Cited by 362Nutrition and Health in AgingBody Composition Measurement TechniquesSarcoma Diagnosis and Treatment

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Sarcopenic obesity: hidden muscle wasting and its impact for survival and complications of cancer therapy

Open access

Baracos, V.E., Arribas, L.·2018·Annals of Oncology

Open this paper in CoChat — free account

Abstract

Body composition, defined as the proportions and distribution of lean and fat tissues in the human body, is an emergent theme in clinical oncology. Severe muscle depletion (sarcopenia) is most easily overlooked in obese patients; the advent of secondary analysis of oncologic images provides a precise and specific assessment of sarcopenia. Here, we review the definitions, prevalence and clinical implications of sarcopenic obesity (SO) in medical and surgical oncology. Reported prevalence of SO varies due to the heterogeneity in the definitions and the variability in the cut points used to define low muscle mass and high fat mass. Prevalence of SO in advanced solid tumor patient populations average 9% (range 2.3%-14.6%) overall, and one in four (24.7%, range 5.9%-39.2%) patients with body mass index ≥ 30 kg/m2 are sarcopenic. SO is independently associated with higher mortality and higher rate of complications in systemic and surgical cancer treatment, across multiple cancer sites and treatment plans. These associations remain unexplained, however, it has been hypothesized that patients with sarcopenia are generally unfit and unable to tolerate stress. Another proposed mechanism relates to increased exposure to antineoplastic therapy, i.e. a large fat mass would be expected to inflate drug dose in BSA-based treatments, causing an increased rate of dose-limiting toxicity. Pharmacokinetic data are needed to confirm or refute this hypothesis. Old age, deconditioning, cancer progression, acute or chronic nonmalignant disease and drug side-effects are suggested causes of muscle loss, and it is unknown the degree to which this can be reversed. Sarcopenia can be readily detected before start of cancer treatment, however, clinical management protocols for SO patients require development. Studies of cancer treatment dose-modulation are in progress.

Integrity signals

Registry

Crossref · 10.1093/annonc/mdx810

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Definition and classification of cancer cachexia: an international consensus
Fearon, K., Strasser, F., Anker, S. D., Bosaeus, I. G., Bruera, E. D., Fainsinger, R. L., Jatoi, A., Loprinzi, C. L., Macdonald, N., Mantovani, G., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70218-7 · Cited by 6,020
Self-citation
The Disease Burden Associated With Overweight and Obesity
Must, A. (1999) · JAMA · doi:10.1001/jama.282.16.1523 · Cited by 4,827
CLINICAL CALORIMETRY
Bois, D. D. (1916) · Archives of Internal Medicine · doi:10.1001/archinte.1916.00080130010002 · Cited by 4,355
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: A population-based study
Prado, C. M., Lieffers, J. R., McCargar, L. J., Reiman, T., Sawyer, M. B., Martin, L., & Baracos, V. E. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70153-0 · Cited by 3,238
Self-citation
Cancer Cachexia in the Age of Obesity: Skeletal Muscle Depletion Is a Powerful Prognostic Factor, Independent of Body Mass Index
Martin, L., Birdsell, L., Macdonald, N., Reiman, T., Clandinin, M. T., McCargar, L. J., Murphy, R. A., Ghosh, S., Sawyer, M. B., & Baracos, V. E. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.2722 · Cited by 2,761
Self-citation
A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care
Mourtzakis, M., Prado, C. M. M., Lieffers, J. R., Reiman, T., McCargar, L. J., & Baracos, V. E. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-075 · Cited by 2,224
Self-citation
Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image
Shen, W., Punyanitya, M., Wang, Z., Gallagher, D., St.-Onge, M.-P., Albu, J., Heymsfield, S. B., & Heshka, S. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00744.2004 · Cited by 1,692
Prognostic value of sarcopenia in adults with solid tumours: A meta-analysis and systematic review
Shachar, S. S., Williams, G. R., Muss, H. B., & Nishijima, T. F. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2015.12.030 · Cited by 1,125
Understanding the mechanisms and treatment options in cancer cachexia
Fearon, K. C. H., Arends, J., & Baracos, V. E. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.209 · Cited by 952
Self-citation

