Japanese multicenter phase II and pharmacokinetic study of rituximab in relapsed or refractory patients with aggressive B-cell lymphoma
Open accessAbstract
Background To evaluate the efficacy and feasibility of rituximab monotherapy in Japanese patients with relapsed or refractory aggressive B-cell lymphoma.Patients and methods Sixty-eight patients were treated with rituximab at 375 mg/m(2) by eight consecutive weekly infusions. Pretreatment variables affecting overall response rate (ORR) and progression-free survival (PFS) and the relationship between pharmacokinetic parameters and efficacy were analyzed.Results The ORRs of 68 enrolled patients and 57 eligible patients were 35% [95% confidence interval (CI) 24% to 48%] and 37% (95% CI 25% to 51%), respectively. Median PFS of 53 evaluable patients was 52 days, whereas time to progression of 21 eligible responders was 245 days. Mild to moderate infusion-related toxicities were observed frequently at the first infusion, but all of them were reversible. Elevated lactate dehydrogenase (LDH) and refractoriness to prior chemotherapy were unfavorable factors affecting ORR and PFS (P <0.01). Serum trough levels of rituximab and area under the concentration-time curve for responders were higher than for non-responders (P <0.05).Conclusions Eight consecutive weekly infusions of rituximab have significant anti-lymphoma activity for relapsed or refractory aggressive B-cell lymphoma. Several pretreatment variables and serum rituximab levels are useful for predicting its efficacy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Previous comparisons of different dosing regimens revealed that trastuzumab or rituximab Cmax did not correlate with clinical efficacy.
“Previous comparisons of different dosing regimens [75, 76] revealed that trastuzumab or rituximab Cmax did not correlate with clinical efficacy.”
From Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities (2018) · cites this paper as [75]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,232 · see citing works
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793 · see citing works
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158 · see citing works
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297 · see citing works
Toxicity and response criteria of the Eastern Cooperative Oncology Group
Oken, M. M., Creech, R. H., Tormey, D. C., Horton, J., Davis, T. E., Mcfadden, E. T., & Carbone, P. P. (1982) · American Journal of Clinical Oncology · doi:10.1097/00000421-198212000-00014 · Cited by 11,607 · see citing works
Harris, N. L., Jaffe, E., Stein, H., Pm, B., Jk, C., Cleary, M. L., Delsol, G., Peeters, C., Falini, B., & Gatter, K. C. (1994) · Blood · doi:10.1182/blood.v84.5.1361.1361 · Cited by 6,312 · see citing works
Coiffier, B., Lepage, E., Brière, J., Herbrecht, R., Tilly, H., Bouabdallah, R., Morel, P., Van Den Neste, E., Salles, G., Gaulard, P., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011795 · Cited by 5,574 · see citing works
A Predictive Model for Aggressive Non-Hodgkin's Lymphoma
The International Non-Hodgkin's Lymphoma Prognostic Factors Project (1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291402 · Cited by 4,950 · see citing works
Cheson, B. D., Horning, S., Coiffier, B., Shipp, M., Fisher, R. I., Connors, J. M., Lister, T., Vose, J., Grillo-López, A., Hagenbeek, A., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.4.1244 · Cited by 3,210 · see citing works
McLaughlin, P. J., Grillo-López, A. J., Link, B. K., Levy, R., Czuczman, M. S., Williams, M. E., Heyman, M. R., Bence‐Bruckler, I., White, C. A., Cabanillas, F., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.8.2825 · Cited by 2,752 · see citing works
Fisher, R. I., Gaynor, E. R., Dahlberg, S., Oken, M. M., Grogan, T. M., Mize, E. M., Glick, J. H., Coltman, C. A., & Miller, T. P. (1993) · New England Journal of Medicine · doi:10.1056/nejm199304083281404 · Cited by 2,148 · see citing works
Nishizawa, T., Okamoto, H., Konishi, K., Yoshizawa, H., Miyakawa, Y., & Mayumi, M. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7765 · Cited by 1,230 · see citing works
Characterization of a human B lymphocyte-specific antigen.
