Gastric acid secretion, gastrin release, and gastric emptying in humans as affected by liquid meal temperature
Abstract
We investigated the effect of the temperature of a liquid meal on intragastric temperature, gastric acid secretion, gastrin release, and gastric emptying in normal human subjects. Coffee (360 mL) was infused into the stomach through a nasogastric tube at 58 (steaming hot), 37, or 4 degrees C (ice cold). Intragastric temperature, measured by an intragastric temperature sensor attached to the nasogastric tube, returned to body temperature 16.7 +/- 2.7 min after the hot meal and 23.8 +/- 1.1 min after the cold meal. Gastric acid secretion increased after hot, warm, and cold coffee but the initial temperature of the meal had no effect on gastric acid secretion. The temperature of the meal also had no effect on serum gastrin concentrations, which increased significantly after all the meals. Gastric emptying of hot, warm, or cold coffee meals was similar. These findings indicate that over a wide temperature range, the temperature of a liquid meal has little effect on gastric function in humans.
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In this study, salivary gastrin values were comparable to plasma gastrin levels reported in other studies.
“In our study, the salivary gastrin values were comparable to plasma gastrin levels reported in other studies [22].”
From Acute Effects of Coffee Consumption on Self-Reported Gastrointestinal Symptoms, Blood Pressure and Stress Indices in Healthy Individuals (2015) · cites this paper as [22]
Cites
A turbidimetric method for the determination of higher polyethylene glycols in biological materials.
Hyden, S. (1956) · Kungliga Lantbrukshogskolans Annaler · Cited by 694 · see citing works
Fordtran, J. S., & Walsh, J. H. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107226 · Cited by 450 · see citing works
New clinical method for measuring the rate of gastric emptying: the double sampling test meal.
George, J. D. (1968) · Gut · doi:10.1136/gut.9.2.237 · Cited by 358 · see citing works
The Determination of Gastric Acidity by the Glass Electrode
Moore, E. W., & Scarlata, R. W. (1965) · Gastroenterology · doi:10.1016/s0016-5085(19)34564-0 · Cited by 187 · see citing works
Effect of a Duodenal Tube on the Gastric Secretion of cid and Pepsin in Man
Berstad, A., & Petersen, H. (1971) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365527109180662 · Cited by 113 · see citing works
Similar acid stimulatory potencies of synthetic human big and little gastrins in man.
Eysselein, V. E., Maxwell, V., Reedy, T. J., Wünsch, E., & Walsh, J. H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111330 · Cited by 82 · see citing works
Pathogenesis of Coffee-Induced Gastrointestinal Symptoms
Cohen, S. (1980) · New England Journal of Medicine · doi:10.1056/nejm198007173030302 · Cited by 76 · see citing works
Effects of meal temperature and volume on the emptying of liquid from the human stomach.
Bateman, D. N. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014383 · Cited by 65 · see citing works
The relationship between the ingestion of hot coffee and intraoesophageal temperature
de Jong, U. W., Day, N. E., Mounier-Kuhn, P., & Haguenauer, J. P. (1972) · Gut · doi:10.1136/gut.13.1.24 · Cited by 55 · see citing works
Gastric Acid and Gastrin Response to Decaffeinated Coffee and a Peptone Meal
Feldman, E. J. (1981) · JAMA · doi:10.1001/jama.1981.03320030040027 · Cited by 32 · see citing works
Ouazzani, T. E., & Mei, N. (1979) · Experimental Brain Research · doi:10.1007/bf00239140 · Cited by 32 · see citing works
Effect of feed temperature and phototherapy on gastric emptying in the neonate.
Blumenthal, I., Lealman, G. T., & Shoesmith, D. R. (1980) · Archives of Disease in Childhood · doi:10.1136/adc.55.7.562 · Cited by 27 · see citing works
Effects of Diet Temperature on Tolerance of Enteral Feedings
Kagawa-Busby, K. S., Heitkemper, M. M., HANSEN, B. C., Hanson, R. L., & Vanderburg, V. (1980) · Nursing Research · doi:10.1097/00006199-198009000-00003 · Cited by 23 · see citing works
Effect of Sham Feeding on Gastric Emptying
Schiller, L. R., Feldman, M. L., & Richardson, C. T. (1980) · Gastroenterology · doi:10.1016/s0016-5085(19)30503-7 · Cited by 22 · see citing works
Self-citationIs it necessary to warm infants' feeds?
