Multimorbidity in primary care: prevalence and trend over the last 20 years
Open accessAbstract
OBJECTIVE: To determine the prevalence of multimorbidity in primary care, by age, sex, and socio-economic class, and to analyse the trend in multimorbidity over the last 20 years. METHODS: We performed an observational study using data from the Continuous Morbidity Registration (CMR) Nijmegen. This registration includes approximately 13 500 enlisted patients. To study the distribution of multimorbidity by age, sex, and socio-economic class, we analysed all patients enlisted in the CMR in 2005. To analyse the trend of multimorbidity over time, we studied the prevalence of multimorbidity from 1985 to 2005. RESULTS: We found that increasing age, female sex, and low socio-economic class are associated with an increasing number of patients with multimorbidity. The prevalence of chronic diseases doubled between 1985 and 2005. The proportion of patients with four or more chronic diseases increased in this period by approximately 300%. CONCLUSION: The increasing amount of multimorbidity in primary care as well as the increasing number of chronic diseases per patient leads to more complex medical care. The general practitioner needs guidelines focusing on multimorbidity to support this care. The registration of chronic diseases by the general practitioner will become more complex and time-consuming.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adults are more likely to have comorbidities that lead to immunodeficiencies and increase the risk of opportunistic infections.
“Fourth, adults are more likely to have comorbidities45, 46 that lead to immunodeficiencies and increase the risk of opportunistic infections.47”
From Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050 (2024) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
van den Akker, M., Buntinx, F., Metsemakers, J. F. M., Roos, S., & Knottnerus, J. A. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(97)00306-5 · Cited by 1,022 · see citing works
Prevalence of multimorbidity among adults seen in family practice
Fortin, M. (2005) · The Annals of Family Medicine · doi:10.1370/afm.272 · Cited by 987 · cited 2× · see citing works
“studied a sample of 980 adults in Canada (12).”
BackgroundChronic Comorbidity and Outcomes of Hospital Care
Librero, J., Peiró, S., & Ordiñana, R. (1999) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00160-7 · Cited by 314 · see citing works
Comorbidity of chronic diseases in general practice
Schellevis, F., van der Velden, J., de Lisdonk, E. V., van Eijk, J. T. M., & van Weel, C. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90024-u · Cited by 304 · see citing works
Multimorbidity is common to family practice: is it commonly researched?
Fortin, M., Lapointe, L., Hudon, C., & Vanasse, A. (2005) · PubMed Central · Cited by 211 · see citing works
Chronic Illness in the United States, Volume I, Prevention of Chronic Illness
Commission on Chronic Illness (1957) · Harvard University Press eBooks · doi:10.4159/harvard.9780674497474 · Cited by 106 · see citing works
Oxford Textbook of Primary Medical Care
(2004) · Huisarts en Wetenschap · doi:10.1007/bf03083912 · Cited by 101 · see citing works
Patterns of comorbidity and the use of health services in the Dutch population
Westert, G. P. (2001) · European Journal of Public Health · doi:10.1093/eurpub/11.4.365 · Cited by 98 · see citing works
Addressing multiple problems in the family practice office visit.
Flocke, S. A., Frank, S., & Wenger, D. (2001) · PubMed · Cited by 98 · see citing works
Validating long term morbidity recording.
van Weel, C. (1995) · Journal of Epidemiology & Community Health · doi:10.1136/jech.49.suppl_1.29 · Cited by 74 · see citing works
Macleod, U., Mitchell, E., Black, M., & Spence, G. (2004) · European Journal of General Practice · doi:10.3109/13814780409094223 · Cited by 44 · see citing works
Primary care research networks
Exworthy, M., Day, P., Robinson, R., Peckham, S., & Evans, D. (1997) · UWE Research Repository (UWE Bristol) · Cited by 16 · see citing works
EFFECT OF COEXISTING DISEASES ON THE TREATMENT OF UNRELATED DISEASE NEEDS MORE STUDIES
Cheng, H. Y. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00772.x · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Wonca. ICHPPC-2-def. Third edition. Oxford: Oxford Uni- versity Press; 1984.
