Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Aβ accumulation
Open accessAbstract
Although deficiencies in the retromer sorting pathway have been linked to late-onset Alzheimer's disease, whether these deficiencies underlie the disease remains unknown. Here we characterized two genetically modified animal models to test separate but related questions about the effects that retromer deficiency has on the brain. First, testing for cognitive defects, we investigated retromer-deficient mice and found that they develop hippocampal-dependent memory and synaptic dysfunction, which was associated with elevations in endogenous Aβ peptide. Second, testing for neurodegeneration and amyloid deposits, we investigated retromer-deficient flies expressing human wild-type amyloid precursor protein (APP) and human β-site APP-cleaving enzyme (BACE) and found that they develop neuronal loss and human Aβ aggregates. By recapitulating features of the disease, these animal models suggest that retromer deficiency observed in late-onset Alzheimer's disease can contribute to disease pathogenesis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The involvement of the retromer pathway in Alzheimer disease was experimentally validated.
“The involvement of this pathway in Alzheimer disease was experimentally validated146.”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [146]
Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
Brand, A. H., & Perrimon, N. (1993) · Development · doi:10.1242/dev.118.2.401 · Cited by 9,510 · see citing works
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572 · see citing works
Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
Lue, L.-F., Kuo, Y.-M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., Beach, T., Kurth, J. H., Rydel, R. E., & Rogers, J. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65184-x · Cited by 1,530 · see citing works
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Rogaeva, E., Meng, Y., Lee, J. H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C. T., Cheng, R., Hasegawa, H., et al. (2007) · Nature Genetics · doi:10.1038/ng1943 · Cited by 1,167 · see citing works
Evolution of the neuropathology of Alzheimer's disease
Braak, H., & Braak, E. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb05866.x · Cited by 710 · see citing works
Noble, W., Planel, E., Zehr, C., Olm, V., Meyerson, J., Suleman, F., Gaynor, K., Wang, L., LaFrancois, J., Feinstein, B., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500466102 · Cited by 709 · see citing works
Self-citationAndersen, O. M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C. A. F., Breiderhoff, T., Jansen, P., Wu, X., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503689102 · Cited by 655 · see citing works
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
Seaman, M. N. J. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312034 · Cited by 624 · see citing works
Model‐guided microarray implicates the retromer complex in Alzheimer's disease
Small, S. A., Kent, K., Pierce, A., Leung, C., Kang, M. S., Okada, H., Honig, L., Vonsattel, J., & Kim, T. (2005) · Annals of Neurology · doi:10.1002/ana.20667 · Cited by 440 · see citing works
Self-citationNeuropsychological detection and characterization of preclinical Alzheimer’s disease
Jacobs, D. M., Sano, M., Dooneief, G., Marder, K., Bell, K. L., & Stern, Y. (1995) · Neurology · doi:10.1212/wnl.45.5.957 · Cited by 409 · see citing works
ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models
Price, D. L., Tanzi, R. E., Borchelt, D. R., & Sisodia, S. S. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.461 · Cited by 406 · see citing works
The role of cerebral amyloid accumulation in common forms of Alzheimer disease
Gandy, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25100 · Cited by 394 · see citing works
Synaptic and neuritic alterations during the progression of Alzheimer's disease
Masliah, E., Mallory, M., Hansen, L., Richard, D., Alford, M., & Terry, R. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90121-x · Cited by 370 · see citing works
Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
Small, S. A., & Gandy, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.001 · Cited by 320 · see citing works
Self-citationLoss of apolipoprotein E receptor LR11 in Alzheimer disease
