Plasma cholesterol responsiveness to saturated fatty acids
Abstract
The variability in responsiveness to saturated fatty acids has not been studied systematically. For this reason data from three dietary studies carried out in our laboratory were pooled and used to evaluate how individuals vary in their responses in plasma concentrations of total cholesterol and low-density-lipoprotein cholesterol to the substitution of saturated fatty acids for unsaturated fatty acids. The data showed a marked variability in response. Some patients demonstrated a striking rise in cholesterol levels whereas others had more modest increases. This finding points to the need for further investigation on this issue.
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Studies have consistently demonstrated improvements in LDL cholesterol when dietary saturated fat is replaced with unsaturated fats.
“In addition, although it is not necessary to restrict total dietary fat to promote heart health, low-fat diets may appeal to those with high blood cholesterol levels because studies have consistently demonstrated improvements in low-density lipoprotein cholesterol when dietary saturated fat is replaced with unsaturated fats.79,80”
From Popular dietary patterns: alignment with American Heart Association 2021 dietary guidance: a scientific statement from the American Heart Association. (2023) · cites this paper as [79]
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Gardner, C. D., Vadiveloo, M. K., Petersen, K. S., Anderson, C. A. M., Springfield, S., Van Horn, L., Khera, A., Lamendola, C., Mayo, S. M., Joseph, J. J., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001146 · Cited by 172 · see citing works
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- Authors
- Grundy, S., & Vega, G.
- Affiliations
- University of Texas Health Science Center at Dallas (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1988-05
- Volume
- 47
- Issue
- 5
- Pages
- 822-824
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2285372434
- Cited by
- 161
- References
- 18
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 2 · 2019: 2 · 2018: 1 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 1
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-292-52)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- serum cholesterol, saturated fatty acids, LDL cholesterol, total cholesterol, unsaturated fatty acids, interindividual variability, dietary response
- MeSH terms
- Cholesterol, Dietary Fats, Fatty Acids, Food, Formulated, Humans, Cholesterol, LDL, Reference Values
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