Genetic mutations, molecular markers and future directions in research

Patel, Kepal N.

doi:10.1016/j.oraloncology.2013.03.437

Cited by 6Thyroid Cancer Diagnosis and TreatmentThyroid and Parathyroid SurgeryThyroid Disorders and Treatments

Genetic mutations, molecular markers and future directions in research

Patel, Kepal N.·2013·Oral Oncology

DOI 10.1016/j.oraloncology.2013.03.437

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Abstract

Recent molecular studies have described a number of abnormalities associated with the pathogenesis of thyroid carcinoma. These distinct molecular events are often associated with specific stages of tumor development and may serve as prognostic factors and therapeutic targets. A better understanding of the mechanisms involved in thyroid cancer pathogenesis, will hopefully help translate these discoveries to improved patient care.

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Crossref · 10.1016/j.oraloncology.2013.03.437

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Cellular dedifferentiation in thyroid carcinoma is accompanied by more aggressive growth, recurrence, distant metastasis, and resistance to RAI.
“Cellular dedifferentiation generally occurs in cases accompanied by more aggressive growth, recurrence, distant metastasis, and resistance to RAI [1, 8–10].”
From Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells (2017) · cites this paper as [8]
Approximately 5-15% of PTC cases are DePTC, associated with poor prognosis and high early-mortality.
“Nevertheless, approximately 5-15% of the cases are dedifferentiated papillary thyroid cancer (DePTC), which is associated with poor prognosis and high early-mortality [7–9].”
From Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells (2017) · cites this paper as [8]

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Prognostic biomarkers in thyroid cancer
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Authors: Patel, K. N.
Affiliations: NYU Langone Health (US)
Corresponding author: Patel, Kepal N.
ORCID: Patel, Kepal N.
Venue: Oral Oncology
Publisher: Elsevier BV
Published: 2013-07
Volume: 49
Issue: 7
Pages: 711-721
ISSN: 1368-8375 (ISSN-L)
DOI: 10.1016/j.oraloncology.2013.03.437
OpenAlex: W2072682157
Cited by: 6
References: 247
Citations by year: 2019: 1 · 2017: 1 · 2015: 1 · 2014: 3
FWCI: 0.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Oral Oncology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Keywords: thyroid cancer, genetic mutations, molecular markers, carcinogenesis, prognostic factors, therapeutic target
MeSH terms: Cell Differentiation, Humans, Mutation, Thyroid Neoplasms, Biomarkers, Tumor

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Genetic mutations, molecular markers and future directions in research

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