Cited by 110Gut microbiota and healthProbiotics and Fermented FoodsGenomics and Phylogenetic Studies

The need for an integrated multi-OMICs approach in microbiome science in the food system

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Ferrocino, Ilario, Rantsiou, Kalliopi, McClure, Ryan, Kostic, Tanja, de Souza, Rafael Soares Correa, Lange, Lene, FitzGerald, Jamie, Kriaa, Aicha +8 more·2023·Comprehensive Reviews in Food Science and Food Safety

Abstract

Microbiome science as an interdisciplinary research field has evolved rapidly over the past two decades, becoming a popular topic not only in the scientific community and among the general public, but also in the food industry due to the growing demand for microbiome-based technologies that provide added-value solutions. Microbiome research has expanded in the context of food systems, strongly driven by methodological advances in different -omics fields that leverage our understanding of microbial diversity and function. However, managing and integrating different complex -omics layers are still challenging. Within the Coordinated Support Action MicrobiomeSupport (https://www.microbiomesupport.eu/), a project supported by the European Commission, the workshop "Metagenomics, Metaproteomics and Metabolomics: the need for data integration in microbiome research" gathered 70 participants from different microbiome research fields relevant to food systems, to discuss challenges in microbiome research and to promote a switch from microbiome-based descriptive studies to functional studies, elucidating the biology and interactive roles of microbiomes in food systems. A combination of technologies is proposed. This will reduce the biases resulting from each individual technology and result in a more comprehensive view of the biological system as a whole. Although combinations of different datasets are still rare, advanced bioinformatics tools and artificial intelligence approaches can contribute to understanding, prediction, and management of the microbiome, thereby providing the basis for the improvement of food quality and safety.

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  • Shotgun metagenomics is the sole approach able to comprehensively survey the microbial composition of a sample and unearth its genomic potential along with the reconstruction of genomes of multiple strains.

    “While cultivation has extended to high-throughput settings, 14 shotgun metagenomics is the sole approach able to comprehensively survey the microbial composition of a sample and unearth its genomic potential 12,15 along with the reconstruction of genomes of multiple strains. 16,17”

    From Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome. (2024) · cites this paper as [15]

    Section 3.3 (page unavailable) says shotgun metagenomics is used to study the components and functions of food ecosystems, and that DNA-based approaches provide a global view of the microbiome and can resolve strain-level differences. It does not establish that shotgun metagenomics is the sole approach able to comprehensively survey any sample. The genome-reconstruction clause has separate citations in the citing sentence, so it is not attributed to this source here. (LLM, conf=0.84)

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Research works printed but not linked: 5

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Authors
Ferrocino, I., Rantsiou, K., McClure, R., Kostic, T., de Souza, R. S. C., Lange, L., FitzGerald, J., Kriaa, A., Cotter, P., Maguin, E., Schelkle, B., Schloter, M., Berg, G., Sessitsch, A., Cocolin, L., & The MicrobiomeSupport Consortium
Affiliations
  • University of Turin (IT)
  • Pacific Northwest National Laboratory (US)
  • AIT Austrian Institute of Technology GmbH (AT)
  • Genomics for Climate Change Research Center (GCCRC) Universidade Estadual de Campinas (UNICAMP) Campinas São Paulo Brazil
  • BioEconomy Research & Advisory Valby Denmark
  • Teagasc - The Irish Agriculture and Food Development Authority (IE)
  • MICALIS, INRA, AgroParisTech Université Paris‐Saclay Jouy‐en‐Josas France
  • AgroParisTech (FR)
  • European Food Information Council (BE)
  • Helmholtz Munich (DE)
  • Graz University of Technology (AT)
Corresponding author
Cocolin, Luca
Venue
Comprehensive Reviews in Food Science and Food Safety
Publisher
Wiley
Published
2023-01-12
Volume
22
Issue
2
Pages
1082-1103
ISSN
1541-4337 (ISSN-L)
OpenAlex
W4315927601
Cited by
110
References
154
Citations by year
2026: 48 · 2025: 39 · 2024: 16 · 2023: 7
FWCI
9.77
Type
journal article
Language
en
Open access
Locations
  • Comprehensive Reviews in Food Science and Food Safety (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
  • PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion, cc-by)
Funders
European Commission (HORIZON2020, 818116)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords
microbiome, multi-omics integration, metagenomics, metaproteomics, metabolomics, food systems, food quality, food safety, microbial diversity
MeSH terms
Multiomics, Artificial Intelligence, Humans, Metabolomics, Metagenomics, Microbiota

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