Stashenko, P., Nadler, L. M., Hardy, R., & Schlossman, S. F. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.125.4.1678 · Cited by 1,076 · see citing works
One-Sample Multiple Testing Procedure for Phase II Clinical Trials
Fleming, T. R. (1982) · Biometrics · doi:10.2307/2530297 · Cited by 1,004 · see citing works
Coiffier, B., Haïoun, C., Ketterer, N., Engert, A., Tilly, H., F., D. D., Johnson, P., Lister, A., Feuring‐Buske, M., Radford, J. A., et al. (1998) · PubMed · doi:10.1182/blood.v92.6.1927 · Cited by 892 · see citing works
Maloney, D. G., Liles, T. M., Czerwinski, D. K., Waldichuk, C., Rosenberg, J., Grillo-López, A. J., & Levy, R. (1994) · Blood · doi:10.1182/blood.v84.8.2457.2457 · Cited by 761 · see citing works
Maloney, D. G., Grillo-López, A. J., Bodkin, D., White, C. A., Liles, T. M., Royston, I., Varns, C., Rosenberg, J., & Levy, R. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.10.3266 · Cited by 633 · see citing works
Berinstein, N. L., Grillo-López, A. J., White, C. A., Bence‐Bruckler, I., Maloney, D. G., Czuczman, M. S., Green, D., Rosenberg, J., McLaughlin, P. J., & Shen, D. (1998) · Annals of Oncology · doi:10.1023/a:1008416911099 · Cited by 526 · see citing works
Foran, J. M., Rohatiner, A. Z. S., Cunningham, D., Popescu, R. A., Solal‐Céligny, P., Ghielmini, M. E. G., Coiffier, B., Johnson, P., Gisselbrecht, C., Reyes, F., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.2.317 · Cited by 470 · see citing works
Vose, J. M., Link, B. K., Grossbard, M. L., Czuczman, M. S., Grillo-López, A. J., Gilman, P. B., Lowe, A., Kunkel, L., & Fisher, R. I. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.2.389 · Cited by 416 · see citing works
Gordon, L. I., Harrington, D. P., Andersen, J., Colgan, J., Glick, J. H., Neiman, R. S., Mann, R. B., Resnick, G. D., Barcos, M. P., Gottlieb, A. J., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199211053271903 · Cited by 323 · see citing works
Toxicity Grading Criteria of the Japan Clinical Oncology Group
Tobinai, K., Kohno, A., Shimada, Y., Watanabe, T., Tamura, T., Takeyama, K., Narabayashi, M., Fukutomi, T., Kondo, H., Shimoyama, M., et al. (1993) · Japanese Journal of Clinical Oncology · doi:10.1093/oxfordjournals.jjco.a039642 · Cited by 168 · see citing works
Self-citationNguyen, D. T., AMESS, J. A. L., Doughty, H. A., Hendry, L., & Diamond, L. W. (1999) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1999.tb01725.x · Cited by 162 · see citing works
Tobinai, K., Kobayashi, Y., Narabayashi, M., Ogura, M., Kagami, Y., MORISHIMA, Y., Ohtsu, T., Igarashi, T., Sasaki, Y., Kinoshita, T., et al. (1998) · Annals of Oncology · doi:10.1023/a:1008265313133 · Cited by 150 · see citing works
Self-citationKadin, M. E., Berard, C. W., Nanba, K., & Wakasa, H. (1983) · Human Pathology · doi:10.1016/s0046-8177(83)80299-8 · Cited by 144 · see citing works
Igarashi, T., Kobayashi, Y., Ogura, M., Kinoshita, T., Ohtsu, T., Sasaki, Y., MORISHIMA, Y., Murate, T., Kasai, M., Uike, N., et al. (2002) · Annals of Oncology · doi:10.1093/annonc/mdf155 · Cited by 139 · see citing works
Self-citationAntibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen.
Mason, D., Comans-Bitter, W. M., Cordell, J. L., Verhoeven, M., & van Dongen, J. J. M. (1990) · Europe PMC (PubMed Central) · Cited by 131 · see citing works
Banno, S., Yoshikawa, K., Nakamura, S., Yamamoto, K., Seito, T., Nitta, M., Takahashi, T., Ueda, R., & Seto, M. (1994) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1994.tb02969.x · Cited by 55 · see citing works
Self-citationTsuda, F., Okamoto, H., Ukita, M., Tanaka, T., Akahane, Y., Konishi, K., Yoshizawa, H., Miyakawa, Y., & Mayumi, M. (1999) · Journal of Virological Methods · doi:10.1016/s0166-0934(98)00154-2 · Cited by 51 · see citing works
Nakamura, S., Seto, M., Banno, S., Suzuki, S., Koshikawa, T., Kitoh, K., Kagami, Y., Ogura, M., Yatabe, Y., Kojima, M., et al. (1994) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1994.tb02940.x · Cited by 49 · see citing works
Self-citationTsai, D., Moore, H., Hardy, C., Porter, D., Loh, E. Y., Vaughn, D. J., Luger, S. M., Schuster, S., & Stadtmauer, E. A. (1999) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1701944 · Cited by 35 · see citing works
Ohshima, K., Suzumiya, J., Sato, K., Kanda, M., Haraoka, S., & Kikuchi, M. (1998) · Cancer Letters · doi:10.1016/s0304-3835(98)00278-x · Cited by 27 · see citing works
Izumo, T., Maseki, N., Mori, S., & Tsuchiya, E. (2000) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2000.tb00952.x · Cited by 20 · see citing works
Self-citation
Flagged first, then by citations
3 of the 36 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Harris NL, Jaffe ES, Stein H et al. A revised European-American classifi- cation of lymphoid neoplasms: a proposal from the International Lymph- oma Study Group. Blood 1994; 84: 1361-1392.
