Natural killer cell activity in elderly men is enhanced by beta-carotene supplementation
Open accessAbstract
Natural killer (NK) cell activity has been postulated to be an immunologic link between beta-carotene and cancer prevention. In a cross-sectional, placebo-controlled, double-blind study we examined the effect of 10-12 y of beta-carotene supplementation (50 mg on alternate days) on NK cell activity in 59 (38 middle-aged men, 51-64 y; 21 elderly men, 65-86 y) Boston area participants in the Physicians' Health Study. No significant difference was seen in NK cell activity due to beta-carotene supplementation in the middle-aged group. The elderly men had significantly lower NK cell activity than the middle-aged men; however, there was no age-associated difference in NK cell activity in men supplemented with beta-carotene. beta-carotene-supplemented elderly men had significantly greater NK cell activity than elderly men receiving placebo. The reason for this is unknown; however, it was not due to an increase in the percentage of NK cells, nor to an increase in interleukin 2 (IL-2) receptor expression, nor to IL-2 production. beta-carotene may be acting directly on one or more of the lytic stages of NK cell cytotoxicity, or on NK cell activity-enhancing cytokines other than IL-2, such as IL-12. Our results show that long-term beta-carotene supplementation enhances NK cell activity in elderly men, which may be beneficial for viral and tumoral surveillance.
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Long-term β-carotene supplementation increased NK cell activity in older adults.
“long-term β-carotene supplementation increased NK cell activity in older adults (139, 140).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [140]
Enhanced NK cell cytotoxicity was observed in participants treated with oral β-carotene.
“Enhanced NK cell cytotoxicity was observed in participants treated with oral β-carotene”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [140]
Cites
T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity
Gillis, S. A., Ferm, M. M., Ou, W., & Smith, K. A. (1978) · The Journal of Immunology · doi:10.4049/jimmunol.120.6.2027 · Cited by 3,273 · see citing works
Robust tests for equality of variances
Levene, H. (1961) · Medical Entomology and Zoology · Cited by 3,271 · see citing works
Final Report on the Aspirin Component of the Ongoing Physicians' Health Study
Steering Committee of the Physicians' Health Study Research Group (1989) · New England Journal of Medicine · doi:10.1056/nejm198907203210301 · Cited by 2,269 · see citing works
Contributions to Probability and Statistics.
Buckland, W. R., Hotelling, H., & Olkin, I. (1962) · Biometrika · doi:10.2307/2333504 · Cited by 1,745 · see citing works
Pross, H. F., Baines, M. G., Rubin, P., Shragge, P. C., & Patterson, M. S. (1981) · Journal of Clinical Immunology · doi:10.1007/bf00915477 · Cited by 691 · see citing works
Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects
Meydani, S. N., Barklund, M., Liu, S., Meydani, M., Miller, R. A., Cannon, J., Morrow, F. D., Rocklin, R. E., & Blumberg, J. B. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.3.557 · Cited by 585 · see citing works
Self-citationA Review of Epidemiologic Evidence that Carotenoids Reduce the Risk of Cancer
Ziegler, R. G. (1989) · Journal of Nutrition · doi:10.1093/jn/119.1.116 · Cited by 554 · see citing works
Sansoni, P., Cossarizza, A., Brianti, V., Fagnoni, F. F., Snelli, G., Monti, D., Marcato, A., Passeri, G., Ortolani, C., & Forti, E. (1993) · Blood · doi:10.1182/blood.v82.9.2767.2767 · Cited by 458 · see citing works
Meydani, S. N., Lichtenstein, A. H., Cornwall, S., Meydani, M., Goldin, B. R., Rasmussen, H., Dinarello, C. A., & Schaefer, E. J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116537 · Cited by 357 · see citing works
Self-citationA new immunodeficiency disorder in humans involving NK cells
Roder, J., Haliotis, T. P., Klein, M., Korec, S., Jett, J. R., Ortaldo, J. R., Heberman, R. B., Katz, P., & Fauci, A. S. (1980) · Nature · doi:10.1038/284553a0 · Cited by 277 · see citing works
Warner, J. F., & Dennert, G. (1982) · Nature · doi:10.1038/300031a0 · Cited by 224 · see citing works
Watson, R., Prabhala, R., Plezia, P., & Alberts, D. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.1.90 · Cited by 158 · see citing works
Role of natural killer cells in cancer.
