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Cited by 38Thyroid Disorders and TreatmentsAlcoholism and Thiamine DeficiencyAlcohol Consumption and Health Effects

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

THYROID FUNCTION IN EARLY AND LATE ALCOHOL WITHDRAWAL: RELATIONSHIP WITH AGGRESSION, FAMILY HISTORY, AND ONSET AGE OF ALCOHOLISM

OZSOY, SALIHA, ESEL, ERTUGRUL, IZGI, HASAN BASRI, SOFUOGLU, SEHER·2006·Alcohol and Alcoholism
DOI 10.1093/alcalc/agl056
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Abstract

AIMS: Thyroid dysfunction is a known finding in alcoholism. Most studies have reported the reduction in peripheral thyroid hormones in acute withdrawal and long-term abstinence periods of alcohol dependence. The aim of the present study was to investigate the alterations of free thyroid hormones in early and late withdrawal and their association with aggression, age of onset, and family history of alcoholism. METHODS: Male inpatients (n = 39; mean age +/- SD: 42.55 +/- 8.02 years) in alcohol withdrawal were compared with healthy men (n = 28; mean age +/- SD: 38.31 +/- 9.26 years). Levels of free thyroxine (fT4), free triiodothyronine, (fT3) and thyrothrophin (TSH) were measured in early (first day) and late (28th day) withdrawal in the patients and only once in the controls. RESULTS: In early withdrawal, levels of thyroid hormones did not differ from those in the controls. In late withdrawal, fT3 and fT4 levels (2.71 +/- 0.56 and 10.80 +/- 1.86 pg/ml) were lower than those of both controls (3.32 +/- 0.41 and 11.95 +/- 1.49 pg/ml, respectively, P < 0.05 in both cases) and patients in early withdrawal (3.18 +/- 0.72 and 12.68 +/- 2.50 pg/ml, respectively, P < 0.05 in both cases). Patients were divided into subgroups according to aggression level, onset age of alcoholism, and family history. While the high-aggression group had lower serum levels of fT3 and fT4 in late withdrawal (2.49 +/- 0.41 and 10.44 +/- 2.15 pg/ml) compared with those of controls (P < 0.05 in both cases), the low-aggression group only had lower serum levels of fT3 in late withdrawal (2.90 +/- 0.62 pg/ml) compared with those of controls (P < 0.05). fT3 and fT4 values in the family history-negative group (2.67 +/- 0.56 and 10.75 +/- 1.88 pg/ml) were lower than those of controls in late withdrawal (P < 0.05 in both cases). Both fT3 and fT4 levels in late withdrawal (2.69 +/- 0.54 and 10.83 +/- 1.96 pg/ml) were decreased in early-onset group compared with those of controls (P < 0.05 in both cases). CONCLUSION: Decreased free thyroid hormone levels may be a result of heavy alcohol consumption or a trait marker of alcoholism, especially in high-aggressive, early-onset and family history-negative patients.

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Research works printed but not linked: 2

  1. Brown, G. L., Ballenger, J. C., Minichiello, M. D. and Goodwin, F. K. (1981) Human aggression and its relationship to CSF 5-HIAA., MHPG and HVA. In Psychopharmacology of Aggression, Sandler, M. ed., pp. 131–147. Raven Press, New York.
  2. Levander, S., Mattson, A., Schalling, D. and Dalteg, A. (1987) Psychoendocrine patterns within a group of male juvenile delinquents as related to early psychosocial stress, diagnostic classification, and follow-up data. In Psychopathology: An Interactional Perspective, Magnusson, D. and Öhman, A. eds, pp. 235–252. Academic Press, Orlando.

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Metadata

Authors
OZSOY, S., ESEL, E., IZGI, H. B., & SOFUOGLU, S.
Affiliations
Erciyes University (TR)
Venue
Alcohol and Alcoholism
Publisher
Oxford University Press (OUP)
Published
2006-07-19
Volume
41
Issue
5
Pages
515-521
ISSN
  • 0735-0414 (ISSN-L)
  • 1464-3502
DOI
10.1093/alcalc/agl056
OpenAlex
W2158543377
Cited by
37
References
41
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2015: 2 · 2014: 2 · 2013: 6
FWCI
0.45
Type
journal article
Language
en
Open access
closed
Locations
  • Alcohol and Alcoholism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
alcohol withdrawal, thyroid dysfunction, free thyroxine, free triiodothyronine, thyroid-stimulating hormone, aggression, family history of alcoholism, alcoholism, thyroid hormones, male inpatients
MeSH terms
Adult, Aggression, Ethanol, Alcoholism, Humans, Male, Middle Aged, Psychometrics, Substance Withdrawal Syndrome, Thyroid Diseases, Thyroid Function Tests, Thyroid Hormones, Chi-Square Distribution, Case-Control Studies, Age of Onset, Statistics, Nonparametric

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