Cited by
Sorted by citations
Naghavi, M., Vollset, S. E., Ikuta, K. S., Swetschinski, L. R., Gray, A. P., Wool, E. E., Robles Aguilar, G., Mestrovic, T., Smith, G., Han, C., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01867-1 · Cited by 3,791 · see citing works
Aging with multimorbidity: A systematic review of the literature
Marengoni, A., Angleman, S., Melis, R., Mangialasche, F., Karp, A., Garmen, A., Meinow, B., & Fratiglioni, L. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.03.003 · Cited by 3,092 · see citing works
Skou, S. T., Mair, F. S., Fortin, M., Guthrie, B., Nunes, B. P., Miranda, J. J., Boyd, C. M., Pati, S., Mtenga, S., & Smith, S. M. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00376-4 · Cited by 1,430 · see citing works
A Systematic Review of Prevalence Studies on Multimorbidity: Toward a More Uniform Methodology
Fortin, M., Stewart, M., Poitras, M.-È., Almirall, J., & Maddocks, H. L. (2012) · The Annals of Family Medicine · doi:10.1370/afm.1337 · Cited by 1,131 · see citing works
Violan, C., Foguet-Boreu, Q., Flores-Mateo, G., Salisbury, C., Blom, J., Freitag, M., Glynn, L., Muth, C., & Valderas, J. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102149 · Cited by 1,125 · see citing works
Epidemiology and impact of multimorbidity in primary care: a retrospective cohort study
Salisbury, C., Johnson, L., Purdy, S., Valderas, J. M., & Montgomery, A. A. (2011) · British Journal of General Practice · doi:10.3399/bjgp11x548929 · Cited by 883 · see citing works
Defining and measuring multimorbidity: a systematic review of systematic reviews
Johnston, M. C., Crilly, M., Black, C., Prescott, G. J., & Mercer, S. W. (2018) · European Journal of Public Health · doi:10.1093/eurpub/cky098 · Cited by 860 · see citing works
Boyd, C. M., & Fortin, M. (2010) · Public health reviews · doi:10.1007/bf03391611 · Cited by 680 · see citing works
The increasing burden and complexity of multimorbidity
Kone, A. P., Bronskill, S. E., Gruneir, A., Calzavara, A. J., Thavorn, K., Petrosyan, Y., Maxwell, C. J., Bai, Y., & Wodchis, W. P. (2015) · BMC Public Health · doi:10.1186/s12889-015-1733-2 · Cited by 598 · see citing works
Fabbri, E., Zoli, M., González‐Freire, M., Salive, M. E., Studenski, S. A., & Ferrucci, L. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.03.013 · Cited by 560 · see citing works
Towards a universal model of family centered care: a scoping review
Kokorelias, K. M., Gignac, M. A. M., Naglie, G., & Cameron, J. I. (2019) · BMC Health Services Research · doi:10.1186/s12913-019-4394-5 · Cited by 515 · see citing works
Perianayagam, A., Uttamacharya, U., Jain, K., Biritwum, R. B., Yawson, A. E., Wu, F., Guo, Y., Maximova, T., Manrique-Espinoza, B. S., Salinas‐Rodríguez, A., et al. (2015) · BMC Medicine · doi:10.1186/s12916-015-0402-8 · Cited by 484 · see citing works
Socioeconomic status and multimorbidity: a systematic review and meta‐analysis
Pathirana, T. I., & Jackson, C. A. (2018) · Australian and New Zealand Journal of Public Health · doi:10.1111/1753-6405.12762 · Cited by 475 · see citing works
Methods for identifying 30 chronic conditions: application to administrative data
Tonelli, M., Wiebe, N., Fortin, M., Guthrie, B., Hemmelgarn, B. R., James, M. T., Klarenbach, S. W., Lewanczuk, R., Manns, B. J., Ronksley, P., et al. (2016) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-015-0155-5 · Cited by 400 · see citing works
Multimorbidity and functional decline in community-dwelling adults: a systematic review
Ryan, Á., Wallace, E., O’Hara, P. V., & Smith, S. M. (2015) · Health and Quality of Life Outcomes · doi:10.1186/s12955-015-0355-9 · Cited by 411 · see citing works
Hughes, L. D., McMurdo, M. E. T., & Guthrie, B. (2013) · Age and Ageing · doi:10.1093/ageing/afs100 · Cited by 506 · see citing works
Afshar, S., Roderick, P. J., Kowal, P. R., Dimitrov, B. D., & Hill, A. G. (2015) · BMC Public Health · doi:10.1186/s12889-015-2008-7 · Cited by 347 · see citing works