Pross, H. F., & Lotzová, E. (1994) · PubMed · Cited by 151 · see citing works
Natural killer function in systemic lupus erythematosus
Hoffman, T. (1980) · Arthritis & Rheumatism · doi:10.1002/art.1780230106 · Cited by 122 · see citing works
Currie, G. A. (1970) · Nature · doi:10.1038/226982a0 · Cited by 122 · see citing works
Nutrition, Aging, and the Elderly
(1989) · Springer eBooks · doi:10.1007/978-1-4899-2537-4 · Cited by 89 · see citing works
PRABHALA, R. H., Maxey, V., Hicks, M. J., & WATSON, R. R. (1989) · Journal of Leukocyte Biology · doi:10.1002/jlb.45.3.249 · Cited by 81 · see citing works
Fotouhi, N., Meydani, M., Santos, M., Meydani, S. N., Hennekens, C. H., & Gaziano, J. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.4.553 · Cited by 75 · see citing works
Self-citationNormal serum response to oral beta-carotene in humans.
Henderson, C. T., Mobarhan, S., Bowen, P. E., Stacewicz‐Sapuntzakis, M., LANGENBERG, P. W., Kiani, R., Lucchesi, D., & Sugerman, S. (1989) · Journal of the American College of Nutrition · doi:10.1080/07315724.1989.10720337 · Cited by 74 · see citing works
Immunoregulatory Effects of Cytokines on Natural Killer Cells
Naume, B., & Espevik, T. (1994) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1994.tb03441.x · Cited by 70 · see citing works
Relations Between Normal Aging and Disease
(1986) · Journal of Gerontology · doi:10.1093/geronj/41.1.124a · Cited by 67 · see citing works
Serum carotenoids and retinoids in ferrets fed canthaxanthin
Tang, G., Dolnikowski, G. G., Blanco, M. C., Fox, J. G., & Russell, R. M. (1993) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(93)90021-n · Cited by 59 · see citing works
Age-associated alterations in human natural killer cells
Krishnaraj, R., & Blandford, G. (1988) · Cellular Immunology · doi:10.1016/0008-8749(88)90261-4 · Cited by 50 · see citing works
Natural killer cells, vitamins, and other blood components of vegetarian and omnivorous men
Malter, M., Schriever, G., & Eilber, U. (1989) · Nutrition and Cancer · doi:10.1080/01635588909514026 · Cited by 35 · see citing works
Nutrition is an important determinant of immunity in old age.
Rk, C. (1990) · PubMed · Cited by 29 · see citing works
Bloom, E. T. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.3.b85 · Cited by 22 · see citing works
Nutrition and Immune Function in the Elderly
Meydani, S. N., & Blumberg, J. B. (1989) · Springer eBooks · doi:10.1007/978-1-4899-2537-4_4 · Cited by 16 · see citing works
Self-citationEnhancement of murine lymphokine-activated killer cell activity by retinoic acid.
