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Cited by 234Hepatitis C virus researchHepatocellular Carcinoma Treatment and PrognosisHepatitis B Virus Studies

Incidence and Cofactors of Hepatitis C Virus-related Hepatocellular Carcinoma: A Prospective Study of 12,008 Men in Taiwan

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Sun, C.-A.·2003·American Journal of Epidemiology
DOI 10.1093/aje/kwg041
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Abstract

In a community-based prospective study, the authors examined the independent and interactive effects of hepatitis C virus (HCV) infection and cofactors, including hepatitis B virus (HBV) infection and lifestyle habits, on the incidence of hepatocellular carcinoma (HCC) in Taiwan. At baseline recruitment, subjects were evaluated with regard to second-generation HCV antibody (anti-HCV), hepatitis B surface antigen, and serum alanine aminotransferase, as well as cigarette smoking, alcohol drinking, and betel quid chewing habits. A total of 12,008 male residents aged 30-64 years without a history of HCC were included in the study. Between July 1990 and June 2001, 112 incident cases of HCC were identified among the subjects and included in the analysis. Persons with anti-HCV positivity alone had a 20-fold increased risk of developing HCC in comparison with those who were negative for anti-HCV. In statistical assessment of additive interaction, HCV and HBV tended to act independently in the pathogenesis of HCC. The results of this study suggest that HCV plays a significant role in hepatocarcinogenesis in an area endemic for chronic HBV infection.

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Crossref · 10.1093/aje/kwg041

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  • Exposure fractions among prevalent liver cirrhosis cases were used as a proxy for population attributable fractions, following the direct method when relative risk is high.

    “We used the resulting predicted exposure fractions among prevalent cases as a proxy for PAFs for liver cirrhosis. This follows from the direct method of approximating PAFs:”

    From Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis (2014) · cites this paper as [32]

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Authors
Sun, C.-A.
Affiliations
National Defense Medical Center (TW)
Corresponding author
Sun, C.-A.
ORCID
Sun, C.-A.
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2003-04-15
Volume
157
Issue
8
Pages
674-682
ISSN
0002-9262 (ISSN-L)
DOI
10.1093/aje/kwg041
OpenAlex
W2110758352
Cited by
234
References
49
Citations by year
2025: 2 · 2024: 2 · 2023: 9 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 14 · 2014: 22 · 2013: 12 · 2012: 16
FWCI
11.53
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • American Journal of Epidemiology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Science Council
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
  • Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
Keywords
hepatitis C virus, hepatocellular carcinoma, hepatitis B virus, HBV/HCV coinfection, cofactors, lifestyle habits, cigarette smoking, alcohol consumption, betel quid chewing, hepatocarcinogenesis, anti-HCV antibodies, men, Taiwan
MeSH terms
Adult, Alanine Transaminase, Follow-Up Studies, Hepatitis B, Hepatitis C, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Male, Middle Aged, Prospective Studies, Risk Factors, Taiwan, Health Behavior, Confounding Factors, Epidemiologic, Incidence

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