Costalos, C., Ross, I., Campbell, A. G. M., & Sofi, M. (1979) · Archives of Disease in Childhood · doi:10.1136/adc.54.11.899 · Cited by 14 · see citing works
Effect of temperature of perorally administered phenol red solution on gastric emptying in the rat.
Erni, W., & Ritschel, W. A. (1977) · PubMed · Cited by 11 · see citing works
Gastric Emptying of Liquid Test Meals of Various Temperatures in the Dog
Teeter, B. C., & Bass, P. (1982) · Experimental Biology and Medicine · doi:10.3181/00379727-169-41384 · Cited by 11 · see citing works
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Human pancreatic exocrine response to nutrients in health and disease
Keller, J., & Layer, P. (2005) · Gut · doi:10.1136/gut.2005.065946 · Cited by 550 · see citing works
Ice Slurry Ingestion Increases Core Temperature Capacity and Running Time in the Heat
Siegel, R. B., Maté, J., Brearley, M. B., Watson, G., Nosaka, K., & Laursen, P. B. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181bf257a · Cited by 209 · see citing works
Fluid and electrolyte loss and replacement in exercise
Maughan, R. J. (1991) · Journal of Sports Sciences · doi:10.1080/02640419108729870 · Cited by 191 · see citing works
Cold Drink Ingestion Improves Exercise Endurance Capacity in the Heat
LEE, J. K. W., Shirreffs, S. M., & Maughan, R. J. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318178465d · Cited by 166 · see citing works
Coffee and Gastrointestinal Function: Facts and Fiction: A Review
J. Boekema, M. S. (1999) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655299750025525 · Cited by 164 · see citing works
Mündel, T., King, J., Collacott, E., & Jones, D. A. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.034223 · Cited by 118 · see citing works
Maughan, R. J., & Noakes, T. D. (1991) · Sports Medicine · doi:10.2165/00007256-199112010-00003 · Cited by 106 · see citing works
The dynamic gastric environment and its impact on drug and formulation behaviour
Abeele, J. V. D., Rubbens, J., Brouwers, J., & Augustijns, P. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.08.060 · Cited by 102 · see citing works
Interactions of Physical Training and Heat Acclimation
Aoyagi, Y., McLellan, T. M., & Shephard, R. J. (1997) · Sports Medicine · doi:10.2165/00007256-199723030-00004 · Cited by 89 · see citing works
Effects of Gravity on Gastric Emptying, Intestinal Transit, and Drug Absorption
Amidon, G. L., DeBrincat, G. A., & Najib, N. M. (1991) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1991.tb03658.x · Cited by 85 · see citing works
LEE, J. K. W., Maughan, R., & Shirreffs, S. M. (2008) · Journal of Sports Sciences · doi:10.1080/02640410701697388 · Cited by 76 · see citing works
Ice slurry ingestion during cycling improves Olympic distance triathlon performance in the heat
Stevens, C. J., Dascombe, B. J., Boyko, A., Sculley, D., & Callister, R. (2013) · Journal of Sports Sciences · doi:10.1080/02640414.2013.779740 · Cited by 73 · see citing works
Prevalence of Gastric Lesions in Racing Alaskan Sled Dogs
Davis, M. S., Willard, Μ. D., Nelson, S., Mandsager, R. E., McKiernan, B. S., Mansell, J., & Lehenbauer, T. W. (2003) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2003.tb02453.x · Cited by 62 · see citing works
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Effect of sodium in a rehydration beverage when consumed as a fluid or meal
Ray, M. L., Bryan, M., Ruden, T. M., Baier, S. M., Sharp, R. L., & King, D. S. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.4.1329 · Cited by 61 · see citing works
Papakonstantinou, E., Kechribari, I., Sotirakoglou, Κ., Tarantilis, P., Gourdomichali, T., Michas, G., Kravvariti, V., Voumvourakis, K., & Zampelas, A. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0146-0 · Cited by 59 · see citing works
“Some studies [15–19], but not all [18, 20, 21], have shown that coffee consumption (independently of caffeine content) increases gastrin secretion, regardless of coffee temperature (cold, warm, hot) [22].”