Lin, T. H., & Chu, T. M. (1990) · PubMed · Cited by 15 · see citing works
Carotenoids in Oral Cancer Preventiona
Garewal, H. S. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb26165.x · Cited by 14 · see citing works
Human Aging research Concepts and Techniques, 1988
Lewis, C. B. (1989) · Topics in Geriatric Rehabilitation · doi:10.1097/00013614-198904000-00012 · Cited by 13 · see citing works
Prabhala (1991) · doi:10.1002/1097-0142(19910315)67:6
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Carotenoid Action on the Immune Response
Chew, B. P., & Park, J. S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.257s · Cited by 795 · see citing works
Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies
Lampe, J. W. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.3.475s · Cited by 786 · see citing works
Chemical composition, functional properties and processing of carrot—a review
Sharma, K. D., Karki, S., Thakur, N. S., & Attri, S. (2011) · Journal of Food Science and Technology · doi:10.1007/s13197-011-0310-7 · Cited by 710 · see citing works
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works
Characterization of vacuum microwave, air and freeze dried carrot slices
Lin, T. M., Durance, T. D., & Scaman, C. H. (1998) · Food Research International · doi:10.1016/s0963-9969(98)00070-2 · Cited by 622 · see citing works
Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.6.833 · Cited by 485 · see citing works
Antioxidants and disease: More questions than answers
Temple, N. J. (2000) · Nutrition Research · doi:10.1016/s0271-5317(00)00138-x · Cited by 466 · see citing works
Exercise, nutrition and immune function
Gleeson, M., Nieman, D. C., & Pedersen, B. K. (2004) · Journal of Sports Sciences · doi:10.1080/0264041031000140590 · Cited by 362 · see citing works
Gill, H. S., Rutherfurd, K. J., & Cross, M. L. (2001) · Journal of Clinical Immunology · doi:10.1023/a:1010979225018 · Cited by 304 · see citing works
Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration
Evans, J. R., & Lawrenson, J. G. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000253.pub4 · Cited by 273 · see citing works
Nutritional skin care: health effects of micronutrients and fatty acids
Boelsma, E., Hendriks, H., & Roza, L. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.5.853 · Cited by 243 · see citing works
Watzl, B., Kulling, S. E., Möseneder, J., Barth, S. W., & Bub, A. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.1052 · Cited by 220 · see citing works
Review of Animal Models in Carotenoid Research
Lee, C. M., Boileau, A. C., Boileau, T. W.-M., Williams, A. W., Swanson, K. S., Heintz, K. A., & Erdman, J. W. (1999) · Journal of Nutrition · doi:10.1093/jn/129.12.2271 · Cited by 200 · see citing works
Procarcinogenic and Anticarcinogenic Effects of β-Carotene
Wang, X., & Russell, R. M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1999.tb01809.x · Cited by 184 · see citing works
Neuhouser, M. L., Patterson, R. E., Thornquist, M. D., Omenn, G. S., King, I. B., & Goodman, G. E. (2003) · PubMed · Cited by 173 · see citing works
Interleukin-6 Production Does Not Increase With Age
Beharka, A. A., Meydani, M., Wu, D., Leka, L. S., Meydani, A., & Meydani, S. N. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.2.b81 · Cited by 169 · see citing works
Self-citationGut microbiota and probiotics: Focus on diabetes mellitus
Tonucci, L. B., dos Santos, K. M. O., Ferreira, C. L. D. L. F., Ribeiro, S. M. R., de Oliveira, L. L., & Martino, H. S. D. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.934438 · Cited by 166 · see citing works
Dietary carotenoids and human immune function
Hughes, D. A. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00638-4 · Cited by 147 · see citing works
Jewell, C., & O’Brien, N. M. (1999) · British Journal Of Nutrition · doi:10.1017/s0007114599000434 · Cited by 147 · see citing works
Effects of carotenoids on human immune function
Hughes, D. A. (1999) · Proceedings of The Nutrition Society · doi:10.1017/s0029665199000932 · Cited by 146 · see citing works
A Case-Control Study of Diet and the Risk of Ovarian Cancer
Pan, S. Y., Ugnat, A., Mao, Y., Wen, S. W., & Johnson, K. C. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.1521.13.9 · Cited by 143 · see citing works
European Consensus Statement on Lung Cancer: risk factors and prevention. Lung Cancer Panel
