Systematic reviews: guidance relevant for studies of older people
Open accessAbstract
Systematic reviews and meta-analyses are increasingly common. This article aims to provide guidance for people conducting systematic reviews relevant to the healthcare of older people. An awareness of these issues will also help people reading systematic reviews to determine whether the results will influence their clinical practice. It is essential that systematic reviews are performed by a team which includes the required technical and clinical expertise. Those performing reviews for the first time should ensure they have appropriate training and support. They must be planned and performed in a transparent and methodologically robust way: guidelines are available. The protocol should be written-and if possible published-before starting the review. Geriatricians will be interested in a table of baseline characteristics, which will help to determine if the studied samples or populations are similar to their patients. Reviews of studies of older people should consider how they will manage issues such as different age cut-offs; non-specific presentations; multiple predictors and outcomes; potential biases and confounders. Systematic reviews and meta-analyses may provide evidence to improve older people's care, or determine where new evidence is required. Newer methodologies, such as meta-analyses of individual level data, network meta-analyses and umbrella reviews, and realist synthesis, may improve the reliability and clinical utility of systematic reviews.
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Cites
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859 · see citing works
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & the PRISMA Group* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00135 · Cited by 37,554 · see citing works
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817 · see citing works
PRISMA-P Group, Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015) · Systematic Reviews · doi:10.1186/2046-4053-4-1 · Cited by 26,223 · see citing works
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,577 · see citing works
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623 · see citing works
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009) · doi:10.1002/9780470743386 · Cited by 14,225 · see citing works
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2021) · doi:10.1002/9781119558378 · Cited by 9,799 · see citing works
Development of AMSTAR: A measurement tool to assess the methodological quality of systematic reviews
Shea, B. J., Grimshaw, J. M., Wells, G. A., Boers, M., Andersson, N., Hamel, C., Porter, A. C., Tugwell, P., Moher, D., & Bouter, L. M. (2007) · BMC Medical Research Methodology · doi:10.1186/1471-2288-7-10 · Cited by 4,374 · see citing works
Realist review - a new method of systematic review designed for complex policy interventions
Pawson, R., Greenhalgh, T., Harvey, G., & Walshe, K. (2005) · Journal of Health Services Research & Policy · doi:10.1258/1355819054308530 · Cited by 3,190 · see citing works
Meta-analysis of individual participant data: rationale, conduct, and reporting
Riley, R. D., Lambert, P. C., & Abo-Zaid, G. (2010) · BMJ · doi:10.1136/bmj.c221 · Cited by 1,701 · see citing works
The Mass Production of Redundant, Misleading, and Conflicted Systematic Reviews and Meta‐analyses
IOANNIDIS, J. P. A. (2016) · The Milbank Quarterly · doi:10.1111/1468-0009.12210 · Cited by 1,483 · see citing works
Self-citationSystematic Reviews in Health Care. Meta-analysis in Context.