BackgroundResultInfluentialGastric emptying of liquid and solid meals at various temperatures
Mishima, Y., Amano, Y., Takahashi, Y., Mishima, Y., Moriyama, N., Miyake, T., Ishimura, N., Ishihara, S., & Kinoshita, Y. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-009-0022-1 · Cited by 50 · see citing works
A Multiphase Flow in the Antroduodenal Portion of the Gastrointestinal Tract: A Mathematical Model
Trusov, P. V., Зайцева, Н. В., & Kamaltdinov, M. R. (2016) · Computational and Mathematical Methods in Medicine · doi:10.1155/2016/5164029 · Cited by 45 · see citing works
The role of fluid temperature and form on endurance performance in the heat
Tan, P. M. S., & LEE, J. K. W. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12366 · Cited by 47 · see citing works
Cornwall, H. L., Edwards, B. A., Curran, J. F., & Boyce, S. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.06.003 · Cited by 36 · see citing works
Lang, R., Bardelmeier, I., Weiß, C., Rubach, M., Somoza, V., & Hofmann, T. F. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903612h · Cited by 34 · see citing works
Detailed In Vivo Analysis of the Role of Helicobacter pylori Fur in Colonization and Disease
Miles, S. M., Piazuelo, M. B., Semino‐Mora, C., Washington, M. K., Dubois, A., Peek, R. M., Correa, P., & Merrell, D. S. (2010) · Infection and Immunity · doi:10.1128/iai.00190-10 · Cited by 31 · see citing works
The Effect of Coffee on Gastric Emptying and Oro-Caecal Transit Time
Boekema, Lo, Samsom, Akkermans, & Smout (2000) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2000.00601.x · Cited by 30 · see citing works
Schubert, M. M., Grant, G. D., Horner, K. M., King, N. A., LEVERITT, M. D., Sabapathy, S., & Desbrow, B. (2014) · Appetite · doi:10.1016/j.appet.2014.09.006 · Cited by 31 · see citing works
Naito, T., Iribe, Y., & Ogaki, T. (2017) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-016-0122-6 · Cited by 29 · see citing works
Helicobacter pylori apo-Fur regulation appears unconserved across species
Miles, S. M., Carpenter, B. M., Gancz, H., & Merrell, D. S. (2010) · The Journal of Microbiology · doi:10.1007/s12275-010-0022-0 · Cited by 28 · see citing works
Effect of meal temperature on the frequency of gastric myoelectrical activity
Verhagen, M. A. M. T., Luijk, H. D., Samsom, M., & Smout, A. J. P. M. (1998) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1998.00089.x · Cited by 28 · see citing works
Effects of temperature and mode of presentation of juice on hunger, thirst and food intake in humans
Rolls, B. J., Fedoroff, I. C., Guthrie, J. F., & Laster, L. J. (1990) · Appetite · doi:10.1016/0195-6663(90)90020-9 · Cited by 28 · see citing works
Rehrer, N. J., Brouns, F. J. P. H., Beckers, E. J., & Saris, W. H. M. (1994) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.1994.tb00421.x · Cited by 26 · see citing works
Accumulation in the blood of a deuterium tracer added to hot and cold beverages
Lambert, C. P., & Maughan, R. (1992) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.1992.tb00323.x · Cited by 23 · see citing works
Temperature: An overlooked factor in tablet disintegration
Basaleh, S., Bisharat, L., Cespi, M., & Berardi, A. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105388 · Cited by 22 · see citing works
In‐play optimal cooling for outdoor match‐play tennis in the heat
Naito, T., Nakamura, M., Muraishi, K., Eda, N., Ando, K., Takemura, A., Akazawa, N., Hasegawa, H., & Takahashi, H. (2021) · European Journal of Sport Science · doi:10.1080/17461391.2020.1870160 · Cited by 15 · see citing works
Fitzpatrick, C. J., Freitas, D., O’Callaghan, T. F., O’Mahony, J. A., & Brodkorb, A. (2024) · Foods · doi:10.3390/foods13223683 · Cited by 13 · see citing works
Effect of Coffee on Motor and Sensory Function of Proximal Stomach
Boekema, P. J., Samsom, M., Roelofs, J. M. M., & Smout, A. J. P. M. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1010733222245 · Cited by 11 · see citing works
Fitzpatrick, C. J., Musse, M., Feng, J., Collewet, G., Lucas, T., Timlin, M., Challois, S., Quellec, S., Dupont, D., Brodkorb, A., et al. (2024) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2024.109864 · Cited by 9 · see citing works
Early and Late Cardiovascular and Metabolic Responses to Mixed Wine: Effect of Drink Temperature
Sarafian, D., Maufrais, C., & Montani, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01334 · Cited by 8 · see citing works
da Silva, R. P., Altoé, J. L., & Marins, J. C. B. (2009) · Revista de Nutrição · doi:10.1590/s1415-52732009000500016 · Cited by 8 · see citing works
Temperature of a test solution influences abdominal symptoms in lactose tolerance tests
Peuhkuri, H. V. K. (2000) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510050185065 · Cited by 8 · see citing works
Should Workers Avoid Consumption of Chilled Fluids in a Hot and Humid Climate?
