The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Acquired chemotherapy resistance in ovarian cancer
Open accessAbstract
Most women diagnosed with high-grade serous ovarian cancer (HGSC) develop recurrent disease and chemotherapy resistance, despite initially responding to treatment. The genomic characteristics of HGSC samples collected at initial surgery have been extensively studied. However, due to challenges of sample collection following treatment, much less is known about the molecular features of recurrent disease. Our recent studies have identified mechanisms of acquired resistance and biomarkers in recurrent HGSCs that could lead to improved treatment approaches.
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“the majority of OvCa patients that initially respond to chemotherapy treatment develop the recurrent disease due to acquired resistance to platinum-based chemotherapy after undergoing multiple cycles of chemotherapy36.”
From Large-scale integrated analysis of ovarian cancer tumors and cell lines identifies an individualized gene expression signature for predicting response to platinum-based chemotherapy (2019) · cites this paper as [36]
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“High-grade serous ovarian cancers (HGSOC) are the most prevalent type of epithelial ovarian tumors (about 75%) and characterized by TP53 driver mutations and extensive genome rearrangement (Christie and Bowtell, 2017).”
From Microphysiological systems as models for immunologically ‘cold’ tumors (2024) · cites this paper as Christie and Bowtell, 2017
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Citations
Cites
Integrated genomic analyses of ovarian carcinoma
Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927
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Whole–genome characterization of chemoresistant ovarian cancer
Patch, A., Christie, E. L., Etemadmoghadam, D., Garsed, D. W., George, J., Fereday, S., Nones, K., Cowin, P. A., Alsop, K., Bailey, P. J., et al. (2015) · Nature · doi:10.1038/nature14410 · Cited by 1,572
Self-citationRethinking ovarian cancer: recommendations for improving outcomes
Vaughan, S., Coward, J. I. G., Bast, R. C., Berchuck, A., Berek, J. S., Brenton, J. D., Coukos, G., Crum, C. P., Drapkin, R., Etemadmoghadam, D., et al. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3144 · Cited by 1,484
Self-citationAlsop, K., Fereday, S., Meldrum, C. J., DeFazio, A., Emmanuel, C., George, J., Dobrovic, A., Birrer, M. J., Webb, P. M., Stewart, C. J. R., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.39.8545 · Cited by 1,204
Self-citationDriver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary
Ahmed, A. A., Etemadmoghadam, D., Temple, J., Lynch, A. G., Riad, M., Sharma, R. N., Stewart, C. J. R., Fereday, S., Caldas, C., DeFazio, A., et al. (2010) · The Journal of Pathology · doi:10.1002/path.2696 · Cited by 815
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Evolution of platinum resistance in high-grade serous ovarian cancer
Cooke, S. L., & Brenton, J. D. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70123-1 · Cited by 213
Christie, E. L., Fereday, S., Doig, K., Pattnaik, S., Dawson, S., & Bowtell, D. D. L. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.70.4627 · Cited by 198
Self-citationDNA-PK Mediates AKT Activation and Apoptosis Inhibition in Clinically Acquired Platinum Resistance
Stronach, E. A., Chen, M. M., Maginn, E. N., Agarwal, R., Mills, G. B., Wasan, H. S., & Gabra, H. (2011) · Neoplasia · doi:10.1593/neo.111032 · Cited by 138
Cowin, P. A., George, J., Fereday, S., Loehrer, E. A., Loo, P. V., Cullinane, C. M., Etemadmoghadam, D., Ftouni, S., Galletta, L., Anglesio, M. S., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0203 · Cited by 109
Self-citationEtemadmoghadam, D., George, J., Cowin, P. A., Cullinane, C. M., Kansara, M., Chenevix‐Trench, G., Gorringe, K. L., Smyth, G. K., & Bowtell, D. D. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015498 · Cited by 105
Self-citationLheureux, S., Bruce, J. P., Burnier, J. V., Karakasis, K., Shaw, P. A., Clarke, B. A., Yang, S. Y. C., Quevedo, R., Li, T., Dowar, M., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.71.3677 · Cited by 92
Standard treatment in advanced ovarian cancer in 2005: the state of the art
Bookman, M. A. (2005) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2005.00444.x · Cited by 70
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Lheureux, S., Gourley, C., Vergote, I. B., & Oza, A. M. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32552-2 · Cited by 2,017
Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer (Review)
Yang, L., Xie, H., Li, Y., Wang, X., Liu, X., & Mai, J. (2022) · Oncology Reports · doi:10.3892/or.2022.8293 · Cited by 327
Zhao, Y., Cao, J., Melamed, A., Worley, M. J., Gockley, A. A., Jones, D., Nia, H. T., Zhang, Y., Stylianopoulos, T., Kumar, A. S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818357116 · Cited by 265
Mahdy, H. A., Ibrahim, M. K., Metwaly, A. M., Belal, A., Mehany, A. B. M., El‐Gamal, K. M., El-Sharkawy, A., Elhendawy, M. A., Radwan, M. M., ElSohly, M. A., et al. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103422 · Cited by 177
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Wang, Q., Peng, H., Qi, X., Wu, M., & Zhao, X. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0199-6 · Cited by 162
Metadata
- Authors
- Christie, E. L., & Bowtell, D. D. L.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Christie, E.L.
- Venue
- Annals of Oncology
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 28
- Issue
- suppl_8
- Pages
- viii13-viii15
- ISSN
- 0923-7534 (ISSN-L)
- OpenAlex
- W2772038399
- Cited by
- 220
- References
- 14
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 31 · 2023: 35 · 2022: 38 · 2021: 47 · 2020: 26 · 2019: 15 · 2018: 2
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Annals of Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council (APP1092856)
- NHMRC (GNT1124309)
- Victorian Cancer Agency (ECSG15012)
- U.S. Army Medical Research and Materiel Command (DAMD17-01-1-0729)
- Topics
- Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- high-grade serous ovarian cancer, recurrent ovarian cancer, biomarkers, drug resistance mechanisms
- MeSH terms
- Antineoplastic Agents, Female, Humans, Neoplasm Recurrence, Local, Ovarian Neoplasms, Cystadenocarcinoma, Serous, Drug Resistance, Neoplasm
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