The DOI matches its Crossref record; 303 of the 309 references it cites were found in a registry or an index.
ESMO consensus guidelines for the management of patients with metastatic colorectal cancer
Open accessAbstract
Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.
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“Patients with CRC who have tumors harboring a KRAS mutation (including KRAS G12C) do not benefit and thus are not eligible for anti-epidermal growth factor receptor-based therapies8,9.”
From Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial (2024) · cites this paper as [9]
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Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer
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Metadata
- Authors
- Van Cutsem, E., Cervantes, A., Adam, R., Sobrero, A., Van Krieken, J. H., Aderka, D., Aranda Aguilar, E., Bardelli, A., Benson, A., Bodoky, G., Ciardiello, F., D'Hoore, A., Diaz-Rubio, E., Douillard, J.-Y., Ducreux, M., Falcone, A., Grothey, A., Gruenberger, T., Haustermans, K., Heinemann, V., Hoff, P., Köhne, C.-H., Labianca, R., Laurent-Puig, P., Ma, B., Maughan, T., Muro, K., Normanno, N., Österlund, P., Oyen, W. J. G., Papamichael, D., Pentheroudakis, G., Pfeiffer, P., Price, T. J., Punt, C., Ricke, J., Roth, A., Salazar, R., Scheithauer, W., Schmoll, H. J., Tabernero, J., Taïeb, J., Tejpar, S., Wasan, H., Yoshino, T., Zaanan, A., & Arnold, D.
- Affiliations
- Universitat de València (ES)
- Hôpital Paul-Brousse (FR)
- Ospedale Policlinico San Martino (IT)
- Tel Aviv University (IL)
- University of Turin (IT)
- Northwestern Medicine (US)
- Unified Szent István and Szent László Hospital (HU)
- University of Campania "Luigi Vanvitelli" (IT)
- Institut de Cancérologie de l'Ouest (FR)
- Université Paris-Saclay (FR)
- University of Pisa (IT)
- Mayo Clinic (US)
- Krankenanstalt Rudolfstiftung der Stadt Wien (AT)
- KU Leuven (BE)
- Ludwig-Maximilians-Universität München (DE)
- Universidade de São Paulo (BR)
- Klinikum Oldenburg (DE)
- Ospedale Papa Giovanni XXIII (IT)
- Chinese University of Hong Kong (HK)
- University of Oxford (GB)
- Aichi Cancer Center (JP)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Institute of Cancer Research (GB)
- Bank of Cyprus Oncology Center (CY)
- University of Ioannina (GR)
- Odense University Hospital (DK)
- Queen Elizabeth Hospital (AU)
- Amsterdam UMC Location University of Amsterdam (NL)
- University Hospital Magdeburg (DE)
- University Hospital of Geneva (CH)
- Institut Català d'Oncologia (ES)
- Comprehensive Cancer Center Vienna (AT)
- Martin Luther University Halle-Wittenberg (DE)
- Vall d'Hebron Hospital Universitari (ES)
- Universitair Ziekenhuis Leuven (BE)
- Imperial College Healthcare NHS Trust (GB)
- National Cancer Center Hospital East (JP)
- Hôpital Européen Georges-Pompidou (FR)
- ORCID
- Cervantes, A.
- Adam, R.
- Sobrero, A.
- Bardelli, A.
- Benson, A.
- Bodoky, G.
- Ciardiello, F.
- Douillard, J.-Y.
- Ducreux, M.
- Falcone, A.
- Grothey, A.
- Gruenberger, T.
- Haustermans, K.
- Heinemann, V.
- Hoff, P.
- Labianca, R.
- Ma, B.
- Maughan, T.
- Muro, K.
- Normanno, N.
- Oyen, W.J.G.
- Papamichael, D.
- Pentheroudakis, G.
- Pfeiffer, P.
- Price, T.J.
- Punt, C.
- Ricke, J.
- Salazar, R.
- Schmoll, H.J.
- Tabernero, J.
- Tejpar, S.
- Wasan, H.
- Yoshino, T.
- Zaanan, A.
- Arnold, D.
- Venue
- Annals of Oncology
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 27
- Issue
- 8
- Pages
- 1386-1422
- ISSN
- 0923-7534 (ISSN-L)
- OpenAlex
- W2470575266
- Cited by
- 3,421
- References
- 309
- Citations by year
- 2026: 199 · 2025: 236 · 2024: 297 · 2023: 364 · 2022: 481 · 2021: 518 · 2020: 444 · 2019: 365 · 2018: 279 · 2017: 189 · 2016: 39
- FWCI
- 155.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Annals of Oncology (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Lirias (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
- Funders
- Cancer Research UK (13363)
- National Institute for Health and Care Research (11/100/50)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
- Keywords
- metastatic colorectal cancer, colorectal cancer, surgical resection of metastases, systemic therapy, multidisciplinary management, treatment decision-making, evidence-based recommendations
- MeSH terms
- Humans, Neoplasm Metastasis, Prognosis, Biomarkers, Tumor, Colorectal Neoplasms, Guidelines as Topic, Molecular Targeted Therapy
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