Biesalski, H. K., Bueno-de-Mesquita, B. H., Chesson, A., Chytil, F., Grimble, R. F., Hermus, R. J. J., Köhrle, J., Lotan, R., Norpoth, K., Pastorino, U., et al. (1998) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.48.3.167 · Cited by 125 · see citing works
Obesity, overnutrition and the immune system
Samartı́n, S., & Chandra, R. K. (2001) · Nutrition Research · doi:10.1016/s0271-5317(00)00255-4 · Cited by 122 · see citing works
Update: Effects of Antioxidant and Non-Antioxidant Vitamin Supplementation on Immune Function
Webb, A. L., & Villamor, E. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00298.x · Cited by 120 · see citing works
Relationship Between Systemic Markers of Inflammation and Serum β-Carotene Levels
Erlinger, T. P., Güallar, E., Miller, E. R., Stolzenberg‐Solomon, R. Z., & Appel, L. J. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.15.1903 · Cited by 116 · see citing works
Carotenoids as a Source of Antioxidants in the Diet
Xavier, A. A. O., & Pérez‐Gálvez, A. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-319-39126-7_14 · Cited by 108 · see citing works
The Enigma of β-Carotene in Carcinogenesis: What Can Be Learned from Animal Studies
Russell, R. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.262s · Cited by 106 · see citing works
Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables
Watzl, B., Bub, A., Brandstetter, B. R., & Rechkemmer, G. (1999) · British Journal Of Nutrition · doi:10.1017/s0007114599001634 · Cited by 106 · see citing works
Dietary factors lead to innate immune activation in asthma
Wood, L. G., & Gibson, P. G. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.03.015 · Cited by 105 · see citing works
Watzl, B., Bub, A., Briviba, K., & Rechkemmer, G. (2003) · Annals of Nutrition and Metabolism · doi:10.1159/000072397 · Cited by 94 · see citing works
The Role of Nutrition in Immunity in the Aged
Lesourd, B., Mazari, L., & Ferry, M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01628.x · Cited by 90 · see citing works
β-Carotene and selenium supplementation enhances immune response in aged humans
Wood, S. M., Beckham, C. J., Yosioka, A., Darban, H., & WATSON, R. R. (2000) · Integrative medicine · doi:10.1016/s1096-2190(00)00009-3 · Cited by 88 · see citing works
AIR IMPINGEMENT DRYING CHARACTERISTICS AND QUALITY OF CARROT CUBES
Xiao, H., Gao, Z., LIN, H., & Yang, W. (2009) · Journal of Food Process Engineering · doi:10.1111/j.1745-4530.2008.00314.x · Cited by 88 · see citing works
Chandra, R. K. (2003) · Ageing Research Reviews · doi:10.1016/j.arr.2003.08.004 · Cited by 85 · see citing works
Effects of dietary retinoids and carotenoids on immune development
Rühl, R. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s002966510600509x · Cited by 85 · see citing works
The immunomodulatory potential of natural compounds in tumor-bearing mice and humans
Pan, P., Huang, Y., Oshima, K., Yearsley, M., Zhang, J., ARNOLD, M. W., Yu, J., & Wang, L.-S. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1537237 · Cited by 83 · see citing works
Low plasma levels of oxygenated carotenoids in patients with coronary artery disease
Lidebjer, C., Leanderson, P., Ernerudh, J., & Jonasson, L. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.02.006 · Cited by 83 · see citing works
From 1989 to 2001: What Have We Learned About the “Biological Actions of Beta-Carotene”?
Bendich, A. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.225s · Cited by 82 · see citing works
Advances in Equine Nutrition II
Pagan, J. D. (2001) · Cited by 81 · see citing works
Kritchevsky, S. B., Tell, G. S., Shimakawa, T., Dennis, B., Li, R., Kohlmeier, L., Steere, E. L., & HEISS, G. M. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.3.726 · Cited by 78 · see citing works
Anti-inflammatory Effects of Plant-based Foods and of their Constituents
Watzl, B. (2008) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.78.6.293 · Cited by 76 · see citing works
Nutritional Aspects of Immunosuppression in Athletes
BISHOP, N. C., Blannin, A. K., Walsh, N. P., Robson, P. J., & Gleeson, M. (1999) · Sports Medicine · doi:10.2165/00007256-199928030-00002 · Cited by 74 · see citing works
The Antioxidants-Vitamin C, Vitamin E, Selenium, and Carotenoids
Johnson, L., Meacham, S., & Kruskall, L. J. (2003) · Journal of Agromedicine · doi:10.1300/j096v09n01_07 · Cited by 74 · see citing works
Immunological Parameters: What Do They Mean?1,
Calder, P. C. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.773s · Cited by 72 · see citing works
Can Nutrition Limit Exercise-Induced Immunodepression?