- Cheson BD, Horning SJ, Coiffier B et al. Report of an international work- shop to standardize response criteria for non-Hodgkin's lymphoma. J Clin Oncol 1999; 17: 1244-1253.
Cited by
Sorted by citations
Rituximab in B-Cell Hematologic Malignancies: A Review of 20 Years of Clinical Experience
Salles, G., Barrett, M., Foà, R., Maurer, J., O'Brien, S. M., Valente, N., Wenger, M., & Maloney, D. G. (2017) · Advances in Therapy · doi:10.1007/s12325-017-0612-x · Cited by 620 · see citing works
Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities
Bittner, B., Richter, W., & Schmidt, J. (2018) · BioDrugs · doi:10.1007/s40259-018-0295-0 · Cited by 447 · see citing works
Witzig, T. E., Vose, J. M., Zinzani, P. L., Reeder, C. B., Buckstein, R. J., Polikoff, J. A., Bouabdallah, R., Haïoun, C., Tilly, H., Guo, P., et al. (2011) · Annals of Oncology · doi:10.1093/annonc/mdq626 · Cited by 392 · see citing works
Review of therapeutic drug monitoring of anticancer drugs part two – Targeted therapies
Widmer, N., Bardin, C., Chatelut, É., Paci, A., Beijnen, J. H., Levêque, D., Veal, G. J., & Astier, A. (2014) · European Journal of Cancer · doi:10.1016/j.ejca.2014.04.015 · Cited by 299 · see citing works
Müller, C., Murawski, N., Wiesen, M. H. J., Held, G., Poeschel, V., Zeynalova, S., Wenger, M., Nickenig, C., Peter, N., Lengfelder, E., et al. (2012) · Blood · doi:10.1182/blood-2011-09-380949 · Cited by 243 · see citing works
Evidence for Therapeutic Drug Monitoring of Targeted Anticancer Therapies
Gao, B., Yeap, S. H., Clements, A., Balakrishnar, B., Wong, M. K., & Gurney, H. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.43.5362 · Cited by 205 · see citing works
Dillman, R. O. (2011) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2010.0902 · Cited by 156 · see citing works
Suboptimal dosing of rituximab in male and female patients with DLBCL
Pfreundschuh, M. G., Müller, C., Zeynalova, S., Kuhnt, E., Wiesen, M. H. J., Held, G., Rixecker, T., Poeschel, V., Zwick, C., Reiser, M., et al. (2013) · Blood · doi:10.1182/blood-2013-07-517037 · Cited by 142 · see citing works
Reactivation of hepatitis B virus with rituximab
Tsutsumi, Y., Kanamori, H., Mori, A., Tanaka, J., Asaka, M., Imamura, M., & Masauzi, N. (2005) · Expert Opinion on Drug Safety · doi:10.1517/14740338.4.3.599 · Cited by 135 · see citing works
Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma
Rubenstein, J. L., Li, J., Chen, L., Advani, R. H., Drappatz, J., Gerstner, E. R., Batchelor, T. T., Krouwer, H. G. J., Hwang, J. Q., Auerback, G. M., et al. (2012) · Blood · doi:10.1182/blood-2012-07-440974 · Cited by 123 · see citing works
Davies, A., Merli, F., Mihaljević, B., Mercadal, S., Siritanaratkul, N., Solal-Céligny, P., Boehnke, A., Berge, C., Genevray, M., Zharkov, A., et al. (2017) · The Lancet Haematology · doi:10.1016/s2352-3026(17)30078-9 · Cited by 125 · see citing works
Pharmacokinetics of rituximab and its clinical use: Thought for the best use?