Flagged first, then by citations

Show all 51 references

Sorted by citations

Items 201–300 of 362

Low Muscle Mass and Radiodensity Associate with Impaired Pulmonary Function and Respiratory Complications in Patients with Esophageal Cancer
Cameron, M. E., Ayzengart, A., Oduntan, O., Judge, S. M., Judge, A. R., & Awad, Z. T. (2023) · Journal of the American College of Surgeons · doi:10.1097/xcs.0000000000000535 · Cited by 7
A cross-sectional survey study on the correlation analysis of nutritional status and intestinal flora in patients with esophageal cancer
Li, L., XinSheng, Z., Xiang, H., Liu, Z., Liu, L., XiuMing, L., Li, Y., Chen, J., KeMing, Z., HongChi, W., et al. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1424039 · Cited by 6
Significance of skeletal muscle index-to-body mass index ratio as a predictor of post-surgical bleeding after mastectomy in patients with breast cancer
Morikawa, H., Oba, T., Kiyosawa, N., Iji, R., Amitani, M., Chino, T., Shimizu, T., Ono, M., Ito, T., Kanai, T., et al. (2023) · Breast Cancer · doi:10.1007/s12282-023-01483-0 · Cited by 6
Association between ICW/TBW ratio and cancer prognosis: Subanalysis of a population-based retrospective multicenter study
Zhang, W., Cui, X., Li, R., Ji, W., Shi, H., & Cui, J. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.12.004 · Cited by 6
Prognostic value of body composition in patients with digestive tract cancers: A prospective cohort study of 8,267 adults from China
Han, J., Liu, X., Tang, M., Tang, M., Xu, J., Tan, S., Liu, X., & Wu, G. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.04.017 · Cited by 6
Exchange of Quantitative Computed Tomography Assessed Body Composition Data Using Fast Healthcare Interoperability Resources as a Necessary Step Toward Interoperable Integration of Opportunistic Screening Into Clinical Practice: Methodological Development Study
Wen, Y., Choo, V. Y., Eil, J. H., Thun, S., dos Santos, D. P., Käst, J., Sigle, S., Prokosch, H., Ovelgönne, D. L., Borys, K., et al. (2025) · Journal of Medical Internet Research · doi:10.2196/68750 · Cited by 6
Febuxostat reduces muscle wasting in tumor-bearing mice with LM8 osteosarcoma cells via inhibition of reactive oxygen species generation
Tsukamoto, T., Tsujii, M., Odake, K., Iino, T., Nakamura, T., Matsumine, A., & Sudo, A. (2021) · Free Radical Research · doi:10.1080/10715762.2021.1947502 · Cited by 6
Prevalence and Impact of Computed Tomography–Defined Sarcopenia on Survival in Patients with Human Papillomavirus–Positive Oropharyngeal Cancer: A Systematic Review
Edwards, A., Hughes, B. G. M., Brown, T. E., & Bauer, J. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac076 · Cited by 7
Impact of Resistance Training Volume on Physical and Perceptual Outcomes of Breast Cancer Survivors Submitted to a Combined Training Program: A Randomized, Single-Blinded Study
Calonego, C., Alberton, C. L., Santagnello, S. B., Schaun, G. Z., Petrarca, C. R., Umpierre, D., Portella, E. G., Andrade, L. S., Pinheiro, R. M., Gomes, M. L. B., et al. (2023) · Journal of Physical Activity and Health · doi:10.1123/jpah.2022-0097 · Cited by 8
Impact of body composition on outcomes of immune checkpoint inhibitor combination therapy in patients with previously untreated advanced renal cell carcinoma
Ishihara, H., Nishimura, K., Ikeda, T., Fukuda, H., Yoshida, K., Iizuka, J., Kondo, T., & Takagi, T. (2024) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2024.04.008 · Cited by 6
Chemotherapy dosing and toxicity in a patient with muscular dystrophy
Lomma, C., & Ransom, D. T. (2018) · Cancer Reports · doi:10.1002/cnr2.1106 · Cited by 6
The gender-specific adverse association of polycyclic aromatic hydrocarbons on skeletal muscle mass and strength in the general adults and the possible mechanisms in experimental rats
Sun, L., Chen, T., Wang, Z., Fan, J., Cai, S., Fan, C., Zhong, Y., & Li, Y. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.132066 · Cited by 6
The changing face of head and neck cancer: are patients with human papillomavirus-positive disease at greater nutritional risk? A systematic review
Edwards, A., Brown, T. E., Hughes, B. G. M., & Bauer, J. D. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-07056-9 · Cited by 6
Every fifth patient suffered a high nutritional risk—Results of a prospective patient survey in an oncological outpatient center
Jendretzki, J., Henniger, D., Schiffmann, L., Wolz, C., Kollikowski, A., Meining, A., Einsele, H., Winkler, M., & Löffler, C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1033265 · Cited by 5
Skeletal muscle is independently associated with grade 3–4 toxicity in advanced stage pancreatic ductal adenocarcinoma patients receiving chemotherapy