Gleeson, M. (2006) · Nutrition Reviews · doi:10.1111/j.1753-4887.2006.tb00195.x · Cited by 71 · see citing works
Comparison of the postprandial chylomicron carotenoid responses in young and older subjects
Cardinault, N., Tyssandier, V., Grolier, P., Winklhofer‐Roob, B. M., Ribalta, J., Bouteloup‐Demange, C., Rock, E., & Borel, P. (2003) · European Journal of Nutrition · doi:10.1007/s00394-003-0426-2 · Cited by 71 · see citing works
Bassig, B. A., Qing Lan, B., Rothman, N., Zhang, Y., & Zheng, T. (2012) · Journal of Cancer Epidemiology · doi:10.1155/2012/978930 · Cited by 69 · see citing works
Micronutrient Supplementation and Immune Function in the Elderly
High, K. P. (1999) · Clinical Infectious Diseases · doi:10.1086/515208 · Cited by 69 · see citing works
Li, M. H., Robinson, E. H., Oberle, D. F., & Zimba, P. V. (2007) · Journal of the World Aquaculture Society · doi:10.1111/j.1749-7345.2007.00130.x · Cited by 68 · see citing works
Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration
Evans, J. R., & Lawrenson, J. G. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000253.pub3 · Cited by 69 · see citing works
Micronutrients in women’s health and immune function
Bendich, A. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00649-9 · Cited by 65 · see citing works
Santos, M. S., Gaziano, J. M., Leka, L. S., Beharka, A. A., Hennekens, C. H., & Meydani, S. N. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.1.164 · Cited by 63 · see citing works
Self-citationAbsorption and Function of Dietary Carotenoids
Nagao, A. (2009) · Forum of nutrition/Bibliotheca Nutritio et dieta · doi:10.1159/000212738 · Cited by 62 · see citing works
Stracke, B. A., Rüfer, C. E., Bub, A., Briviba, K., Seifert, S., Kunz, C., & Watzl, B. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508116269 · Cited by 60 · see citing works
Santos, M., Leka, L. S., Ribaya‐Mercado, J. D., Russell, R., Meydani, M., Hennekens, C. H., Gaziano, J., & Meydani, S. N. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.4.917 · Cited by 60 · see citing works
Self-citationReduced Immune Function and Malnutrition in the Elderly.
Kawakami, K., Kadota, J., Iida, K., Shirai, R., Abe, K., & Kohno, S. (1999) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.187.157 · Cited by 57 · see citing works
Hazlewood, L. C., Wood, L. G., Hansbro, P. M., & Foster, P. S. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.12.003 · Cited by 55 · see citing works
Arab, L., Steck‐Scott, S., & Bowen, P. E. (2001) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a000803 · Cited by 54 · see citing works
Carroll, Y. L., Corridan, B. M., & Morrissey, P. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600827 · Cited by 52 · see citing works
Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration
Evans, J. R., & Henshaw, K. S. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000253.pub2 · Cited by 52 · see citing works
Antioxidant Vitamins and Human Immune Responses
Bendich, A. (1996) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60406-9 · Cited by 50 · see citing works
Kim, D., Kim, Y., & Kim, Y. (2019) · Journal of Cancer Prevention · doi:10.15430/jcp.2019.24.4.224 · Cited by 48 · see citing works
Hughes, D. A., Wright, A. J. A., Finglas, P. M., Polley, A. C. J., Bailey, A. L., ASTLEY, S. B., & Southon, S. (2000) · The Journal of Infectious Diseases · doi:10.1086/315910 · Cited by 49 · see citing works
Dietary antioxidants and human immune function
Hughes, D. A. (2000) · Nutrition Bulletin · doi:10.1046/j.1467-3010.2000.00016.x · Cited by 49 · see citing works
Effect of carotenoids on the respiratory burst of rat peritoneal macrophages
Zhao, W., Han, Y., Zhao, B., Hirota, S., Hou, J., & Xin, W. (1998) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00013-0 · Cited by 49 · see citing works
Corridan, B. M., O’Donoghue, M., HUGHES, D. A., & Morrissey, P. (2001) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601187 · Cited by 44 · see citing works
Bestwick, C. S. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00212-3 · Cited by 44 · see citing works
Wolvers, D. A. W., Broekmans, W. M. R., Logman, M. H., van der Wielen, R. P. J., & Albers, R. (2006) · Nutrition Journal · doi:10.1186/1475-2891-5-28 · Cited by 43 · see citing works
The antiproliferative effect of β‐carotene requires p21waf1/cip1 in normal human fibroblasts
Stivala, L. A., Savio, M., Quarta, S., Scotti, C., Cazzalini, O., Rossi, L. H., Scovassi, A. I., Pizzala, R., Melli, R., Bianchi, L. C., et al. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01236.x · Cited by 40 · see citing works
NK cell apoptosis in coronary artery disease
Li, W., Lidebjer, C., Yuan, X., Szymanowski, A., Backteman, K., Ernerudh, J., Leanderson, P., Nilsson, L. J., Swahn, E., & Jonasson, L. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.10.031 · Cited by 39 · see citing works
The Impact of Carotenoids on Immunity (Review)
Печинский, С. В., & Kuregyan, A. G. (2014) · Pharmaceutical Chemistry Journal · doi:10.1007/s11094-014-0992-z · Cited by 36 · see citing works
Effect of Age on the Gastrointestinal-Associated Mucosal Immune Response of Humans
Beharka, A. A., de Paiva, S. A. R., Leka, L. S., Ribaya‐Mercado, J. D., Russell, R. M., & Meydani, S. N. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.5.b218 · Cited by 36 · see citing works
Self-citationSupplementation with vitamins or minerals and immune function: can the elderly benefit?
