Cited by 281Cytomegalovirus and herpesvirus researchViral-associated cancers and disordersImmune responses and vaccinations

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Cytomegalovirus Antibody Levels, Inflammation, and Mortality Among Elderly Latinos Over 9 Years of Follow-up

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Roberts, E. T., Haan, M. N., Dowd, J. B., Aiello, A. E.·2010·American Journal of Epidemiology

DOI 10.1093/aje/kwq177PMC PMC2950794

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Abstract

This study examined the relation between immune response to cytomegalovirus (CMV) and all-cause and cardiovascular disease (CVD) mortality, and possible mediating mechanisms. Data were derived from the Sacramento Area Latino Study on Aging, a population-based study of older Latinos (aged 60-101 years) in California followed in 1998-2008. CMV immunoglobulin G (IgG), tumor necrosis factor, and interleukin-6 were assayed from baseline blood draws. Data on all-cause and CVD mortality were abstracted from death certificates. Analyses included 1,468 of 1,789 participants. For individuals with CMV IgG antibody titers in the highest quartile compared with lower quartiles, fully adjusted models showed that all-cause mortality was 1.43 times (95% confidence interval: 1.14, 1.79) higher over 9 years. In fully adjusted models, the hazard of CVD mortality was also elevated (hazard ratio = 1.35, 95% confidence interval: 1.01, 1.80). A composite measure of tumor necrosis factor and interleukin-6 mediated a substantial proportion of the association between CMV and all-cause (18.9%, P < 0.001) and CVD (29.0%, P = 0.02) mortality. This study is the first known to show that high CMV IgG antibody levels are significantly related to mortality and that the relation is largely mediated by interleukin-6 and tumor necrosis factor. Further studies investigating methods for reducing IgG antibody response to CMV are warranted.

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“Smoking status, hypertension, low density lipoprotein cholesterol, and high density lipoprotein cholesterol were assessed as covariates because they are associated with death (22, 23) and CMV infection.”
Background
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Authors: Roberts, E. T., Haan, M. N., Dowd, J. B., & Aiello, A. E.
Affiliations: University of Michigan (US)
City University of New York (US)
Corresponding author: Aiello, A. E.
ORCID: Haan, M. N.
Dowd, J. B.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 2010-07-21
Volume: 172
Issue: 4
Pages: 363-371
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/aje/kwq177
PMC: PMC2950794
OpenAlex: W2116172333
Cited by: 281
References: 40
Citations by year: 2026: 7 · 2025: 11 · 2024: 10 · 2023: 12 · 2022: 10 · 2021: 18 · 2020: 22 · 2019: 22 · 2018: 17 · 2017: 21 · 2016: 21 · 2015: 16 · 2014: 23 · 2013: 18 · 2012: 23
FWCI: 16.29
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: American Journal of Epidemiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: City University of New York
School of Public Health, University of Michigan
National Institutes of Health (NIH5P60 DK20572, DK20572)
National Institute on Aging (AG-12975, R01AG012975, R03AG033751)
National Institute of Nursing Research (R21NR011181)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-60753, DK20572, P60DK020572, R01DK060753)
National Institute on Minority Health and Health Disparities (P60MD002249)
Topics: Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: cytomegalovirus, CMV IgG antibodies, all-cause mortality, cardiovascular mortality, TNF-α, interleukin-6, inflammation, mediation analysis, Latino older adults, aging, Sacramento Area Latino Study on Aging
MeSH terms: Age Factors, Aged, Aged, 80 and over, California, Cardiovascular Diseases, Cytomegalovirus Infections, Cytomegalovirus, Female, Follow-Up Studies, Hispanic or Latino, Humans, Immunoglobulin G, Inflammation, Male, Middle Aged, Mortality, Prospective Studies, Tumor Necrosis Factor-alpha, Interleukin-6

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Cytomegalovirus Antibody Levels, Inflammation, and Mortality Among Elderly Latinos Over 9 Years of Follow-up

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