Aberle, M. R., Coolsen, M. M. E., Wenmaekers, G., Volmer, L., Brecheisen, R., van Dijk, D. P. J., Wee, L., van Dam, R. M., de Vos‐Geelen, J., Rensen, S. S., et al. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.11.004 · Cited by 5
Synergy of Body Composition, Exercise Oncology, and Pharmacokinetics: A Narrative Review of Personalizing Paclitaxel Treatment for Breast Cancer
Adriaenssens, N., Wuyts, S. C. M., Steurbaut, S., Sutter, P. D., Vermeulen, A., de Haar-Holleman, A., Beckwée, D., Provyn, S., Casteele, S. V., Zhou, J., et al. (2025) · Cancers · doi:10.3390/cancers17081271 · Cited by 5
What's next in using CT scans to better understand cachexia?
Antoun, S., Rossoni, C., & Lanoy, É. (2018) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000388 · Cited by 5
Onkoloji Hastalarında Beslenme Sorunlarının Yönetimi ve Hemşirenin Rolü
Çömlekçi, N., & Can, G. (2021) · İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi · doi:10.38079/igusabder.981033 · Cited by 5
Comprehensive abdominal composition evaluation of rectal cancer patients with anastomotic leakage compared with body mass index-matched controls
Shao, S., Li, Y.-K., Qin, J., & Liu, L. (2022) · World Journal of Gastrointestinal Surgery · doi:10.4240/wjgs.v14.i11.1250 · Cited by 5
Fat mass index and airway hyperresponsiveness in Korean adults
Shim, J., Kim, S.-S., Lee, S.-H., Kim, M., Cho, Y.-J., & Park, H. (2023) · Postgraduate Medicine · doi:10.1080/00325481.2023.2188000 · Cited by 5
Effects of sarcopenia and myosteatosis are alleviated in reduced port surgery for diverticulitis
Schaffler‐Schaden, D., Mittermair, C., Bittner, F., Zintl, R., Schaffler‐Schaden, D., & Weiss, H. G. (2023) · International Journal of Colorectal Disease · doi:10.1007/s00384-023-04492-9 · Cited by 5
Effect of Sarcopenic Obesity on Weight Loss Outcomes and Quality of Life after Laparoscopic Sleeve Gastrectomy: A Retrospective Cohort Study
Shang‐Guan, Z., Lin, G., Liu, Z.-Y., Zhong, Q., Huang, Q., Li, P., Xie, J., Wang, J.-B., Lü, J., Chen, Q., et al. (2024) · Obesity Surgery · doi:10.1007/s11695-024-07146-z · Cited by 6
The Role of Interleukin-6/GP130 Cytokines in Cancer Cachexia
Jengelley, D. H. A., & Zimmers, T. A. (2022) · Springer eBooks · doi:10.1007/978-3-031-09518-4_6 · Cited by 6
Sarcopenic Obesity
Zamboni, M. M., Macchi, F., Nori, N., & Rossi, A. P. (2021) · Wiley eBooks · doi:10.1002/9781119597896.ch12 · Cited by 5
Synergic value of 3D CT-derived body composition and triglyceride glucose body mass for survival prognostic modeling in unresectable pancreatic cancer
Xu, K., Wang, X., Zhou, C., Zuo, J., Zeng, C., Zhou, P., Zhang, L., Gao, X., & Wang, X. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1499188 · Cited by 4
Measurement of body composition by DXA, BIA, Leg-to-leg BIA and near-infrared spectroscopy in breast cancer patients – comparison of the four methods
Klement, R. J., Joos, F., Reuss-Borst, M. A., & Kämmerer, U. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.02.013 · Cited by 4
The effect of body mass index on quality of life in modified single stoma cutaneous ureterostomy or ileal conduit after radical cystectomy
Zhang, W., Huang, X., Lin, B., Zheng, W., Ke, Z., Lin, X., Chen, J., Cai, H., Lin, Y., Chen, Y., et al. (2023) · Cancer Medicine · doi:10.1002/cam4.6638 · Cited by 4
Nomograms combining computed tomography-based body composition changes with clinical prognostic factors to predict survival in locally advanced cervical cancer patients
Fu, B., Wei, L., Wang, C., Xiong, B., Bo, J., Jiang, X., Zhang, Y., Jia, H., & Dong, J. (2024) · Journal of X-Ray Science and Technology · doi:10.3233/xst-230212 · Cited by 4
Skeletal Muscle Density as a Predictive Marker for Pathologic Complete Response in Triple-Negative Breast Cancer Treated with Neoadjuvant Chemoimmunotherapy
Mun, H. S., Kim, S. H., Lee, J., Park, S. J., Lee, A., Kang, J. K., Park, W. C., Bae, S. Y., Choi, B. O., Hong, J. H., et al. (2025) · Cancers · doi:10.3390/cancers17111768 · Cited by 4
Psoas muscle depletion correlates with poor prognosis and compromised immunity in resectable gastric cancer: A multicenter study
Zhou, H., Zhong, L., Jin, Z., Hou, X., Tang, H., Yang, S., He, Y., Wu, S., Zhang, C., & Wei, Z. (2025) · Seminars in Oncology · doi:10.1016/j.seminoncol.2025.152400 · Cited by 4
Sarcopenic obesity exacerbates gastric cancer prognosis via increased intermuscular and visceral fat accumulation
Li, C.-W., Li, Q., Liu, Y., Zhang, Y., Wang, Z.-K., Xing, Y., Niu, Y.-S., Pang, Y., & Yu, K. (2025) · European journal of medical research · doi:10.1186/s40001-025-03251-6 · Cited by 4
Chemotherapy dose per kilogram lean body mass increased dose-limiting toxicity event in male head and neck cancer with taxane and platinum-based induction therapy
Hung, C.-J., Kang, B., Chang, K.-M., Kang, Y., Yin, C.-H., & Lee, C. (2022) · BMC Cancer · doi:10.1186/s12885-022-10152-y · Cited by 4