Cartron, G., Blasco, H., Paintaud, G., Watier, H., & Guellec, C. B. (2007) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2006.09.004 · Cited by 122 · see citing works
Leonard, J. P., Friedberg, J. W., Younes, A., Fisher, D. C., Gordon, L. I., Moore, J. O., Czuczman, M. S., Miller, T. P., Stiff, P. J., Cheson, B. D., et al. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm114 · Cited by 116 · see citing works
Davies, A., Merli, F., Mihaljevic, B., Siritanaratkul, N., Solal-Céligny, P., Barrett, M., Berge, C., Bittner, B., Boehnke, A., McIntyre, C., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70005-1 · Cited by 114 · see citing works
Cancer Chemotherapy: The Case for Therapeutic Drug Monitoring
Knezevic, C. E., & Clarke, W. A. (2019) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000701 · Cited by 111 · see citing works
Buckstein, R. J., Kerbel, R. S., Shaked, Y., Nayar, R., Foden, C., Turner, R. A., Lee, C. R., Taylor, D., Zhang, L., Man, S., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0474 · Cited by 110 · see citing works
McDonald, V., Manns, K., Mackie, I. J., Machin, S. J., & Scully, M. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03818.x · Cited by 109 · see citing works
Pruritus in patients treated with targeted cancer therapies: Systematic review and meta-analysis
Ensslin, C. J., Rosen, A. C., Wu, S., & Lacouture, M. E. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.06.038 · Cited by 101 · see citing works
Tout, M., Casasnovas, O., Meignan, M. A., Lamy, T., Morschhauser, F., Salles, G., Gyan, E., Haïoun, C., Mercier, M., Feugier, P., et al. (2017) · Blood · doi:10.1182/blood-2016-10-744292 · Cited by 98 · see citing works
Pharmacokinetic Behavior of Rituximab
Regazzi, M. B., Iacona, I., Avanzini, M. A., Arcaini, L., Merlini, G., Perfetti, V., Zaja, F. F., Montagna, M., Morra, E., & Lazzarino, M. (2005) · Therapeutic Drug Monitoring · doi:10.1097/01.ftd.0000184162.60197.c1 · Cited by 92 · see citing works
Munnink, T. H. O., Henstra, M. J., Segerink, L., Movig, K. L. L., & Brummelhuis-Visser, P. (2015) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.211 · Cited by 91 · see citing works
Winter, M. C., & Hancock, B. W. (2009) · Expert Opinion on Drug Safety · doi:10.1517/14740330902750114 · Cited by 89 · see citing works
Puisset, F., White‐Koning, M., Kamar, N., Huart, A., Haberer, F., Blasco, H., Guellec, C. B., Lafont, T., Grand, A., Rostaing, L. P. E., et al. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12098 · Cited by 81 · see citing works
Population Pharmacokinetics of Rituximab in Patients With Chronic Lymphocytic Leukemia
Li, J., Zhi, J., Wenger, M., Valente, N., Dmoszyńska, A., Robak, T., Mangat, R., Joshi, A., & Visich, J. E. (2012) · The Journal of Clinical Pharmacology · doi:10.1177/0091270011430506 · Cited by 79 · see citing works
Compagno, N., Cinetto, F., Semenzato, G., & Agostini, C. (2014) · Haematologica · doi:10.3324/haematol.2013.101261 · Cited by 72 · see citing works
Barnes, J. A., Jacobsen, E. D., Feng, Y., Freedman, A. S., Hochberg, E. P., LaCasce, A. S., Armand, P. A., Joyce, R., Sohani, A. R., Rodig, S. J., et al. (2012) · Haematologica · doi:10.3324/haematol.2012.075184 · Cited by 67 · see citing works
Davies, A. J., Berge, C., Boehnke, A., Dadabhoy, A., Lugtenburg, P. J., Rule, S. A., Rummel, M., McIntyre, C., Smith, R. B. W., & Badoux, X. C. A. (2017) · Advances in Therapy · doi:10.1007/s12325-017-0610-z · Cited by 67 · see citing works
Use of rituximab in diffuse large B‐cell lymphoma in the salvage setting
Gisselbrecht, C. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07383.x · Cited by 62 · see citing works
Rožman, S., Grabnar, I., Novaković, S., Mrhar, A., & Novaković, B. J. (2017) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13271 · Cited by 58 · see citing works
Paci, A., Desnoyer, A., Delahousse, J., Blondel, L., Maritaz, C., Chaput, N., Mir, O., & Broutin, S. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.01.005 · Cited by 57 · see citing works
Damen, C. W. N., Schellens, J. H. M., & Beijnen, J. H. (2009) · Human Antibodies · doi:10.3233/hab-2009-0206 · Cited by 53 · see citing works
Pharmacokinetics of therapeutic monoclonal antibodies used in oncology.
