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limmaGUI: A graphical user interface for linear modeling of microarray data

Open access
Wettenhall, James M., Smyth, Gordon K.·2004·Bioinformatics

Abstract

Summary: limmaGUI is a graphical user interface (GUI) based on R-Tcl/Tk for the exploration and linear modeling of data from two-color spotted microarray experiments, especially the assessment of differential expression in complex experiments. limmaGUI provides an interface to the statistical methods of the limma package for R, and is itself implemented as an R package. The software provides point and click access to a range of methods for background correction, graphical display, normalization, and analysis of microarray data. Arbitrarily complex microarray experiments involving multiple RNA sources can be accomodated using linear models and contrasts. Empirical Bayes shrinkage of the gene-wise residual variances is provided to ensure stable results even when the number of arrays is small. Integrated support is provided for quantitative spot quality weights, control spots, within-array replicate spots and multiple testing. limmaGUI is available for most platforms on the which R runs including Windows, Mac and most flavors of Unix. Availability: http://bioinf.wehi.edu.au/limmaGUI

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Metadata

Authors
Wettenhall, J. M., & Smyth, G. K.
Venue
Bioinformatics
Published
2004-08-05
Volume
20
Issue
18
Pages
3705-3706
ISSN
  • 1367-4803 (ISSN-L)
  • 1367-4811
OpenAlex
W2101163066
Cited by
722
References
2
FWCI
7.11
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: limmaGUI: A graphical user interface for linear modeling of microarray data. https://app.cochat.ai/papers/10.1093/bioinformatics/bth449
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Wettenhall, J. M., & Smyth, G. K. (2004). limmaGUI: A graphical user interface for linear modeling of microarray data. Bioinformatics. https://doi.org/10.1093/bioinformatics/bth449

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