The DOI matches its Crossref record; 161 of the 171 references it cites were found in a registry or an index.
Long non-coding RNA in lung cancer
Abstract
Lung cancer is the leading cause of cancer-related death worldwide. Owing to the difficulty in early diagnosis and the lack of effective treatment strategies, the 5-year survival rates for lung cancer remain very low. With the development of whole genome and transcriptome sequencing technology, long non-coding RNA (lncRNA) has attracted increasing attention. LncRNAs regulate gene expression at the epigenetic, transcriptional and post-transcriptional levels and are widely involved in a variety of diseases, including tumorigenesis. In lung cancer studies, multiple differentially expressed lncRNAs have been identified; several lncRNAs were identified as oncogenic lncRNAs with tumor-driving effects, while other lncRNAs play a role in tumor inhibition and are called tumor-suppressive lncRNAs. These tumor-suppressive lncRNAs are involved in multiple physiological processes such as cell proliferation, apoptosis, and metastasis and thus participate in tumor progression. In this review, we discussed the oncogenic and tumor-suppressive lncRNAs in lung cancer, as well as their biological functions and regulatory mechanisms. Furthermore, we found the potential significance of lncRNAs in clinical diagnosis and treatment.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“they can influence the expression of other genes through multiple mechanisms to cause a wide range of disorders.215–218”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [216]
Citations
Cites
8 retracted
Li, W., Sun, M., Zang, C., Ma, P., He, J., Zhang, M., Huang, Z., Ding, Y., & Shu, Y. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.126 · Cited by 183
RetractedLei, Y., Wang, G., Chen, B., Chen, L., Gong, J., & Li, W. (2018) · Oncology Reports · doi:10.3892/or.2018.6762 · Cited by 169
RetractedXue, Y., Ni, T., Jiang, Y., & Li, Y. (2017) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504017x14850182723737 · Cited by 118
RetractedJin, B., Jin, H., Wu, H., Xu, J., & Li, B. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26543 · Cited by 91
RetractedMei, Y., Si, J., Wang, Y., Huang, Z., Zhu, H., Feng, S., Wu, X.-Z., & Wu, L. (2017) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504016x14822800040451 · Cited by 66
RetractedLi, X., Zhang, X., Yang, C., Cui, S., Shen, Q., & Xu, S. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1496745 · Cited by 58
RetractedZhao, W., Zhang, L.-N., Wang, X., Zhang, J., & Yu, H. (2018) · The FASEB Journal · doi:10.1096/fj.201800408r · Cited by 29
RetractedWen, X., Han, X., Wang, Y., Fan, S., Zhuang, J., Zhang, Z.-F., Shan, Q., Li, M., Hu, B., Sun, C., et al. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26344 · Cited by 23
RetractedSiegel, R. L., Miller, K. D., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21332 · Cited by 16,003
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Gupta, R. A., Shah, N., Wang, K., Kim, J., Horlings, H. M., Wong, D. J., Tsai, M.-C., Hung, T., Argani, P., Rinn, J. L., et al. (2010) · Nature · doi:10.1038/nature08975 · Cited by 5,291
Research works printed but not linked: 1
- Lei, 2018, Tumorreleased lncRNA H19 promotes gefitinib resistance via packaging into exosomes in nonsmall cell lung cancer, Oncol. Rep., 40, 3438
Cited by
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246
Zhang, Y., Wang, C., Zou, X., Tian, X., Hu, J., & Zhang, C. (2021) · Nano Letters · doi:10.1021/acs.nanolett.0c05137 · Cited by 54
Khan, N. A., Asim, M., Biswas, K. H., Alansari, A. N., Saman, H. T., Sarwar, M. Z., Osmonaliev, K., & Shahab Uddin, M. S. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02753-7 · Cited by 51
Non-Coding RNAs in Lung Tumor Initiation and Progression
Santos, R. M., Moreno, C., & Zhang, W. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082774 · Cited by 49
Advances in the Molecular Landscape of Lung Cancer Brain Metastasis
Souza, V. G. P., de Araújo, R. P., Santesso, M. R., Seneda, A. L., Minutentag, I. W., Felix, T. F., Filho, P. T. H., Pewarchuk, M. E., Brockley, L. J., Marchi, F. A., et al. (2023) · Cancers · doi:10.3390/cancers15030722 · Cited by 43
Metadata
- Authors
- Chen, Z., Lei, T., Chen, X., Gu, J., Huang, J., Lu, B., & Wang, Z.
- Affiliations
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Corresponding author
- Lu, Binbin
- Wang, Zhaoxia
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 504
- Pages
- 190-200
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W2990143159
- Cited by
- 65
- References
- 171
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 18 · 2021: 9 · 2020: 8
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Jiangsu Science and Technology Department (BE2019760)
- National Natural Science Foundation of China (81672307, 81871871, 81902333)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Keywords
- long non-coding RNA, lung cancer, oncogenic lncRNA, lncRNA regulation of gene expression, epigenetic regulation, tumor progression, metastasis, cell proliferation, apoptosis
- MeSH terms
- Humans, Lung Neoplasms, Gene Expression Regulation, Neoplastic, RNA, Long Noncoding
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Long non-coding RNA in lung cancer. https://app.cochat.ai/papers/10.1016/j.cca.2019.11.031
- The paper
- Chen, Z., Lei, T., Chen, X., Gu, J., Huang, J., Lu, B., & Wang, Z. (2020). Long non-coding RNA in lung cancer. Clinica Chimica Acta. https://doi.org/10.1016/j.cca.2019.11.031
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
