Age-dependent dysregulation of innate immunity

Inflammation and Atherosclerosis

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Myeloid-derived-suppressor cells as regulators of the immune system

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A role for mitochondria in nlrp3 inflammasome activation

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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

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The senescence-associated secretory phenotype: the dark side of tumor suppression

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Gut microbiota composition correlates with diet and health in the elderly

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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Genomic responses in mouse models poorly mimic human inflammatory diseases

Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005 · see citing works

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

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Human natural killer cells

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Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

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Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

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Cell intrinsic alterations underlie hematopoietic stem cell aging

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Systemic inflammation and disease progression in Alzheimer disease

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Fat tissue, aging, and cellular senescence

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p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype

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Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

Pang, W. W., Price, E. A., Sahoo, D., Beerman, I., Maloney, W. J., Rossi, D. J., Schrier, S. L., & Weissman, I. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116110108 · Cited by 991 · see citing works

Immunobiology of the TAM receptors

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Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

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Systems biology of vaccination for seasonal influenza in humans

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Serum IL‐6 Level and the Development of Disability in Older Persons

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Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

Lee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W., & Hong, J. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-37 · Cited by 772 · see citing works

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

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Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

Iyer, S. S., Pulskens, W. P., Sadler, J. J., Butter, L. M., Teske, G. J., Ulland, T. K., Eisenbarth, S. C., Florquin, S., Flavell, R. A., Leemans, J. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908698106 · Cited by 691 · see citing works

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

Youm, Y.-H., Grant, R. W., McCabe, L. R., Albarado, D. C., Nguyen, K. Y., Ravussin, A., Pistell, P., Newman, S., Carter, R., Laque, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.010 · Cited by 674 · see citing works

Increased cytokine production in mononuclear cells of healthy elderly people

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Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

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Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

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Cutting edge: impaired toll-like receptor expression and function in aging

Renshaw, M., Rockwell, J., Engleman, C., Gewirtz, A., Katz, J., & Sambhara, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4697 · Cited by 626 · see citing works

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome

Imaeda, A. B., Watanabe, A., Sohail, M. A., Mahmood, S., Mohamadnejad, M., Sutterwala, F. S., Flavell, R. A., & Mehal, W. Z. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35958 · Cited by 604 · see citing works

The ageing haematopoietic stem cell compartment

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CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation

Reed-Geaghan, E. G., Savage, J. C., Hise, A. G., & Landreth, G. E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3158-09.2009 · Cited by 591 · see citing works

Cytomegalovirus Reactivation in Critically Ill Immunocompetent Patients

Limaye, A. P., Kirby, K. A., Rubenfeld, G. D., Leisenring, W. M., Bulger, E. M., Neff, M. J., Gibran, N. S., Huang, M.-L., Hayes, T. K. S., Corey, L., et al. (2008) · JAMA · doi:10.1001/jama.300.4.413 · Cited by 578 · see citing works

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

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Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

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Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response

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Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

Hearps, A. C., Martin, G. E., Angelovich, T. A., Cheng, W., Maisa, A., Landay, A. L., Jaworowski, A., & Crowe, S. M. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00851.x · Cited by 547 · see citing works

Autophagy and aging: keeping that old broom working

Cuervo, A. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.002 · Cited by 527 · see citing works

Inflammaging: disturbed interplay between autophagy and inflammasomes

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2012) · Aging · doi:10.18632/aging.100444 · Cited by 511 · see citing works

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

Cribbs, D. H., Berchtold, N. C., Perreau, V., Coleman, P. D., Rogers, J., Tenner, A. J., & Cotman, C. W. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-179 · Cited by 499 · see citing works

Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

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A High Plasma Concentration of TNF- Is Associated With Dementia in Centenarians

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Effect of age on human neutrophil function

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Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans

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Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway

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AGING AND CANCER IN AMERICA

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Flagellin as an Adjuvant: Cellular Mechanisms and Potential

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Epidemiology and Unique Aspects of Aging and Infectious Diseases

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Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults

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Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

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Obesity and inflammation: the effects of weight loss

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A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

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Age-Associated Defect in Human TLR-1/2 Function

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Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination—an impact of immunosenescence

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Human NK cells display major phenotypic and functional changes over the life span

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Signal transduction and functional changes in neutrophils with aging

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Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

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Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly

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Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells

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Reactivation of Cytomegalovirus Infection in Critically Ill Immunocompetent Patients—Reply

Limaye, A. P. (2008) · JAMA · doi:10.1001/jama.2008.697 · Cited by 313 · see citing works

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging

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Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor.

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Toll-Like Receptor 2 Acts as a Natural Innate Immune Receptor to Clear Amyloid β1–42and Delay the Cognitive Decline in a Mouse Model of Alzheimer's Disease

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Aging Up-Regulates Expression of Inflammatory Mediators in Mouse Adipose Tissue

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Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood

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Cytomegalovirus Antibody Levels, Inflammation, and Mortality Among Elderly Latinos Over 9 Years of Follow-up

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Peripheral blood dendritic cells and monocytes are differently regulated in the elderly

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Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing

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Chronic herpesvirus reactivation occurs in aging

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Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity

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The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection

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NK phenotypic markers and IL2 response in NK cells from elderly people

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Age effects on B cells and humoral immunity in humans

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17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism.

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Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression

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Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

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Impaired immune responses in the lungs of aged mice following influenza infection

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Hypercoagulability in centenarians: the paradox of successful aging

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Impaired functions of peripheral blood monocyte subpopulations in aged humans

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Blood CD33(+)HLA-DR(−) myeloid-derived suppressor cells are increased with age and a history of cancer

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Frailty, inflammation, and immunity.

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Dysregulation of TLR3 Impairs the Innate Immune Response to West Nile Virus in the Elderly

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Interleukin-6 Production Does Not Increase With Age

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Induction of Toll-Like Receptor 9 Signaling as a Method for Ameliorating Alzheimer's Disease-Related Pathology

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B cell maintenance and function in aging

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Increased Reactivity of Dendritic Cells from Aged Subjects to Self-Antigen, the Human DNA

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Ageing is associated with a decline in peripheral blood CD56bright NK cells

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Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo

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Menopause and Ovariectomy Cause a Low Grade of Systemic Inflammation that May Be Prevented by Chronic Treatment with Low Doses of Estrogen or Losartan

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Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza–flagellin fusion vaccine (VAX125, STF2.HA1 SI)

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Prevaccine Determination of the Expression of Costimulatory B7 Molecules in Activated Monocytes Predicts Influenza Vaccine Responses in Young and Older Adults

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Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis.

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Age‐associated elevation in TLR5 leads to increased inflammatory responses in the elderly

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Evaluating the role of Toll-like receptors in diseases of the central nervous system.

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Age-Associated Increase in Cytokine Production During Systemic Inflammation: Adipose Tissue as a Major Source of IL-6

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Age-related changes in CD8 T cell homeostasis and immunity to infection

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Impaired Dendritic Cell Function in Aging Leads to Defective Antitumor Immunity

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Impaired Interferon Signaling in Dendritic Cells From Older Donors Infected In Vitro With West Nile Virus

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Aging Enhances the Basal Production of IL-6 and CCL2 in Vascular Smooth Muscle Cells

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Aging Impairs IFN Regulatory Factor 7 Up-Regulation in Plasmacytoid Dendritic Cells during TLR9 Activation

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The impact of CMV infection on survival in older humans

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Microglia Activated with the Toll-Like Receptor 9 Ligand CpG Attenuate Oligomeric Amyloid β Neurotoxicity in in Vitro and in Vivo Models of Alzheimer’s Disease

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A Role for Immature Myeloid Cells in Immune Senescence

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Impact of aging on antigen presentation cell function of dendritic cells