Scherzer, C. R., Offe, K., Gearing, M., Rees, H. D., Fang, G., Heilman, C. J., Schaller, C., Bujo, H., Levey, A. I., & Lah, J. J. (2004) · Archives of Neurology · doi:10.1001/archneur.61.8.1200 · Cited by 316 · see citing works
Recycle your receptors with retromer
Seaman, M. N. J. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.12.004 · Cited by 309 · see citing works
Haft, C. R., Sierra, M. D. L. L., Bafford, R. A., Lesniak, M. A., Barr, V. A., & Taylor, S. I. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4105 · Cited by 304 · see citing works
The Profile of Soluble Amyloid β Protein in Cultured Cell Media
Wang, R., Sweeney, D. A., Gandy, S., & Sisodia, S. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.31894 · Cited by 293 · see citing works
Age-Dependent Neurodegeneration and Alzheimer-Amyloid Plaque Formation in Transgenic Drosophila
Greeve, I., Kretzschmar, D., Tschäpe, J., Beyn, A., Brellinger, C., Schweizer, M., Nitsch, R. M., & Reifegerste, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0283-04.2004 · Cited by 284 · see citing works
Offe, K., Dodson, S. E., Shoemaker, J. T., Fritz, J. J., Gearing, M., Levey, A. I., & Lah, J. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4946-05.2006 · Cited by 279 · see citing works
Ferrari, G. V. D., Papassotiropoulos, A., Biechele, T. L., DeVriéze, F. W., Ávila, M. E., Major, M. B., Myers, A., Sáez, K. L., Henríquez, J. P., Zhao, A. S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603523104 · Cited by 266 · see citing works
Fox, N. C. (1998) · Brain · doi:10.1093/brain/121.9.1631 · Cited by 263 · see citing works
Planel, E., Miyasaka, T., Launey, T., Chui, D.-H., Tanemura, K., Sato, S., Murayama, O., Ishiguro, K., Tatebayashi, Y., & Takashima, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5561-03.2004 · Cited by 261 · see citing works
Self-citationPresenilin Couples the Paired Phosphorylation of β-Catenin Independent of Axin
Kang, D. E., Soriano, S., Xia, X., Eberhart, C. G., Strooper, B. D., Zheng, H., & Koo, E. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00970-4 · Cited by 232 · see citing works
Burns, M. P., Gaynor, K., Olm, V., Mercken, M. H., LaFrancois, J. J., Wang, L., Mathews, P. M., Noble, W. J., Matsuoka, Y., & Duff, K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05645.2003 · Cited by 172 · see citing works
Self-citationThe mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor
Vergés, M., Luton, F., Gruber‐Traub, C., Tiemann, F., Reinders, L. G., Huang, L., Burlingame, A. L., Haft, C. R., & Mostov, K. E. (2004) · Nature Cell Biology · doi:10.1038/ncb1153 · Cited by 142 · see citing works
BACE overexpression alters the subcellular processing of APP and inhibits Aβ deposition in vivo
Lee, E. B., Zhang, B., Liu, K., Greenbaum, E. A., Doms, R. W., Trojanowski, J. Q., & Lee, V. M.-Y. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200407070 · Cited by 140 · see citing works
Eaton, S. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.014 · Cited by 90 · see citing works
Lee, J. J., Radice, G. L., Perkins, C. P., & Costantini, F. D. (1992) · Development · doi:10.1242/dev.115.1.277 · Cited by 89 · see citing works
Petrone, A., Battaglia, F., Wang, C., Dusa, A., Su, J. D., Zagzag, D., Bianchi, R., Casaccia‐Bonnefil, P., Arancio, O., & Sap, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg399 · Cited by 85 · see citing works
Self-citationExpression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease
Johnston, J. A., Liu, W. W., Todd, S., Coulson, D. T. R., Murphy, S., Irvine, G. B., & Passmore, A. P. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051096 · Cited by 76 · see citing works
ELISA Method for Measurement of Amyloid-β Levels
Schmidt, S. D., Nixon, R. A., & Mathews, P. M. (2005) · Humana Press eBooks · doi:10.1385/1-59259-874-9:279 · Cited by 75 · see citing works
The genes for the human VPS10 domain-containing receptors are large and contain many small exons
Hampe, W., Rezgaoui, M., Hermans‐Borgmeyer, I., & Schaller, C. H. (2001) · Human Genetics · doi:10.1007/s004390100504 · Cited by 63 · see citing works
Transgenic mouse models of Alzheimer's disease: phenotype and mechanisms of pathogenesis
Duff, K. (2001) · Biochemical Society Symposia · doi:10.1042/bss0670195 · Cited by 26 · see citing works
Self-citationSantangelo, A., Trinchese, F., & Arancio, O. (2003) · Neurochemical Research · doi:10.1023/a:1023251005197 · Cited by 18 · see citing works
Self-citation
