The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Do Men Have a Higher Case Fatality Rate of Severe Acute Respiratory Syndrome than Women Do?
Open accessAbstract
Severe acute respiratory syndrome (SARS) has been reported in 30 countries and regions, with a cumulative total of 8,099 probable cases and 774 deaths as of July 31, 2003, according to the World Health Organization. In Hong Kong, People's Republic of China, 1,755 SARS cases and 299 deaths had occurred as of September 22, 2003. The authors analyzed data from the Department of Health, Hong Kong SAR. The data series includes details regarding sex, age, and chronic disease history. Using data from early March to September 22, 2003, the authors found that males had a significantly (p < 0.0001) higher case fatality rate than females did, 21.9% versus 13.2%; the relative risk was 1.66 (95% confidence interval (CI): 1.35, 2.05), and it was 1.62 (95% CI: 1.21, 2.16) after adjustment for age. Subgroup analysis was conducted by excluding health care workers (n = 386) from the analysis. The overall crude relative risk of mortality was 1.41 (95% CI: 1.15, 1.74), and the adjusted relative risk was 1.48 (95% CI: 1.10, 2.00). Thus, among SARS patients, males may be more severely affected by the disease than females are. This finding could be related to a nonuniform case definition of SARS disease, a different treatment regimen, a past smoking history, work-environment factors, or gender-specific immune-defense factors, for instance.
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Donnelly, C. A., Ghani, A. C., Leung, G. M., Hedley, A. J., Fraser, C., Riley, S., Abu-Raddad, L. J., Ho, L.-M., Thach, T.-Q., Chau, P., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13410-1 · Cited by 940 · cited 1×
“(3) concluded that only the age of patients strongly affected outcome, while the role of gender was not considered in their study.”
Background
Cited by
Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission
Peckham, H., de Gruijter, N. M., Raine, C., Radziszewska, A., Ciurtin, C., Wedderburn, L. R., Rosser, E. C., Webb, K., & Deakin, C. T. (2020) · Nature Communications · doi:10.1038/s41467-020-19741-6 · Cited by 1,503
Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation
Chen, J., Jiang, Q., Xia, X., Liu, K., Yu, Z., Tao, W., Gong, W., & Han, J. J. (2020) · Aging Cell · doi:10.1111/acel.13168 · Cited by 436
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Sex and age differences in COVID-19 mortality in Europe
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Scully, E. P., Schumock, G., Fu, M., Massaccesi, G., Muschelli, J., Betz, J., Klein, E. Y., West, N. E., Robinson, M., Garibaldi, B. T., et al. (2021) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofab448 · Cited by 73
Metadata
- Authors
- Karlberg, J.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-02-01
- Volume
- 159
- Issue
- 3
- Pages
- 229-231
- ISSN
- 0002-9262 (ISSN-L)
- OpenAlex
- W2110219816
- Cited by
- 425
- References
- 1
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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