Levêque, D., Wisniewski, S., & Jehl, F. (2005) · PubMed · Cited by 47 · see citing works
Assouline, S. E., Buccheri, V., Delmer, A. J., Gaïdano, G., Trněný, M., Berthillon, N., Brewster, M., Catalani, O., Li, S., McIntyre, C., et al. (2016) · The Lancet Haematology · doi:10.1016/s2352-3026(16)00004-1 · Cited by 45 · see citing works
Coiffier, B., Losic, N., Rønn, B. B., Leprêtre, S., Pedersen, L. M., Gadeberg, O., Frederiksen, H., van Oers, M. H. J., Wooldridge, J. E., Kloczko, J. S., et al. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08193.x · Cited by 39 · see citing works
Rationale for optimal obinutuzumab/GA101 dosing regimen in B-cell non-Hodgkin lymphoma
Cartron, G., Hourcade‐Potelleret, F., Morschhauser, F., Salles, G., Wenger, M., Truppel-Hartmann, A., & Carlile, D. J. (2015) · Haematologica · doi:10.3324/haematol.2015.133421 · Cited by 36 · see citing works
Onea, A. S., & Jazirehi, A. R. (2016) · PubMed Central · Cited by 35 · see citing works
Mogamulizumab for the treatment of T-cell lymphoma
Makita, S., & Tobinai, K. (2017) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2017.1347634 · Cited by 35 · see citing works
Self-citationPharmacokinetics of rituximab associated with CHOP chemotherapy in B‐cell non‐Hodgkin lymphoma
Blasco, H., Chatelut, É., Bretagne, I. B., Congy‐Jolivet, N., & Guellec, C. B. (2009) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2009.00714.x · Cited by 30 · see citing works
Tout, M., Gagez, A.-L., Leprêtre, S., Gouilleux‐Gruart, V., Azzopardi, N., Delmer, A. J., Mercier, M., Ysebaert, L., Laribi, K., Gonzalez, H., et al. (2016) · Clinical Pharmacokinetics · doi:10.1007/s40262-016-0470-8 · Cited by 30 · see citing works
Ohmachi, K., Kinoshita, T., Tobinai, K., Ogawa, G., Mizutani, T., Yamauchi, N., Fukuhara, N., Uchida, T., Yamamoto, K., Miyazaki, K., et al. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020002567 · Cited by 29 · see citing works
Self-citationTobinai, K., Ogura, M., Kobayashi, Y., Uchida, T., Watanabe, T., Oyama, T., Maruyama, D., Suzuki, T., Mori, M., Kasai, M., et al. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01809.x · Cited by 29 · see citing works
Self-citationMarin, C., Khoudour, N., Millet, A., Lebert, D., Bros, P., Thomas, F., Ternant, D., Lacarelle, B., Guitton, J., Ciccolini, J., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14080796 · Cited by 28 · see citing works
Tsukasaki, K., Tobinai, K., Hotta, T., & Shimoyama, M. (2011) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyr168 · Cited by 27 · see citing works
Self-citationCasulo, C., Vose, J. M., Ho, W., Kahl, B. S., Brunvand, M. W., Goy, A. H., Kasamon, Y. L., Cheson, B. D., & Friedberg, J. W. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.06.005 · Cited by 26 · see citing works
Liu, W., Bennett, A. L., Ning, W., Tan, H. Y., Berwanger, J. D., Zeng, X., & Bruening, M. L. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b03183 · Cited by 25 · see citing works
Outcomes of primary thyroid non-Hodgkin’s Lymphoma
Čolović, M., Matić, S., Kryeziu, E., Tomin, D., Čolović, N., & Atkinson, H. D. (2007) · Medical Oncology · doi:10.1007/bf02698041 · Cited by 25 · see citing works
Model‐based design of rituximab dosage optimization in follicular non‐Hodgkin's lymphoma
Ternant, D., Cartron, G., Hénin, É., Tod, M. M., Girard, P., & Paintaud, G. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2011.04125.x · Cited by 24 · see citing works
Identification of patients with indolent B cell lymphoma sensitive to rituximab monotherapy
Cornec, D., Tempescul, A., Querellou, S., Hutin, P., Pers, J., Jamin, C., Bendaoud, B., Berthou, C., Renaudineau, Y., & Youinou, P. (2011) · Annals of Hematology · doi:10.1007/s00277-011-1369-y · Cited by 23 · see citing works
Rituximab in chronic lymphocytic leukemia
James, D. F., & Kipps, T. J. (2011) · Advances in Therapy · doi:10.1007/s12325-011-0032-2 · Cited by 21 · see citing works