Brearley, M. B. (2017) · Safety and Health at Work · doi:10.1016/j.shaw.2017.07.001 · Cited by 7 · see citing works
Beckers, E. J., Rehrer, N. J., Brouns, F. J. P. H., & Saris, W. H. M. (1992) · Science & Sports · doi:10.1016/s0765-1597(05)80182-0 · Cited by 5 · see citing works
Medical Surveillance of Endurance Sport
Shepard, R. J. (2000) · doi:10.1002/9780470694930.ch44 · Cited by 4 · see citing works
Feng, J., Lee, J., Mathieu, V., Gouar, Y. L., Jeantet, R., Dupont, D., & Feunteun, S. L. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117869 · Cited by 3 · see citing works
Kagaya, M., Iwata, N., Toda, Y., Mitsui, T., Nakae, Y., & Kondo, T. (1999) · PubMed · doi:10.18999/nagjms.62.1-2.57 · Cited by 3 · see citing works
Impact of Coffee on Gastric Acid Secretion
Rubach, M., & Somoza, V. (2012) · doi:10.1002/9781119949893.ch16 · Cited by 3 · see citing works
Post-Exercise Rehydration: No Change in Diuresis from Water Ingested at Different Temperatures
Pérez-Idárraga, A., & Aragón-Vargas, L. F. (2010) · Medicina Sportiva · doi:10.2478/v10036-010-0015-4 · Cited by 2 · see citing works
Naito, T., Yamaguchi, Y., & Ogaki, T. (2016) · International Journal of Sport and Health Science · doi:10.5432/ijshs.201615 · Cited by 2 · see citing works
J., F. C., Freitas, D., Comi, I., Vegarud, G. E., Røseth, A. G., Hayes, E., O'Callaghan, T., O'Mahony, J. A., & Brodkorb, A. (2026) · Scientific Reports · doi:10.1038/s41598-026-38033-5 · Cited by 1 · see citing works
Naito, T., Yamaguchi, Y., & Ogaki, T. (2016) · Taiikugaku kenkyu (Japan Journal of Physical Education Health and Sport Sciences) · doi:10.5432/jjpehss.15012 · Cited by 1 · see citing works
Rastmanesh, R., & Flack, K. D. (2023) · JMIR Research Protocols · doi:10.2196/42846 · Cited by 1 · see citing works
Tsymbalyuk, О. V., & Sa, K. (2012) · Studia Biologica · doi:10.30970/sbi.0602.213 · Cited by 1 · see citing works
FACTORES QUE INFLUYEN SOBRE EL VACIADO GÁSTRICO DE BEBIDAS DEPORTIVAS DURANTE EL EJERCICIO
López-Román, F. J., Gonzálvez, A. B. M., Luque, A., Mulero, F., & Contreras, J. M. (2005) · Archivos de medicina del deporte: revista de la Federación Española de Medicina del Deporte y de la Confederación Iberoamericana de Medicina del Deporte · Cited by 1 · see citing works
Thermoregulatory and exercise performance : responses to cooling with ice slurry ingestion
Siegel, R. B. (2011) · Australasian Journal of Paramedicine · Cited by 1 · see citing works
Stevens, C. J., & Dascombe, B. J. (2015) · Human performance in extreme environments · doi:10.7771/2327-2937.1067
King, D. S., Bryan, M., Ruden, T. M., Baier, S. M., Rick, L., Burke, L. M., Shapiro, S. A., Roth, J., Mahoney, S., Mohseni, M., et al. (2015)
Dosil, J. (2008) · Wiley eBooks · doi:10.1002/9780470725047.refs
- Authors
- McArthur, K. E., & Feldman, M.
- Affiliations
- United States Department of Veterans Affairs (US)
- ORCID
- Feldman, M
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 49
- Issue
- 1
- Pages
- 51-54
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2096352324
- Cited by
- 56
- References
- 17
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am016816-12)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- gastric acid secretion, gastrin release, gastric emptying, liquid meal, coffee, gastric function
- MeSH terms
- Adult, Beverages, Coffee, Drinking, Female, Gastric Acid, Gastric Emptying, Gastrins, Humans, Intubation, Gastrointestinal, Male, Temperature
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