Gunn, J. M., Ayton, D., Densley, K., Pallant, J., Chondros, P., Herrman, H., & Dowrick, C. F. (2010) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-010-0330-z · Cited by 340 · see citing works
Prevalence estimates of multimorbidity: a comparative study of two sources
Fortin, M., Hudon, C., Haggerty, J. L., van den Akker, M., & Almirall, J. (2010) · BMC Health Services Research · doi:10.1186/1472-6963-10-111 · Cited by 286 · see citing works
van Oostrom, S. H., Gijsen, R., Stirbu, I., Korevaar, J. C., Schellevis, F., Picavet, H. S. J., & Hoeymans, N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160264 · Cited by 277 · see citing works
Multimorbidity and comorbidity in the Dutch population – data from general practices
van Oostrom, S. H., Picavet, H. S. J., van Gelder, B. M., Lemmens, L. C., Hoeymans, N., van Dijk, C. E., Verheij, R. A., Schellevis, F., & Baan, C. A. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-715 · Cited by 253 · see citing works
Fabbri, E., An, Y., Zoli, M., Simonsick, E. M., Guralnik, J. M., Bandinelli, S., Boyd, C. M., & Ferrucci, L. (2015) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu127 · Cited by 240 · see citing works
Willadsen, T. G., Bebe, A. C. K. M., Køster‐Rasmussen, R., Jarbøl, D. E., Guassora, A. D., Waldorff, F. B., Reventlow, S. D., & Olivarius, N. D. F. (2016) · Scandinavian Journal of Primary Health Care · doi:10.3109/02813432.2016.1153242 · Cited by 244 · see citing works
Do replicable profiles of multimorbidity exist? Systematic review and synthesis
Busija, L., Lim, K., Szoeke, C. E. I., Sanders, K. M., & McCabe, M. P. (2019) · European Journal of Epidemiology · doi:10.1007/s10654-019-00568-5 · Cited by 211 · see citing works
Sinnige, J., Braspenning, J. C. C., Schellevis, F., Stirbu-Wagner, I., Westert, G. P., & Korevaar, J. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079641 · Cited by 207 · see citing works
A Scoping Review and Thematic Classification of Patient Complexity: Offering a Unifying Framework
Schaink, A. K., Kuluski, K., Lyons, R., Fortin, M., Jadad, A. R., Upshur, R. E. G., & Wodchis, W. P. (2012) · Journal of Comorbidity · doi:10.15256/joc.2012.2.15 · Cited by 205 · see citing works
Prior, A., Fenger-Grøn, M., Larsen, K. K., Larsen, F. B., Robinson, K. M., Nielsen, M. G., Christensen, K. S., Mercer, S. W., & Vestergaard, M. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kwv324 · Cited by 202 · see citing works
Pati, S., Agrawal, S., Swain, S., Lee, J. T., Vellakkal, S., Hussain, M. A., & Millett, C. J. (2014) · BMC Health Services Research · doi:10.1186/1472-6963-14-451 · Cited by 197 · see citing works
Multimorbidity in older adults with intellectual disabilities
Hermans, H., & Evenhuis, H. M. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.01.022 · Cited by 190 · see citing works
Hopman, P., de Bruin, S. R., Forjaz, M. J., Rodríguez‐Blázquez, C., Tonnara, G., Lemmens, L. C., Onder, G., Baan, C. A., & Rijken, M. (2016) · Health Policy · doi:10.1016/j.healthpol.2016.04.002 · Cited by 189 · see citing works
Vancampfort, D., Koyanagi, A., Ward, P. B., Rosenbaum, S., Schuch, F. B., Mugisha, J., Richards, J. A., Firth, J., & Stubbs, B. (2017) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-017-0463-5 · Cited by 181 · see citing works
Larsen, F. B., Pedersen, M. H., Friis, K., Glümer, C., & Lasgaard, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169426 · Cited by 180 · see citing works
A Systematic Review of Cost-of-Illness Studies of Multimorbidity
Wang, L., Si, L., Cocker, F., Palmer, A. J., & Sanderson, K. (2018) · Applied Health Economics and Health Policy · doi:10.1007/s40258-017-0346-6 · Cited by 178 · see citing works
Hudon, C., Fortin, M., Haggerty, J. L., Loignon, C., Lambert, M., & Poitras, M.-È. (2012) · Patient Education and Counseling · doi:10.1016/j.pec.2012.01.009 · Cited by 177 · see citing works