Tobinai, K., Igarashi, T., Itoh, K., Kurosawa, M., Nagai, H., Hiraoka, A., Kinoshita, T., Uike, N., Ogura, M., Nawano, S., et al. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02001.x · Cited by 20 · see citing works
Self-citationMonoclonal Antibody Monitoring: Clinically Relevant Aspects, A Systematic Critical Review
Regazzi, M. B., Golay, J., & Molinaro, M. (2019) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000681 · Cited by 19 · see citing works
Improved therapeutic outcomes of DLBCL after introduction of rituximab in Korean patients
Lymphoma Study Division of the Korean Cancer Study Group, Park, Y. H., Lee, J. J., Ryu, M., Kim, S. Y., Kim, D. H., Do, Y. R., Lee, K. H., Oh, S. J., Kim, Y. K., et al. (2006) · Annals of Hematology · doi:10.1007/s00277-005-0060-6 · Cited by 19 · see citing works
Clinical Trials for Malignant Lymphoma in Japan
Tobinai, K., & Hotta, T. (2004) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyh060 · Cited by 18 · see citing works
Self-citationBelada, D., Georgiev, P., Dakhil, S. R., Inhorn, L. F., Andorsky, D. J., Beck, J. T., Quick, D. P., Pettengell, R., Daly, R., Dean, J. P., et al. (2016) · Future Oncology · doi:10.2217/fon-2016-0137 · Cited by 17 · see citing works
Li, J., Wang, L., Shen, Y., Xia, Z. G., Chen, Y., Chen, Q. S., Chen, Y., Zeng, X., You, J. H., Qian, Y., et al. (2007) · Annals of Hematology · doi:10.1007/s00277-007-0320-8 · Cited by 17 · see citing works
Jung, S., Lee, J., Kim, W. S., Lee, W., Do, Y. R., Oh, S. Y., Kim, M. K., Mun, Y., Shin, H., Kwak, J., et al. (2014) · European Journal Of Haematology · doi:10.1111/ejh.12459 · Cited by 16 · see citing works
Prevention of Hepatitis B Virus Reactivation Under Rituximab Therapy
Tsutsumi, Y., Yamamoto, Y., Tanaka, J., Asaka, M., Imamura, M., & Masauzi, N. (2009) · Immunotherapy · doi:10.2217/imt.09.59 · Cited by 15 · see citing works
Sano, T., Sakai, H., Takimoto, K., & Ohno, H. (2007) · International Journal of Clinical Oncology · doi:10.1007/s10147-006-0627-9 · Cited by 15 · see citing works
The Influence of Different Disease States on Rituximab Pharmacokinetics
Wang, X., Du, W., Zhang, X., & Li, P. (2020) · Current Drug Metabolism · doi:10.2174/1389200221666200719004035 · Cited by 14 · see citing works
Hill, S. L., & Davies, A. J. (2018) · Future Oncology · doi:10.2217/fon-2017-0574 · Cited by 12 · see citing works
Thuresson, P.-O., Velde, N. V., Gupta, P., & Talbot, J. (2020) · Advances in Therapy · doi:10.1007/s12325-020-01507-7 · Cited by 12 · see citing works
Effects of ultrasound on apoptosis induced by anti-CD20 antibody in CD20-positive B lymphoma cells
Danno, D., Kanno, M., Fujimoto, S., Feril, L. B., Kondo, T., & Nakamura, S. (2007) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2007.08.004 · Cited by 12 · see citing works
Self-citationGui, L., Han, X., He, X., Song, Y., Yao, J., Yang, J., Liu, P., Qin, Y., Zhang, S., Zhang, W., et al. (2016) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2016.02.07 · Cited by 10 · see citing works
Jamois, C., Gibiansky, E., Gibiansky, L. V., Chavanne, C., Morcos, P. N., McIntyre, C., Barrett, M., Lundberg, L., Zharkov, A., Boehnke, A., et al. (2021) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2308 · Cited by 9 · see citing works
Dillman, R. O. (2009) · Springer eBooks · doi:10.1007/978-90-481-2289-9_10 · Cited by 9 · see citing works
for the West-Japan Hematology and Oncology Group (West-JHOG), Nishimori, H., Matsuo, K., Maeda, Y., Nawa, Y., Sunami, K., Togitani, K., Takimoto, H., Hiramatsu, Y., Kiguchi, T., et al. (2009) · International Journal of Hematology · doi:10.1007/s12185-009-0259-8 · Cited by 9 · see citing works
Dyer, M. J. S. (2012) · Therapeutic Advances in Hematology · doi:10.1177/2040620712445329 · Cited by 9 · see citing works
Robles-Bañuelos, B., Romo‐Pérez, A., Domínguez-Gómez, G., Chávez-Blanco, A. D., González‐Fierro, A., & Dueñas‐González, A. (2023) · Clinical & Translational Oncology · doi:10.1007/s12094-023-03352-w · Cited by 8 · see citing works
Single-Agent and Associated Therapies with Monoclonal Antibodies: What About Follicular Lymphoma?