Artificial Neural Network Models for Accurate Predictions of Fat-Free and Fat Masses, Using Easy-to-Measure Anthropometric Parameters
Mitu, I., Dimitriu, C.-D., Mitu, O., Preda, C., Mitu, F., & Ciocoiu, M. (2023) · Biomedicines · doi:10.3390/biomedicines11020489 · Cited by 6
An Investigation of the Role of Phase Angle in Malnutrition Risk Evaluation and Clinical Outcomes in Patients with Head and Neck or Brain Tumors Undergoing Radiotherapy
Emir, K. N., Demirel, B., & Atasoy, B. M. (2024) · Nutrition and Cancer · doi:10.1080/01635581.2023.2300496 · Cited by 4
Influence of nutritional status and body composition on postoperative events and outcome in patients treated for primary localized retroperitoneal sarcoma
Ramanovic, M., Novak, M., Perhavec, A., Jordan, T., Popuri, K., & Kozjek, N. R. (2024) · Radiology and Oncology · doi:10.2478/raon-2024-0013 · Cited by 4
Effect of Multimodal Prehabilitation on Muscle Mass in Rectal Cancer Patients Receiving Neoadjuvant Treatment
Yadav, Y., Gupta, A., Singh, A., Kapoor, D., Bisht, S. S., Chaudhary, R., Perwaiz, A., & Chaudhary, A. (2024) · Indian Journal of Surgical Oncology · doi:10.1007/s13193-024-02007-8 · Cited by 4
Body Composition Analysis in Metastatic Non-Small-Cell Lung Cancer: Depicting Sarcopenia in Portuguese Tertiary Care
Mendes, J. L., Ferreira, R. Q., Mata, I., Barreira, J. V., Rodrigues, Y. C. V., Dias, D. D. S., Capelas, M. L., Mäkitie, A. A., Guerreiro, I. M., Pimenta, N. M., et al. (2025) · Cancers · doi:10.3390/cancers17030539 · Cited by 4
The Relationship between Unintentional Weight Loss, Grading System and Overall Survival in Gastric Cancer Patients
Schiessel, D. L., Cavagnari, M. A. V., Mazur, C. E., Melhem, A. R. D. F., Gavarrete, D. D., de Andrade, R. M., & Antunes, L. B. B. (2022) · Nutrition and Cancer · doi:10.1080/01635581.2021.1964545 · Cited by 4
Prognostic value of the modified advanced lung cancer inflammation index in overweight or obese patients with lung cancer: Results from a multicenter study
Xie, H., Ruan, G., Wei, L., Zhang, Q., Ge, Y., Song, M., Zhang, X., Lin, S., Liu, X., Li, X., et al. (2022) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2441 · Cited by 4
Association between quantitative CT body composition analysis and prognosis in cetuximab-based first-line treatment for advanced colorectal cancer patients
Dang, W., Wu, S., Liu, X., Shen, H., Chen, Y., Zhang, Z., Wang, H., Cai, Z., Li, M., Sun, M., et al. (2024) · BMC Cancer · doi:10.1186/s12885-024-13338-8 · Cited by 4
Prediction of hematologic toxicity in luminal type breast cancer patients receiving neoadjuvant chemotherapy using CT L1 level skeletal muscle index
Chen, M., Wang, P., Li, Y., Jin, Z., An, Y., Zhang, Y., & Yuan, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-58433-9 · Cited by 3
Association between muscle mass, visceral adiposity, and histologic tumor stromal features in colon cancer
Ravensbergen, C. J., van Kooten, R. T., Crobach, S., Putter, H., Grootjans, W., Cañete, A. N., Peeters, K. C. M. J., Tollenaar, R. A. �. �., & Mesker, W. E. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.12.012 · Cited by 3
Validation of nutritional screening tools in patients undergoing cancer surgery in low- and middle-income countries
Sremanakova, J., Knight, S. R., Lapitan, M. C., Yenli, E. M. T.-A., Tabiri, S., Ghosh, D., Kingsley, P. A., Valparaiso, A. P., Harrison, E. M., Thomas, M., et al. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1576916 · Cited by 3
Impact of Sarcopenic Obesity on Postoperative Outcomes in Patients With IBD After Bowel Resection Surgery: A Retrospective Cohort Study
Xu, Y., Song, T., Cao, L., Li, Y., Zhu, W., Gong, J., Xu, Z., & Guo, Z. (2025) · Diseases of the Colon & Rectum · doi:10.1097/dcr.0000000000004013 · Cited by 3
Exosomal microRNAs as Central Regulators of Cancer Cachexia: Multi-Omics Insights into Muscle Wasting and Adipose Browning
Khan, F. F., El‐Awady, R., Mehmood, S., Hussain, Z., Othman, M. I., & Majeed, A. B. A. (2026) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5c01051 · Cited by 3
The different survival impacts of body mass index in elderly and non-elderly patients with gastric carcinoma
Sugawara, K., Yamashita, H., Urabe, M., Okumura, Y., Yagi, K., Aikou, S., & Seto, Y. (2021) · Surgical Oncology · doi:10.1016/j.suronc.2021.101549 · Cited by 3
Impact of Sarcopenia on Survival in Patients Treated with FOLFIRINOX in a First-Line Setting for Metastatic Pancreatic Carcinoma
Lellouche, L., Barat, M., Pellat, A., Leroux, J., Corre, F., Hallit, R., Assaf, A., Brézault, C., Dhooge, M., Soyer, P. A., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062211 · Cited by 3
Functional effect of adiponectin and body composition assessment in lung cancer subjects after video‐assisted thoracoscopic surgery ( VATS ) lobectomy