The Prevalence of Chronic Diseases and Multimorbidity in Primary Care Practice: A PPRNet Report
Ornstein, S. M., Nietert, P. J., Jenkins, R., & Litvin, C. B. (2013) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2013.05.130012 · Cited by 177 · see citing works
Association of Depression and Anxiety With the Accumulation of Chronic Conditions
Bobo, W. V., Grossardt, B. R., Virani, S., Sauver, J. L. S., Boyd, C. M., & Rocca, W. A. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.9817 · Cited by 177 · see citing works
Dhalwani, N. N., O’Donovan, G., Zaccardi, F., Hamer, M., Yates, T. E., Davies, M. J., & Khunti, K. K. (2016) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-016-0330-9 · Cited by 163 · see citing works
Head, A., Fleming, K. M., Kypridemos, C., Schofield, P., Pearson‐Stuttard, J., & O’Flaherty, M. (2021) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00146-x · Cited by 162 · see citing works
Willadsen, T. G., Siersma, V., Nicolaisdóttir, D., Køster‐Rasmussen, R., Jarbøl, D. E., Reventlow, S. D., Mercer, S. W., & Olivarius, N. D. F. (2018) · Journal of Comorbidity · doi:10.1177/2235042x18804063 · Cited by 150 · see citing works
Atypical presentations of older adults at the emergency department and associated factors
Limpawattana, P., Phungoen, P., Mitsungnern, T., Laosuangkoon, W., & Tansangworn, N. (2015) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2015.08.016 · Cited by 145 · see citing works
Multimorbidity and rheumatic conditions—enhancing the concept of comorbidity
Radner, H., Yoshida, K., Smolen, J. S., & Solomon, D. H. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.212 · Cited by 145 · see citing works
Verma, A. A., Guo, Y., Kwan, J. L., Lapointe-Shaw, L., Rawal, S., Tang, T., Weinerman, A., Cram, P., Dhalla, I. A., Hwang, S. W., et al. (2017) · CMAJ Open · doi:10.9778/cmajo.20170097 · Cited by 145 · see citing works
GPs' and pharmacists' experiences of managing multimorbidity: a ‘Pandora's box’
Smith, S. M., O'Kelly, S., & O’Dowd, T. (2010) · British Journal of General Practice · doi:10.3399/bjgp10x514756 · Cited by 144 · see citing works
No paradox, no progress: inverse cancer comorbidity in people with other complex diseases
Tabarés‐Seisdedos, R., Dumont, N., Baudot, A., Valderas, J. M., Climent, J., Valencia, A., Crespo‐Facorro, B., Vieta, E., Gómez-Beneyto, M., Martı́nez, S., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70041-9 · Cited by 136 · see citing works
Patient experiences with technology enabled care across healthcare settings- a systematic review
Leonardsen, A. L., Hardeland, C., Helgesen, A. K., & Grøndahl, V. A. (2020) · BMC Health Services Research · doi:10.1186/s12913-020-05633-4 · Cited by 139 · see citing works
Hernández, B., Reilly, R. B., & Kenny, R. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-51135-7 · Cited by 129 · see citing works
Age- and gender-related prevalence of multimorbidity in primary care: the swiss fire project
Rizza, A., Kaplan, V., Senn, O., Rosemann, T. J., Bhend, H., & Tandjung, R. (2012) · BMC Family Practice · doi:10.1186/1471-2296-13-113 · Cited by 130 · see citing works
Epidemiology of knee osteoarthritis in general practice: a registry-based study
Spitaels, D., Mamouris, P., Vaes, B., Smeets, M., Luyten, F. P., Hermens, R., & Vankrunkelsven, P. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-031734 · Cited by 129 · see citing works
Tómasdóttir, M. Ó., Sigurdsson, J. A., Pétursson, H., Kirkengen, A. L., Krokstad, S., McEwen, B. S., Hetlevik, I., & Getz, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130591 · Cited by 132 · see citing works
Thavorn, K., Maxwell, C. J., Gruneir, A., Bronskill, S. E., Bai, Y., Kone, A. P., Petrosyan, Y., & Wodchis, W. P. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-017264 · Cited by 120 · see citing works
