The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Cytomegalovirus Antibody Levels, Inflammation, and Mortality Among Elderly Latinos Over 9 Years of Follow-up
Open accessAbstract
This study examined the relation between immune response to cytomegalovirus (CMV) and all-cause and cardiovascular disease (CVD) mortality, and possible mediating mechanisms. Data were derived from the Sacramento Area Latino Study on Aging, a population-based study of older Latinos (aged 60-101 years) in California followed in 1998-2008. CMV immunoglobulin G (IgG), tumor necrosis factor, and interleukin-6 were assayed from baseline blood draws. Data on all-cause and CVD mortality were abstracted from death certificates. Analyses included 1,468 of 1,789 participants. For individuals with CMV IgG antibody titers in the highest quartile compared with lower quartiles, fully adjusted models showed that all-cause mortality was 1.43 times (95% confidence interval: 1.14, 1.79) higher over 9 years. In fully adjusted models, the hazard of CVD mortality was also elevated (hazard ratio = 1.35, 95% confidence interval: 1.01, 1.80). A composite measure of tumor necrosis factor and interleukin-6 mediated a substantial proportion of the association between CMV and all-cause (18.9%, P < 0.001) and CVD (29.0%, P = 0.02) mortality. This study is the first known to show that high CMV IgG antibody levels are significantly related to mortality and that the relation is largely mediated by interleukin-6 and tumor necrosis factor. Further studies investigating methods for reducing IgG antibody response to CMV are warranted.
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“Some studies have found that human CMV infection in older individuals is associated with increased cardiovascular and all-cause mortality, negative immune risk profile, inflammageing, and lower antibody responses to influenza125–129.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [125]
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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
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Metadata
- Authors
- Roberts, E. T., Haan, M. N., Dowd, J. B., & Aiello, A. E.
- Affiliations
- University of Michigan (US)
- City University of New York (US)
- Corresponding author
- Aiello, A. E.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-07-21
- Volume
- 172
- Issue
- 4
- Pages
- 363-371
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- PMC
- PMC2950794
- OpenAlex
- W2116172333
- Cited by
- 281
- References
- 40
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 10 · 2023: 12 · 2022: 10 · 2021: 18 · 2020: 22 · 2019: 22 · 2018: 17 · 2017: 21 · 2016: 21 · 2015: 16 · 2014: 23 · 2013: 18 · 2012: 23
- FWCI
- 16.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Epidemiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- City University of New York
- School of Public Health, University of Michigan
- National Institutes of Health (NIH5P60 DK20572, DK20572)
- National Institute on Aging (AG-12975, R01AG012975, R03AG033751)
- National Institute of Nursing Research (R21NR011181)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-60753, DK20572, P60DK020572, R01DK060753)
- National Institute on Minority Health and Health Disparities (P60MD002249)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- cytomegalovirus, CMV IgG antibodies, all-cause mortality, cardiovascular mortality, TNF-α, interleukin-6, inflammation, mediation analysis, Latino older adults, aging, Sacramento Area Latino Study on Aging
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, California, Cardiovascular Diseases, Cytomegalovirus Infections, Cytomegalovirus, Female, Follow-Up Studies, Hispanic or Latino, Humans, Immunoglobulin G, Inflammation, Male, Middle Aged, Mortality, Prospective Studies, Tumor Necrosis Factor-alpha, Interleukin-6
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