Kleijnen, J., & Antes, G. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.3.697 · Cited by 1,373 · see citing works
Kim, S. Y., Park, J. E., Lee, Y. J., Seo, H.-J., Sheen, S.-S., Hahn, S., Jang, B.-H., & Son, H.-J. (2013) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2012.09.016 · Cited by 1,165 · see citing works
The Effects of Exercise on Falls in Elderly Patients
Province, M. A. (1995) · JAMA · doi:10.1001/jama.1995.03520410035023 · Cited by 1,034 · see citing works
Demystifying trial networks and network meta-analysis
Mills, E. J., Thorlund, K., & Ioannidis, J. P. A. (2013) · BMJ · doi:10.1136/bmj.f2914 · Cited by 742 · see citing works
Self-citationRealist synthesis: illustrating the method for implementation research
Rycroft-Malone, J., McCormack, B., Hutchinson, A. M., DeCorby, K., Bucknall, T. K., Kent, B., Schultz, A., Snelgrove-Clarke, E., Stetler, C. B., Titler, M., et al. (2012) · Implementation Science · doi:10.1186/1748-5908-7-33 · Cited by 742 · see citing works
Mons, U., Müezzinler, A., Gellert, C., Schöttker, B., Abnet, C. C., Bobák, M., de Groot, C. P. G. M., Freedman, N. D., Jansen, E. H. J. M., Kee, F., et al. (2015) · BMJ · doi:10.1136/bmj.h1551 · Cited by 533 · see citing works
Haby, M. M., Chapman, E., Clark, R., Barreto, J. O. M., Revéiz, L., & Lavis, J. N. (2016) · Health Research Policy and Systems · doi:10.1186/s12961-016-0155-7 · Cited by 410 · see citing works
The attitudes to ageing questionnaire (AAQ): development and psychometric properties
Laidlaw, K., Power, M., & Schmidt, S. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1683 · Cited by 343 · see citing works
Ioannidis, J. P. A. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-097621 · Cited by 189 · see citing works
Self-citationEbrahim, S., Bance, S., Athale, A., Malachowski, C., & Ioannidis, J. P. A. (2016) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2015.08.021 · Cited by 107 · see citing works
Self-citationEffective health care for older people living and dying in care homes: a realist review
Goodman, C. M., Dening, T., Gordon, A. L., Davies, S. L., Meyer, J. E., Martin, F. C., Gladman, J. R. F., Bowman, C., Victor, C. R., Handley, M., et al. (2016) · BMC Health Services Research · doi:10.1186/s12913-016-1493-4 · Cited by 100 · see citing works
Thorlund, K., Druyts, E., Wu, P., Balijepalli, C., Keohane, D., & Mills, E. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13395 · Cited by 79 · see citing works
Observational evidence and strength of evidence domains: case examples
O'Neil, M. E., Berkman, N. D., Hartling, L., Chang, S., Anderson, J., Motu’apuaka, M. L., Guise, J., & McDonagh, M. S. (2014) · Systematic Reviews · doi:10.1186/2046-4053-3-35 · Cited by 51 · see citing works
Denison, H. J., Dodds, R. M., Ntani, G., Cooper, R., Cooper, C. C., Sayer, A. A., & Baird, J. (2013) · Archives of Public Health · doi:10.1186/0778-7367-71-21 · Cited by 49 · see citing works
Self-citationA meta-analysis but not a systematic review: an evaluation of the Global BMI Mortality Collaboration
Flegal, K. M., & Ioannidis, J. P. A. (2017) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2017.04.007 · Cited by 20 · see citing works
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- The very long list of references supporting this review has meant that only the first 36 are listed here. The full list of references is available on the journal website http://www.ageing.oxfordjournals.org/ as Appendix.
- [10]Egger M, Davey Smith G, Schneider M Systematic reviews of observational studies In: Egger M, Davey Smith G, Altman D eds Systematic Reviews in Healthcare: Meta-Analysis in Context. London: WIley, 2008: pp. 211– 27.
