the recycling of BACE1 back to the plasma membrane (PM) via the recycling endosomes has been established previously (Chia et al., 2013; Toh et al., 2018).”
From Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production (2020) · cites this paper as Toh et al., 2018
GGA1 is not required for post-Golgi export of BACE1.
“In contrast, GGA1, which is also found at the Golgi, is not required for the post-Golgi export of BACE1.”
From Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production (2020) · cites this paper as Toh et al., 2018
The Results section on GGA1 depletion and the Discussion address BACE1 transport from early endosomes to recycling endosomes, not its export from the Golgi. A search for post-Golgi export and Golgi-to-plasma-membrane trafficking found no passage in our copy establishing whether GGA1 is required for that step. (LLM, conf=0.72)
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Cites
Muhammad, A., Flores, I., Zhang, H., Yu, R., Staniszewski, A., Planel, E., Herman, M., Ho, L., Kreber, R., Honig, L. S., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802545105 · Cited by 248 · see citing works
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Research works printed but not linked: 81
- Andersen OM Reiche J Schmidt V Gotthardt M Spoelgen R Behlke J von Arnim CA Breiderhoff T Jansen P Wu X Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein Proc Natl Acad Sci USA 2005 102 13461 13466 16174740 PMC1224625
- Arighi CN Hartnell LM Aguilar RC Haft CR Bonifacino JS Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor J Cell Biol 2004 165 123 133 15078903 PMC2172094
- Balana B Maslennikov I Kwiatkowski W Stern KM Bahima L Choe S Slesinger PA Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27 Proc Natl Acad Sci USA 2011 108 5831 5836 21422294 PMC3078414
- Berman DE Ringe D Petsko GA Small SA The use of pharmacological retromer chaperones in Alzheimer’s disease and other endosomal-related disorders Neurotherapeutics 2015 12 12 18 25472693 PMC4322078
- Bero AW Yan P Roh JH Cirrito JR Stewart FR Raichle ME Lee JM Holtzman DM Neuronal activity regulates the regional vulnerability to amyloid-beta deposition Nat Neurosci 2011 14 750 756 21532579 PMC3102784
- Bonifacino JS The GGA proteins: adaptors on the move Nat Rev Mol Cell Biol 2004 5 23 32 14708007
- Buggia-Prevot V Fernandez CG Riordan S Vetrivel KS Roseman J Waters J Bindokas VP Vassar R Thinakaran G Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase Mol Neurodegener 2014 9 1 17 24386896 PMC4031619
- Buggia-Prevot V Fernandez CG Udayar V Vetrivel KS Elie A Roseman J Sasse VA Lefkow M Meckler X Bhattacharyya S A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer’s disease Abeta production Cell Rep 2013 5 1552 1563 24373286 PMC3932704
- Burgos PV Mardones GA Rojas AL daSilva LL Prabhu Y Hurley JH Bonifacino JS Sorting of the Alzheimer’s disease amyloid precursor protein mediated by the AP-4 complex Dev Cell 2010 18 425 436 20230749 PMC2841041
- Chia PZ Ramdzan YM Houghton FJ Hatters DM Gleeson PA High-throughput quantitation of intracellular trafficking and organelle disruption by flow cytometry Traffic 2014 15 572 582 24612275
- Chia PZ Toh WH Sharples R Gasnereau I Hill AF Gleeson PA Intracellular itinerary of internalised beta-secretase, BACE1, and its potential impact on beta-amyloid peptide biogenesis Traffic 2013 14 997 1013 23773724
- Cirrito JR Yamada KA Finn MB Sloviter RS Bales KR May PC Schoepp DD Paul SM Mennerick S Holtzman DM Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo Neuron 2005 48 913 922 16364896
- Clairfeuille T Mas C Chan AS Yang Z Tello-Lafoz M Chandra M Widagdo J Kerr MC Paul B Merida I A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex Nat Struct Mol Biol 2016 23 921 932 27595347
- Collins BM The structure and function of the retromer protein complex Traffic 2008 9 1811 1822 18541005
- Cullen PJ Korswagen HC Sorting nexins provide diversity for retromer-dependent trafficking events Nat Cell Biol 2012 14 29 37 PMC3613977 22193161
- Danysz W Parsons CG Alzheimer’s disease, beta-amyloid, glutamate, NMDA receptors and memantine—searching for the connections Br J Pharmacol 2012 167 324 352 22646481 PMC3481041
- Das U Scott DA Ganguly A Koo EH Tang Y Roy S Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway Neuron 2013 79 447 460 23931995 PMC3741682
- Das UK Daifuku SL Gorelsky SI Korobkov I Neidig ML Le Roy JJ Murugesu M Baker RT Mononuclear, dinuclear, and trinuclear iron complexes featuring a new monoanionic SNS thiolate ligand Inorg Chem 2016 55 987 997 26741465
- Finan GM Okada H Kim TW BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin J Biol Chem 2011 286 12602 12616 21245145 PMC3069461
- Gallon M Clairfeuille T Steinberg F Mas C Ghai R Sessions RB Teasdale RD Collins BM Cullen PJ A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer Proc Natl Acad Sci USA 2014 111 E3604 E3613 25136126 PMC4156734
- Gallon M Cullen PJ Retromer and sorting nexins in endosomal sorting Biochem Soc Trans 2015 43 33 47 25619244
- Ghai R Bugarcic A Liu H Norwood SJ Skeldal S Coulson EJ Li SS Teasdale RD Collins BM Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins Proc Natl Acad Sci USA 2013 110 E643 E652 23382219 PMC3581954
- Ginsberg SD Mufson EJ Alldred MJ Counts SE Wuu J Nixon RA Che S Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer’s disease J Chem Neuroanat 2011 42 102 110 21669283 PMC3163754
- Grant BD Donaldson JG Pathways and mechanisms of endocytic recycling Nat Rev Mol Cell Biol 2009 10 597 608 19696797 PMC3038567
- He X Li F Chang WP Tang J GGA proteins mediate the recycling pathway of memapsin 2 (BACE) J Biol Chem 2005 280 11696 11703 15615712
- Herskowitz JH Offe K Deshpande A Kahn RA Levey AI Lah JJ GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-beta production Mol Biol Cell 2012 23 2645 2657 22621900 PMC3395654
- Hsu VW Bai M Li J Getting active: protein sorting in endocytic recycling Nat Rev Mol Cell Biol 2012 13 323 328 22498832
- Hsu VW Prekeris R Transport at the recycling endosome Curr Opin Cell Biol 2010 22 528 534 20541925 PMC2910225
- Huse JT Pijak DS Leslie GJ Lee VM Doms RW Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer’s disease beta-secretase J Biol Chem 2000 275 33729 33737 10924510
- Kamenetz F Tomita T Hsieh H Seabrook G Borchelt D Iwatsubo T Sisodia S Malinow R APP processing and synaptic function Neuron 2003 37 925 937 12670422
- Kang EL Cameron AN Piazza F Walker KR Tesco G Ubiquitin regulates GGA3-mediated degradation of BACE1 J Biol Chem 2010 285 24108 24119 20484053 PMC2911305
- Kim NY Cho MH Won SH Kang HJ Yoon SY Kim DH Sorting nexin-4 regulates beta-amyloid production by modulating beta-site-activating cleavage enzyme-1 Alzheimers Res Ther 2017 9 4 28109317 PMC5251330
- Kinoshita A Fukumoto H Shah T Whelan CM Irizarry MC Hyman BT Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes J Cell Sci 2003 116 3339 3346 12829747
- Koo EH Squazzo SL Selkoe DJ Koo CH Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody J Cell Sci 1996 109 Pt 5 991 998 8743946
- Lieu ZZ Gleeson PA Endosome-to-Golgi transport pathways in physiological processes Histol Histopathol 2011 26 395 408 21210352
- Lim JP Teasdale RD Gleeson PA SNX5 is essential for efficient macropinocytosis and antigen processing in primary macrophages Biol Open 2012 1 904 914 23213485 PMC3507233
- Lorenzen A Samosh J Vandewark K Anborgh PH Seah C Magalhaes AC Cregan SP Ferguson SS Pasternak SH Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway Mol Brain 2010 3 11 20409323 PMC2868040
- McKenzie JE Raisley B Zhou X Naslavsky N Taguchi T Caplan S Sheff D Retromer guides STxB and CD8-M6PR from early to recycling endosomes, EHD1 guides STxB from recycling endosome to Golgi Traffic 2012 13 1140 1159 22540229 PMC3396774
- Mecozzi VJ Berman DE Simoes S Vetanovetz C Awal MR Patel VM Schneider RT Petsko GA Ringe D Small SA Pharmacological chaperones stabilize retromer to limit APP processing Nat Chem Biol 2014 10 443 449 24747528 PMC4076047
- Oishi M Nairn AC Czernik AJ Lim GS Isohara T Gandy SE Greengard P Suzuki T The cytoplasmic domain of Alzheimer’s amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells Mol Med 1997 3 111 123 9085254 PMC2230054
- Pastorino L Ikin AF Nairn AC Pursnani A Buxbaum JD The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta) Mol Cell Neurosci 2002 19 175 185 11860271
- Peric A Annaert W Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction Acta Neuropathol 2015 129 363 381 25556159 PMC4331606
