The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
New insights into the roles of CHOP-induced apoptosis in ER stress
Open accessAbstract
Endoplasmic reticulum stress (ER stress) is triggered due to a loss of homeostasis in the ER, resulting in accumulation of misfolded proteins in the ER lumen. ER stress activates a series of adaptive mechanisms known as the unfolded protein response. Perturbation of the ER is a powerful inducer of the transcription factor C/EBP homologous protein (CHOP). Although it has been proved that excessive or adverse stress to the ER triggers apoptosis, the specific mechanisms underlying these processes induced by CHOP remain unclear. By now, CHOP-induced apoptosis in ER stress has been implicated in numerous human diseases, such as neurodegenerative diseases, diabetes, ischemic diseases, tumor, and so on. In this review, we summarized the current understanding of the roles of CHOP in the development of several diseases from the laboratory to the clinic.
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2 retracted
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Roles of CHOP/GADD153 in endoplasmic reticulum stress
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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
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Cited by
Li, W., Yang, J., Luo, L., Jiang, M., Qin, B., Yin, H., Zhu, C., Yuan, X., Zhang, J., Luo, Z., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11269-8 · Cited by 1,120
The Pathogenesis of Sepsis and Potential Therapeutic Targets
Huang, M., Cai, S., & Su, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215376 · Cited by 776
Autophagy: The spotlight for cellular stress responses
Ravanan, P., Srikumar, I. F., & Talwar, P. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.08.029 · Cited by 580
The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases
Rozpędek-Kamińska, W., Siwecka, N., Wawrzynkiewicz, A., Wojtczak, R., Pytel, D., Diehl, J. A., & Majsterek, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062108 · Cited by 84
C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis
Rahman, K., Liu, Y., Kumar, P., Smith, T., Thorn, N. E., Farris, A. B., & Anania, F. A. (2016) · Laboratory Investigation · doi:10.1038/labinvest.2016.61 · Cited by 39
Metadata
- Authors
- Li, Y., Guo, Y., Tang, J., Jiang, J., & Chen, Z.
- Venue
- Acta Biochimica et Biophysica Sinica
- Published
- 2014-08-01
- Volume
- 46
- Issue
- 8
- Pages
- 629-640
- ISSN
- 1672-9145 (ISSN-L)
- OpenAlex
- W2096388436
- Cited by
- 527
- References
- 77
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, Y., Guo, Y., Tang, J., Jiang, J., & Chen, Z. (2014). New insights into the roles of CHOP-induced apoptosis in ER stress. Acta Biochimica et Biophysica Sinica. https://doi.org/10.1093/abbs/gmu048
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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