Cited by
Sorted by citations
Alqenae, F. A., Steinke, D. T., & Keers, R. N. (2020) · Drug Safety · doi:10.1007/s40264-020-00918-3 · Cited by 291 · see citing works
Yuan, L., Chang, M., & Wang, J. (2021) · Age and Ageing · doi:10.1093/ageing/afab039 · Cited by 251 · see citing works
Demurtas, J., Schoene, D., Torbahn, G., Marengoni, A., Grande, G., Zou, L., Petrović, M., Maggi, S., Cesari, M., Lamb, S. E., et al. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.08.031 · Cited by 246 · see citing works
Self-citationVideo calls for reducing social isolation and loneliness in older people: a rapid review
Noone, C., McSharry, J., Smalle, M., Burns, A., Dwan, K., Devane, D., & Morrissey, E. C. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013632 · Cited by 226 · see citing works
Bosello, O., & Vanzo, A. (2019) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-019-00815-4 · Cited by 190 · see citing works
Miller, K. J., Gonçalves-Bradley, D. C., Areerob, P., Hennessy, D., Mesagno, C., & Grace, F. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100999 · Cited by 152 · see citing works
Barriers to older adults seeking sexual health advice and treatment: A scoping review
Ezhova, I., Savidge, L., Bonnett, C., Cassidy, J., Okwuokei, A., & Dickinson, T. (2020) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2020.103566 · Cited by 128 · see citing works
Sarcopenia and health-related outcomes: an umbrella review of observational studies
the Special Interest Groups in Systematic Reviews and Meta-analyses for healthy ageing Sarcopenia and Frailty and resilience in older persons of the European Geriatric Medicine Society (EuGMS), Veronese, N., Demurtas, J., Soysal, P., Smith, L., Torbahn, G., Schoene, D., Schwingshackl, L., Sieber, C. C., Bauer, J. M., et al. (2019) · European Geriatric Medicine · doi:10.1007/s41999-019-00233-w · Cited by 125 · see citing works
Defining and Analyzing the Problem
Demiris, G., Oliver, D. P., & Washington, K. T. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814449-7.00003-x · Cited by 105 · see citing works
Shao, S., Lai, C.-C., Chen, Y., Chen, Y., Hung, M., & Liao, S. (2021) · Age and Ageing · doi:10.1093/ageing/afab103 · Cited by 104 · see citing works
Withdrawal of antihypertensive drugs in older people
Reeve, E., Jordan, V., Thompson, W., Sawan, M. J., Todd, A., Gammie, T. M., Hopper, I., Hilmer, S. N., & Gnjidic, D. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012572.pub2 · Cited by 103 · see citing works
Trait resilience and mental health in older adults: A meta-analytic review.
Färber, F., & Rosendahl, J. (2020) · Personality and Mental Health · doi:10.1002/pmh.1490 · Cited by 73 · see citing works
Healy, D., Flynn, A., Conlan, O., McSharry, J., & Walsh, J. (2022) · JMIR Serious Games · doi:10.2196/35802 · Cited by 77 · see citing works
“As there is no generally accepted definition of older adults, we included those studies in which the mean age of the study sample was ≥60 years as this is a commonly used cutoff in aging research [31].”
BackgroundThe treatment of cognitive dysfunction in dementia: a multiple treatments meta-analysis
Perng, C., Chang, Y., & Tzang, R. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4867-y · Cited by 69 · see citing works
Fuller, G. W., Pandor, A., Essat, M., Sabir, L., Buckley‐Woods, H., Chatha, H., Holt, C., Keating, S., & Turner, J. (2021) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000003039 · Cited by 56 · see citing works
Methodological Guidance for a Quality Review Article