van Leersum, N. J., Janssen-Heijnen, M. L. G., Wouters, M. W. J. M., Rutten, H. J. T., Coebergh, J. W. W., Tollenaar, R. A. E. M., & Lemmens, V. E. P. P. (2012) · International Journal of Cancer · doi:10.1002/ijc.27871 · Cited by 117 · see citing works
de Souza, D. L. B., Oliveras-Fàbregas, A., Minobes‐Molina, E., Cancela, M. D. C., Galbany‐Estragués, P., & Jerez‐Roig, J. (2021) · BMC Public Health · doi:10.1186/s12889-020-10084-x · Cited by 118 · see citing works
Incidence and Predictors of Multimorbidity in the Elderly: A Population-Based Longitudinal Study
Melis, R. J. F., Marengoni, A., Angleman, S. B., & Fratiglioni, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103120 · Cited by 115 · see citing works
Fortin, M., Contant, É., Savard, C., Hudon, C., Poitras, M.-È., & Almirall, J. (2011) · BMC Family Practice · doi:10.1186/1471-2296-12-74 · Cited by 111 · see citing works
Adoption of Clinical Decision Support in Multimorbidity: A Systematic Review
Fraccaro, P., Casteleiro, M. A., Ainsworth, J. D., & Buchan, I. E. (2015) · JMIR Medical Informatics · doi:10.2196/medinform.3503 · Cited by 109 · see citing works
Vancampfort, D., Koyanagi, A., Hallgren, M., Probst, M., & Stubbs, B. (2017) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2016.11.002 · Cited by 108 · see citing works
Banjare, P., & Pradhan, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097832 · Cited by 108 · see citing works
Vancampfort, D., Koyanagi, A., Ward, P. B., Veronese, N., Carvalho, A. F., Solmi, M., Mugisha, J., Rosenbaum, S., Binder, M. D., & Stubbs, B. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx159 · Cited by 106 · see citing works
Reducing complexity: a visualisation of multimorbidity by combining disease clusters and triads
Schäfer, I., Kaduszkiewicz, H., Wagner, H.-O., Schön, G., Scherer, M., & van den Bussche, H. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-1285 · Cited by 100 · see citing works
Mondor, L., Maxwell, C. J., Bronskill, S. E., Gruneir, A., & Wodchis, W. P. (2016) · Quality of Life Research · doi:10.1007/s11136-016-1281-y · Cited by 97 · see citing works
Hopman, P., Heins, M. J., Rijken, M., & Schellevis, F. (2015) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2015.02.006 · Cited by 96 · see citing works
Predicting Incident Multimorbidity
Mounce, L. T. A., Campbell, J. L., Henley, W., Arreal, M. C. T., Porter, I. H., & Valderas, J. M. (2018) · The Annals of Family Medicine · doi:10.1370/afm.2271 · Cited by 95 · see citing works
Trends in multimorbidity and polypharmacy in the Flemish-Belgian population between 2000 and 2015
van den Akker, M., Vaes, B., Goderis, G., Pottelbergh, G. V., Burghgraeve, T. D., & Henrard, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212046 · Cited by 94 · see citing works
Estimating multimorbidity prevalence with the Canadian Chronic Disease Surveillance System
Feely, A., Lix, L. M., & Reimer, K. (2017) · Health Promotion and Chronic Disease Prevention in Canada · doi:10.24095/hpcdp.37.7.02 · Cited by 93 · see citing works
Kumar, V., Recupero, D. R., Riboni, D., & Helaoui, R. (2020) · IEEE Access · doi:10.1109/access.2020.3043221 · Cited by 93 · see citing works
Gill, A., Kuluski, K., Jaakkimainen, L., Naganathan, G., Upshur, R. E. G., & Wodchis, W. P. (2014) · Healthcare policy · doi:10.12927/hcpol.2014.23811 · Cited by 92 · see citing works
Comorbidity in Patients With Small-Cell Lung Cancer: Trends and Prognostic Impact
Aarts, M. J., Aerts, J. G. J. V., van den Borne, B. E., Biesma, B., Lemmens, V. E. P. P., & Kloover, J. S. (2014) · Clinical Lung Cancer · doi:10.1016/j.cllc.2014.12.003 · Cited by 91 · see citing works
McKenzie, K. J., Pierce, D., & Gunn, J. M. (2015) · Journal of Comorbidity · doi:10.15256/joc.2015.5.55 · Cited by 89 · see citing works
Kudesia, P., Salimarouny, B., Stanley, M., Fortin, M., Stewart, M., Terry, A. L., & Ryan, B. L. (2021) · Journal of Multimorbidity and Comorbidity · doi:10.1177/26335565211032880 · Cited by 86 · see citing works
