Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination
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These miRs play important roles during myelination.
“In these studies, over-expression of miR-219-5p, miR-338-5p, and miR-338-3p was shown to promote rodent OPC differentiation, indicating that these miRs play important roles during myelination (Lau et al., 2008; Budde et al., 2010; Dugas et al., 2010).”
From Regulation of miRNA 219 and miRNA Clusters 338 and 17-92 in Oligodendrocytes (2012) · cites this paper as Dugas et al., 2010
Over-expression of miR-219-5p, miR-338-5p, and miR-338-3p promotes rodent OPC differentiation.
“In these studies, over-expression of miR-219-5p, miR-338-5p, and miR-338-3p was shown to promote rodent OPC differentiation, indicating that these miRs play important roles during myelination (Lau et al., 2008; Budde et al., 2010; Dugas et al., 2010).”
From Regulation of miRNA 219 and miRNA Clusters 338 and 17-92 in Oligodendrocytes (2012) · cites this paper as Dugas et al., 2010
The miR-338 cluster is expressed in human OLs.
“In summary, we provide the first evidence that miR-338 cluster is expressed in human OLs, as previously demonstrated in rodents (Lau et al., 2008; Dugas et al., 2010; Zhao et al., 2010).”
From Regulation of miRNA 219 and miRNA Clusters 338 and 17-92 in Oligodendrocytes (2012) · cites this paper as Dugas et al., 2010
Expression profiling studies with rodent OLs have reported that several miR species are dramatically regulated during OPC differentiation.
“Expression profiling studies with rodent OLs have reported that several miR species are dramatically regulated during OPC differentiation (Lau et al., 2008; Budde et al., 2010; Dugas et al., 2010).”
From Regulation of miRNA 219 and miRNA Clusters 338 and 17-92 in Oligodendrocytes (2012) · cites this paper as Dugas et al., 2010
Disruptions in miRNA networks involving miR-219-5p, miR-338-5p, and miR-23a/b destabilize myelin maintenance, axonal metabolic support, and cytoskeletal integrity, contributing to early cognitive decline and impaired signal transmission in AD.
“The combined actions of miR-219-5p, miR-338-5p, and miR-23a/b highlight how disruptions in miRNA networks destabilize myelin maintenance, axonal metabolic support, and cytoskeletal integrity, contributing to early cognitive decline and impaired signal transmission in AD (Absalon et al., 2013; Dugas et al., 2010; Li et al., 2018; Lin et al., 2013; Qian et al., 2018).”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Dugas et al., 2010
miR-219-5p is the most consistently validated oligodendrocyte-enriched miRNA required for OPC differentiation and expression of mature myelin genes.
“Furthermore, miR-219-5p is the most consistently validated oligodendrocyte-enriched miRNA required for OPC differentiation and expression of mature myelin genes (Dugas et al., 2010).”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Dugas et al., 2010
Because miR-219-5p is required for oligodendrocyte maturation and expression of major myelin proteins, its loss impairs myelin maintenance and axonal support while simultaneously promoting tau pathology through de-repression of these kinases.
“Because miR-219-5p is required for oligodendrocyte maturation and expression of major myelin proteins, its loss impairs myelin maintenance and axonal support while simultaneously promoting tau pathology through de-repression of these kinases (Dugas et al., 2010; Li et al., 2018).”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Dugas et al., 2010
Restoring miR-219-5p enhances OL differentiation, preserves myelin integrity, and improves cognitive function.
“Restoring miR-219-5p enhances OL differentiation, preserves myelin integrity, and improves cognitive function (Dugas et al., 2010; Li et al., 2018).”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Dugas et al., 2010
Oligodendrocyte miRNAs, most prominently miR-219-5p and miR-338-5p, bridge myelin maintenance, OPC maturation, and tau-kinase or APP/BACE1 regulation, linking white-matter degeneration to classical AD pathology.
“Oligodendrocyte miRNAs, most prominently miR-219-5p and miR-338-5p, bridge myelin maintenance, OPC maturation, and tau-kinase or APP/BACE1 regulation, linking white-matter degeneration to classical AD pathology (Dugas et al., 2010; Li et al., 2018; Qian et al., 2018).”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Dugas et al., 2010
miR-219 and miR-338 are preferentially and abundantly expressed in mature oligodendrocytes.
“Among them, miR-219 and miR-338 are preferentially and abundantly expressed in mature OLs (Dugas et al., 2010; Lau et al., 2008; Zhao et al., 2010).”
From miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS (2017) · cites this paper as Dugas et al., 2010
In vitro culture studies suggest miR-219 is critical for OPC differentiation and acts through suppressing expression of OL differentiation inhibitors, including PDGFRα, Sox6, and Zfp238.
“In vitro culture studies suggest that miR-219 is critical for OPC differentiation and acts through suppressing expression of OL differentiation inhibitors, including PDGFRα, Sox6, and Zfp238, predicted by computational algorithms (Dugas et al., 2010; Zhao et al., 2010);”
From miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS (2017) · cites this paper as Dugas et al., 2010
miR-219 is mainly expressed in differentiated OL during development and adulthood.
“miR-219 is mainly expressed in differentiated OL during development and adulthood (Dugas et al., 2010; Zhao et al., 2010)”
From miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS (2017) · cites this paper as Dugas et al., 2010
PDGFRα is a miR-219 target.
“a miR-219 target PDGFRα (Dugas et al., 2010; Zhao et al., 2010)”
From miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS (2017) · cites this paper as Dugas et al., 2010
miR-338-3p induces maturation and differentiation of spinal cord oligodendrocyte precursors by repressing Sox5 and Hes6.
“MiR-338-3p is also expressed in spinal cord oligodendrocytes, where it exerts a related effect, inducing maturation and differentiation of precursors into mature oligodendrocytes by repressing Sox5 and Hes6, two maturation-inhibiting transcription factors [31, 32].”
From MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation. (2017) · cites this paper as [31]
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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
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- Authors
- Dugas, J. C., Cuellar, T. L., Scholze, A., Ason, B., Ibrahim, A., Emery, B., Zamanian, J. L., Foo, L. C., McManus, M. T., & Barres, B. A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 65
- Issue
- 5
- Pages
- 597-611
- ISSN
- 0896-6273
- PMC
- PMC2843397
- Cited by
- 527
- References
- 5
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1270 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Funders
- Myelin Repair Foundation
- National Institutes of Health (5R03DA022201)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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