Pan-Asian adapted ESMO consensus guidelines for the management of patients with metastatic colorectal cancer: a JSMO–ESMO initiative endorsed by CSCO, KACO, MOS, SSO and TOS
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The most recent version of the European Society for Medical Oncology (ESMO) consensus guidelines for the treatment of patients with metastatic colorectal cancer (mCRC) was published in 2016, identifying both a more strategic approach to the administration of the available systemic therapy choices, and a greater emphasis on the use of ablative techniques, including surgery. At the 2016 ESMO Asia Meeting, in December 2016, it was decided by both ESMO and the Japanese Society of Medical Oncology (JSMO) to convene a special guidelines meeting, endorsed by both ESMO and JSMO, immediately after the JSMO 2017 Annual Meeting. The aim was to adapt the ESMO consensus guidelines to take into account the ethnic differences relating to the toxicity as well as other aspects of certain systemic treatments in patients of Asian ethnicity. These guidelines represent the consensus opinions reached by experts in the treatment of patients with mCRC identified by the Presidents of the oncological societies of Japan (JSMO), China (Chinese Society of Clinical Oncology), Korea (Korean Association for Clinical Oncology), Malaysia (Malaysian Oncological Society), Singapore (Singapore Society of Oncology) and Taiwan (Taiwan Oncology Society). The voting was based on scientific evidence and was independent of both the current treatment practices and the drug availability and reimbursement situations in the individual participating Asian countries.
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Anti-PD1 blockade with pembrolizumab is the new standard of care for patients with dMMR/MSI-H mCRC.
“Consequently, anti-PD1 blockade with pembrolizumab became the new standard of care for patients with dMMR/MSI-H mCRC.8 23 102”
From Current and emerging concepts for systemic treatment of metastatic colorectal cancer (2025) · cites this paper as [23]
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- Authors
- Yoshino, T., Arnold, D., Taniguchi, H., Pentheroudakis, G., Yamazaki, K., Xu, R.-H., Kim, T. W., Ismail, F., Tan, I. B., Yeh, K.-H., Grothey, A., Zhang, S., Ahn, J. B., Mastura, M. Y., Chong, D., Chen, L.-T., Kopetz, S., Eguchi-Nakajima, T., Ebi, H., Ohtsu, A., Cervantes, A., Muro, K., Tabernero, J., Minami, H., Ciardiello, F., & Douillard, J.-Y.
- Affiliations
- National Cancer Center Hospital East (JP)
- Aichi Cancer Center (JP)
- University of Ioannina (GR)
- Shizuoka Cancer Center (JP)
- Sun Yat-sen University (CN)
- Asan Medical Center (KR)
- National Cancer Centre Singapore (SG)
- National Taiwan University (TW)
- Mayo Clinic (US)
- Zhejiang University (CN)
- Yonsei Cancer Hospital (KR)
- Pantai Hospital, Kuala Lumpur (MY)
- National Health Research Institutes (TW)
- The University of Texas MD Anderson Cancer Center (US)
- Kanazawa University (JP)
- Universitat de València (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Kobe University Hospital (JP)
- University of Campania "Luigi Vanvitelli" (IT)
- European Society for Medical Oncology (CH)
- Corresponding author
- Yoshino, T.
- ORCID
- Venue
- Annals of Oncology
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 29
- Issue
- 1
- Pages
- 44-70
- ISSN
- 0923-7534 (ISSN-L)
- OpenAlex
- W2787981425
- Cited by
- 573
- References
- 194
- Citations by year
- 2026: 16 · 2025: 41 · 2024: 72 · 2023: 81 · 2022: 95 · 2021: 103 · 2020: 80 · 2019: 52 · 2018: 32
- FWCI
- 19.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Annals of Oncology (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, cc-by-nc)
- Funders
- Amgen
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Celgene
- Boehringer Ingelheim Japan
- Eisai
- Astellas Pharma
- European Society for Medical Oncology
- Japanese Society of Medical Oncology
- Symphogen
- Sirtex Medical
- Chugai Pharmaceutical
- Eli Lilly Japan
- Japan Society for the Promotion of Science (16K07164)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
- Keywords
- metastatic colorectal cancer, Asian patients, systemic therapy, ablative surgery, treatment options
- MeSH terms
- China, Humans, Malaysia, Neoplasm Metastasis, Taiwan, Colorectal Neoplasms, Asian People, Republic of Korea
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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