Messina, G., Natale, G., Fiorelli, A., Puca, M. A., Moscatelli, F., Monda, V., Monda, M., Domenico, M. D., Corte, C. M. D., Marsala, G., et al. (2024) · Thoracic Cancer · doi:10.1111/1759-7714.15260 · Cited by 3
Association of Computed Tomography Scan-Assessed Body Composition with Immune and PI3K/AKT Pathway Proteins in Distinct Breast Cancer Tumor Components
Cheng, T. D., Fu, D. A., Falzarano, S. M., Zhang, R., Datta, S., Zhang, W., Omilian, A. R., Aduse‐Poku, L., Bian, J., Irianto, J., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413428 · Cited by 3
Identifying potential beneficiaries of neoadjuvant therapy in borrmann type III and IV gastric cancer: A treatment heterogeneity analysis using causal survival forests
Xing, J., Wang, Y., Cao, M., Shan, F., Li, S., Jia, Y., Xue, K., Miao, R., Li, Z., Yan, C., et al. (2025) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2025.109752 · Cited by 3
Prognostic Value of Sarcopenia and Metabolic Parameters of 18F-FDG-PET/CT in Patients with Advanced Gastroesophageal Cancer
Hinzpeter, R., Mirshahvalad, S. A., Kulanthaivelu, R., Murad, V., Ortega, C., Metser, U., Liu, Z. A., Elimova, E. C., Wong, R. K. S., Yeung, J. C., et al. (2023) · Diagnostics · doi:10.3390/diagnostics13050838 · Cited by 3
Clinical impact of sarcopenia for overweight or obese patients with colorectal cancer
Chen, W., Lin, F., Yu, D., Ren, Q., Zhang, F., Shen, Z.-L., Chen, W., Dong, Q., & Yu, Z. (2023) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyad139 · Cited by 3
Influence of sarcopenia on postoperative complications in patients undergoing autologous microsurgical breast reconstruction: an inverse probability of treatment weighting analysis
Lee, S., Yang, Y.-J., Lee, D. W., Song, S. Y., Lew, D., & Yang, E. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1211593 · Cited by 3
Identification of cachexia in lung cancer patients with an ensemble learning approach
Jia, P., Zhao, Q., Wu, X., Shen, F., Sun, K., & Wang, X. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1380949 · Cited by 3
Association between body composition phenotypes and treatment toxicity in women with cervical cancer undergoing chemoradiotherapy.
Aredes, M., de Paula, N. S. D., & Chaves, G. V. (2024) · Nutrition (Burbank, Los Angeles County, Calif.) · doi:10.1016/j.nut.2024.112539 · Cited by 2
CT-based skeletal muscle loss predicts long term prognosis in patients with distal cholangiocarcinoma undergone pancreaticoduodenectomy
Qu, G., Lyu, S., Zhang, Y., Gao, K., & Zhou, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-87458-x · Cited by 2
Influence of capping chemotherapy prescriptions on efficacy and tolerability in medium and high-risk early-stage breast cancer
Bouleftour, W., Aurane, R., Tinquaut, F., Rivoirard, R., & Forges, F. (2025) · Scientific Reports · doi:10.1038/s41598-025-14279-3 · Cited by 2
Prognostic Value of Body Fat Density in Colorectal Cancer Adjuvant Treatment: A Retrospective Cohort Study
André, J. C. S., Murad, L. B., Martins, T. V., Silva, G. D. S. V., de Oliveira, L. C., Chaves, G. V., & Peres, W. A. F. (2025) · Nutrition and Cancer · doi:10.1080/01635581.2025.2603567 · Cited by 2
Abnormal body composition related to the early clinical adverse outcome after HSCT
Zong, L.-L., Zhang, X., Jiang, S.-S., Hu, B., Ge, Y., Zhu, X., Xue, S., & Yang, J. (2022) · Bone Marrow Transplantation · doi:10.1038/s41409-022-01687-6 · Cited by 2
The prevalence of sarcopenia amongst non-small cell lung cancer patients, assessed using computed tomography, prior to treatment in a South African setting
Metelo-Liquito, L. D., Solomon, C., & Bhana-Nathoo, D. (2022) · South African Journal of Oncology · doi:10.4102/sajo.v6i0.218 · Cited by 2
Erector Spinae Muscle to Epicardial Visceral Fat Ratio on Chest CT Predicts the Severity of Coronavirus Disease 2019
Shimada, T., Maetani, T., Chubachi, S., Tanabe, N., Asakura, T., Namkoong, H., Tanaka, H., Azekawa, S., Otake, S., Nakagawara, K., et al. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13721 · Cited by 2
Pharmacokinetic Study of Carboplatin Using Various Overweight-Correcting Dosing Algorithms and Biomarkers in Patients With Varying BMI Categories
Kicken, M. P., Bethlehem, C., Beunen, K., de Jong, P., van Voorthuizen, T., van den Hudding, J. J., Moes, D.-J. A. R., van Luin, M., ter Heine, R., Smit, H. J. M., et al. (2025) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000001328 · Cited by 2
Impact of fat distribution and muscle on survival in overweight and obese breast cancer patients
Zhao, H., Li, X., Liu, C., Zheng, X., Chen, Y., Liu, X., Bu, Z., & Shi, H. (2025) · Nutrition · doi:10.1016/j.nut.2025.112882 · Cited by 2
Sarcopenia in Urothelial Bladder Carcinoma: A Narrative Review
Vrabie, C. R., Paroșanu, A. I., & Niţipir, C. (2025) · Medicina · doi:10.3390/medicina61071307 · Cited by 3