Galenkamp, H., Braam, A. W., Huisman, M. A., & Deeg, D. J. H. (2012) · European Journal of Public Health · doi:10.1093/eurpub/cks031 · Cited by 89 · see citing works
Søndergaard, E., Willadsen, T. G., Guassora, A. D., Vestergaard, M., Tómasdóttir, M. Ó., Borgqúist, L., Holmberg‐Marttila, D., Olivarius, N. D. F., & Reventlow, S. D. (2015) · Scandinavian Journal of Primary Health Care · doi:10.3109/02813432.2015.1041828 · Cited by 88 · see citing works
Ge, L., Ong, R., Yap, C. W., & Heng, B. H. (2018) · Nursing and Health Sciences · doi:10.1111/nhs.12585 · Cited by 88 · see citing works
Weimann, A., Dai, D., & Oni, T. (2016) · Social Science & Medicine · doi:10.1016/j.socscimed.2016.06.055 · Cited by 85 · see citing works
Wedekind, D., Broocks, A., Weiss, N., Engel, K. R., Neubert, K., & Bandelow, B. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.489620 · Cited by 84 · see citing works
Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity
McEvoy, L., Carr, D. F., & Pirmohamed, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.684162 · Cited by 84 · see citing works
Burden of comorbidities among patients with atrial fibrillation
LaMori, J. C., Mody, S. H., Gross, H. J., DiBonaventura, M., Patel, A. A., Schein, J. R., & Nelson, W. W. (2012) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944712464101 · Cited by 82 · see citing works
Attitudes of General Practitioners Toward Prescription of Mobile Health Apps: Qualitative Study
Sarradon‐Eck, A., Bouchez, T., Auroy, L., Schuers, M., & Darmon, D. (2021) · JMIR mhealth and uhealth · doi:10.2196/21795 · Cited by 81 · see citing works
Goldberg, R. J., McManus, Nguyen, H. L., Tisminetzky, Bourell, & Saczynski, J. S. (2012) · Clinical Epidemiology · doi:10.2147/clep.s30883 · Cited by 80 · see citing works
Adverse events in older patients undergoing ERCP: a systematic review and meta-analysis
Day, L. W., Lin, L. D., & Somsouk, M. (2014) · Endoscopy International Open · doi:10.1055/s-0034-1365281 · Cited by 77 · see citing works
Predicting mortality from change-over-time in the Charlson Comorbidity Index
Fraccaro, P., Kontopantelis, E., Sperrin, M., Peek, N. B., Mallen, C. D., Urban, P. M., Buchan, I. E., & Mamas, M. A. (2016) · Medicine · doi:10.1097/md.0000000000004973 · Cited by 77 · see citing works
Chauhan, S., Kumar, S., Bharti, R., & Patel, R. (2022) · BMC Geriatrics · doi:10.1186/s12877-021-02659-z · Cited by 76 · see citing works
Hopman, P., Heins, M. J., Korevaar, J. C., Rijken, M., & Schellevis, F. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.08.025 · Cited by 76 · see citing works
Toro, N. (2011) · International Journal of Integrated Care · doi:10.5334/ijic.800 · Cited by 70 · see citing works
Agur, K., McLean, G., Hunt, K., Guthrie, B., & Mercer, S. W. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13040391 · Cited by 73 · see citing works
The Structural Burden of Caregiving: Shared Challenges in the United States and Canada
Taylor, M. G., & Quesnel‐Vallée, A. (2016) · The Gerontologist · doi:10.1093/geront/gnw102 · Cited by 72 · see citing works
The impact of socioeconomic status and multimorbidity on mortality: a population-based cohort study
Jensen, N. L., Pedersen, H., Vestergaard, M., Mercer, S. W., Glümer, C., & Prior, A. (2017) · Clinical Epidemiology · doi:10.2147/clep.s129415 · Cited by 71 · see citing works
Disparities in the Prevalence of Childhood Obesity-Related Comorbidities: A Systematic Review
Obita, G., & AlKhatib, A. H. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.923744 · Cited by 69 · see citing works
Bhattarai, N., Charlton, J., Rudisill, C., & Gulliford, M. C. (2012) · Psychological Medicine · doi:10.1017/s0033291712002498 · Cited by 67 · see citing works
Co-morbidity: we need a guideline for each patient not a guideline for each disease
Dawes, M. G. (2010) · Family Practice · doi:10.1093/fampra/cmp106 · Cited by 67 · see citing works
Multimorbidity, Care Complexity and Prescribing for the Elderly
