The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Sarcopenia and mortality risk in frail older persons aged 80 years and older: results from ilSIRENTE study
Abstract
BACKGROUND AND AIMS: sarcopenia has been indicated as a reliable marker of frailty and poor prognosis among the oldest individuals. We evaluated the impact of sarcopenia on the risk of all-cause death in a population of frail older persons living in community. METHODS: we analysed data from the Aging and Longevity Study, a prospective cohort study that collected data on all subjects aged 80 years and older residing in the Sirente geographic area (n = 364). The present analysis was conducted among those subjects who were between 80 and 85 years of age at the time of the baseline assessment (n = 197). The main outcome measure was all-cause mortality over 7-year follow-up. According to the European Working Group on Sarcopenia in Older People (EWGSOP) criteria, the diagnosis of sarcopenia required the documentation of low muscle mass and the documentation of either low muscle strength or low physical performance. Cox proportional regression models were used to estimate crude and adjusted hazard ratios and 95% confidence intervals of death by the presence of sarcopenia. RESULTS: using the EWGSOP-suggested criteria, 43 subjects with sarcopenia (21.8%) were identified. During the 7-year follow-up, 29 (67.4%) participants died among subjects with sarcopenia compared with 63 subjects (41.2%) without sarcopenia (P < 0.001). After adjusting for potential confounders including age, gender, education, activities of daily living (ADL) impairment, body mass index, hypertension, congestive heart failure, chronic obstructive pulmonary disease, number of diseases, TNF-α, participants with sarcopenia had a higher risk of death for all causes compared with non-sarcopenic subjects (HR: 2.32, 95% CI: 1.01-5.43). CONCLUSIONS: our results obtained from a representative sample of very old and frail subjects show that sarcopenia is associated with mortality, independently of age and other clinical and functional variables.
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Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
Self-citationFielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256 · cited 1×
“Despite a growing interest of scientific community to such condition [1, 8, 9], information on sarcopenia among community living older subjects and its relation to survival is still lacking.”
BackgroundSelf-citationObjectively measured physical capability levels and mortality: systematic review and meta-analysis
Cooper, R., Kuh, D., Hardy, R., Mortality Review Group, & teams, O. B. O. T. F. A. H. S. (2010) · BMJ · doi:10.1136/bmj.c4467 · Cited by 1,166 · cited 1×
“However, some recent studies suggested that muscle function may be a more powerful predictor of disability and mortality than the muscle mass [11, 12].”
BackgroundThomas, D. R. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.03.008 · Cited by 521 · cited 1×
“Third, many experts in sarcopenia believe that anthropometric measures are poor markers of muscle mass and cast doubts on their role in this kind of studies [25, 26].”
BackgroundSarcopenia and Mortality among Older Nursing Home Residents
Landi, F., Liperoti, R., Fusco, D., Mastropaolo, S., Quattrociocchi, D., Proia, A., Tosato, M., Bernabei, R., & Onder, G. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.07.004 · Cited by 344 · cited 1×
“Furthermore, it has been associated with an increased risk of death, hospitalisation, need for long-term care and higher health care expenditures [1, 2, 22, 23].”
BackgroundSelf-citationMuscle strength, disability and mortality
Rantanen, T. (2003) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1034/j.1600-0838.2003.00298.x · Cited by 317 · cited 1×
“However, some recent studies suggested that muscle function may be a more powerful predictor of disability and mortality than the muscle mass [11, 12].”
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Cited by
Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553
Self-citationCruz-Jentoft, A. J., Landi, F., Schneider, S. M., Zuniga, C., Arai, H., Boirie, Y., Chen, L.-K., Fielding, R. A., Martin, F. C., Michel, J.-P., et al. (2014) · Age and Ageing · doi:10.1093/ageing/afu115 · Cited by 1,963
Self-citationDent, E., Morley, J. E., Cruz-Jentoft, A. J., Arai, H., Kritchevsky, S. B., Guralnik, J., Bauer, J. M., Pahor, M., Clark, B. C., Cesari, M., et al. (2018) · The Journal of nutrition, health and aging · doi:10.1007/s12603-018-1139-9 · Cited by 1,130
Self-citationInflammation and sarcopenia: A systematic review and meta-analysis
Bano, G., Trevisan, C., Carraro, S., Solmi, M., Luchini, C., Stubbs, B., Manzato, E., Sergi, G., & Veronese, N. (2017) · Maturitas · doi:10.1016/j.maturitas.2016.11.006 · Cited by 801
Insulin resistance and sarcopenia: mechanistic links between common co-morbidities
Cleasby, M. E., Jamieson, P. M., & Atherton, P. J. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0533 · Cited by 596
Metadata
- Authors
- Landi, F., Cruz-Jentoft, A. J., Liperoti, R., Russo, A., Giovannini, S., Tosato, M., Capoluongo, E., Bernabei, R., & Onder, G.
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-01-15
- Volume
- 42
- Issue
- 2
- Pages
- 203-209
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- OpenAlex
- W2166636130
- Cited by
- 619
- References
- 8
- FWCI
- 33.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Landi, F., Cruz-Jentoft, A. J., Liperoti, R., Russo, A., Giovannini, S., Tosato, M., Capoluongo, E., Bernabei, R., & Onder, G. (2013). Sarcopenia and mortality risk in frail older persons aged 80 years and older: results from ilSIRENTE study. Age and Ageing. https://doi.org/10.1093/ageing/afs194
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