Mitchell, B. L., Ulrich, C. M., & McTiernan, A. (2003) · Nutrition Research · doi:10.1016/s0271-5317(02)00545-6 · Cited by 35 · see citing works
Effect of aging on immunocompetent and inflammatory cells
McArthur, W. P. (1998) · Periodontology 2000 · doi:10.1111/j.1600-0757.1998.tb00116.x · Cited by 35 · see citing works
Dangour, A. D., Sibson, V. L., & Fletcher, A. E. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.7.b659 · Cited by 34 · see citing works
Goodman, M. T., Shvetsov, Y. B., McDuffie, K., Wilkens, L. R., Zhu, X., Franke, A. A., Bertram, C. C., Kessel, B., Bernice, M., Sunoo, C., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0313 · Cited by 33 · see citing works
Broekmans, W. M. R., Klöpping-Ketelaars, I. A. A., Weststrate, J. A., Tijburg, L. B. M., van Poppel, G., Vink, A. A., Berendschot, T. T. J. M., Bots, M. L., Castenmiller, W. A. M., & Kardinaal, A. F. M. (2003) · Journal of Nutrition · doi:10.1093/jn/133.3.720 · Cited by 31 · see citing works
Effect of carrot powder incorporation on the quality of pasta
Sule, S., Oneh, A. J., & Agba, I. M. (2019) · MOJ Food Processing & Technology · doi:10.15406/mojfpt.2019.07.00227 · Cited by 28 · see citing works
Docking Studies of Pakistani HCV NS3 Helicase: A Possible Antiviral Drug Target
Fatima, K., Mathew, S., Suhail, M., Ali, A., Damanhouri, G. A., Azhar, E. I., & Qadri, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106339 · Cited by 28 · see citing works
Carotenoids and Their Interaction with the Immune System
Medina-García, M., Baeza-Morales, A., Martínez-Peinado, P., Pascual-García, S., Pujalte-Satorre, C., Martínez‐Espinosa, R. M., & Sempere-Ortells, J. M. (2025) · Antioxidants · doi:10.3390/antiox14091111 · Cited by 27 · see citing works
Wassef, E. A., Chatzifotis, S., Sakr, E. M., & Saleh, N. E. (2010) · Journal of Applied Aquaculture · doi:10.1080/10454438.2010.497741 · Cited by 27 · see citing works
Maity, T., Bawa, A. S., & Raju, P. S. (2017) · Drying Technology · doi:10.1080/07373937.2017.1300590 · Cited by 26 · see citing works
Aging, Nutritional Status, and Infection in the Developing World
Meydani, A., Ahmed, T., & Meydani, S. N. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00379.x · Cited by 25 · see citing works
Self-citationKakutani, R., Adachi, Y., Kajiura, H., Takata, H., Kuriki, T., & Ohno, N. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.10.017 · Cited by 24 · see citing works
Terao, R., Murata, A., Sugamoto, K., Watanabe, T., Nagahama, K., Nakahara, K., Kondo, T., Murakami, N., Fukui, K., Hattori, H., et al. (2018) · Food & Function · doi:10.1039/c8fo01971a · Cited by 24 · see citing works
Farges, M.-C., Minet-Quinard, R., Walrand, S., Thivat, E., Ribalta, J., Winklhofer-Roob, B., Rock, E., & Vasson, M.-P. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512000177 · Cited by 22 · see citing works
Comparison of the Bioavailability of Natural Palm Oil Carotenoids and Synthetic β-Carotene in Humans
Hof, K. H. V. H., Gärtner, C., Wiersma, A., Tijburg, L. B. M., & Weststrate, J. A. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf981091a · Cited by 22 · see citing works
Plasma carotenoid concentrations in relation to acute respiratory infections in elderly people
Graat, J. M., Kok, F. J., & Schouten, E. G. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041155 · Cited by 21 · see citing works
Role of vitamin A supplementation in the treatment of tuberculosis.