Roughead, E. E., Vitry, A. I., Caughey, G. E., & Gilbert, A. L. (2011) · Aging Health · doi:10.2217/ahe.11.64 · Cited by 65 · see citing works
Development of a multimorbidity index: Impact on quality of life using a rheumatoid arthritis cohort
Radner, H., Yoshida, K., Mjaavatten, M. D., Aletaha, D., Frits, M. L., Lü, B., Iannaccone, C. K., Shadick, N. A., Weinblatt, M. E., Hmamouchi, I., et al. (2015) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2015.06.010 · Cited by 65 · see citing works
Bahrmann, A., Benner, L., Christ, M., Bertsch, T., Sieber, C. C., Katus, H. A., & Bahrmann, P. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-1067-x · Cited by 64 · see citing works
Goldberg, R. J., Chen, H.-Y., Saczynski, J. S., McManus, Lessard, Yarzebski, J., Lapane, K. L., & Gore (2013) · Clinical Epidemiology · doi:10.2147/clep.s49485 · Cited by 64 · see citing works
Aarts, S., van den Akker, M., Bosma, H., Tan, F. E. S., Verhey, F. R. J., Metsemakers, J. F. M., & van Boxtel, M. P. J. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2012.05.014 · Cited by 63 · see citing works
Moth, G., Vestergaard, M., & Vedsted, P. (2012) · BMC Family Practice · doi:10.1186/1471-2296-13-52 · Cited by 63 · see citing works
Patterns of Multimorbidity in Primary Care Patients at High Risk of Future Hospitalization
Freund, T., Kunz, C. U., Ose, D. J., Szécsényi, J., & Peters-Klimm, F. (2012) · Population Health Management · doi:10.1089/pop.2011.0026 · Cited by 63 · see citing works
Trends in obesity and multimorbidity in Canada
Lebenbaum, M., Zaric, G. S., Thind, A., & Sarma, S. (2018) · Preventive Medicine · doi:10.1016/j.ypmed.2018.08.025 · Cited by 63 · see citing works
Garnett, A., Ploeg, J., Markle‐Reid, M., & Strachan, P. H. (2018) · SAGE Open Nursing · doi:10.1177/2377960817752471 · Cited by 62 · see citing works
Burden of heart failure in Flemish general practices: a registry-based study in the Intego database
Smeets, M., Vaes, B., Mamouris, P., van den Akker, M., Pottelbergh, G. V., Goderis, G., Janssens, S. P., Aertgeerts, B., & Henrard, S. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-022972 · Cited by 64 · see citing works
Patterns of multimorbidity and pharmacotherapy: a total population cross-sectional study
Forslund, T., Carlsson, A. C., Ljunggren, G., Ärnlöv, J., & Wachtler, C. (2020) · Family Practice · doi:10.1093/fampra/cmaa056 · Cited by 58 · see citing works
- Authors
- Uijen, A. A., & van de Lisdonk, E. H.
- Affiliations
- Radboud University Medical Center (NL)
- Department of General Practice, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
- Corresponding author
- Uijen, Annemarie A.
- ORCID
- Uijen, Annemarie A.
- Venue
- European Journal of General Practice
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 14
- Issue
- sup1
- Pages
- 28-32
- ISSN
- 1381-4788 (ISSN-L)
- 1751-1402
- OpenAlex
- W2169722090
- Cited by
- 505
- References
- 13
- Citations by year
- 2026: 8 · 2025: 23 · 2024: 27 · 2023: 33 · 2022: 38 · 2021: 57 · 2020: 35 · 2019: 30 · 2018: 35 · 2017: 28 · 2016: 36 · 2015: 31 · 2014: 29 · 2013: 28 · 2012: 29
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of General Practice (publishedVersion)
- PubMed (publishedVersion)
- BIBSYS Brage (BIBSYS (Norway)) (submittedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Health Sciences › Health Professions › General Health Professions › Primary Care and Health Outcomes
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- multimorbidity, chronic disease, prevalence trends, primary care, socioeconomic class, age and sex differences, general practitioner workload, complex care
- MeSH terms
- Adolescent, Adult, Aged, Child, Preschool, Chronic Disease, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Morbidity, Netherlands, Primary Health Care, Registries, Social Class, Prevalence, Age Distribution, Sex Distribution, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review