The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)
Open accessAbstract
Background: In order to facilitate implementation of precision medicine in clinical management of cancer, there is a need to harmonise and standardise the reporting and interpretation of clinically relevant genomics data. Methods: The European Society for Medical Oncology (ESMO) Translational Research and Precision Medicine Working Group (TR and PM WG) launched a collaborative project to propose a classification system for molecular aberrations based on the evidence available supporting their value as clinical targets. A group of experts from several institutions was assembled to review available evidence, reach a consensus on grading criteria and present a classification system. This was then reviewed, amended and finally approved by the ESMO TR and PM WG and the ESMO leadership. Results: This first version of the ESMO Scale of Clinical Actionability for molecular Targets (ESCAT) defines six levels of clinical evidence for molecular targets according to the implications for patient management: tier I, targets ready for implementation in routine clinical decisions; tier II, investigational targets that likely define a patient population that benefits from a targeted drug but additional data are needed; tier III, clinical benefit previously demonstrated in other tumour types or for similar molecular targets; tier IV, preclinical evidence of actionability; tier V, evidence supporting co-targeting approaches; and tier X, lack of evidence for actionability. Conclusions: The ESCAT defines clinical evidence-based criteria to prioritise genomic alterations as markers to select patients for targeted therapies. This classification system aims to offer a common language for all the relevant stakeholders in cancer medicine and drug development.
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Cited by
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Liquid biopsy enters the clinic — implementation issues and future challenges
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Oesophageal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
Obermannová, R., Alsina, M., Cervantes, A., Leong, T., Lordick, F., Nilsson, M., van Grieken, N. C. T., Vogel, A., & Smyth, E. C. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.07.003 · Cited by 730
Metadata
- Authors
- Mateo, J., Chakravarty, D., Dienstmann, R., Jezdic, S., Gonzalez-Perez, A., Lopez-Bigas, N., Ng, C. K. Y., Bedard, P. L., Tortora, G., Douillard, J.-Y., Van Allen, E. M., Schultz, N., Swanton, C., André, F., & Pusztai, L.
- Venue
- Annals of Oncology
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 29
- Issue
- 9
- Pages
- 1895-1902
- ISSN
- 0923-7534 (ISSN-L)
- OpenAlex
- W2888034354
- Cited by
- 815
- References
- 18
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Mateo, J., Chakravarty, D., Dienstmann, R., Jezdic, S., Gonzalez-Perez, A., Lopez-Bigas, N., Ng, C. K. Y., Bedard, P. L., Tortora, G., Douillard, J.-Y., Van Allen, E. M., Schultz, N., Swanton, C., André, F., & Pusztai, L. (2018). A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT). Annals of Oncology. https://doi.org/10.1093/annonc/mdy263
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