The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Long non-coding RNA HOTAIR in carcinogenesis and metastasis
Open accessAbstract
Long non-coding RNAs (lncRNAs) have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA (HOTAIR), a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression and promote breast cancer metastasis. Mechanistically, HOTAIR interacts with and recruits polycomb repressive complex 2 (PRC2) and regulates chromosome occupancy by EZH2 (a subunit of PRC2), which leads to histone H3 lysine 27 trimethylation of the HOXD locus. Moreover, HOTAIR is pervasively overexpressed in most human cancers compared with noncancerous adjacent tissues. This review summarizes the studies on the HOTAIR lncRNA over the past 6 years.
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Cites
GENCODE: The reference human genome annotation for The ENCODE Project
Harrow, J., Frankish, A., Gonzalez, J. M., Tapanari, E., Diekhans, M., Kokocinski, F., Aken, B. L., Barrell, D., Zadissa, A., Searle, S., et al. (2012) · Genome Research · doi:10.1101/gr.135350.111 · Cited by 4,585
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290 · cited 1×
“Subsequent studies further elucidated that a 50 domain of HOTAIR binds PRC2, whereas a 30 domain of HOTAIR binds the LSD1/CoREST/REST complex [26].”
BackgroundKhalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872
Cited by
The emerging role of lncRNAs in cancer
Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,702
The functional role of long non-coding RNAs and epigenetics
Cao, J. (2014) · Biological Procedures Online · doi:10.1186/1480-9222-16-11 · Cited by 357
Long non-coding RNA in lung cancer
Chen, Z., Lei, T., Chen, X., Gu, J., Huang, J., Lu, B., & Wang, Z. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.11.031 · Cited by 65
Metadata
- Authors
- Zhang, J., Zhang, P., Wang, L., Piao, H.-L., & Ma, L.
- Venue
- Acta Biochimica et Biophysica Sinica
- Published
- 2014-01-01
- Volume
- 46
- Issue
- 1
- Pages
- 1-5
- ISSN
- 1672-9145 (ISSN-L)
- OpenAlex
- W2168619725
- Cited by
- 171
- References
- 3
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, J., Zhang, P., Wang, L., Piao, H.-L., & Ma, L. (2014). Long non-coding RNA HOTAIR in carcinogenesis and metastasis. Acta Biochimica et Biophysica Sinica. https://doi.org/10.1093/abbs/gmt117
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