Cancer Cachexia in Clinical Practice: A Review of Treatment Barriers Among Cancer Patients
Alamawi, N., Alsharawneh, A., Abualruz, H., & Aburuz, S. (2025) · European Journal of Cancer Care · doi:10.1155/ecc/6659047 · Cited by 2
The Role of Energy Balance on Colorectal Cancer Survival
Purcell, S. A., Xiao, J., Ford, K. L., & Prado, C. M. M. (2018) · Current Colorectal Cancer Reports · doi:10.1007/s11888-018-0423-8 · Cited by 2
Body Composition Analysis of 10 Years versus 5 Years of Adjuvant Endocrine Therapy in Patients with Nonmetastatic Breast Cancer
Hu, R., Cheng, X., Liu, J., Xu, L., Wang, R., Yu, D., Fan, Y., & Yu, Z. (2021) · Journal of Oncology · doi:10.1155/2021/6659680 · Cited by 2
Sarcopenic obesity in early breast cancer patients with metabolic syndrome: a cross-sectional study
Bulut, G., & Atçı, N. (2022) · Future Oncology · doi:10.2217/fon-2022-0155 · Cited by 2
Rapid Standardized CT-Based Method to Determine Lean Body Mass SUV for PET—A Significant Improvement Over Prediction Equations
Riauka, T., Baracos, V., Reif, R., Juengling, F., Robinson, D. M., Wieler, M., & McEwan, A. B. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.812777 · Cited by 2
Self-citation
Medication-related adverse events in patients with cancer and discrepancies in cystatin C- versus creatinine-based eGFRPreprint
Hanna, P. E., Wang, Q., Strohbehn, I. A., Moreno, D., Harden, D., Ouyang, T., Katz‐Agranov, N., Seethapathy, H. S., Reynolds, K. L., Gupta, S., et al. (2023) · medRxiv · doi:10.1101/2023.01.18.23284656 · Cited by 2
The Modulation of Adipokines, Adipomyokines, and Sleep Disorders on Carcinogenesis
Brzecka, A., Martynowicz, H., Daroszewski, C., MAJCHRZAK, M. W., Ejma, M., Misiuk‐Hojło, M., Somasundaram, S. G., Kirkland, C. E., & Kosacka, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12072655 · Cited by 1
The Prognostic Nutritional Index in patients with microsatellite instability-high metastatic gastric or gastroesophageal cancers receiving immune checkpoint inhibitors
Ghelardi, F., Fucà, G., Cavalli, C., Shitara, K., Cohen, R., Ambrosini, M., Maron, S. B., Cerantola, R., Nasca, V., Liberti, G. D., et al. (2024) · Digestive and Liver Disease · doi:10.1016/j.dld.2024.05.005 · Cited by 1
Prediction of lymph node metastasis in T1 colorectal cancer based on combination of body composition and vascular invasion
Zhou, S., Yuan, Q., Liu, L., Wang, K., Miao, J., Wang, H., Ding, C., & Guan, W. (2024) · International Journal of Colorectal Disease · doi:10.1007/s00384-024-04653-4 · Cited by 1
Body Composition Assessment Provides Prognostic Information in Patients With Cancer Affected by Chronic Graft vs. Host Disease
Mishra, A., Thapa, R., Bigam, K. D., Extermann, M., Faramand, R. G., Khimani, F., Wang, X., Baracos, V. E., & Pidala, J. A. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13759 · Cited by 1
Self-citation
Development and External Validation of a Nomogram Predicting Early Recurrence of Gallbladder Cancer Using Preoperatively Available Prognosticators: A Korean Multicenter Retrospective Study
Jeon, H. J., Yoon, S. K., Park, B., Kim, H. S., Chae, H., Kim, H., Shin, S. H., Han, I. W., Heo, J. S., Lee, O., et al. (2025) · Cancers · doi:10.3390/cancers17091450 · Cited by 1
Longitudinal changes in body composition during palliative systemic chemotherapy and survival outcomes in metastatic colorectal cancer
Jeong, H., Ko, Y., Kim, K. W., Lee, J. S., Seo, S., Kim, S. Y., Hong, Y. S., Kim, J. E., & Kim, T. W. (2025) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v17.i5.103479 · Cited by 1
48 Week body composition changes in persons with HIV switching to dolutegravir plus lamivudine: a planned subanalysis of the DOLAM randomized clinical trial
de Lazzari, E., Gregorio, S. D., Rojas, J., Curran, A., Domingo, P., Negredo, E., Tiraboschi, J. M., Gonzalez‐Cordón, A., Torres, B., Sempere, A., et al. (2025) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaf192 · Cited by 1
Preoperative weight loss and postoperative pancreatic fistula risk affected by body mass index: a National Surgical Quality Improvement Program study
Sun, J. X., Hwang, J., Fredette, J. D., Papai, E., Miller, L., Krempa, J., Rives, H., & Reddy, S. S. (2025) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2025.102157 · Cited by 1
Exploring awareness, perceptions, and practices relating to nutritional status and low muscle mass in patients with ovarian cancer
Benna-Doyle, S., Kiss, N. K., Laing, E., Loeliger, J. M., & Baguley, B. J. (2025) · Supportive Care in Cancer · doi:10.1007/s00520-025-09739-5 · Cited by 1
Patient‐Reported Outcomes and Body Composition Changes in Patients With Colorectal Cancer During Chemotherapy: A Longitudinal Study
Wu, Y., Yu, X., Huang, S., Luo, X., Lv, D., Du, H., Zhang, J., Ke, X., & Liu, D. (2025) · Journal of Nursing Management · doi:10.1155/jonm/1268096 · Cited by 1