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Genetics of Parkinson's DiseasePreprint
Klein, C., & Westenberger, A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a008888 · Cited by 1,370 · see citing works
VPS35 Mutations in Parkinson Disease
Vilariño‐Güell, C., Wider, C. W., Ross, O. A., Dächsel, J. C., Kachergus, J. M., Lincoln, S., Soto‐Ortolaza, A. I., Cobb, S. A., Wilhoite, G. J., Bacon, J. A., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.06.001 · Cited by 877 · see citing works
The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration
Hu, Y.-B., Dammer, E. B., Ren, R., & Wang, G. (2015) · Translational Neurodegeneration · doi:10.1186/s40035-015-0041-1 · Cited by 666 · see citing works
Amyloid-β-independent regulators of tau pathology in Alzheimer disease
van der Kant, R., Goldstein, L. S. B., & Ossenkoppele, R. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0240-3 · Cited by 580 · see citing works
Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis
Small, S. A., & Duff, K. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.007 · Cited by 546 · see citing works
Self-citationRAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk
MacLeod, D. A., Rhinn, H., Kuwahara, T., Zolin, A., Paolo, G. D., McCabe, B. D., Marder, K. S., Honig, L. S., Clark, L. N., Small, S. A., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.033 · Cited by 519 · see citing works
Self-citationThe retromer complex – endosomal protein recycling and beyond
Seaman, M. N. J. (2012) · Journal of Cell Science · doi:10.1242/jcs.103440 · Cited by 455 · see citing works
Retromer: A Master Conductor of Endosome Sorting
Burd, C., & Cullen, P. J. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016774 · Cited by 435 · see citing works
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders
Parikshak, N. N., Gandal, M. J., & Geschwind, D. H. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3934 · Cited by 430 · see citing works
Nixon, R. A. (2017) · The FASEB Journal · doi:10.1096/fj.201700359 · Cited by 400 · see citing works
Seaman, M. N. J., Harbour, M. E., Tattersall, D., Read, E. K. C., & Bright, N. A. (2009) · Journal of Cell Science · doi:10.1242/jcs.048686 · Cited by 367 · see citing works
Salminen, A., Kaarniranta, K., Kauppinen, A., Ojala, J. O., Haapasalo, A., Soininen, H. S., & Hiltunen, M. O. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.002 · Cited by 366 · see citing works
Sorting nexins provide diversity for retromer-dependent trafficking events
Cullen, P. J., & Korswagen, H. C. (2011) · Nature Cell Biology · doi:10.1038/ncb2374 · Cited by 348 · see citing works
The Allen Brain Atlas: 5 years and beyond
Jones, A. R., Overly, C. C., & Sunkin, S. M. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2722 · Cited by 322 · see citing works
Drosophila as an In Vivo Model for Human Neurodegenerative Disease
McGurk, L., Berson, A., & Bonini, N. M. (2015) · Genetics · doi:10.1534/genetics.115.179457 · Cited by 314 · see citing works
Teasdale, R. D., & Collins, B. M. (2011) · Biochemical Journal · doi:10.1042/bj20111226 · Cited by 282 · see citing works
Tang, F., Liu, W., Hu, J.-X., Erion, J., Ye, J., Mei, L., & Xiong, W. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.001 · Cited by 274 · see citing works
VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology
Wen, L., Tang, F., Hong, Y., Luo, S.-W., Wang, C.-L., He, W., Shen, C., Jung, J.-U., Xiong, F., Lee, D.-H., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201105109 · Cited by 264 · see citing works
Fjorback, A. W., Seaman, M. N. J., Gustafsen, C., Mehmedbašić, A., Gokool, S., Wu, C., Militz, D., Schmidt, V., Madsen, P., Nyengaard, J. R., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2272-11.2012 · Cited by 253 · see citing works
Structure, function, and regulation of mitofusin‐2 in health and disease
Chandhok, G., Lazarou, M., & Neumann, B. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12378 · Cited by 251 · see citing works
VPS10P-domain receptors — regulators of neuronal viability and function
Willnow, T. E., Petersen, C. M., & Nykjær, A. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2516 · Cited by 250 · see citing works
Wang, X., Zhao, Y., Zhang, X., Badie-Mahdavi, H., Zhou, Y., Mu, Y., Loo, L. S., Cai, L., Thompson, R. C., Yang, B., et al. (2013) · Nature Medicine · doi:10.1038/nm.3117 · Cited by 241 · see citing works
Retromer in Alzheimer disease, Parkinson disease and other neurological disorders
Small, S. A., & Petsko, G. A. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3896 · Cited by 235 · see citing works
Self-citationRetromer and sorting nexins in endosomal sorting
Gallon, M., & Cullen, P. J. (2015) · Biochemical Society Transactions · doi:10.1042/bst20140290 · Cited by 231 · see citing works
Pharmacological chaperones stabilize retromer to limit APP processing
Mecozzi, V. J., Berman, D. E., Simoes, S., Vetanovetz, C. P., Awal, M. R., Patel, V. M., Schneider, R. T., Petsko, G. A., Ringe, D., & Small, S. A. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1508 · Cited by 225 · see citing works
Self-citationMorel, E., Chamoun, Z., Lasiecka, Z. M., Chan, R. B., Williamson, R. L., Vetanovetz, C., Dall’Armi, C., Simoes, S., Point Du Jour, K. S., McCabe, B. D., et al. (2013) · Nature Communications · doi:10.1038/ncomms3250 · Cited by 222 · see citing works
Self-citationBryleva, E. Y., Rogers, M. A., Chang, C. C. Y., Buen, F., Harris, B. T., Rousselet, E., Seidah, N. G., Oddo, S., LaFerla, F. M., Spencer, T. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913828107 · Cited by 209 · see citing works
SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways
Steinberg, F., Heesom, K. J., Bass, M. D., & Cullen, P. J. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201111121 · Cited by 206 · see citing works
Miura, E., Hasegawa, T., Konno, M., Suzuki, M., Sugeno, N., Fujikake, N., Geisler, S., Tabuchi, M., Oshima, R., Kikuchi, A., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.07.014 · Cited by 195 · see citing works
Moulton, M. J., Barish, S., Ralhan, I., Chang, J., Goodman, L. D., Harland, J. G., Marcogliese, P. C., Johansson, J. O., Ioannou, M. S., & Bellen, H. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112095118 · Cited by 180 · see citing works
Gallon, M., Clairfeuille, T., Steinberg, F., Mas, C., Ghai, R., Sessions, R. B., Teasdale, R. D., Collins, B. M., & Cullen, P. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410552111 · Cited by 176 · see citing works
SNX–BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting
van Weering, J. R. T., Verkade, P., & Cullen, P. J. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.11.009 · Cited by 171 · see citing works
Çağlayan, Ş., Takagi‐Niidome, S., Liao, F., Carlo, A.-S., Schmidt, V., Burgert, T., Kitago, Y., Füchtbauer, E., Füchtbauer, A. C., Holtzman, D. M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007747 · Cited by 169 · see citing works
Lane, R. F., Raines, S. M., Steele, J., Ehrlich, M. E., Lah, J. J., Small, S. A., Tanzi, R. E., Attie, A., & Gandy, S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3872-10.2010 · Cited by 165 · see citing works
Self-citationIdentification of Alzheimer disease-associated variants in genes that regulate retromer function
Vardarajan, B. N., Bruesegem, S. Y., Harbour, M. E., George‐Hyslop, P. S., Seaman, M. N. J., & Farrer, L. A. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.04.020 · Cited by 162 · see citing works
WNT secretion and signalling in human disease
Herr, P., Hausmann, G., & Basler, K. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.06.008 · Cited by 158 · see citing works
Polyamine pathway contributes to the pathogenesis of Parkinson disease
Lewandowski, N. M., Ju, S., Verbitsky, M., Ross, B., Geddie, M. L., Rockenstein, E. M., Adame, A., Muhammad, A., Vonsattel, J. P., Ringe, D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011751107 · Cited by 156 · see citing works
Self-citationBäck, M., Dahlén, S., Drazen, J. M., Evans, J. F., Serhan, C. N., Shimizu, T., Yokomizo, T., & Rovati, G. E. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.004184 · Cited by 151 · see citing works
A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex
Clairfeuille, T., Mas, C., Chan, A. S. M., Yang, Z., Tello‐Lafoz, M., Chandra, M., Widagdo, J., Kerr, M. C., Paul, B., Mérida, I., et al. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3290 · Cited by 150 · see citing works
Munsie, L. N., Milnerwood, A. J., Seibler, P., Beccano-Kelly, D. A., Tatarnikov, I., Khinda, J., Volta, M., Kadgien, C., Cao, L. P., Tapia, L., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu582 · Cited by 143 · see citing works
Vieira, S. I., Rebelo, S., Esselmann, H., Wiltfang, J., Lah, J. J., Lane, R. F., Small, S. A., Gandy, S., Silva, E. F. D. C. E., & Silva, O. A. B. D. C. E. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-40 · Cited by 141 · see citing works
