CoChat
Sign Up
Cited by 115Nutritional Studies and DietFatty Acid Research and HealthDiet, Metabolism, and Disease

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Dietary fat and adult diseases and the implications for childhood nutrition: an epidemiologic approach

Open access
Law, Malcolm·2000·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/72.5.1291s
Open this paper in CoChat — free account

Abstract

Reducing dietary saturated fat by 7% of energy, a realistic target, would reduce serum cholesterol by 10% and mortality from ischemic heart disease by 25-30%. Randomized trials show that this mortality reduction is attained rapidly, usually by the third year after initial reduction of dietary saturated fat intake. Dietary change in adulthood may therefore reverse the adverse health effects of a high-fat diet in childhood. In the absence of such change, however, dietary fat in childhood may increase the risk of cardiovascular disease in adult life because of a longer duration of exposure to a high-fat diet. Assessing the effects of diet on cancer risk is more difficult. The intermediary markers of risk that are analogous to serum cholesterol are less satisfactory and there are negligible trial data. Cohort studies of diet and cancer, although subject to bias, do not favor a direct causal relation between dietary fat and cancer. But a reduction in risk is likely when dietary fat is reduced as part of a general change toward a healthier diet. The trend toward increased energy intake and body size in childhood and relatively low dietary fiber contribute to the decreasing age at menarche, which is associated with an increased risk of breast cancer. Low dietary fiber, low fruit and vegetable consumption, and high red meat consumption are associated with colon cancer and other cancers, and important causal effects of diet on cancer are likely. As with cardiovascular disease, this dietary trend that is commenced in childhood is likely to increase age-specific rates of colon cancer in adult life, but the risk may be reversed with later dietary change.

Overview

Integrity signals

Registry

Crossref · 10.1093/ajcn/72.5.1291s

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Citations

Cites

Research works printed but not linked: 1

  1. Willett, 1992, Dietary fat and fiber in relation to risk of breast cancer. An eight year follow up, Am J Epidemiol, 268, 2037

Cited by

Sorted by citations

See all 115

Related

See all

Metadata

Authors
Law, M.
Affiliations
St Bartholomew's Hospital (GB)
Corresponding author
Law, Malcolm
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2000-11
Volume
72
Issue
5
Pages
1291s-1296s
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/72.5.1291s
OpenAlex
W2765052961
Cited by
115
References
43
Citations by year
2025: 2 · 2024: 3 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 6 · 2012: 7
FWCI
0.84
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
dietary fat, saturated fat, child nutrition, cardiovascular disease, ischemic heart disease mortality, serum cholesterol, cancer risk, dietary fiber, colon cancer, breast cancer, age at menarche, energy intake, red meat consumption, fruit and vegetable intake
MeSH terms
Adult, Cardiovascular Diseases, Child, Child Nutritional Physiological Phenomena, Diet, Dietary Fats, Female, Humans, Male, Neoplasms, Risk Factors, Global Health, Cohort Studies, Case-Control Studies, Stroke

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review