CoChat
Sign Up
Cited by 353Nutritional Studies and DietAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant Activities

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Fruit, Vegetable, and Antioxidant Intake and All-Cause, Cancer, and Cardiovascular Disease Mortality in a Community-dwelling Population in Washington County, Maryland

Genkinger, J. M., Platz, E. A., Hoffman, S. C., Comstock, G. W., Helzlsouer, K. J.·2004·American Journal of Epidemiology
DOI 10.1093/aje/kwh339
Open this paper in CoChat — free account

Abstract

Higher intake of fruits, vegetables, and antioxidants may help protect against oxidative damage, thus lowering cancer and cardiovascular disease risk. This Washington County, Maryland, prospective study examined the association of fruit, vegetable, and antioxidant intake with all-cause, cancer, and cardiovascular disease death. CLUE participants who donated a blood sample in 1974 and 1989 and completed a food frequency questionnaire in 1989 (N = 6,151) were included in the analysis. Participants were followed to date of death or January 1, 2002. Compared with those in the bottom fifth, participants in the highest fifth of fruit and vegetable intake had a lower risk of all-cause (cases = 910; hazard ratio (HR) = 0.63, 95% confidence interval (CI): 0.51, 0.78; p-trend = 0.0004), cancer (cases = 307; HR = 0.65, 95% CI: 0.45, 0.93; p-trend = 0.08), and cardiovascular disease (cases = 225; HR = 0.76, 95% CI: 0.54, 1.06; p-trend = 0.15) mortality. Higher intake of cruciferous vegetables was associated with lower risk of all-cause mortality (HR = 0.74, 95% CI: 0.60, 0.91; p-trend = 0.04). No statistically significant associations were observed between dietary vitamin C, vitamin E, and beta-carotene intake and mortality. Overall, greater intake of fruits and vegetables was associated with lower risk of all-cause, cancer, and cardiovascular disease death. These findings support the general health recommendation to consume multiple servings of fruits and vegetables (5-9/day).

Overview

Integrity signals

Registry

Crossref · 10.1093/aje/kwh339

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 48 references

Research works printed but not linked: 4

  1. Hertog, 1996, Cancer Epidemiology Biomarkers & Prevention, 5, 673
  2. 1995, The American Journal of Clinical Nutrition, 62(suppl), 1427s
  3. Patrick, 2000, Alternative medicine review : a journal of clinical therapeutic, 5, 530
  4. Sinzinger, 2000, Lymphology, 33, 24

Cited by

Sorted by citations

Items 101–200 of 353

Related

See all

Metadata

Authors
Genkinger, J. M., Platz, E. A., Hoffman, S. C., Comstock, G. W., & Helzlsouer, K. J.
Affiliations
Johns Hopkins University (US)
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2004-12-06
Volume
160
Issue
12
Pages
1223-1233
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/aje/kwh339
OpenAlex
W2122872164
Cited by
351
References
48
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 14 · 2021: 22 · 2020: 10 · 2019: 18 · 2018: 12 · 2017: 20 · 2016: 22 · 2015: 21 · 2014: 23 · 2013: 27 · 2012: 20
FWCI
13.58
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Defense
  • New York City Department of Health and Mental Hygiene
  • National Institute on Aging (U01AG018033, 1U01AG18033)
  • National Heart, Lung, and Blood Institute (K06HL021670, HL 21670)
  • National Cancer Institute (1U01 CA 86308, U01CA086308)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords
fruit and vegetable intake, antioxidant intake, dietary antioxidants, cancer mortality, cardiovascular mortality, all-cause mortality, cruciferous vegetables, vitamin C, vitamin E, beta-carotene, dietary recommendations, Washington County, Maryland
MeSH terms
Adult, Aged, Aged, 80 and over, Antioxidants, Ascorbic Acid, Cardiovascular Diseases, Cause of Death, Diet, Female, Fruit, Humans, Male, Maryland, Middle Aged, Neoplasms, Smoking, Vegetables, Cohort Studies, Body Mass Index, beta Carotene, alpha-Tocopherol

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review