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Cited by 102Cancer Risks and FactorsMetabolism, Diabetes, and CancerEndometrial and Cervical Cancer Treatments

Diabetes and endometrial cancer: an evaluation of the modifying effects of other known risk factors

Saltzman, B. S., Doherty, J. A., Hill, D. A., Beresford, S. A., Voigt, L. F., Chen, C., Weiss, N. S.·2007·American Journal of Epidemiology
DOI 10.1093/aje/kwm333
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Abstract

To determine whether risk of endometrial cancer among women with type 2 diabetes differs with respect to other endometrial cancer risk factors, the authors used data from a population-based case-control study (1,303 cases and 1,779 controls) conducted in western Washington State during 1985-1999. History of type 2 diabetes was associated with endometrial cancer (odds ratio (OR) = 1.7, 95% confidence interval (CI): 1.2, 2.3), more strongly among women with a recent diabetes diagnosis (<5 years) (OR = 2.6, CI: 1.5, 4.7) than among those with a more distant diagnosis (> or =5 years) (OR = 1.3, CI: 0.8, 1.9). Type 2 diabetes was associated with endometrial cancer among women with a body mass index (BMI) (weight (kg)/height (m)(2)) less than 35 but not among women with a BMI of 35 or more. The observed associations persisted after finer adjustment for BMI to control for residual confounding. History of diabetes was associated with a twofold increased risk of endometrial cancer among hypertensive women, but no association was observed among nonhypertensive women. The risk associated with type 2 diabetes appeared not to vary greatly with respect to other endometrial cancer risk factors. These results support the hypothesis that type 2 diabetes is associated with endometrial cancer irrespective of the presence of other risk factors for this disease, except possibly hypertension and extreme obesity.

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Crossref · 10.1093/aje/kwm333

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  • For endometrial cancer, the new-onset diabetics (<5 years) have a two-fold risk compared with those with long-standing diabetes (≥5 years).

    “For endometrial cancer, the new-onset diabetics (<5 years) have a two-fold risk compared with those with long-standing diabetes (≥5 years) (121).”

    From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [121]

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Related

Authors
Saltzman, B. S., Doherty, J. A., Hill, D. A., Beresford, S. A., Voigt, L. F., Chen, C., & Weiss, N. S.
Affiliations
  • University of Washington (US)
  • University of New Mexico (US)
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2007-12-12
Volume
167
Issue
5
Pages
607-614
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/aje/kwm333
OpenAlex
W2164625300
Cited by
102
References
23
Citations by year
2026: 3 · 2025: 3 · 2024: 8 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 9 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 9 · 2012: 13
FWCI
2.02
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute (R01CA047749, K05CA092002, R35 CA 39779, R01 CA47749, K05 CA92002, R01-CA75977, R01CA075977, R35CA039779)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (N01 HD 23166)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords
type 2 diabetes, endometrial cancer, cancer risk factors, hypertension, body mass index, obesity, diabetes duration, residual confounding
MeSH terms
Aged, Diabetes Mellitus, Type 2, Female, Humans, Insulin, Interviews as Topic, Middle Aged, Obesity, Population Surveillance, Risk Factors, Washington, Body Mass Index, Incidence, Case-Control Studies, Endometrial Neoplasms, Risk Assessment, Adiposity

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