Self-citationDomingo, A., & Klein, C. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63233-3.00014-2 · Cited by 132 · see citing works
Bhalla, A., Vetanovetz, C. P., Morel, E., Chamoun, Z., Di Paolo, G., & Small, S. A. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.030 · Cited by 130 · see citing works
Self-citationDysregulation of protein trafficking in neurodegeneration
Wang, X., Huang, T. Y., Bu, G., & Xu, H. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-31 · Cited by 124 · see citing works
Sorting receptor SORLA – a trafficking path to avoid Alzheimer disease
Willnow, T. E., & Andersen, O. M. (2013) · Journal of Cell Science · doi:10.1242/jcs.125393 · Cited by 121 · see citing works
Western, D., Timsina, J., Wang, L., Wang, C., Yang, C., Phillips, B., Wang, Y., Liu, M., Ali, M., Beric, A., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01972-8 · Cited by 111 · see citing works
Transgenic Drosophila models of Alzheimer’s disease and tauopathies
Iijima‐Ando, K., & Iijima, K. (2009) · Brain Structure and Function · doi:10.1007/s00429-009-0234-4 · Cited by 110 · see citing works
BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin
Finan, G. M., Okada, H., & Kim, T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.170217 · Cited by 108 · see citing works
Rovelet-Lecrux, A., Charbonnier, C., Wallon, D., Nicolas, G., Seaman, M. N. J., Pottier, C., Breusegem, S. Y., Mathur, P. P., Jenardhanan, P., Le Guennec, K., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.100 · Cited by 106 · see citing works
Linhart, R., Wong, S. A., Cao, J., Tran, M. L., Huynh, A., Ardrey, C., Park, J. M., Hsu, C., Taha, S., Peterson, R., et al. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-23 · Cited by 105 · see citing works
Young, J. E., Fong, L. K., Frankowski, H., Petsko, G. A., Small, S. A., & Goldstein, L. S. B. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.01.031 · Cited by 105 · see citing works
Self-citationThe Retromer Complex: From Genesis to Revelations
Seaman, M. N. J. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.12.009 · Cited by 104 · see citing works
Can Parkinson's disease pathology be propagated from one neuron to another?
Dunning, C. J. R., Reyes, J. F., Steiner, J. A., & Brundin, P. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.11.003 · Cited by 104 · see citing works
McGough, I. J., Steinberg, F., Gallon, M., Yatsu, A., Ohbayashi, N., Heesom, K. J., Fukuda, M., & Cullen, P. J. (2014) · Journal of Cell Science · doi:10.1242/jcs.156299 · Cited by 102 · see citing works
Retromer disruption promotes amyloidogenic APP processing
Sullivan, C. P., Jay, A. G., Stack, E. C., Pakaluk, M., Wadlinger, E., Fine, R. E., Wells, J. M., & Morin, P. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.002 · Cited by 100 · see citing works
Li, J.-G., Chiu, J., Ramanjulu, M. M., Blass, B. E., & Praticò, D. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0350-4 · Cited by 97 · see citing works
The Retromer Supports AMPA Receptor Trafficking During LTP
Temkin, P. A., Morishita, W., Goswami, D., Arendt, K. L., Chen, L., & Malenka, R. C. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.020 · Cited by 96 · see citing works
Endosomal sorting and trafficking, the retromer complex and neurodegeneration
Vagnozzi, A. N., & Praticò, D. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0221-3 · Cited by 95 · see citing works
The VPS35 gene and Parkinson's disease
Deng, H., Gao, K., & Jankovic, J. J. (2013) · Movement Disorders · doi:10.1002/mds.25430 · Cited by 92 · see citing works
Bidirectional traffic between the Golgi and the endosomes – machineries and regulation
Progida, C., & Bakke, O. (2016) · Journal of Cell Science · doi:10.1242/jcs.185702 · Cited by 92 · see citing works
The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases
Zhang, H., Huang, T. Y., Hong, Y., Yang, W., Zhang, X., Luo, H., Xu, H., & Wang, X. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00079 · Cited by 89 · see citing works
Self-citationThe synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration
Борисович, Б. И., & Hiesinger, P. R. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-23 · Cited by 88 · see citing works
β‐Site APP‐cleaving enzyme 1 trafficking and Alzheimer’s disease pathogenesis
