The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Network approaches to systems biology analysis of complex disease: integrative methods for multi-omics data
Open accessAbstract
In the past decade, significant progress has been made in complex disease research across multiple omics layers from genome, transcriptome and proteome to metabolome. There is an increasing awareness of the importance of biological interconnections, and much success has been achieved using systems biology approaches. However, because of the typical focus on one single omics layer at a time, existing systems biology findings explain only a modest portion of complex disease. Recent advances in multi-omics data collection and sharing present us new opportunities for studying complex diseases in a more comprehensive fashion, and yet simultaneously create new challenges considering the unprecedented data dimensionality and diversity. Here, our goal is to review extant and emerging network approaches that can be applied across multiple biological layers to facilitate a more comprehensive and integrative multilayered omics analysis of complex diseases.
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Cited by
Multi-omics Data Integration, Interpretation, and Its Application
Subramanian, I., Verma, S., Kumar, S., Jere, A., & Anamika, K. (2020) · Bioinformatics and Biology Insights · doi:10.1177/1177932219899051 · Cited by 1,609
Integration strategies of multi-omics data for machine learning analysis
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Menyhárt, O., & Győrffy, B. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.01.009 · Cited by 380
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The need for an integrated multi-OMICs approach in microbiome science in the food system
Ferrocino, I., Rantsiou, K., McClure, R., Kostic, T., de Souza, R. S. C., Lange, L., FitzGerald, J., Kriaa, A., Cotter, P., Maguin, E., et al. (2023) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13103 · Cited by 110
Metadata
- Authors
- Yan, J., Risacher, S. L., Shen, L., & Saykin, A. J.
- Venue
- Briefings in Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-06-30
- Volume
- 19
- Issue
- 6
- Pages
- 1370-1381
- ISSN
- 1467-5463 (ISSN-L)
- 1477-4054
- OpenAlex
- W2733047156
- Cited by
- 325
- References
- 109
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- green
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