Heyn, P. C., Meeks, S., & Pruchno, R. A. (2018) · The Gerontologist · doi:10.1093/geront/gny123 · Cited by 55 · see citing works
Drug-related Problems in Home-dwelling Older Adults: A Systematic Review
Plácido, A. I., Herdeiro, M. T., Morgado, M., Figueiras, A., & Roque, F. (2020) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.02.005 · Cited by 51 · see citing works
Miller, K. J., Areerob, P., Hennessy, D., Gonçalves-Bradley, D. C., Mesagno, C., & Grace, F. (2020) · F1000Research · doi:10.12688/f1000research.27123.1 · Cited by 41 · see citing works
Prediction of resting energy expenditure in healthy older adults: A systematic review
Cioffi, I., Marra, M., Pasanisi, F., & Scalfi, L. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.11.027 · Cited by 42 · see citing works
Fu, Z., Yan, M., & Chao, M. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.935544 · Cited by 39 · see citing works
What Factors are Associated with Posttraumatic Growth in Older Adults? A Systematic Review
Kadri, A., Gracey, F., & Leddy, A. (2022) · Clinical Gerontologist · doi:10.1080/07317115.2022.2034200 · Cited by 38 · see citing works
Andreato, L. V., de Oliveira, D. V., Follmer, B., & Bertolini, S. M. M. G. (2020) · Australian Journal on Ageing · doi:10.1111/ajag.12782 · Cited by 30 · see citing works
Stearns, J. A., Avedzi, H. M., Yim, D., Spence, J. C., Labbaf, F., Lamboglia, C. G., Ko, F., Farmer, C., Lytvyak, E., Kennedy, M., et al. (2023) · Public health reviews · doi:10.3389/phrs.2023.1605474 · Cited by 28 · see citing works
Leung, L. Y. L., Tam, H. L., & Ho, J. K.-M. (2022) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2022.104796 · Cited by 28 · see citing works
Anticholinergic Burden and Fractures: A Systematic Review with Methodological Appraisal
Reinold, J., Schäfer, W., Christianson, L., Barone‐Adesi, F., Riedel, O., & Pisa, F. E. (2020) · Drugs & Aging · doi:10.1007/s40266-020-00806-6 · Cited by 25 · see citing works
Mortality Risk Following Delirium in Older Inpatients: A Systematic Review and Meta‐Analysis
Pérez‐Ros, P., Plaza‐Ortega, N., & Martínez‐Arnau, F. M. (2025) · Worldviews on Evidence-Based Nursing · doi:10.1111/wvn.70027 · Cited by 20 · see citing works
Miller, K. J., Areerob, P., Hennessy, D., Gonçalves-Bradley, D. C., Mesagno, C., & Grace, F. (2021) · F1000Research · doi:10.12688/f1000research.27123.2 · Cited by 20 · see citing works
Properties of Pain Assessment Tools for Use in People Living With Stroke: Systematic Review
Edwards, S., Ioannou, A., Carin-Levy, G., Cowey, E., Brady, M., Morton, S., Sande, T. A., Mead, G. E., & Quinn, T. J. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00792 · Cited by 18 · see citing works
Conducting and reporting trials for older people
Witham, M. D., & Stott, D. J. (2017) · Age and Ageing · doi:10.1093/ageing/afx153 · Cited by 18 · see citing works
Deprescribing in cardiometabolic conditions in older patients: a systematic review
Hickman, E., Seewoodharry, M., Gillies, C. L., Khunti, K. K., & Seidu, S. (2023) · GeroScience · doi:10.1007/s11357-023-00852-z · Cited by 17 · see citing works
Mortality prediction models for community-dwelling older adults: A systematic review
Exmann, C. J., Kooijmans, E. C. M., Joling, K. J., Burchell, G. L., Hoogendijk, E. O., & van Hout, H. P. J. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102525 · Cited by 16 · see citing works
Incidence of delirium in older people with cancer: Systematic review and meta-analysis