The role of nutritional support in advanced cancer: a systematic review of weight, quality of life, and treatment tolerance outcomes
Vega, M., Regö, S., Gabor, S., Niernberger, T., Urban, I., & Pichler, M. (2025) · European surgery. Supplement/European surgery · doi:10.1007/s10353-025-00892-z · Cited by 1
Visceral fat assessment in rectal adenocarcinoma: the role of computed tomography, sagittal abdominal diameter, and waist circumference
Mônaco-Ferreira, D. V., Magro, D. O., Cardia, P. P., Fratta, C. L., Martins, D. L., Martinez, C. A. R., & Coy, C. S. R. (2025) · Acta Cirúrgica Brasileira · doi:10.1590/acb407925 · Cited by 1
Retrospective Analysis of the Association Between Sarcopenia and Fall Risk in Older Breast Cancer Patients Using Real World Data ( TriNetX )
Namoos, A. M., Ramadan, R., Ramadan, D. A., Liang, A., & Thomson, N. D. (2025) · Cancer Medicine · doi:10.1002/cam4.71404 · Cited by 1
Association between neutrophil percentage to albumin ratio and sarcopenia among cancer patients: evidence from both the Chinese and American cohorts
Yu, Y., & Chen, B. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1709323 · Cited by 1
A simple score of sarcopenic obesity predicts all-cause mortality in patients with cirrhosis
Yang, Y., Wei, T., Yang, S., Fei, R., Tie, C., Han, R., Ma, D., Jin, Q., Wang, J., Wang, Z., et al. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1719899 · Cited by 1
Dual-center development and validation of an immunoinflammatory-based preoperative model for predicting postoperative cachexia in colorectal cancer
Liang, J., Zhang, C., Zhao, F., & Wang, D. (2026) · Updates in Surgery · doi:10.1007/s13304-025-02494-6 · Cited by 1
Investigating the Prognostic Value of Pretreatment Body Composition in Women with Ovarian Cancer: Impact on Clinical Outcomes
Benna-Doyle, S., Laing, E., Baguley, B. J., Hardcastle, N., Abbott, G., & Kiss, N. K. (2026) · Cancers · doi:10.3390/cancers18091478 · Cited by 1
Association of TyG-BMI and malnutrition with reduced survival outcomes in patients with cancer: a prospective study
Gong, Y., Zhang, B.-M., Liao, C., Zhu, L., & Ruan, G. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1887549 · Cited by 1
Aetiology, classification, assessment, and treatment of the anorexia-cachexia syndrome
Baracos, V. E., & Watanabe, S. (2021) · doi:10.1093/med/9780198821328.003.0056 · Cited by 1
Self-citation
A convenient calf proportion index calculator for survival prediction in overweight and obese patients with cancer
Huang, J., Zhang, X., Zhu, W., Tang, M. Y., Song, C., Cui, J., Yang, M. A., Zhao, C., Wang, C., Shi, H., et al. (2024) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2024.07.003 · Cited by 1
Powikłania terapii hormonalnej (ADT – androgen deprivation therapy) a układ ruchu u pacjentów z rakiem prostaty
Korczak, J. (2020) · Letters in Oncology Science · doi:10.21641/los.2020.17.1.156 · Cited by 1
Exercise Oncology from Post-treatment to End of Life: An Overview of Outcomes and Considerations
Bloomquist, K., & Hayes, S. C. (2020) · Springer eBooks · doi:10.1007/978-3-030-42011-6_11 · Cited by 1
Adipose Tissue and Cancer Cachexia: What Nurses Need to Know
McClement, S. (2021) · Asia-Pacific Journal of Oncology Nursing · doi:10.4103/apjon.apjon-2134 · Cited by 1
Weight-adjusted urinary creatinine excretion predicts transplant outcomes in adult patients with acute myeloid leukemia in complete remission
Nagata, A., Otsuka, Y., Konuma, R., Adachi, H., Wada, A., Kishida, Y., Konishi, T., Yamada, Y., Nagata, R., Noguchi, Y., et al. (2022) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2022.2109334 · Cited by 1
Body-mass index and metastatic melanoma outcomes
Daly, L. E., Ryan, A. M., & Power, D. G. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30263-8 · Cited by 1
Significance of Body Composition and Systemic Inflammation in Patients with Operable Colon Cancer Treated with Curative Intent
Hsin, W., Moore, M. M., Rouse, H. C., & Hong, W. (2019) · Annals of Clinical Oncology · doi:10.31487/j.aco.2019.03.01
Composição corporal de pacientes com carcinoma hepatocelular no prognóstico clínico da doença, por meio de impedância bioelétrica por espectroscopia e ressonância magnética
Pagano, A. P. (2020) · doi:10.11606/d.17.2020.tde-17122019-144806
Is body composition linked to prostate cancer survival?
Csizmadi, I., & Aronson, W. J. (2021) · Nature Reviews Urology · doi:10.1038/s41585-021-00427-7
Sarcopenia in head and neck cancer
Chargi, N. (2021) · doi:10.33540/804
The relationship between evolving sarcopenia and efficacy of immune checkpoint inhibitor in non‐small cell lung cancer patients
Makiguchi, T., Tanaka, H., Taima, K., Tatsuo, S., Iida, S., Kakeda, S., & Tasaka, S. (2021) · JCSM Clinical Reports · doi:10.1002/crt2.40

