The DOI matches its Crossref record.
Anaplastic Thyroid Carcinoma: A Study of 70 Cases
Abstract
Seventy cases of anaplastic thyroid carcinomas studied at the Universities of Florence (Italy) and Minnesota are presented. Three morphologic patterns were seen: spindle, giant cell, and squamoid, sometimes in combination. Ultrastructurally, evidence of epithelial differentiation was seen in most but not all cases studied. Immunohistochemically, a stain for cytokeratin using a monoclonal antibody was found the most useful adjunct to diagnosis. Unexpected positivity for carcinoembryonic antigen (CEA) was found in several squamoid tumors. The alleged frequent positivity of this tumor type for thyroglobulin and calcitonin was not confirmed. A third of the tumors were associated with a better differentiated component, of which, presumably, they represented a dedifferentiation. The extremely aggressive behavior of anaplastic thyroid carcinomas was confirmed amply in this series: all of the patients in whom follow-up information was available died of their tumor. Small cell tumors should not be included into the anaplastic category, since they invariably belong to other groups, i.e., malignant lymphoma, medullary carcinoma, and poorly differentiated ("insular") carcinoma.
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Cited by
Knauf, J. A., Ma, X., Smith, E. P., Zhang, L., Mitsutake, N., Liao, X.-H., Refetoff, S., Nikiforov, Y. E., & Fagin, J. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0047 · Cited by 414
AACE/AAES MEDICAL/SURGICAL Guidelines for Clinical Practice: Management of Thyroid Carcinoma
Cobin, R. H., Gharib, H., Bergman, D. A., Clark, O. H., Cooper, D. S., Daniels, G. H., Dickey, R. A., Duick, D. S., Garber, J. R., Hay, I. D., et al. (2001) · Endocrine Practice · doi:10.4158/ep.7.3.202 · Cited by 365
Ain, K. B., Egorin, M. J., DeSimone, P. A., & Collaborative Anaplastic Thyroid Cancer Health Intervention Trials (CATCHIT) Group* (2000) · Thyroid · doi:10.1089/thy.2000.10.587 · Cited by 295
Unusual tumors associated with the hereditary nonpolyposis colorectal cancer syndrome
Broaddus, R. R., Lynch, P. M., Lu, K. H., Luthra, R., & Michelson, S. J. (2004) · Modern Pathology · doi:10.1038/modpathol.3800150 · Cited by 69
Genetic mutations, molecular markers and future directions in research
Patel, K. N. (2013) · Oral Oncology · doi:10.1016/j.oraloncology.2013.03.437 · Cited by 6
Metadata
- Authors
- Carcangiu, M. L., Steeper, T., Zampi, G., & Rosai, J.
- Venue
- American Journal of Clinical Pathology
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-02-01
- Volume
- 83
- Issue
- 2
- Pages
- 135-158
- ISSN
- 0002-9173 (ISSN-L)
- 1943-7722
- OpenAlex
- W2320646232
- Cited by
- 469
- References
- 0
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Carcangiu, M. L., Steeper, T., Zampi, G., & Rosai, J. (1985). Anaplastic Thyroid Carcinoma: A Study of 70 Cases. American Journal of Clinical Pathology. https://doi.org/10.1093/ajcp/83.2.135
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