Martínez‐Arnau, F. M., Buigues, C., & Pérez‐Ros, P. (2023) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2023.102457 · Cited by 16 · see citing works
Hire, A. J., & Franklin, B. D. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-04858-w · Cited by 16 · see citing works
Lucia, A. D., Perlini, C., Chiarotto, A., Pachera, S., Pasini, I., Piccolo, L. D., & Donisi, V. (2024) · Journal of Medical Internet Research · doi:10.2196/55366 · Cited by 16 · see citing works
Duong, M. H., Gnjidic, D., McLachlan, A. J., Redston, M. R., Goyal, P., Mathieson, S., & Hilmer, S. N. (2024) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.16223 · Cited by 15 · see citing works
Mason, M. C., Zamparo, G., & Pauluzzo, R. (2023) · International Journal of Bank Marketing · doi:10.1108/ijbm-06-2022-0256 · Cited by 14 · see citing works
Alsulaimani, R. A., & Quinn, T. J. (2021) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2021.100012 · Cited by 13 · see citing works
D’Hooghe, S., Inaç, Y., Clercq, E. M. D., Deforche, B. I., Dury, S., Vandevijvere, S., de Weghe, N. V., Dyck, D. V., & Ridder, K. D. (2022) · Archives of Public Health · doi:10.1186/s13690-022-00956-6 · Cited by 12 · see citing works
Tian, S., Liang, Z., Tian, M., Qiu, F., Yu, Y., Mou, H., & Gao, Y. (2024) · Age and Ageing · doi:10.1093/ageing/afae211 · Cited by 12 · see citing works
Pandor, A., Fuller, G. W., Essat, M., Sabir, L., Holt, C., Woods, H. B., & Chatha, H. (2022) · British Paramedic Journal · doi:10.29045/14784726.2022.03.6.4.26 · Cited by 11 · see citing works
Analysis of the Treatment and Survival of Sinonasal Extramedullary Plasmacytoma
Gao, J., Tseng, C. C., Barinsky, G. L., Fang, C. H., Grube, J. G., Hsueh, W. D., Baredes, S., & Eloy, J. A. (2022) · American Journal of Rhinology and Allergy · doi:10.1177/19458924221092529 · Cited by 11 · see citing works
Healy, D., Flynn, A., Conlan, O., McSharry, J., & Walsh, J. (2021) · International Journal of Qualitative Methods · doi:10.1177/16094069211009682 · Cited by 10 · see citing works
Huang, K., Zhang, G., Gains, H., He, R., Jiao, Y., Jia, Y., & Chen, L. (2025) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2025.105583 · Cited by 12 · see citing works
Transparency in Cognitive Training Meta-analyses: A Meta-review
Sandoval‐Lentisco, A., López‐Nicolás, R., Tortajada, M., López-López, J. A., & Sánchez‐Meca, J. (2024) · Neuropsychology Review · doi:10.1007/s11065-024-09638-2 · Cited by 10 · see citing works
Torbahn, G., Schoene, D., Schwingshackl, L., Rücker, G., Knüttel, H., KEMMLER, W. K., Sieber, C. C., Batsis, J. A., Villareal, D. T., Stroebele‐Benschop, N., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-038330 · Cited by 9 · see citing works
Power assist add-ons for adult manual wheelchair users: A scoping review
Atoyebi, O. A., Wister, A., Mattie, J., Beadle, J., GUTMAN, G. M., Chaudhury, H., Sparrey, C. J., Jones, O. Y., Mortenson, W. B., O’Dea, E., et al. (2025) · Assistive Technology · doi:10.1080/10400435.2025.2451933 · Cited by 7 · see citing works
Braghiroli, K. S., Einav, S., Heesen, M. A., Bôas, P. J. F. V., Bráz, J. R. C., Corrente, J. E., Porto, D. D. S. M., de Morais, A. C., Neves, G. C., Braz, M. G., et al. (2020) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2020.110160 · Cited by 7 · see citing works
Yılmaz, N. G., Timmermans, D. R. M., van Weert, J. C. M., & Damman, O. C. (2023) · Health Informatics Journal · doi:10.1177/14604582231155279 · Cited by 5 · see citing works
Yang, Z., Wang, C., Tang, Z., & Song, X. (2019) · Aging Medicine · doi:10.1002/agm2.12090 · Cited by 6 · see citing works
