Cited by 158Antioxidant Activity and Oxidative StressRetinoids in leukemia and cellular processesExercise and Physiological Responses

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Effect of β-carotene on lymphocyte subpopulations in elderly humans: evidence for a dose-response relationship

Watson, RR, Prabhala, RH, Plezia, PM, Alberts, DS·1991·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/53.1.90

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Abstract

The effects of various doses (0, 15, 30, 45, and 60 mg/d) of supplementary beta-carotene were evaluated. The percentage of lymphoid cells with surface markers for T-helper and natural killer (NK) cells and cells with interleukin 2 (IL-2) and transferrin receptors were significantly and substantially increased in peripheral blood mononuclear cells collected from older human adult volunteers after supplementation with greater than or equal to 30 mg beta-carotene/d for 2 mo. The increase in the percentage of cells with markers of NK cells and in expression of IL-2 receptors was dose dependent. The plasma concentrations of beta-carotene were also elevated significantly; however, there was no increase in the amount of retinol present in plasma. This indicated that immunomodulation induced by beta-carotene may be due to the carotenoid rather than to an increased amount, and hence actions, of vitamin A. These results support the role of immunostimulation as a potential mechanism of action of beta-carotene with cancer-prevention potential.

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WATSON, R. R. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.2.433

Authors: Watson, R., Prabhala, R., Plezia, P., & Alberts, D.
Affiliations: University of Arizona (US)
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 1991-01
Volume: 53
Issue: 1
Pages: 90-94
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/53.1.90
OpenAlex: W1910857921
Cited by: 158
References: 14
Citations by year: 2025: 3 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 4 · 2013: 5 · 2012: 7
FWCI: 10.21
Type: journal article
Language: en
Update notices: erratum (1991-04-01)
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p50aa008037-05, 5r01da004827-02)
National Institute on Alcohol Abuse and Alcoholism (AA-08037)
National Institute on Drug Abuse (DA 04827)
National Cancer Institute (CA-25702)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: beta-carotene, lymphocyte subsets, natural killer cells, T helper cells, interleukin-2 receptor, transferrin receptor, dose-response relationship, immunomodulation, older adults, vitamin A, carotenoids, cancer prevention, dietary supplementation
MeSH terms: Aged, Aging, Carotenoids, Dose-Response Relationship, Drug, Female, T-Lymphocytes, Helper-Inducer, Humans, Killer Cells, Natural, Male, Middle Aged, Receptors, Transferrin, Vitamin A, Receptors, Interleukin-2, T-Lymphocyte Subsets, beta Carotene, T-Lymphocytes, Regulatory

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Effect of β-carotene on lymphocyte subpopulations in elderly humans: evidence for a dose-response relationship

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