- Popoff V Mardones GA Bai SK Chambon V Tenza D Burgos PV Shi A Benaroch P Urbe S Lamaze C Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes Traffic 2009 10 1868 1880 19874558
- Popoff V Mardones GA Tenza D Rojas R Lamaze C Bonifacino JS Raposo G Johannes L The retromer complex and clathrin define an early endosomal retrograde exit site J Cell Sci 2007 120 2022 2031 17550971
- Prabhu Y Burgos PV Schindler C Farias GG Magadan JG Bonifacino JS Adaptor protein 2-mediated endocytosis of the beta-secretase BACE1 is dispensable for amyloid precursor protein processing Mol Biol Cell 2012 23 2339 2351 22553349 PMC3374752
- Puertollano R Bonifacino JS Interactions of GGA3 with the ubiquitin sorting machinery Nat Cell Biol 2004 6 244 251 15039775
- Rajendran L Honsho M Zahn TR Keller P Geiger KD Verkade P Simons K Alzheimer’s disease beta-amyloid peptides are released in association with exosomes Proc Natl Acad Sci USA 2006 103 11172 11177 16837572 PMC1544060
- Rajendran L Knolker HJ Simons K Subcellular targeting strategies for drug design and delivery Nat Rev Drug Discov 2010 9 29 42 20043027
- Ramdzan YM Polling S Chia CP Ng IH Ormsby AR Croft NP Purcell AW Bogoyevitch MA Ng DC Gleeson PA Hatters DM Tracking protein aggregation and mislocalization in cells with flow cytometry Nat Methods 2012 9 467 470 22426490
- Ren M Xu G Zeng J De Lemos-Chiarandini C Adesnik M Sabatini DD Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes Proc Natl Acad Sci USA 1998 95 6187 6192 9600939 PMC27621
- Rogaeva E Meng Y Lee JH Gu Y Kawarai T Zou F Katayama T Baldwin CT Cheng R Hasegawa H The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease Nat Genet 2007 39 168 177 17220890 PMC2657343
- Scherzer CR Offe K Gearing M Rees HD Fang G Heilman CJ Schaller C Bujo H Levey AI Lah JJ Loss of apolipoprotein E receptor LR11 in Alzheimer disease Arch Neurol 2004 61 1200 1205 15313836
- Schneider C Sutherland R Newman R Greaves M Structural features of the cell surface receptor for transferrin that is recognized by the monoclonal antibody OKT9 J Biol Chem 1982 257 8516 8522 6282884
- Seaman MN Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval J Cell Sci 2007 120 2378 2389 17606993
- Sharples RA Vella LJ Nisbet RM Naylor R Perez K Barnham KJ Masters CL Hill AF Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes FASEB J 2008 22 1469 1478 18171695
- Shiba T Kametaka S Kawasaki M Shibata M Waguri S Uchiyama Y Wakatsuki S Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1 Traffic 2004 5 437 448 15117318
- Siegenthaler BM Rajendran L Retromers in Alzheimer’s disease Neurodegener Dis 2012 10 116 121 22398391
- Small SA Gandy S Sorting through the cell biology of Alzheimer’s disease: intracellular pathways to pathogenesis Neuron 2006 52 15 31 17015224 PMC4820242
- Small SA Kent K Pierce A Leung C Kang MS Okada H Honig L Vonsattel JP Kim TW Model-guided microarray implicates the retromer complex in Alzheimer’s disease Ann Neurol 2005 58 909 919 16315276
- Small SA Petsko GA Retromer in Alzheimer disease, Parkinson disease and other neurological disorders Nat Rev Neurosci 2015 16 126 132 25669742
- Sullivan CP Jay AG Stack EC Pakaluk M Wadlinger E Fine RE Wells JM Morin PJ Retromer disruption promotes amyloidogenic APP processing Neurobiol Dis 2011 43 338 345 21515373 PMC3114192
- Tesco G Koh YH Kang EL Cameron AN Das S Sena-Esteves M Hiltunen M Yang SH Zhong Z Shen Y Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity Neuron 2007 54 721 737 17553422 PMC1973166
- Toh WH Gleeson PA Dysregulation of intracellular trafficking and endosomal sorting in Alzheimer’s disease: controversies and unanswered questions Biochem J 2016 473 1977 1993 27407168
- Toh WH Houghton FJ Chia PZ Ramdzan YM Hatters DM Gleeson PA Application of flow cytometry to analyze intracellular location and trafficking of cargo in cell populations Methods Mol Biol 2015 1270 227 238 25702121
- Toh WH Tan JZ Zulkefli KL Houghton FJ Gleeson PA Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway Traffic 2016 18 159 175 28000370
- Traer CJ Rutherford AC Palmer KJ Wassmer T Oakley J Attar N Carlton JG Kremerskothen J Stephens DJ Cullen PJ SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment Nat Cell Biol 2007 9 1370 1380 17994011
