Performance of plasma trigonelline as a marker of coffee consumption in an epidemiologic setting

Midttun, Øivind; Ulvik, Arve; Nygård, Ottar; Ueland, Per M

doi:10.1093/ajcn/nqy059

Cited by 50Coffee research and impactsNutritional Studies and DietAlcohol Consumption and Health Effects

Performance of plasma trigonelline as a marker of coffee consumption in an epidemiologic setting

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Midttun, Øivind, Ulvik, Arve, Nygård, Ottar, Ueland, Per M·2018·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/nqy059

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Abstract

Background Coffee is a widely consumed beverage, and studies suggest that drinking coffee has beneficial health effects. The phytohormone trigonelline is present in large amounts in coffee beans, and circulating concentrations of trigonelline have been shown to be positively related to dietary intake of coffee and to increase significantly after the consumption of a bolus dose of coffee.Objective We cross-sectionally investigated the utility of plasma trigonelline as a marker of coffee consumption in an epidemiologic setting. We secondarily investigated if coffee intake is related to plasma concentrations of vitamin B-3 (niacin) forms.Design In a Norwegian cohort of 3503 participants, we combined questionnaire data on the number of cups of coffee consumed per day with plasma trigonelline to evaluate trigonelline as a marker of coffee intake. The suitability of plasma trigonelline to discriminate those not consuming from those consuming coffee was investigated by receiver operating characteristic (ROC) analysis. Plasma collected at 2 time points 1 y apart was used to determine the within-person reproducibility of trigonelline.Results We found that plasma trigonelline concentrations increased strongly with increasing amounts of coffee consumed. ROC analysis showed that trigonelline had an area under the curve of 0.92 (95% CI: 0.90, 0.94) for distinguishing coffee abstainers from coffee drinkers. Plasma trigonelline had a good within-person reproducibility (0.66; 95% CI: 0.64, 0.68) for samples collected 1 y apart. The amount of coffee consumed was not associated with plasma concentrations of the niacin vitamers nicotinamide and N1-methylnicotinamide.Conclusions Plasma trigonelline performs well as a marker of coffee intake. Data used in this study were derived from the clinical trial registered at www.clinicaltrials.gov as NCT00354081.

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Trigonelline is particularly abundant in plant-derived food products, such as coffee beans and fenugreek seeds, which have been reported to modulate endogenous trigonelline levels in humans.
“trigonelline is particularly abundant in plant-derived food products, such as coffee beans and fenugreek seeds, which have been reported to modulate endogenous trigonelline levels in humans4,51,52.”
From Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia (2024) · cites this paper as [51]

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Sorted by citations

Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia
Membrez, M., Migliavacca, E., Christen, S., Yaku, K., Trieu, J., Lee, A. K., Morandini, F., Giner, M. P., Stiner, J., Makarov, M. V., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00997-x · Cited by 148 · see citing works
“Consequently, trigonelline is particularly abundant in plant-derived food products, such as coffee beans and fenugreek seeds, which have been reported to modulate endogenous trigonelline levels in humans 4,51,52 .”
Background

Authors: Midttun, Ø., Ulvik, A., Nygård, O., & Ueland, P. M.
Affiliations: Bevital (Norway) (NO)
Haukeland University Hospital (NO)
ORCID: Midttun, Øivind
Ulvik, Arve
Ueland, Per M
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2018-06
Volume: 107
Issue: 6
Pages: 941-947
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/nqy059
OpenAlex: W2803420884
Cited by: 50
References: 40
Citations by year: 2026: 3 · 2025: 4 · 2024: 9 · 2023: 6 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 7
FWCI: 3.87
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1708 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Coffee research and impacts
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: coffee consumption, nicotinic acid, nicotinamide, N1-methylnicotinamide
MeSH terms: Adult, Aged, Alkaloids, Coffee, Cross-Sectional Studies, Drinking, Female, Humans, Male, Middle Aged, Norway, Cohort Studies, Biomarkers

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Performance of plasma trigonelline as a marker of coffee consumption in an epidemiologic setting

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