Cancemi, G., Campo, C., Caserta, S., Rizzotti, I., & Mannina, D. (2025) · Cancers · doi:10.3390/cancers17101602 · Cited by 8 · see citing works
Murayama, K., Kiguchi, T., Izutsu, K., Kameoka, Y., Hidaka, M., Kato, H., Rai, S., Kuroda, J., Ishizawa, K., Ichikawa, S., et al. (2022) · Annals of Hematology · doi:10.1007/s00277-022-04801-2 · Cited by 8 · see citing works
Self-citationAydin, S., Dührsen, U., & Nückel, H. (2007) · Annals of Hematology · doi:10.1007/s00277-006-0243-9 · Cited by 8 · see citing works
Modeling combined chemo- and immunotherapy of high-grade non-Hodgkin lymphoma
Roesch, K., Scholz, M. R., & Hasenclever, D. (2015) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2015.1110746 · Cited by 8 · see citing works
Jamois, C., Gibiansky, E., Gibiansky, L. V., Buchheit, V., Sahin, D., Cartron, G., Marcus, R. E., Hiddemann, W., Seymour, J. F., Strefford, J. C., et al. (2019) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13920 · Cited by 8 · see citing works
Liu, S., Huang, H., Chen, R., Wang, Z., Guan, Y.-P., Chen, P., Fang, X., Chen, Z., Guan, S., Zhu, X., et al. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0479-2 · Cited by 7 · see citing works
Liu, S., Wang, Z., Chen, R., Huang, H., Wang, X., Chen, P., Guan, Y., Fang, X., Guan, S., Huang, H., et al. (2021) · Clinical and Translational Science · doi:10.1111/cts.13186 · Cited by 6 · see citing works
Han, X., Zhang, M., Wang, H., Zhang, Q., Li, W., Hao, M.-W., Gao, Y., Jin, J., Ren, H., Tang, Y., et al. (2022) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2022.06.08 · Cited by 6 · see citing works
García, M., Feijoo, M. A. F., & Hernández, M. Á. C. (2009) · Farmacia Hospitalaria · doi:10.1016/s1130-6343(09)72973-3 · Cited by 6 · see citing works
Phase I Dose Escalation Study with the Lewis Y Carbohydrate Specific Humanized Antibody IGN311
Oruzio, D. V., Waxenecker, G., Aulmann, C., Märkl, B., Wagner, T., Mudde, G. C., Schuster, M., Eller, N., Mayer, A., Stranner, S., et al. (2011) · Journal of Cancer Therapy · doi:10.4236/jct.2011.25102 · Cited by 6 · see citing works
Rekeland, I. G., Fluge, Ø., Alme, K., Risa, K., Sørland, K., Mella, O., de Vries, A., & Schjøtt, J. D. (2018) · Clinical Therapeutics · doi:10.1016/j.clinthera.2018.10.019 · Cited by 6 · see citing works
Lavezzi, S. M., de Jong, J., Neyens, M., Cramer, P., Demırkan, F., Fraser, G. A. M., Bartlett, N. L., Dilhuydy, M., Loscertales, J., Avigdor, A., et al. (2019) · Pharmaceutical Research · doi:10.1007/s11095-019-2605-8 · Cited by 6 · see citing works
García, M., Feijoo, M. A. F., & Hernández, M. Á. C. (2009) · Farmacia Hospitalaria (English Edition) · doi:10.1016/s2173-5085(09)70094-2 · Cited by 5 · see citing works
Vendramin, C., & Scully, M. (2019) · La Presse Médicale · doi:10.1016/j.lpm.2019.10.006 · Cited by 5 · see citing works
4. Antibody Therapy for Malignant Lymphoma
Tobinai, K. (2007) · Internal Medicine · doi:10.2169/internalmedicine.46.1782 · Cited by 5 · see citing works
Self-citationMondello, P., Mian, M., Arrigo, C., & Pitini, V. V. (2014) · SpringerPlus · doi:10.1186/2193-1801-3-342 · Cited by 4 · see citing works
37 Drugs that act on the immune system: cytokines and monoclonal antibodies
Vial, T., Descotes, J., Braun, F., & Behrend, M. (2007) · Side effects of drugs annual · doi:10.1016/s0378-6080(06)29037-8 · Cited by 3 · see citing works
Treatment of thrombotic thrombocytopenic purpura
Galstyan, G. M., Maschan, A., Евгеньевна, К. Е., & Калинина, И. И. (2021) · Terapevticheskii arkhiv · doi:10.26442/00403660.2021.06.200894 · Cited by 3 · see citing works
Rituximab dosing in hematological malignancies: an old question, revisited
Morcos, P. N., Boehnke, A., Valente, N., & Mager, D. E. (2019) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-019-03818-1 · Cited by 3 · see citing works
Koguchi, Y., & Redmond, W. L. (2022) · Immunological Investigations · doi:10.1080/08820139.2022.2131570 · Cited by 3 · see citing works
Defining the Starting Dose: Should It Be mg/kg, mg/m2, or Fixed?