Tan, J., & Evin, G. M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07623.x · Cited by 87 · see citing works
The retromer complex in development and disease
Wang, S., & Bellen, H. J. (2015) · Development · doi:10.1242/dev.123737 · Cited by 86 · see citing works
Attar, N., & Cullen, P. J. (2009) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2009.10.002 · Cited by 86 · see citing works
Trafficking, a key player in regulated intramembrane proteolysis
Sannerud, R., & Annaert, W. G. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.11.004 · Cited by 84 · see citing works
Tian, Y., Tang, F., Sun, X.-D., Wen, L., Mei, L., Tang, B.-S., & Xiong, W. (2015) · Molecular Brain · doi:10.1186/s13041-015-0156-4 · Cited by 82 · see citing works
Appel, J. R., Ye, S., Tang, F., Sun, D., Zhang, H., Mei, L., & Xiong, W. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3621-17.2018 · Cited by 82 · see citing works
Self-citationCao, J., Zhong, M. B., Toro, C. A., Zhang, L., & Cai, D. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.03.016 · Cited by 80 · see citing works
Alzheimer culprits: Cellular crossroads and interplay
Claeysen, S., Cochet, M., Donneger, R., Dumuis, A., Bockaert, J., & Giannoni, P. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.05.008 · Cited by 79 · see citing works
Sorting Nexin 27 Regulates Aβ Production through Modulating γ-Secretase Activity
Wang, X., Huang, T., Zhao, Y., Zheng, Q., Thompson, R. C., Bu, G., Zhang, Y.-W., Hong, W., & Xu, H. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.037 · Cited by 77 · see citing works
Wang, S., Tan, K. L., Agosto, M. A., Xiong, B., Yamamoto, S., Sandoval, H., Jaiswal, M., Bayat, V., Zhang, K., Charng, W., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001847 · Cited by 77 · see citing works
Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes
Lane, R. F., George‐Hyslop, P. S., Hempstead, B. L., Small, S. A., Strittmatter, S. M., & Gandy, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3359-12.2012 · Cited by 77 · see citing works
Self-citationAlternative fates of newly formed PrPSc upon prion conversion on the plasma membrane
Goold, R., McKinnon, C., Rabbanian, S., Collinge, J., Schiavo, G., & Tabrizi, S. J. (2013) · Journal of Cell Science · doi:10.1242/jcs.120477 · Cited by 76 · see citing works
The physical approximation of APP and BACE‐1: A key event in alzheimer's disease pathogenesis
Sun, J., & Roy, S. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22556 · Cited by 75 · see citing works
Wang, C.-L., Tang, F., Peng, Y. W., Shen, C.-Y., Mei, L., & Xiong, W. (2012) · Biology Open · doi:10.1242/bio.20122451 · Cited by 75 · see citing works
Toh, W. H., Tan, J. Z. A., Zulkefli, K. L., Houghton, F. J., & Gleeson, P. A. (2017) · Traffic · doi:10.1111/tra.12465 · Cited by 75 · see citing works
Eggert, S., Thomas, C., Kins, S., & Hermey, G. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0806-x · Cited by 74 · see citing works
From endosomes to the trans-Golgi network
Lü, L., & Hong, W. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.04.024 · Cited by 73 · see citing works
Seaman, M. N. J., Mukadam, A. S., & Breusegem, S. Y. (2018) · Journal of Cell Science · doi:10.1242/jcs.217398 · Cited by 70 · see citing works
Huang, T. Y., Zhao, Y., Li, X., Wang, X., Tseng, I.-C., Thompson, R., Tu, S., Willnow, T. E., Zhang, Y.-W., & Xu, H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0206-16.2016 · Cited by 69 · see citing works
Physiology and Pathology of Endosome‐to‐Golgi Retrograde Sorting
Burd, C. G. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01188.x · Cited by 69 · see citing works
Chia, P. Z. C., Toh, W. H., Sharples, R., Gasnereau, I., Hill, A. F., & Gleeson, P. A. (2013) · Traffic · doi:10.1111/tra.12088 · Cited by 67 · see citing works
Evolution and Diversity of the GolgiPreprint
Klute, M. J., Melançon, P., & Dacks, J. B. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007849 · Cited by 67 · see citing works
Implication of mouse Vps26b–Vps29–Vps35 retromer complex in sortilin trafficking
Kim, E., Lee, Y., Lee, H.-J., Kim, J. S., Song, B., Huh, J., Lee, S., Kim, S., Kim, S., Hong, Y., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.121 · Cited by 62 · see citing works
Toh, W. H., & Gleeson, P. A. (2016) · Biochemical Journal · doi:10.1042/bcj20160147 · Cited by 62 · see citing works
