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Cited by 209

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Characterization of the folding degree of proteins

Open access
Estrada, Ernesto·2002·Bioinformatics

Abstract

Motivation: The characterization of the folding degree of chains is central to the elucidation of structure--function relationships in proteins. Here we present a new index for characterizing the folding degree of a (protein) chain. This index shows a range of features that are desirable for the study of the relation between structure and function in proteins. Results: A novel index characterizing the folding degree of (protein) chains is developed based on the spectral moments of a matrix representing the dihedral angles (φ, ω and ε) of the protein main chain. The proposed index is normalized to the chain size, is not correlated to the gyration radius of the backbone chain and is able to distinguish between structures for which the sum of the main-chain dihedral angles is identical. The index is well correlated to the percentages of helix and strand in proteins, shows a linear dependence with temperature changes, and is able to differentiate among protein families. Availability: On request from the author. Contact: estrada66@yahoo.com

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Crossref · 10.1093/bioinformatics/18.5.697

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Metadata

Authors
Estrada, E.
Venue
Bioinformatics
Published
2002-05-01
Volume
18
Issue
5
Pages
697-704
ISSN
  • 1367-4803 (ISSN-L)
  • 1367-4811
OpenAlex
W2164412882
Cited by
209
References
3
FWCI
1.19
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Characterization of the folding degree of proteins. https://app.cochat.ai/papers/10.1093/bioinformatics/18.5.697
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Estrada, E. (2002). Characterization of the folding degree of proteins. Bioinformatics. https://doi.org/10.1093/bioinformatics/18.5.697

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