Authors: Baracos, V. E., & Arribas, L.
Affiliations: University of Alberta (CA)
Institut d'Investigació Biomédica de Bellvitge (ES)
Corresponding author: Baracos, V.E.
ORCID: Baracos, V.E.
Arribas, L.
Venue: Annals of Oncology
Publisher: Elsevier BV
Published: 2018-02
Volume: 29
Issue: suppl_2
Pages: ii1-ii9
ISSN: 0923-7534 (ISSN-L)
DOI: 10.1093/annonc/mdx810
OpenAlex: W2794311213
Cited by: 362
References: 51
Citations by year: 2026: 36 · 2025: 41 · 2024: 41 · 2023: 55 · 2022: 54 · 2021: 56 · 2020: 41 · 2019: 25 · 2018: 13
FWCI: 23.30
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 631 d)
Locations: Annals of Oncology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
Keywords: sarcopenic obesity, sarcopenia, obesity, muscle atrophy, body composition, cancer treatment complications, survival, dose-limiting toxicity, antineoplastic therapy, body mass index, pharmacokinetics, surgical oncology, medical oncology
MeSH terms: Antineoplastic Agents, Body Composition, Clinical Trials as Topic, Humans, Neoplasms, Obesity, Postoperative Complications, Surgical Procedures, Operative, Body Mass Index, Prevalence, Survival Analysis, Muscle, Skeletal, Neoadjuvant Therapy, Sarcopenia, Chemoradiotherapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sarcopenic obesity: hidden muscle wasting and its impact for survival and complications of cancer therapy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks