Guidelines for People Not for Diseases: The Challenges of Applying UK Clinical Guidelines to People with Multimorbidity
Abstract
Background currently one of the major challenges facing clinical guidelines is multimorbidity. Current guidelines are not designed to consider the cumulative impact of treatment recommendations on people with several conditions, nor to allow comparison of relative benefits or risks. This is despite the fact that multimorbidity is a common phenomenon. Objective to examine the extent to which National Institute of Health and Clinical Excellence (NICE) guidelines address patient comorbidity, patient centred care and patient compliance to treatment recommendations. Methods five NICE clinical guidelines were selected for review (type-2 diabetes mellitus, secondary prevention for people with myocardial infarction, osteoarthritis, chronic obstructive pulmonary disease and depression) as these conditions are common causes of comorbidity and the guidelines had all been produced since 2007. Two authors extracted information from each full guideline and noted the extent to which the guidelines accounted for patient comorbidity, patient centred care and patient compliance. The cumulative recommended treatment, follow-up and self-care regime for two hypothetical patients were then created to illustrate the potential cumulative impact of applying single disease recommendations to people with multimorbidity. Results comorbidity and patient adherence were inconsistently accounted for in the guidelines, ranging from extensive discussion to none at all. Patient centred care was discussed in ge…
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When multiple guidelines are used simultaneously, patients experience cumulative treatment burdens.
“When multiple guidelines are used simultaneously, patients will experience cumulative treatment burdens.”
From Toward Safer Diagnoses: A SEIPS-Based Narrative Review of Diagnostic Errors (2026) · cites this paper as [155]
If clinicians were to adhere strictly to every NICE guideline for specific diseases, patients would face numerous appointments and be prescribed excessive medication.
“If clinicians were to adhere strictly to every NICE guideline for specific diseases, patients would face numerous appointments and be prescribed excessive medication [155].”
From Toward Safer Diagnoses: A SEIPS-Based Narrative Review of Diagnostic Errors (2026) · cites this paper as [155]
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- Authors
- Hughes, L. D., McMurdo, M. E. T., & Guthrie, B.
- Affiliations
- University of Dundee (GB)
- Corresponding author
- Hughes, L. D.
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-08-21
- Volume
- 42
- Issue
- 1
- Pages
- 62-69
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- OpenAlex
- W2116189532
- Cited by
- 506
- References
- 4
- Citations by year
- 2026: 16 · 2025: 29 · 2024: 43 · 2023: 34 · 2022: 40 · 2021: 36 · 2020: 42 · 2019: 41 · 2018: 35 · 2017: 42 · 2016: 42 · 2015: 43 · 2014: 39 · 2013: 20 · 2012: 2
- FWCI
- 24.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Age and Ageing (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- multimorbidity, clinical guidelines, NICE guidelines, comorbidities, patient-centered care, medication adherence, treatment burden, polypharmacy, type 2 diabetes, osteoarthritis, chronic obstructive pulmonary disease, depression, self-care
- MeSH terms
- Aged, Aged, 80 and over, Chronic Disease, United Kingdom, Humans, Patient Compliance, Self Care, Comorbidity, Practice Guidelines as Topic, Patient-Centered Care, Polypharmacy
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