Novel soybean oils with different fatty acid profiles alter cardiovascular disease risk factors in moderately hyperlipidemic subjects
Open accessAbstract
Background A variety of soybean oils were developed with improved oxidative stability and functional characteristics for use as alternatives to partially hydrogenated fat. Objective The objective was to assess the effect of selectively bred and genetically modified soybean oils with altered fatty acid profiles, relative to common soybean and partially hydrogenated soybean oils, on cardiovascular disease risk factors. Design Thirty subjects (16 women and 14 men) aged >50 y with LDL-cholesterol concentrations >130 mg/dL at screening consumed 5 experimental diets in random order for 35 d each. Diets contained the same foods and provided 30% of energy as fat, of which two-thirds was either soybean oil (SO), low-saturated fatty acid soybean oil (LoSFA-SO), high-oleic acid soybean oil (HiOleic-SO), low-alpha-linolenic acid soybean oil (LoALA-SO), or partially hydrogenated soybean oil (Hydrog-SO). Results Plasma phospholipid patterns reflected the predominant fat in the diet. LDL-cholesterol concentrations were 3.66 +/- 0.67(b), 3.53 +/- 0.77(b), 3.70 +/- 0.66(b), 3.71 +/- 0.64(a,b), and 3.92 +/- 0.70(a) mol/L; HDL-cholesterol concentrations were 1.32 +/- 0.32(a,b), 1.32 +/- 0.35(b), 1.36 +/- 0.33(a), 1.32 +/- 0.33(b), and 1.32 +/- 0.32(a,b) mol/L for the SO, LoSFA-SO, HiOleic-SO, LoALA-SO, and Hydrog-SO diets, respectively (values with different superscript letters are significantly different, P Conclusions All varieties of soybean oils resulted in more favorable lipoprotein profil…
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Among the 24 included trials, only 6 trials required participants to have an elevated LDL cholesterol; the remaining 18 trials included participants with normal and elevated LDL cholesterol.
“Among the 24 included trials, only 6 trials required participants to have an elevated LDL cholesterol [25,30,33,37,39,47]; the remaining 18 trials included participants with normal and elevated LDL cholesterol.”
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Effects of Different Forms of Dietary Hydrogenated Fats on Serum Lipoprotein Cholesterol Levels
Lichtenstein, A. H., Ausman, L. M., Jalbert, S. M., & Schaefer, E. J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906243402501 · Cited by 352 · see citing works
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Brouwer, I. A., Wanders, A. J., & Katan, M. B. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009434 · Cited by 317 · see citing works
Johnson, G. H., & Fritsche, K. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.03.029 · Cited by 268 · see citing works
Flock, M. R., Green, M. H., & Kris-Etherton, P. M. (2011) · Advances in Nutrition · doi:10.3945/an.111.000422 · Cited by 82 · see citing works
Hart, T. L., Damani, J. J., DiMattia, Z. S., Tate, K. E., Jafari, F., & Petersen, K. S. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100502 · Cited by 16 · see citing works
“Among the 24 included trials, only 6 trials required participants to have an elevated LDL cholesterol [25,30,33,37, 39,47]; the remaining 18 trials included participants with normal and elevated LDL cholesterol.”
- Authors
- Lichtenstein, A. H., Matthan, N. R., Jalbert, S. M., Resteghini, N. A., Schaefer, E. J., & Ausman, L. M.
- Affiliations
- Tufts University (US)
- Corresponding author
- Lichtenstein, Alice H
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 84
- Issue
- 3
- Pages
- 497-504
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2106987554
- Cited by
- 116
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 9 · 2017: 8 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 7 · 2012: 9
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL054727, HL 54727)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- soybean oil, fatty acid composition, cardiovascular risk factors, hyperlipidemia, LDL cholesterol, HDL cholesterol, lipoprotein profile, partially hydrogenated soybean oil, dietary fat, plasma phospholipids, C-reactive protein
- MeSH terms
- Apolipoproteins, Apolipoproteins B, Cardiovascular Diseases, Fatty Acids, Female, Humans, Hydrogenation, Hyperlipidemias, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Risk Factors, Soybean Oil, Triglycerides, Lipoprotein(a), Cross-Over Studies, Plants, Genetically Modified, Trans Fatty Acids
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