Toh, W. H., Chia, P. Z. C., Hossain, M. I., & Gleeson, P. A. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-05-0270 · Cited by 61 · see citing works
RAB10: an Alzheimer’s disease resilience locus and potential drug target
Tavana, J. P., Rosene, M. J., Jensen, N. O., Ridge, P. G., Kauwe, J. S. K., & Karch, C. M. M. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s159148 · Cited by 60 · see citing works
Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila
Maruzs, T., Lőrincz, P., Szatmári, Z., Széplaki, S., Sándor, Z., Lakatos, Z., Puska, G., Juhász, G., & Sass, M. (2015) · Traffic · doi:10.1111/tra.12309 · Cited by 59 · see citing works
Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles
Deng, Z., Dong, Y., Zhou, X., Lu, J.-H., & Yue, Z. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.12.009 · Cited by 58 · see citing works
Wu, S., Fagan, R. R., Uttamapinant, C., Lifshitz, L. M., Fogarty, K. E., Ting, A. Y., & Melikian, H. E. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3885-16.2017 · Cited by 58 · see citing works
VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking
Zhou, M., Wiener, H. H., Su, W., Zhou, Y., Liot, C., Ahearn, I. M., Hancock, J. F., & Philips, M. R. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201604061 · Cited by 56 · see citing works
Lee, J. H., Cheng, R., Vardarajan, B., Lantigua, R., Reyes-Dumeyer, D., Ortmann, W., Graham, R. R., Bhangale, T., Behrens, T. W., Medrano, M., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1424 · Cited by 55 · see citing works
Simoes, S., Guo, J., Buitrago, L., Qureshi, Y. H., Feng, X., Kothiya, M., Cortes, E. P., Patel, V. M., Kannan, S., Kim, Y., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110182 · Cited by 55 · see citing works
Self-citationAssembly and fission of tubular carriers mediating protein sorting in endosomes
Gopaldass, N., Chen, K., Collins, B. M., & Mayer, A. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00746-8 · Cited by 54 · see citing works
Sortilins: new players in lipoprotein metabolism
Willnow, T. E., Kjølby, M., & Nykjær, A. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283416f2b · Cited by 54 · see citing works
Retromer: Structure, function, and roles in mammalian disease
Trousdale, C., & Kim, K. (2015) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2015.07.002 · Cited by 54 · see citing works
Mechanisms of AMPA Receptor Endosomal Sorting
Parkinson, G. T., & Hanley, J. G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00440 · Cited by 53 · see citing works
A genetically modified minipig model for Alzheimer’s disease with SORL1 haploinsufficiency
Andersen, O. M., Bøgh, N., Landau, A. M., Pløen, G. G., Jensen, A. M. G., Monti, G., Ulhøi, B. P., Nyengaard, J. R., Jacobsen, K. R., Jørgensen, A. L., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100740 · Cited by 53 · see citing works
Self-citationSmall, S. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.030 · Cited by 52 · see citing works
Self-citation
- Authors
- Muhammad, A., Flores, I., Zhang, H., Yu, R., Staniszewski, A., Planel, E., Herman, M., Ho, L., Kreber, R., Honig, L. S., Ganetzky, B., Duff, K., Arancio, O., & Small, S. A.
- Affiliations
- Columbia University Irving Medical Center (US)
- *Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and
- University of Wisconsin–Madison (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-05-20
- Volume
- 105
- Issue
- 20
- Pages
- 7327-7332
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2386077
- OpenAlex
- W2049746112
- Cited by
- 248
- References
- 39
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 11 · 2019: 10 · 2018: 17 · 2017: 19 · 2016: 21 · 2015: 19 · 2014: 22 · 2013: 18 · 2012: 19
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG172116, AG025161, R01AG025161, P50AG008702)
- National Institute of Neurological Disorders and Stroke (NS48447, P01NS048447, R01NS049442, R01NS015390, NS015390, NS049442)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- retromer complex, Alzheimer's disease, late-onset Alzheimer's disease, hippocampal-dependent memory, synaptic dysfunction, amyloid-beta deposition, amyloid precursor protein, neurodegeneration, neuronal loss, Drosophila model
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, Drosophila, Electrophysiology, Heterozygote, Hippocampus, Humans, Models, Biological, Amyloid beta-Peptides, Mice, Knockout, Neurodegenerative Diseases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review