Arentz, S., Hunter, J., & Deed, G. (2020) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2020.0028 · Cited by 6 · see citing works
Fu, Z., Yan, M., Han, X., Zhang, K., & Zhao, X. (2025) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2025.106056 · Cited by 5 · see citing works
Priority nutrients to address malnutrition and diet-related diseases in Australia and New Zealand
Starck, C. S., Cassettari, T., Beckett, E., Marshall, S., & Fayet‐Moore, F. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1370550 · Cited by 6 · see citing works
Robertson, M. A., Petersen, E. E., Ross‐White, A., Plazas, P. C., Andrew, M., & Egan, R. G. (2024) · JBI Evidence Synthesis · doi:10.11124/jbies-23-00334 · Cited by 5 · see citing works
Kshatri, J. S., Rehman, T., Janssen, D. J. A., Shenkin, S. D., Palo, S. K., & Pati, S. (2025) · Discover Public Health · doi:10.1186/s12982-025-00686-4 · Cited by 5 · see citing works
Self-citationInterventions for treating urinary incontinence in older women: a network meta-analysis
Vesentini, G., O’Connor, N., Berre, M. L., Nabhan, A. F., Wagg, A., Wallace, S. A., & Dumoulin, C. L. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015376.pub2 · Cited by 4 · see citing works
Pojmonpiti, S., Syed, S. S., Srinivasan, M., Tsakos, G., Müller, F., & Janssens, B. E. (2026) · Gerodontology · doi:10.1111/ger.70072 · Cited by 4 · see citing works
Shi, Y., Stanmore, E., McGarrigle, L., & Todd, C. J. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-086124 · Cited by 4 · see citing works
Santilli, G., Martino, M., Pacini, P., Agostini, F., Bernetti, A., Giuliani, L., Gaudio, G. D., Mangone, M., Colonna, V., Vetrano, M., et al. (2024) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk10010002 · Cited by 4 · see citing works
New horizons in evidence synthesis for older adults
Cooper, N. J., Germeni, E., Freeman, S. C., Jaiswal, N., Nevill, C. R., Sutton, A. J., Rowan, M. T., & Quinn, T. J. (2023) · Age and Ageing · doi:10.1093/ageing/afad211 · Cited by 4 · see citing works
Salmanian, S., Rodemerk, J., Al-Rubaiey, S., Ahmadzai, M., Timner, E., Schock, L., Dinger, T. F., Gembruch, O., Jabbarli, R., Dammann, P. R., et al. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14217856 · Cited by 3 · see citing works
Galluzzi, S., Solorzano, C. S., Marizzoni, M., Gatti, E., Gualco, C., Lanfredi, M., Rossi, R., Cattaneo, A., Frisoni, G. B., Crescentini, C., et al. (2025) · Mindfulness · doi:10.1007/s12671-025-02718-1 · Cited by 3 · see citing works
Fulceri, F., Caruso, A., Micai, M., Notari, M. V., Cocchi, C., Cerri, A., Onder, G., & Scattoni, M. L. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1739380 · Cited by 4 · see citing works
Freudenberg‐Hua, Y., Giliberto, L., d’Abramo, C., Li, W., Ma, Y., Goate, A., & Koppel, J. L. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03098-7 · Cited by 3 · see citing works
Exogenous Melatonin and Sleep Quality: A Scoping Review of Systematic Reviews
Iyer, S., Monk, V., Slater, R., & Baxter, L. (2025) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.70115 · Cited by 3 · see citing works
Representation of Older Adults and Women in Randomized Trials of Noninvasive Imaging for Chest Pain
Lim, P., Eris, T., Shaw, L. J., Gelfman, L. P., Gelijns, A. C., Moskowitz, A., Bagiella, E., Lin, F. Y.-H., Bhatt, D. L., Stone, G. W., et al. (2025) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.125.018295 · Cited by 3 · see citing works