Mathur, M. L. (2007) · PubMed · Cited by 20 · see citing works
Serum concentrations of micronutrient antioxidants in an adult Arab population
Abiaka, C., Olusi, S. O., & Simbeye, A. (2002) · Asia Pacific Journal of Clinical Nutrition · doi:10.1046/j.1440-6047.2002.00260.x · Cited by 19 · see citing works
Inserra, P. F., Jiang, S., Solkoff, D., Lee, J., Zhang, Z., Xu, M., Hesslink, R. L., Wise, J. A., & WATSON, R. R. (1999) · Integrative medicine · doi:10.1016/s1096-2190(99)00010-4 · Cited by 19 · see citing works
Froehle, A. W., & Schoeninger, M. J. (2006) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20475 · Cited by 18 · see citing works
Toward a Core Nutraceutical Program for Cancer Management
McCarty, M. F., & Block, K. I. (2006) · Integrative Cancer Therapies · doi:10.1177/1534735406288443 · Cited by 18 · see citing works
Carrot and carotene and multiple health outcomes: an umbrella review of the evidence
Yi, X., Li, J. H., Liao, D., Peng, G., Zheng, X., Xu, H., Zhang, T., & Ai, J. (2023) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12425 · Cited by 17 · see citing works
Gu, J., Gong, T., Wu, Q., Liu, F.-H., Wen, Z.-Y., Gao, C., Wei, Y., & Yang, Z. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.758178 · Cited by 17 · see citing works
Animal Models in Carotenoids Research and Lung Cancer Prevention
Kim, J., & Kim, Y. (2011) · Translational Oncology · doi:10.1593/tlo.11184 · Cited by 17 · see citing works
Improvement in Nutritional Status Reduces the Clinical Impact of Infections in Older Adults
Forster, S. E., Powers, H. J., Foulds, G. A., Flower, D. J., Hopkinson, K., Parker, S. G., Young, T. A., Saxton, J., Pockley, A. G., & Williams, E. A. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04118.x · Cited by 17 · see citing works
King, J. C., Black, R. E., Doyle, M. P., Fritsche, K. L., Halbrook, B. H., Levander, O. A., Meydani, S. N., Walker, W. A., & Woteki, C. E. (2000) · Journal of Nutrition · doi:10.1093/jn/130.10.2613 · Cited by 16 · see citing works
Self-citationAntioxidant vitamin and mineral supplements for preventing age-related macular degeneration
Evans, J. R., & Henshaw, K. S. (1999) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000253 · Cited by 16 · see citing works
Chew, B. P., & Park, J. S. (2009) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7501-0_17 · Cited by 15 · see citing works
- Authors
- Santos, M., Meydani, S., Leka, L., Wu, D., Fotouhi, N., Meydani, M., Hennekens, C., & Gaziano, J.
- Affiliations
- Tufts University (US)
- ORCID
- Wu, D
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 64
- Issue
- 5
- Pages
- 772-777
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1867192595
- Cited by
- 163
- References
- 31
- Citations by year
- 2025: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 8 · 2013: 4 · 2012: 6
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2t32ag000209-06)
- National Institute on Aging (T32 AG 00209)
- National Heart, Lung, and Blood Institute (HL-34595, HL 26490, R01HL034595)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- natural killer cells, beta-carotene supplementation, older men, age-related immune decline, NK cell cytotoxicity, interleukin-2 receptor, interleukin-2, IL-12, cancer prevention, viral surveillance, long-term supplementation
- MeSH terms
- Aged, Aged, 80 and over, Double-Blind Method, Food, Fortified, Humans, Immunity, Innate, Interleukin-2, Killer Cells, Natural, Male, Middle Aged, Prospective Studies, Receptors, Interleukin-2, beta Carotene
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