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GLA-SE, a Synthetic Toll-like Receptor 4 Agonist, Enhances T-Cell Responses to Influenza Vaccine in Older Adults

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Phenotypic and functional changes of circulating monocytes and polymorphonuclear leucocytes from elderly persons

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Cutting Edge: Necrosis Activates the NLRP3 Inflammasome

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Aging Promotes Neutrophil-Induced Mortality by Augmenting IL-17 Production during Viral Infection

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Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking

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Invariant NKT and NKT-like lymphocytes: Two different T cell subsets that are differentially affected by ageing

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Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia

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Innate Immune Dysfunctions in Aged Mice Facilitate the Systemic Dissemination of Methicillin-Resistant S. aureus

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Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions

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Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure

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Characterization of age-related changes in natural killer cells during primary influenza infection in mice

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Ceramide-induced and Age-associated Increase in Macrophage COX-2 Expression Is Mediated through Up-regulation of NF-κB Activity

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Thymic function failure and C-reactive protein levels are independent predictors of all-cause mortality in healthy elderly humans

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Aging Mice Exhibit a Functional Defect in Mucosal Dendritic Cell Response against an Intracellular Pathogen

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Impaired NLRP3 Inflammasome Function in Elderly Mice during Influenza Infection Is Rescued by Treatment with Nigericin

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Chronic inflammation and aging: DNA damage tips the balance

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Variation of human natural killer cell phenotypes with age: Identification of a unique KLRG1-negative subset

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Impaired antigen-induced CD8+ T cell clonal expansion in aging is due to defects in antigen presenting cell function

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Aging and Neutrophils: There Is Still Much To Do

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GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals

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Murine myeloid dendritic cell‐dependent toll‐like receptor immunity is preserved with aging

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Alterations in Marginal Zone Macrophages and Marginal Zone B Cells in Old Mice

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Enumeration of human peripheral blood dendritic cells throughout the life

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Influenza-Induced Production of Interferon-Alpha is Defective in Geriatric Individuals

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Vα24+ NKT cells are decreased in elderly humans

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The relationship of patient age to the pathobiology of the clonal myeloid diseases

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Age-associated alteration in naive and memory Th17 cell response in humans

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Should the Human Microbiome Be Considered When Developing Vaccines?

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Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro

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Age‐associated alterations in CD8α+ dendritic cells impair CD8 T‐cell expansion in response to an intracellular bacterium

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Impaired in vivo CD4+ T cell expansion and differentiation in aged mice is not solely due to T cell defects: Decreased stimulation by aged dendritic cells

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Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: The Vitality 90+ Study

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Natural killer cell function is altered during the primary response of aged mice to influenza infection

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Effects of aging on triggering receptor expressed on myeloid cells (TREM)‐1‐induced PMN functions

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Age‐dependent change in reactive oxygen species and nitric oxide generation by rat alveolar macrophages*

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Dehydroepiandrosterone Sulfate Directly Activates Protein Kinase C-β to Increase Human Neutrophil Superoxide Generation

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Nuclear factor‐κB‐dependent reversal of aging‐induced alterations in T cell cytokines

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Differential Ability of Exogenous Chemotactic Agents to Disrupt Transendothelial Migration of Flowing Neutrophils

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ADRENAL AND GONADAL STEROIDS INHIBIT IL-6 SECRETION BY HUMAN MARROW CELLS

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Adipose Tissue-Derived Tumor Necrosis Factor- Activity Is Elevated in Older Rats

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Age‐Related Decline in Murine Macrophage Production of Nitric Oxide

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Influence of aging on murine neutrophil and macrophage function againstCandida albicans

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Aging and Marrow Neutrophil Reserves

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Age-Associated Augmentation of the Synthetic Ligand- Mediated Function of Mouse NK1.1 Ag+ T Cells: Their Cytokine Production and Hepatotoxicity In Vivo and In Vitro

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Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation.

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