Reinold, J., Schäfer, W., Christianson, L., Barone‐Adesi, F., Riedel, O., & Pisa, F. E. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-030205 · Cited by 3 · see citing works
Veronese, N., Torbahn, G., Demurtas, J., Beaudart, C., Soysal, P., Marengoni, A., Shenkin, S. D., Petrović, M., Sieber, C. C., Cherubini, A., et al. (2020) · European Geriatric Medicine · doi:10.1007/s41999-020-00369-0 · Cited by 3 · see citing works
Self-citationYazdani, N., Falzarano, F., Zucchetto, J. M., & Siedlecki, K. L. (2024) · The International Journal of Aging & Human Development · doi:10.1177/00914150241240122 · Cited by 2 · see citing works
Regional Cerebral Oxygen Saturation and Risk of Delirium: A Systematic Review and Meta-Analysis
Rochina-Rodríguez, B., Martínez‐Arnau, F. M., & Pérez‐Ros, P. (2025) · Diseases · doi:10.3390/diseases13120383 · Cited by 2 · see citing works
Interventions for treating urinary incontinence in older women: a network meta-analysis
Vesentini, G., O’Connor, N., Elders, A., Berre, M. L., Nabhan, A. F., Wagg, A., Cacciari, L., & Dumoulin, C. L. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015376 · Cited by 2 · see citing works
Robertson, M. A., Petersen, E. E., Ross‐White, A., & Egan, R. G. (2023) · JBI Evidence Synthesis · doi:10.11124/jbies-22-00270 · Cited by 3 · see citing works
Shi, Y., Stanmore, E., McGarrigle, L., & Todd, C. J. (2024) · medRxiv · doi:10.1101/2024.03.06.24303856 · Cited by 2 · see citing works
Alagood, J., Senn, W. D., & Prybutok, G. (2025) · Healthcare · doi:10.3390/healthcare13233031 · Cited by 1 · see citing works
Lin, J., Lin, Z., Chen, Y., Wang, X., Huang, Y.-F., Zhang, H., Zhu, L. F., Xu, Z., Gao, X., Zhang, Y., et al. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2493769 · Cited by 1 · see citing works
Lin, D., Gunaga, S., Mowbray, F., Isaacs, E. D., Markwalter, D., George, N. R., Hay, A., Manfredi, R. A., Westlake, E., Akhter, M., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-095894 · Cited by 1 · see citing works
Harrison, N. L., Dassanayake, S. N., Heppenstall-Harris, G., Skolarikos, A. A., Chawla, A. K., LIATSIKOS, E. N., Zeng, G., Tsaturyan, A., Tokas, T., Guven, S., et al. (2026) · European Urology Focus · doi:10.1016/j.euf.2026.01.004 · Cited by 1 · see citing works
Nowak, Ł., Martínez, B. B., Krajewski, W. R., Somani, B. K., Pietropaolo, A., Tomczak, W. A., Łaszkiewicz, J., Boeykens, M., Tailly, T. O., Spinos, T., et al. (2026) · World Journal of Urology · doi:10.1007/s00345-026-06429-7 · Cited by 1 · see citing works
Seeing the forest (plot) for the trees—the importance of evidence synthesis in older adult care
Shenkin, S. D., & Quinn, T. J. (2023) · Age and Ageing · doi:10.1093/ageing/afad194 · Cited by 1 · see citing works
Self-citationHealy, D., Flynn, A., Conlan, O., McSharry, J., & Walsh, J. C. (2021) · doi:10.2196/preprints.35802 · Cited by 1 · see citing works
Veronese, N., Demurtas, J., Maggi, S., Cherubini, A., Solfrizzi, V., Cella, A., Fimognari, F. L., Ferrari, A., & Pilotto, A. (2020) · Geriatric Care · doi:10.4081/gc.2020.9339
Hints for Meta-research on Ageing for Family Doctors
Veronese, N., & Demurtas, J. (2021) · Practical issues in geriatrics · doi:10.1007/978-3-030-78923-7_27
Meta-research in geriatric medicine: tips from an associate editor
Veronese, N. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02114-y
LIU, J., Gao, S.-Q., & Zhang, L.-C. (2022) · medRxiv · doi:10.1101/2022.06.26.22276887
Zhu, A., Tang, R., Rajendran, S., Hajian, H., & Aitken, S. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-079668