Gao, B., Klümpen, H., & Gurney, H. (2013) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4614-9135-4_4 · Cited by 2 · see citing works
Ishikawa, H., Amikura, K., Kawashima, Y., Sakamoto, H., Tanaka, Y., & Nishimura, Y. (2015) · Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) · doi:10.3919/jjsa.76.1362 · Cited by 2 · see citing works
Giraud, M., Cathébras, P. J., Roblin, X., Thibaudin, D., Lamure, S., Mariat, C., Paul, S., & Killian, M. (2021) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2021.02.006 · Cited by 2 · see citing works
rHuPH20-Facilitated Subcutaneous Administration of Monoclonal Antibodies in Cancer Therapy
Dong, W., Chen, M., Wang, J., Xia, L., Wang, Q., Nie, X., Feng, Y., & Fang, Y. (2020) · Immunotherapy · doi:10.2217/imt-2020-0204 · Cited by 1 · see citing works
GLUCOCORTICOIDS AND DISEASE – MODIFYING ANTIRHEUMATIC DRUGS
(2010) · Elsevier eBooks · doi:10.1016/b978-0-444-53273-2.50007-9 · Cited by 1 · see citing works
Research Progress on Quantification Methods of Drug Concentration of Monoclonal Antibodies
Hu, L., Zhang, J., & Shao, H. (2022) · Current Pharmaceutical Analysis · doi:10.2174/1573412918666220329110712 · Cited by 1 · see citing works
Jiang, D., Parshad, S., Zhan, L. J., Sim, H., Siu, L. L., Liu, G., Shapiro, J. D., Price, T. J., Jonker, D. J., Karapetis, C. S., et al. (2023) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2023.08.006 · Cited by 1 · see citing works
Biological therapy of B and T cell lymphoproliferative disorders
Dillman, R. O. (2009) · Springer eBooks · doi:10.1007/978-90-481-2289-9_27 · Cited by 1 · see citing works
Model-based design of rituximab dosing optimization in follicular non-hodgkin lymphoma
Ternant, D., Cartron, G., Hénin, É., Tod, M. M., Girard, P., & Paintaud, G. (2011) · HAL · Cited by 1 · see citing works
Zheng, S., Wang, W., & Zhou, H. (2015) · Pharmaceutical Sciences Encyclopedia · doi:10.1002/9780470571224.pse545 · Cited by 1 · see citing works
Hoque, M. E., Karim, S., Hasan, M. N., & Siddiqui, M. M. R. (2015) · Anwer Khan Modern Medical College Journal · doi:10.3329/akmmcj.v6i1.24982
An update on90Y-ibritumomab tiuxetan in autologous stem cell transplantation
Gisselbrecht, C. (2009) · Hematology Meeting Reports (formerly Haematologica Reports) · doi:10.4081/hmr.v1i5.645
- Authors
- Tobinai, K., Igarashi, T., Itoh, K., Kobayashi, Y., Taniwaki, M., Ogura, M., Kinoshita, T., Hotta, T., Aikawa, K., Tsushita, K., Hiraoka, A., Matsuno, Y., Nakamura, S., Mori, S., & Ohashi, Y.
- Affiliations
- National Cancer Center Hospital (JP)
- National Cancer Center Hospital East (JP)
- Kyoto Prefectural University of Medicine (JP)
- Aichi Cancer Center (JP)
- Nagoya University Hospital (JP)
- Tokai University (JP)
- Sapporo National Hospital (JP)
- Higashi Nagoya National Hospital (JP)
- Osaka International Cancer Institute (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Corresponding author
- Tobinai, K.
- Venue
- Annals of Oncology
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 15
- Issue
- 5
- Pages
- 821-830
- ISSN
- 0923-7534 (ISSN-L)
- OpenAlex
- W2114676941
- Cited by
- 108
- References
- 36
- Citations by year
- 2026: 3 · 2025: 1 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 4 · 2012: 6
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Annals of Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- IC Design Education Center
- Fujita Health University
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
- Health Sciences › Medicine › Neurology › CNS Lymphoma Diagnosis and Treatment
- Keywords
- rituximab, relapsed or refractory B-cell lymphoma, aggressive B-cell lymphoma, rituximab monotherapy, pharmacokinetics, trough concentration, area under the concentration-time curve, overall response rate, progression-free survival, lactate dehydrogenase, infusion-related toxicity, Japanese patients, predictive biomarkers
- MeSH terms
- Rituximab, Adult, Aged, Antibodies, Monoclonal, Antineoplastic Agents, Drug Administration Schedule, Female, Humans, Infusions, Intravenous, Male, Middle Aged, Lymphoma, B-Cell, Disease-Free Survival, Antibodies, Monoclonal, Murine-Derived
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review