- Udayar V Buggia-Prevot V Guerreiro RL Siegel G Rambabu N Soohoo AL Ponnusamy M Siegenthaler B Bali J Aesg, Simons M A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of beta-amyloid production Cell Rep 2013 5 1536 1551 24373285 PMC4004174
- Ullrich O Reinsch S Urbe S Zerial M Parton RG Rab11 regulates recycling through the pericentriolar recycling endosome J Cell Biol 1996 135 913 924 8922376 PMC2133374
- van Ijzendoorn SC Recycling endosomes J Cell Sci Suppl 2006 119 1679 1681 16636069
- van Weering JR Cullen PJ Membrane-associated cargo recycling by tubule-based endosomal sorting Semin Cell Dev Biol 2014 31 40 47 24641888
- Vardarajan BN Bruesegem SY Harbour ME Inzelberg R Friedland R St George-Hyslop P Seaman MN Farrer LA Identification of Alzheimer disease-associated variants in genes that regulate retromer function Neurobiol Aging 2012 33 2215–2231 22673115 PMC3391348
- Vieira SI Rebelo S Domingues SC da Cruz e Silva EF da Cruz e Silva OA S655 phosphorylation enhances APP secretory traffic Mol Cell Biochem 2009 328 145 154 19381782
- Vieira SI Rebelo S Esselmann H Wiltfang J Lah J Lane R Small SA Gandy S da Cruz ESEF da Cruz ESOA Retrieval of the Alzheimer’s amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated Mol Neurodegener 2010 5 40 20937087 PMC2994555
- von Arnim CAF Tangredi MM Peltan ID Lee BM Irizarry MC Kinoshita A Hyman BT Demonstration of BACE ({beta}-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy J Cell Sci 2004 117 5437 5445 15466887
- Wahle T Prager K Raffler N Haass C Famulok M Walter J GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network Mol Cell Neurosci 2005 29 453 461 15886016
- Walter J Fluhrer R Hartung B Willem M Kaether C Capell A Lammich S Multhaup G Haass C Phosphorylation regulates intracellular trafficking of beta-secretase J Biol Chem 2001 276 14634 14641 11278841
- Wang X Huang T Bu G Xu H Dysregulation of protein trafficking in neurodegeneration Mol Neurodegener 2014 9 31 25152012 PMC4237948
- Wassmer T Attar N Harterink M van Weering JR Traer CJ Oakley J Goud B Stephens DJ Verkade P Korswagen HC Cullen PJ The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network Dev Cell 2009 17 110 122 19619496 PMC2714578
- Wen L Tang FL Hong Y Luo SW Wang CL He W Shen C Jung JU Xiong F Lee DH VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology J Cell Biol 2011 195 765 779 22105352 PMC3257571
- Wersto RP Chrest FJ Leary JF Morris C Stetler-Stevenson MA Gabrielson E Doublet discrimination in DNA cell-cycle analysis Cytometry 2001 46 296 306 11746105
- Woodcroft BJ Hammond L Stow JL Hamilton NA Automated organelle-based colocalization in whole-cell imaging Cytometry A 2009 75 941 950 19746416
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Self-citationAging impact on amyloid precursor protein neuronal trafficking
Burrinha, T., & Guimas Almeida, C. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102524 · Cited by 26 · see citing works
- Authors
- Toh, W. H., Chia, P. Z. C., Hossain, M. I., & Gleeson, P. A.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Gleeson, Paul A.
- Venue
- Molecular Biology of the Cell
- Published
- 2018-01-15
- Volume
- 29
- Issue
- 2
- Pages
- 191-208
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC5909931
- OpenAlex
- W2770255428
- Cited by
- 61
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 15 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 6
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- Molecular Biology of the Cell (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-sa)
- Funders
- University of Bristol
- University of Melbourne
- Medical Research Council
- National Health and Medical Research Council (1082600)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Keywords
- GGA1, BACE1, recycling endosomes, amyloid-beta production, APP processing, endosomal trafficking, retromer, protein phosphorylation, early endosomes, primary neurons
- MeSH terms
- Animals, Brain, Female, HeLa Cells, Humans, Mice, Inbred C57BL, Neurons, Pregnancy, Protein Processing, Post-Translational, Endosomes, Amyloid beta-Peptides, Aspartic Acid Endopeptidases, Amyloid beta-Protein Precursor, Adaptor Proteins, Vesicular Transport, Mice, Amyloid Precursor Protein Secretases, Sorting Nexins
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