Morimoto, N., Jamil, H., Alakkari, M., Joyama, Y., Anzai, T., Takahashi, K., & Iimori, S. (2024) · Systematic Reviews · doi:10.1186/s13643-024-02603-3
Systematic Reviews and Meta-Analysis in Aging Research
Villasís-Keever, M. Á., Macías, M. E. R., & Medina-Campos, R. H. (2024) · Springer eBooks · doi:10.1007/978-3-031-76469-1_12
Healy, D., Flynn, A., Reilly, G., Conlan, O., Browne, A. C., & Walsh, J. C. (2025) · Psychology and Health · doi:10.1080/08870446.2024.2414807
Kang, G., Yoon, J. Y., & Shin, J. H. (2025) · Archives of Public Health · doi:10.1186/s13690-025-01574-8
Does objective feedback decrease sedentary behavior in geriatric rehabilitation? A systematic reviewPreprint
Debeij, S. M., Haaksma, M. L., van de Hoef, P. A., Achterberg, W. P., & van Isselt, E. F. V. D. (2025) · medRxiv · doi:10.1101/2025.06.24.25327890
Coleman-Jones, E., Evans, P., Mingham, J., Everett, R., & Wadey, C. A. (2025) · Research Square · doi:10.21203/rs.3.rs-7478903/v1
Qian, C., & Guo, Q. (2025) · Quantitative Science Studies · doi:10.1162/qss.a.399
Marín, M. P. R., Bautista, H., & Meléndez-Rhenals, S. (2024) · Revista de Salud Pública · doi:10.15446/rsap.v26n5.114031
Morimoto, N., Jamil, H., Alakkari, M., Joyama, Y., Anzai, T., Takahashi, K., & Iimori, S. (2024) · Figshare · doi:10.6084/m9.figshare.26322704
Kim, S. H., Kim, J. S., Kang, M. G., Kim, M. J., Han, D., Kim, Y., Min, K. H., Kim, S., Sohn, J. W., Yoo, K. H., et al. (2026) · Respiratory Research · doi:10.1186/s12931-025-03470-9
Barth, J., Davila, H. W., O’Malley, K. A., Shin, M. H., Montano, A.-R. L., Howe, R. J., Levine, A. A., Evans, E., Pimentel, C. B., & Sullivan, J. L. (2026) · Global Implementation Research and Applications · doi:10.1007/s43477-025-00204-3
de Vries, K., Greaves, B., & Brown, J. (2026) · Aging & Mental Health · doi:10.1080/13607863.2025.2606874
- Authors
- Shenkin, S. D., Harrison, J. K., Wilkinson, T., Dodds, R. M., & Ioannidis, J. P. A.
- Affiliations
- University of Edinburgh (GB)
- Alzheimer Scotland (GB)
- University of Southampton (GB)
- Stanford University (US)
- Corresponding author
- Shenkin, Susan D.
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-06-24
- Volume
- 46
- Issue
- 5
- Pages
- 722-728
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- PMC
- PMC5860219
- OpenAlex
- W2718509272
- Cited by
- 109
- References
- 27
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 20 · 2023: 8 · 2022: 10 · 2021: 8 · 2020: 17 · 2019: 7 · 2018: 2 · 2017: 1
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Age and Ageing (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
- Newcastle University ePrints (Newcastle Univesity) (cc-by)
- Funders
- Lifelong Health and Wellbeing Initiative (MR/L501530/1)
- MRC Clinical Research Training (MR/P001823/1)
- NIHR
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
- Health Sciences › Health Professions › General Health Professions › Health Sciences Research and Education
- Keywords
- systematic reviews, older adults, elderly care, transparency, age cut-off, confounding, bias, network meta-analysis, umbrella review, realist synthesis, evidence-based care
- MeSH terms
- Systematic Reviews as Topic, Age Factors, Aged, Aged, 80 and over, Aging, Geriatrics, Health Services for the Aged, Health Services Research, Humans, Middle Aged, Research Design, Meta-Analysis as Topic, Practice Guidelines as Topic, Evidence-Based Medicine, Biomedical Research
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